| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Yi Zhang, Ren-Xiong Wei, Xiao-Bin Zhu, Lin Cai, Wei Jin, Hao H. Tanshinone IIA induces apoptosis and inhibits the proliferation, migration, and invasion of the osteosarcoma MG-63 cell line in vitro. Anti-cancer drugs. vol 23. issue 2. 2012-05-31. PMID:22126901. |
furthermore, we detected possible molecular mechanisms for tan iia activity by examining the levels of bcl-2, bax expression, and caspase-3, caspase-8, and caspase-9 activities that regulate apoptosis, matrix metalloproteinase (mmp)-2, and mmp-9 involved in regulating migration and invasion. |
2012-05-31 |
2023-08-12 |
human |
| Kyung Hee Jung, Myung-Joo Choi, Seunghee Hong, Hyunseung Lee, Sang-Won Hong, Hong-Mei Zheng, Hee-Seung Lee, Sungwoo Hong, Soon-Sun Hon. HS-116, a novel phosphatidylinositol 3-kinase inhibitor induces apoptosis and suppresses angiogenesis of hepatocellular carcinoma through inhibition of the PI3K/AKT/mTOR pathway. Cancer letters. vol 316. issue 2. 2012-05-31. PMID:22182943. |
also, hs-116 induced apoptosis by increasing the proportion of sub-g1 apoptotic cells from 1.8% to 35% and increasing the expressions of bax, cleaved-caspase-3, and cleaved-parp as well as decreasing the expression of bcl-2. |
2012-05-31 |
2023-08-12 |
mouse |
| Zhi-Gang Liu, Li Liu, Li-Hua Xu, Wei Yi, Ya-Lan Tao, Zi-Wei Tu, Man-Zhi Li, Mu-Sheng Zeng, Yun-Fei Xi. Bmi-1 induces radioresistance in MCF-7 mammary carcinoma cells. Oncology reports. vol 27. issue 4. 2012-05-30. PMID:22209830. |
furthermore, bmi-1 knockdown induced loss of mitochondrial membrane potential and enhanced apoptosis by up-regulating p53, p21, bax expression and down-regulating p-akt and bcl-2 expression. |
2012-05-30 |
2023-08-12 |
human |
| Liana Cerioni, Mara Fiorani, Catia Azzolini, Orazio Canton. A moderate decline in U937 cell GSH levels triggers PI3 kinase/Akt-dependent Bad phosphorylation, thereby preventing an otherwise prompt apoptotic response. Pharmacological research. vol 65. issue 3. 2012-05-30. PMID:22214866. |
interestingly, inhibition of this pathway was associated with an unexpected delayed lethal response, preceded by the translocation and enforced accumulation of bad and bax in the mitochondrial compartment, prevented by inhibitors of mitochondrial permeability transition and characterized by morphological and biochemical features of apoptosis. |
2012-05-30 |
2023-08-12 |
Not clear |
| Elong Lin, Wen-Hsin Lin, Sheng-Yang Wang, Chih-Sheng Chen, Jiuun-Wang Liao, Hsueh-Wei Chang, Ssu-Ching Chen, Kai-Yuan Lin, Lai Wang, Hsin-Ling Yang, You-Cheng Hse. Flavokawain B inhibits growth of human squamous carcinoma cells: Involvement of apoptosis and cell cycle dysregulation in vitro and in vivo. The Journal of nutritional biochemistry. vol 23. issue 4. 2012-05-29. PMID:21543203. |
flavokawain b also down-regulate bcl-2 with concomitant increase in bax level, which resulted in release of cytochrome c. taken together, the induction of apoptosis by flavokawain b involved in both death receptor and mitochondrial pathway. |
2012-05-29 |
2023-08-12 |
mouse |
| Jessica Dal Col, Katy Mastorci, Damiana Antonia Faè, Elena Muraro, Debora Martorelli, Giorgio Inghirami, Riccardo Dolcett. Retinoic acid/alpha-interferon combination inhibits growth and promotes apoptosis in mantle cell lymphoma through Akt-dependent modulation of critical targets. Cancer research. vol 72. issue 7. 2012-05-24. PMID:22311672. |
furthermore, ra/ifn-α combination also induces apoptosis by triggering both caspases-8 and -9 resulting in bax and bak activation. |
2012-05-24 |
2023-08-12 |
Not clear |
| Piotr Pluta, Piotr Smolewski, Agnieszka Pluta, Barbara Cebula-Obrzut, Agnieszka Wierzbowska, Dariusz Nejc, Tadeusz Robak, Radzisław Kordek, Leszek Gottwald, Janusz Piekarski, Arkadiusz Jeziorsk. Significance of Bax expression in breast cancer patients. Polski przeglad chirurgiczny. vol 83. issue 10. 2012-05-23. PMID:22189282. |
bax protein, the proapoptotic member of bcl-2 protein family, plays the key role in apoptosis pathway. |
2012-05-23 |
2023-08-12 |
Not clear |
| S Giunta, A Castorina, S Scuderi, C Patti, V D'Agat. Epidermal growth factor receptor (EGFR) and neuregulin (Neu) activation in human airway epithelial cells exposed to nickel acetate. Toxicology in vitro : an international journal published in association with BIBRA. vol 26. issue 2. 2012-05-22. PMID:22210268. |
conversely, beas-2b cells exposed to equivalent concentrations of ni(2+) did not show evident signs of apoptosis and dna damage, hence showing increased expression and phosphorylation of both egfr and neu, increased bcl-2 and reduced bax expression. |
2012-05-22 |
2023-08-12 |
human |
| Fu Sheng Lin, Shi Qiang Shen, Zu Bing Chen, Rui Chen Ya. 17β-estradiol attenuates reduced-size hepatic ischemia/reperfusion injury by inhibition apoptosis via mitochondrial pathway in rats. Shock (Augusta, Ga.). vol 37. issue 2. 2012-05-21. PMID:22089190. |
apoptosis ratio; expression of cytochrome c, bcl-2, and bax proteins; and enzymatic activities of caspase 9 and caspase 3 were performed in the samples at 12 h after reperfusion. |
2012-05-21 |
2023-08-12 |
rat |
| Fu Sheng Lin, Shi Qiang Shen, Zu Bing Chen, Rui Chen Ya. 17β-estradiol attenuates reduced-size hepatic ischemia/reperfusion injury by inhibition apoptosis via mitochondrial pathway in rats. Shock (Augusta, Ga.). vol 37. issue 2. 2012-05-21. PMID:22089190. |
furthermore, e2 inhibited hepatocellular apoptosis by upregulating the ratio of bcl-2 and bax expression, reduced cytosolic cytochrome c level, and decreased caspase 9 and caspase 3 activities. |
2012-05-21 |
2023-08-12 |
rat |
| Avinash Appukuttan, Sascha A Kasseckert, Mustafa Micoogullari, Jan-Paul Flacke, Sanjeev Kumar, Alexandra Woste, Yaser Abdallah, Lutz Pott, H Peter Reusch, Yury Ladilo. Type 10 adenylyl cyclase mediates mitochondrial Bax translocation and apoptosis of adult rat cardiomyocytes under simulated ischaemia/reperfusion. Cardiovascular research. vol 93. issue 2. 2012-05-21. PMID:22106416. |
type 10 adenylyl cyclase mediates mitochondrial bax translocation and apoptosis of adult rat cardiomyocytes under simulated ischaemia/reperfusion. |
2012-05-21 |
2023-08-12 |
rat |
| Ossama Sharaf el dein, Cindy Gallerne, Catherine Brenner, Christophe Lemair. Increased expression of VDAC1 sensitizes carcinoma cells to apoptosis induced by DNA cross-linking agents. Biochemical pharmacology. vol 83. issue 9. 2012-05-21. PMID:22285227. |
the opening of ptp and subsequent apoptosis was reduced in bax deficient cells and in cells with elevated bcl-2 level, but not in cells invalidated for bak. |
2012-05-21 |
2023-08-12 |
Not clear |
| Gabriella Marfè, Marco Tafani, Filomena Fiorito, Ugo Pagnini, Giuseppe Iovane, Luisa De Martin. Involvement of FOXO transcription factors, TRAIL-FasL/Fas, and sirtuin proteins family in canine coronavirus type II-induced apoptosis. PloS one. vol 6. issue 11. 2012-05-18. PMID:22087287. |
furthermore, we found that virus infection increased both bax translocation into mitochondria and decreased bcl-2 expression in cytosol in a time-dependent manner.these data suggest that foxo transcription factors mediate pro-apoptotic effects of ccov-ii, in part due to activation of extrinsic apoptosis pathway, while some sirtuin family members (such as sirt3 and sirt4) may be involved in intrinsic apoptotic pathway. |
2012-05-18 |
2023-08-12 |
Not clear |
| Toshikage Nagao, Gaku Oshikawa, Nan Wu, Tetsuya Kurosu, Osamu Miur. DNA damage stress and inhibition of Jak2-V617F cause its degradation and synergistically induce apoptosis through activation of GSK3β. PloS one. vol 6. issue 11. 2012-05-18. PMID:22087308. |
studies with pharmacological inhibitors and genetic manipulations further showed that downregulation of the pi3k/akt pathway leading to the activation of gsk3β may be involved in downregulation of jak2 or jak2-v617f as well as in synergistic induction of bax activation and apoptosis. |
2012-05-18 |
2023-08-12 |
Not clear |
| Tripti Singh, Som D Sharma, Santosh K Katiya. Grape proanthocyanidins induce apoptosis by loss of mitochondrial membrane potential of human non-small cell lung cancer cells in vitro and in vivo. PloS one. vol 6. issue 11. 2012-05-18. PMID:22087318. |
here, we report that grape seed proanthocyanidins (gsps) induce apoptosis of nsclc cells, a549 and h1299, in vitro which is mediated through increased expression of pro-apoptotic protein bax, decreased expression of anti-apoptotic proteins bcl2 and bcl-xl, disruption of mitochondrial membrane potential, and activation of caspases 9, 3 and poly (adp-ribose) polymerase (parp). |
2012-05-18 |
2023-08-12 |
mouse |
| Sung Hee Jang, Joo Weon Lim, Tomohiro Morio, Hyeyoung Ki. Lycopene inhibits Helicobacter pylori-induced ATM/ATR-dependent DNA damage response in gastric epithelial AGS cells. Free radical biology & medicine. vol 52. issue 3. 2012-05-17. PMID:22178412. |
the results showed that h. pylori induced apoptosis in ags cells with increased bax and decreased bcl-2 expression as well as parp-1 cleavage. |
2012-05-17 |
2023-08-12 |
Not clear |
| Jing An, Wen Zou, Yufang Zhong, Xinyu Zhang, Minghong Wu, Zhiqiang Yu, Tianwen Y. The toxic effects of Aroclor 1254 exposure on the osteoblastic cell line MC3T3-E1 and its molecular mechanism. Toxicology. vol 295. issue 1-3. 2012-05-17. PMID:22406624. |
after aroclor 1254 exposure, the expression level of calcium transport related protein trpv6 was down-regulated, while the expression level of apoptosis related proteins apaf-1 and bax up-regulated in a dose dependant manner. |
2012-05-17 |
2023-08-12 |
Not clear |
| Yiyu Qin, Shenglai Zhang, Wei Gong, Jiyu Li, Jianguang Jia, Zhiwei Qua. Adenovirus-mediated gene transfer of tissue factor pathway inhibitor-2 inhibits gallbladder carcinoma growth in vitro and in vivo. Cancer science. vol 103. issue 4. 2012-05-16. PMID:22320835. |
apoptosis analysis and western blotting assay demonstrated that ad5-tfpi-2 could induce the apoptosis of both gbc cell lines and tissues by promoting the activities of cytochrome c, bax, caspase-3 and -9 and suppressing bcl-2 activity. |
2012-05-16 |
2023-08-12 |
Not clear |
| Lihong Fan, Xiaoqian Dang, Zhibin Shi, Chen Zhang, Kunzheng Wan. Hydroxysafflor yellow A protects PC12 cells against the apoptosis induced by oxygen and glucose deprivation. Cellular and molecular neurobiology. vol 31. issue 8. 2012-05-14. PMID:21688125. |
hoechst 33258 staining and flow cytometric analysis were used to detect apoptosis; western blotting was used to detect the expression of bcl-2, bax, and cytochrome c protein. |
2012-05-14 |
2023-08-12 |
rat |
| Daniela Impellizzeri, Emanuela Esposito, Emanuela Mazzon, Irene Paterniti, Rosanna Di Paola, Placido Bramanti, Valeria Maria Morittu, Antonio Procopio, Enzo Perri, Domenico Britti, Salvatore Cuzzocre. The effects of a polyphenol present in olive oil, oleuropein aglycone, in an experimental model of spinal cord injury in mice. Biochemical pharmacology. vol 83. issue 10. 2012-05-14. PMID:22342994. |
the treatment with oleuropein aglycone significantly decreased: (1) histological damage, (2) motor recovery, (3) nuclear factor (nf)-κb expression and ikb-α degradation, (4) protein kinase a (pka) activity and expression, (5) pro-inflammatory cytokines production such as tumor necrosis factor (tnf-α) and interleukin-1β (il-1β), 6) inducible nitric oxide synthase (inos) expression, (7) neutrophil infiltration, (8) lipid peroxidation, (9) nitrotyrosine and poly-adp-ribose (par) formation, (10) glial cell-derived neurotrophic factor (gdnf) levels, (11) apoptosis (tunel staining, fas ligand expression, caspase 3, bax and bcl-2 expression). |
2012-05-14 |
2023-08-12 |
mouse |