| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Silvia Pavlová, Karolina Klucska, Dušan Vašíček, Ján Kotwica, Alexander V Sirotki. Transcription factor NF-κB (p50/p50, p65/p65) controls porcine ovarian cells functions. Animal reproduction science. vol 128. issue 1-4. 2012-03-01. PMID:21996578. |
the accumulation of proteins p50 and p65, as well as of proliferation markers (pcna and mapk/erk1,2) and marker of apoptosis (bax) in cells was detected by using sds-page-western immunoblotting and immunocytochemistry. |
2012-03-01 |
2023-08-12 |
human |
| B Saha, A Adhikary, P Ray, S Saha, S Chakraborty, S Mohanty, K Das, S Mukherjee, M Mazumdar, L Lahiri, D M S Hossain, G Sa, T Da. Restoration of tumor suppressor p53 by differentially regulating pro- and anti-p53 networks in HPV-18-infected cervical cancer cells. Oncogene. vol 31. issue 2. 2012-02-29. PMID:21765464. |
that restored p53 is functional has been confirmed by its ability of transactivating bax and p53-upregulated modulator of apoptosis, which in turn switch on the apoptotic machinery in these cells. |
2012-02-29 |
2023-08-12 |
human |
| Nitza Goldenberg-Cohen, Olga Dratviman-Storobinsky, Shimrit Dadon Bar El, Yelena Cheporko, Edith Hochhause. Protective effect of Bax ablation against cell loss in the retinal ganglion layer induced by optic nerve crush in transgenic mice. Journal of neuro-ophthalmology : the official journal of the North American Neuro-Ophthalmology Society. vol 31. issue 4. 2012-02-29. PMID:21799446. |
bax expression is a prerequisite for retinal ganglion cell (rgc) apoptosis. |
2012-02-29 |
2023-08-12 |
mouse |
| Jorge Luis Rosas-Trigueros, José Correa-Basurto, Claudia Guadalupe Benítez-Cardoza, Absalom Zamorano-Carrill. Insights into the structural stability of Bax from molecular dynamics simulations at high temperatures. Protein science : a publication of the Protein Society. vol 20. issue 12. 2012-02-29. PMID:21936009. |
bax is a member of the bcl-2 protein family that participates in mitochondrion-mediated apoptosis. |
2012-02-29 |
2023-08-12 |
Not clear |
| Shang H Lin, Meenu N Perera, Toan Nguyen, Debra Datskovskiy, Megan Miles, Marco Colombin. Bax forms two types of channels, one of which is voltage-gated. Biophysical journal. vol 101. issue 9. 2012-02-29. PMID:22067154. |
when activated, the proapoptotic protein bax permeabilizes the mitochondrial outer membrane, allowing the release of proteins into the cytosol and thus initiating the execution phase of apoptosis. |
2012-02-29 |
2023-08-12 |
Not clear |
| Meta Volcic, Sabine Karl, Bernd Baumann, Daniela Salles, Peter Daniel, Simone Fulda, Lisa Wiesmülle. NF-κB regulates DNA double-strand break repair in conjunction with BRCA1-CtIP complexes. Nucleic acids research. vol 40. issue 1. 2012-02-27. PMID:21908405. |
it was not mediated by the transcriptional nf-κb targets bcl2, bax or ku70, known for their dual roles in apoptosis and dsb repair. |
2012-02-27 |
2023-08-12 |
Not clear |
| Yilong Dong, Nan Yang, Yanyong Liu, Qing Li, Pingping Zu. The neuroprotective effects of phytoestrogen α-zearalanol on β-amyloid-induced toxicity in differentiated PC-12 cells. European journal of pharmacology. vol 670. issue 2-3. 2012-02-27. PMID:21946104. |
in addition, aβ₂₅₋₃₅ caused a significant cell apoptosis and increased apoptotic rate, accompanied by decreasing of bcl-2 expression and increasing bax, caspase-3 expression, pretreatment of the cells with α-zal or 17β-e2 ameliorated these changes induced by aβ₂₅₋₃₅. |
2012-02-27 |
2023-08-12 |
Not clear |
| Lin-Li Zhou, Zhi-Xiu Lin, Kwok-Pui Fung, Christopher H K Cheng, Chun-Tao Che, Ming Zhao, Shi-Hua Wu, Zhong Zu. Celastrol-induced apoptosis in human HaCaT keratinocytes involves the inhibition of NF-κB activity. European journal of pharmacology. vol 670. issue 2-3. 2012-02-27. PMID:21951963. |
in addition, western blot analysis revealed a significant augmentation in the protein expression of bax and attenuation in bcl-2, suggesting that the celastrol-induced apoptosis acts through both death receptor and mitochondrial pathways. |
2012-02-27 |
2023-08-12 |
human |
| Jieming Xie, Wenzhong Que, Huili Liu, Mei Liu, Aiqin Yang, Minghuang Che. Anti-proliferative effects of cucurmosin on human hepatoma HepG2 cells. Molecular medicine reports. vol 5. issue 1. 2012-02-27. PMID:21964700. |
our data indicate that cus has potential anticancer activity for human hepatoma, which can be attributed in part to its inhibition of proliferation and apoptosis, induced by decreasing the bcl-2:bax ratio and caspase-3 activation. |
2012-02-27 |
2023-08-12 |
mouse |
| Lixia Zhao, Feng He, Haiyang Liu, Yushan Zhu, Weili Tian, Ping Gao, Hongping He, Wen Yue, Xiaobo Lei, Biyun Ni, Xiaohui Wang, Haijing Jin, Xiaojiang Hao, Jialing Lin, Quan Che. Natural diterpenoid compound elevates expression of Bim protein, which interacts with antiapoptotic protein Bcl-2, converting it to proapoptotic Bax-like molecule. The Journal of biological chemistry. vol 287. issue 2. 2012-02-27. PMID:22065578. |
overwhelming evidence indicates that bax and bak are indispensable for mediating cytochrome c release from mitochondria during apoptosis. |
2012-02-27 |
2023-08-12 |
mouse |
| Lixia Zhao, Feng He, Haiyang Liu, Yushan Zhu, Weili Tian, Ping Gao, Hongping He, Wen Yue, Xiaobo Lei, Biyun Ni, Xiaohui Wang, Haijing Jin, Xiaojiang Hao, Jialing Lin, Quan Che. Natural diterpenoid compound elevates expression of Bim protein, which interacts with antiapoptotic protein Bcl-2, converting it to proapoptotic Bax-like molecule. The Journal of biological chemistry. vol 287. issue 2. 2012-02-27. PMID:22065578. |
therefore, the diterpenoid compound induces a structural and functional conversion of bcl-2 through bim to permeabilize the mitochondrial outer membrane, thereby inducing apoptosis independently of bax and bak. |
2012-02-27 |
2023-08-12 |
mouse |
| Suryakant K Niture, Anil K Jaiswa. Inhibitor of Nrf2 (INrf2 or Keap1) protein degrades Bcl-xL via phosphoglycerate mutase 5 and controls cellular apoptosis. The Journal of biological chemistry. vol 286. issue 52. 2012-02-27. PMID:22072718. |
further studies showed that overexpression of inrf2 enhanced degradation of pgam5-bcl-xl complex, led to etoposide-mediated accumulation of bax, increased release of cytochrome c from mitochondria, activated caspase-3/7, and enhanced dna fragmentation and apoptosis. |
2012-02-27 |
2023-08-12 |
Not clear |
| Suryakant K Niture, Anil K Jaiswa. Inhibitor of Nrf2 (INrf2 or Keap1) protein degrades Bcl-xL via phosphoglycerate mutase 5 and controls cellular apoptosis. The Journal of biological chemistry. vol 286. issue 52. 2012-02-27. PMID:22072718. |
in addition, antioxidant (tert-butylhydroquinone) treatment destabilized the nrf2-inrf2-pgam5-bcl-xl complex, which resulted in release of nrf2 in cytosol and mitochondria, release of bcl-xl in mitochondria, increase in bcl-xl heterodimerization with bax in mitochondria, and reduced cellular apoptosis. |
2012-02-27 |
2023-08-12 |
Not clear |
| Ying Wang, Arun K Rishi, Wenjuan Wu, Lisa Polin, Sunita Sharma, Edi Levi, Steven Albelda, Harvey I Pass, Anil Wal. Curcumin suppresses growth of mesothelioma cells in vitro and in vivo, in part, by stimulating apoptosis. Molecular and cellular biochemistry. vol 357. issue 1-2. 2012-02-24. PMID:21594647. |
curcumin activated the stress-activated p38 kinase, caspases 9 and 3, caused elevated levels of proapoptotic proteins bax, stimulated parp cleavage, and apoptosis. |
2012-02-24 |
2023-08-12 |
human |
| Jun Ying, Wei Yang, Chun-Ying Xie, Qin-Chun Ni, Xue-Diao Pan, Jin-Hua Dong, Zhi-Min Liu, Xi-Sha Wan. Induction of caspase-3-dependent apoptosis in human leukemia HL-60 cells by δ-elemene. Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan. vol 131. issue 9. 2012-02-24. PMID:21881314. |
during δ-elemene-induced apoptosis, cytochrome c and apoptosis-inducing factor were released into the cytosol and bax was translocated from the cytosol to mitochondria. |
2012-02-24 |
2023-08-12 |
human |
| Xiang-yong Li, Yiu-kay Lai, Jin-fang Zhang, Hai-qing Luo, Mei-hong Zhang, Ke-yuan Zhou, Hsiang-fu Kun. Lentivirus-mediated RNA interference targeting Bax inhibitor-1 suppresses ex vivo cell proliferation and in vivo tumor growth of nasopharyngeal carcinoma. Human gene therapy. vol 22. issue 10. 2012-02-21. PMID:21545297. |
bax inhibitor-1 (bi-1), an anti-apoptotic protein that belongs to the bcl-2 family, plays an important role in the mitochondrial apoptosis pathway to suppress bax-induced apoptosis. |
2012-02-21 |
2023-08-12 |
mouse |
| Zhao-Hui Pei, Bao-Ying Chen, Ru Tie, Hai-Feng Zhang, Ge Zhao, Ping Qu, Xiao-Xing Zhu, Miao-Zhang Zhu, Jun Y. Infrasound exposure induces apoptosis of rat cardiac myocytes by regulating the expression of apoptosis-related proteins. Cardiovascular toxicology. vol 11. issue 4. 2012-02-21. PMID:21773807. |
the expression of proapoptotic proteins such as bax, caspase-3, caspase-8, caspase-9, and fas was significantly up-regulated, with concomitant down-regulated expression of antiapoptotic proteins such as bcl-x, and the inhibitory apoptosis proteins family proteins including xiap, ciap-1, and ciap-2. |
2012-02-21 |
2023-08-12 |
rat |
| Kiyotada Watanabe, Syu-Ichi Kanno, Ayako Tomizawa, Shin Yomogida, Masaaki Ishikaw. Acacetin induces apoptosis in human T cell leukemia Jurkat cells via activation of a caspase cascade. Oncology reports. vol 27. issue 1. 2012-02-17. PMID:21993665. |
in addition, acacetin promoted the expression of faf1, phosphor-fadd, apaf-1 and cytochrome c. acacetin-induced apoptosis was also accompanied by upregulation of bax, and downregulation of bcl-2. |
2012-02-17 |
2023-08-12 |
human |
| Xi Zhang, Yao Liu, Ying-jian Si, Xing-hua Chen, Zhong-jun Li, Lei Gao, Li Gao, Cheng Zhan. Effect of Cx43 gene-modified leukemic bone marrow stromal cells on the regulation of Jurkat cell line in vitro. Leukemia research. vol 36. issue 2. 2012-02-16. PMID:22030334. |
furthermore, compared with leukemic cells alone, the proliferation and apoptosis of leukemic cells co-cultured with bmscs were inhibited, the percentage of g0-phase cells was higher; and expression of p53 increased and bax decreased. |
2012-02-16 |
2023-08-12 |
Not clear |
| Michael Wenzel, Michael Wunderlich, Robert Besch, Hendrik Poeck, Simone Willms, Astrid Schwantes, Melanie Kremer, Gerd Sutter, Stefan Endres, Andreas Schmidt, Simon Rothenfusse. Cytosolic DNA triggers mitochondrial apoptosis via DNA damage signaling proteins independently of AIM2 and RNA polymerase III. Journal of immunology (Baltimore, Md. : 1950). vol 188. issue 1. 2012-02-16. PMID:22140256. |
this cell death induced by foreign dna is independent of caspase-8 and carries features of mitochondrial apoptosis: dependence on bax, apaf-1, and caspase-9. |
2012-02-16 |
2023-08-12 |
mouse |