| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Jingchun Wang, Weifeng Ding, Baolan Sun, Rongrong Jing, Hua Huang, Gongsheng Shi, Huimin Wan. Targeting of colorectal cancer growth, metastasis, and anti-apoptosis in BALB/c nude mice via APRIL siRNA. Molecular and cellular biochemistry. vol 363. issue 1-2. 2012-07-02. PMID:22170570. |
meanwhile, pathological tools were utilized to observe the alterations on the aspects of proliferation, metastasis, apoptosis and cellular necrosis by means of detecting proliferating cell nuclear antigen, ki-67, mmp-2, mmp-9, timp-3, timp-4, bcl-2, bax and bcl-xl of crc. |
2012-07-02 |
2023-08-12 |
mouse |
| Naveen Muppani, Ulrika Nyman, Bertrand Josep. TAp73alpha protects small cell lung carcinoma cells from caspase-2 induced mitochondrial mediated apoptotic cell death. Oncotarget. vol 2. issue 12. 2012-06-29. PMID:22201672. |
here, we report that tap73alpha represses caspase-2 enzymatic activity and by this means reduce caspase-2 induced bax activation, loss of mitochondrial transmembrane potential and resulting apoptosis. |
2012-06-29 |
2023-08-12 |
Not clear |
| Yu-Xian Li, Zuo-Li Xia, Lian-Bi Chen, Wen-Jing Ye, Ming-Feng Yang, Qiao-Ling Su. [The changes of bcl-2, bax expression and neuron apoptosis in the hippocampus after the blockade of cervical lymphatics of rats]. Sheng li xue bao : [Acta physiologica Sinica]. vol 57. issue 1. 2012-06-28. PMID:15719136. |
[the changes of bcl-2, bax expression and neuron apoptosis in the hippocampus after the blockade of cervical lymphatics of rats]. |
2012-06-28 |
2023-08-12 |
rat |
| Yu-Xian Li, Zuo-Li Xia, Lian-Bi Chen, Wen-Jing Ye, Ming-Feng Yang, Qiao-Ling Su. [The changes of bcl-2, bax expression and neuron apoptosis in the hippocampus after the blockade of cervical lymphatics of rats]. Sheng li xue bao : [Acta physiologica Sinica]. vol 57. issue 1. 2012-06-28. PMID:15719136. |
to investigate the changes in bcl-2, bax expression and neuron apoptosis in the hippocampus after the blockade of cervical lymphatics, the model of lymphostatic encephalopathy was established by occluding and removing both the superficial and deep cervical lymph nodes in rats. |
2012-06-28 |
2023-08-12 |
rat |
| Yu-Xian Li, Zuo-Li Xia, Lian-Bi Chen, Wen-Jing Ye, Ming-Feng Yang, Qiao-Ling Su. [The changes of bcl-2, bax expression and neuron apoptosis in the hippocampus after the blockade of cervical lymphatics of rats]. Sheng li xue bao : [Acta physiologica Sinica]. vol 57. issue 1. 2012-06-28. PMID:15719136. |
these results suggest that lymphostatic encephalopathy following the blockade of cervical lymphatics result in changes in bcl-2 and bax expression in the hippocampus and that apoptosis is the main form of neuron death. |
2012-06-28 |
2023-08-12 |
rat |
| Yi-Fen Wang, Huey-Wen Shyu, Yi-Chuang Chang, Wei-Chang Tseng, Yeou-Lih Huang, Kuan-Hua Lin, Miao-Chen Chou, Heng-Ling Liu, Chang-Yu Che. Nickel (II)-induced cytotoxicity and apoptosis in human proximal tubule cells through a ROS- and mitochondria-mediated pathway. Toxicology and applied pharmacology. vol 259. issue 2. 2012-06-28. PMID:22245127. |
cell apoptosis triggered by nickel (ii) was characterized by the reduced protein expression of bcl-2 and bcl-xl and the induced the protein expression of bad, bcl-xs, bax, cytochrome c and caspases 9, 3 and 6. |
2012-06-28 |
2023-08-12 |
human |
| Ali M Sharifi, Sayeh Mottagh. Finasteride as a potential tool to improve mesenchymal stem cell transplantation for myocardial infarction. Medical hypotheses. vol 78. issue 4. 2012-06-28. PMID:22289340. |
this pathway could lead to decreased apoptosis of the mscs via increasing the expression of bcl-2 and reducing bax expression. |
2012-06-28 |
2023-08-12 |
Not clear |
| Y-L Zhu, J Cen, Y-Y Zhang, Y-D Feng, Y Yang, Y-M Li, W-L Huan. The multidrug resistant modulator HZ08 reverses multidrug resistance via P-glycoprotein inhibition and apoptosis sensitization in human epidermoid carcinoma cell line KBV200. Arzneimittel-Forschung. vol 62. issue 5. 2012-06-28. PMID:22344570. |
further studies revealed that hz08 increased vincristine-induced apoptosis, characterized as an intrinsic apoptosis pathway with enhanced g2/m phase arrest, since hz08 had an effect on the intrinsic apoptotic regulator bcl-2 and bax. |
2012-06-28 |
2023-08-12 |
human |
| Yufeng Xie, Haitao Lv, Weihua Sheng, Jingcheng Miao, Jim Xiang, Jicheng Yan. Synergistic tumor suppression by adenovirus-mediated inhibitor of growth 4 and interleukin-24 gene cotransfer in hepatocarcinoma cells. Cancer biotherapy & radiopharmaceuticals. vol 26. issue 6. 2012-06-26. PMID:21988227. |
it was demonstrated that ad-ing4-il-24 induced synergistic growth inhibition, apoptosis, invasion suppression, as well as an enhanced effect on upregulation of p21, p27, fas, fasl, fadd, bad, bax, bak, cleaved bid, cleaved caspase-8, -9, and -3, and cleaved parp, downregulation of bcl-2, bcl-x(l), matrix metalloproteinase (mmp)-2, 9, vascular endothelial growth factor (vegf), il-8, cd34, and microvessel density, and cytochrome c release from mitochondria into cytosol in in vitro smmc-7721 and hepg2 hepatocarcinoma cells and/or in vivo smmc-7721 hepatocarcinoma subcutaneous xenografted tumors in athymic nude mice. |
2012-06-26 |
2023-08-12 |
mouse |
| Yanna Ma, Aihua Zhang, Zhiyu Shi, Chenghua He, Jujing Ding, Xichun Wang, Jifei Ma, Haibin Zhan. A mitochondria-mediated apoptotic pathway induced by deoxynivalenol in human colon cancer cells. Toxicology in vitro : an international journal published in association with BIBRA. vol 26. issue 3. 2012-06-26. PMID:22269384. |
to this aim, we have monitored the effects of don on (i) cellular morphological changes via optical and transmission electron microscopy, especially in regards to cell viability and mitochondria changes, and (ii) its effects on key regulators of cell apoptosis, including cytochrome c, caspase-9, caspase-3, bcl-2, bax, and bid. |
2012-06-26 |
2023-08-12 |
human |
| Derek Wakeman, Jun Guo, Jethrina A Santos, Wambui S Wandu, John E Schneider, Mark E McMellen, Jennifer A Leinicke, Christopher R Erwin, Brad W Warne. p38 MAPK regulates Bax activity and apoptosis in enterocytes at baseline and after intestinal resection. American journal of physiology. Gastrointestinal and liver physiology. vol 302. issue 9. 2012-06-25. PMID:22383494. |
p38 mapk regulates bax activity and apoptosis in enterocytes at baseline and after intestinal resection. |
2012-06-25 |
2023-08-12 |
mouse |
| Derek Wakeman, Jun Guo, Jethrina A Santos, Wambui S Wandu, John E Schneider, Mark E McMellen, Jennifer A Leinicke, Christopher R Erwin, Brad W Warne. p38 MAPK regulates Bax activity and apoptosis in enterocytes at baseline and after intestinal resection. American journal of physiology. Gastrointestinal and liver physiology. vol 302. issue 9. 2012-06-25. PMID:22383494. |
expression of the proapoptotic factor bax has been shown to be required for resection-induced apoptosis. |
2012-06-25 |
2023-08-12 |
mouse |
| Derek Wakeman, Jun Guo, Jethrina A Santos, Wambui S Wandu, John E Schneider, Mark E McMellen, Jennifer A Leinicke, Christopher R Erwin, Brad W Warne. p38 MAPK regulates Bax activity and apoptosis in enterocytes at baseline and after intestinal resection. American journal of physiology. Gastrointestinal and liver physiology. vol 302. issue 9. 2012-06-25. PMID:22383494. |
it has also been demonstrated that p38-α mapk (p38) is necessary for bax activation and apoptosis in vitro. |
2012-06-25 |
2023-08-12 |
mouse |
| Derek Wakeman, Jun Guo, Jethrina A Santos, Wambui S Wandu, John E Schneider, Mark E McMellen, Jennifer A Leinicke, Christopher R Erwin, Brad W Warne. p38 MAPK regulates Bax activity and apoptosis in enterocytes at baseline and after intestinal resection. American journal of physiology. Gastrointestinal and liver physiology. vol 302. issue 9. 2012-06-25. PMID:22383494. |
p38-regulated bax activation appears to be an important mechanism underlying resection-induced apoptosis. |
2012-06-25 |
2023-08-12 |
mouse |
| Chi-Tai Yeh, Yerra Koteswara Rao, Min Ye, Wen-Shi Wu, Tung-Chen Chang, Liang-Shun Wang, Chih-Hsiung Wu, Alexander T H Wu, Yew-Min Tzen. Preclinical evaluation of destruxin B as a novel Wnt signaling target suppressing proliferation and metastasis of colorectal cancer using non-invasive bioluminescence imaging. Toxicology and applied pharmacology. vol 261. issue 1. 2012-06-25. PMID:22465936. |
additionally, db induced apoptosis in ht29 cells by decreased expression level of anti-apoptotic proteins bcl-2 and bcl-xl while increased pro-apoptotic bax. |
2012-06-25 |
2023-08-12 |
mouse |
| Yukari Yoshihara, Dan Wu, Natsumi Kubo, Meixiang Sang, Akira Nakagawara, Toshinori Ozak. Inhibitory role of E2F-1 in the regulation of tumor suppressor p53 during DNA damage response. Biochemical and biophysical research communications. vol 421. issue 1. 2012-06-22. PMID:22480684. |
importantly, sirna-mediated knockdown of e2f-1 stimulated apoptosis in response to adr, which was associated with an accelerated response of p21(waf1) and bax. |
2012-06-22 |
2023-08-12 |
Not clear |
| Qian Qi, Weishan Huang, Yuting Bai, Gabriel Balmus, Robert S Weiss, Avery Augus. A unique role for ITK in survival of invariant NKT cells associated with the p53-dependent pathway in mice. Journal of immunology (Baltimore, Md. : 1950). vol 188. issue 8. 2012-06-21. PMID:22403441. |
in contrast, the increased apoptosis observed in itk(-/-) splenic inkt cells is not affected by txk overexpression, likely due to the lack of effect on the elevated expression of p53 regulated proapoptotic pathways fas, bax, and bad in those cells. |
2012-06-21 |
2023-08-12 |
mouse |
| Nai-Jia Huang, Liguo Zhang, Wanli Tang, Chen Chen, Chih-Sheng Yang, Sally Kornblut. The Trim39 ubiquitin ligase inhibits APC/CCdh1-mediated degradation of the Bax activator MOAP-1. The Journal of cell biology. vol 197. issue 3. 2012-06-21. PMID:22529100. |
it was previously reported that modulator of apoptosis protein 1 (moap-1), an enhancer of bax activation induced by dna damage, is stabilized by trim39, a protein of unknown function. |
2012-06-21 |
2023-08-12 |
Not clear |
| Nai-Jia Huang, Liguo Zhang, Wanli Tang, Chen Chen, Chih-Sheng Yang, Sally Kornblut. The Trim39 ubiquitin ligase inhibits APC/CCdh1-mediated degradation of the Bax activator MOAP-1. The Journal of cell biology. vol 197. issue 3. 2012-06-21. PMID:22529100. |
accordingly, small interfering ribonucleic acid-mediated knockdown of cdh1 stabilized moap-1, thereby enhancing etoposide-induced bax activation and apoptosis. |
2012-06-21 |
2023-08-12 |
Not clear |
| Chun Gao, Wen-Juan Guo, Ai-Ying Wan. Significance of decreased apoptosis, role of Bid expression and Bcl-Xl/Bid ratio in human jejunal stromal tumors. APMIS : acta pathologica, microbiologica, et immunologica Scandinavica. vol 120. issue 3. 2012-06-19. PMID:22339673. |
given that the studies on human small intestinal stromal tumors are very limited, our study was designed to determine the significance of apoptosis, the role of some apoptosis-related proteins, including bax, bad, bid, bcl-2, bcl-xl, and bcl-w, in jejunal stromal tumors (jst). |
2012-06-19 |
2023-08-12 |
human |