| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Annika Müer, Tim Overkamp, Bernd Gillissen, Antje Richter, Thomas Pretzsch, Ana Milojkovic, Bernd Dörken, Peter T Daniel, Philipp Hemmat. p14(ARF)-induced apoptosis in p53 protein-deficient cells is mediated by BH3-only protein-independent derepression of Bak protein through down-regulation of Mcl-1 and Bcl-xL proteins. The Journal of biological chemistry. vol 287. issue 21. 2012-07-23. PMID:22354970. |
vice versa, knockdown of bak by rna interference attenuates p14(arf)-induced apoptosis, whereas down-regulation of bax has no effect. |
2012-07-23 |
2023-08-12 |
Not clear |
| Annika Müer, Tim Overkamp, Bernd Gillissen, Antje Richter, Thomas Pretzsch, Ana Milojkovic, Bernd Dörken, Peter T Daniel, Philipp Hemmat. p14(ARF)-induced apoptosis in p53 protein-deficient cells is mediated by BH3-only protein-independent derepression of Bak protein through down-regulation of Mcl-1 and Bcl-xL proteins. The Journal of biological chemistry. vol 287. issue 21. 2012-07-23. PMID:22354970. |
taken together, these data indicate that in the absence of functional p53 and bax, p14(arf) triggers mitochondrial apoptosis signaling by activating bak, which is facilitated by down-regulating anti-apoptotic mcl-1 and bcl-x(l). |
2012-07-23 |
2023-08-12 |
Not clear |
| Lalita Sharma, Jagdeep Kaur, Geeta Shukl. Role of oxidative stress and apoptosis in the placental pathology of Plasmodium berghei infected mice. PloS one. vol 7. issue 3. 2012-07-23. PMID:22396790. |
interestingly, it was observed that there was down regulation of anti-apoptotic protein bcl-2 and up regulation of pro-apoptotic protein bax in infected placenta, suggesting the involvement of mitochondrial pathway of apoptosis which was further confirmed by activation of caspase 9. |
2012-07-23 |
2023-08-12 |
mouse |
| Pedro Eitz Ferrer, Paul Frederick, Jacqueline M Gulbis, Grant Dewson, Ruth M Kluc. Translocation of a Bak C-terminus mutant from cytosol to mitochondria to mediate cytochrome C release: implications for Bak and Bax apoptotic function. PloS one. vol 7. issue 3. 2012-07-23. PMID:22442658. |
one of two proapoptotic bcl-2 proteins, bak or bax, is required to permeabilize the mitochondrial outer membrane during apoptosis. |
2012-07-23 |
2023-08-12 |
Not clear |
| Pedro Eitz Ferrer, Paul Frederick, Jacqueline M Gulbis, Grant Dewson, Ruth M Kluc. Translocation of a Bak C-terminus mutant from cytosol to mitochondria to mediate cytochrome C release: implications for Bak and Bax apoptotic function. PloS one. vol 7. issue 3. 2012-07-23. PMID:22442658. |
in addition, whether the distinct subcellular distributions of bak and bax contributes to their differential regulation during apoptosis remains unclear. |
2012-07-23 |
2023-08-12 |
Not clear |
| Farasat Zaman, Dionisios Chrysis, Kirsten Huntjens, Bengt Fadeel, Lars Sävendah. Ablation of the pro-apoptotic protein Bax protects mice from glucocorticoid-induced bone growth impairment. PloS one. vol 7. issue 3. 2012-07-23. PMID:22442678. |
here, we hypothesized that bax, a pro-apoptotic member of the bcl-2 family, plays a key role in dexa-induced chondrocyte apoptosis and bone growth impairment. |
2012-07-23 |
2023-08-12 |
mouse |
| Farasat Zaman, Dionisios Chrysis, Kirsten Huntjens, Bengt Fadeel, Lars Sävendah. Ablation of the pro-apoptotic protein Bax protects mice from glucocorticoid-induced bone growth impairment. PloS one. vol 7. issue 3. 2012-07-23. PMID:22442678. |
indeed, experiments in the human hcs-2/8 chondrocytic cell line demonstrated that silencing of bax expression using small-interfering (si) rna efficiently blocked dexa-induced apoptosis. |
2012-07-23 |
2023-08-12 |
mouse |
| Nishant Mohan, Naren L Banik, Swapan K Ra. Synergistic efficacy of a novel combination therapy controls growth of Bcl-x(L) bountiful neuroblastoma cells by increasing differentiation and apoptosis. Cancer biology & therapy. vol 12. issue 9. 2012-07-20. PMID:21878749. |
protein gel blotting manifested that combination therapy increased apoptosis with downregulation of the anti-apoptotic proteins bcl-x(l), bcl-2 and mcl-1 and upregulation of the pro-apoptotic proteins bax, p53, puma (p53 upregulated modulator of apoptosis), and noxa, ultimately causing activation of caspase-3. |
2012-07-20 |
2023-08-12 |
human |
| Lymor Ringer, Paul Sirajuddin, Mary Heckler, Anup Ghosh, Frank Suprynowicz, Venkata M Yenugonda, Milton L Brown, Jeffrey A Toretsky, Aykut Uren, YiChien Lee, Tobey J MacDonald, Olga Rodriguez, Robert I Glazer, Richard Schlegel, Chris Albanes. VMY-1-103 is a novel CDK inhibitor that disrupts chromosome organization and delays metaphase progression in medulloblastoma cells. Cancer biology & therapy. vol 12. issue 9. 2012-07-20. PMID:21885916. |
vmy-1-103 increased the sub g(1) fraction of apoptotic cells, induced parp and caspase-3 cleavage and increased the levels of the death receptors dr4 and dr5, bax and bad while decreasing the number of viable cells, all supporting apoptosis as a mechanism of cell death. |
2012-07-20 |
2023-08-12 |
Not clear |
| Karuppaiyah Selvendiran, Shabnam Ahmed, Alex Dayton, M Lakshmi Kuppusamy, Brian K Rivera, Tamás Kálai, Kálmán Hideg, Periannan Kuppusam. HO-3867, a curcumin analog, sensitizes cisplatin-resistant ovarian carcinoma, leading to therapeutic synergy through STAT3 inhibition. Cancer biology & therapy. vol 12. issue 9. 2012-07-20. PMID:21885917. |
apoptosis was induced by activation of bax, cytochrome c release, and stimulated cleavage of caspase-9, caspase-3, and parp. |
2012-07-20 |
2023-08-12 |
mouse |
| Krishnamurthy Kavitha, Ramamurthi Vidya Priyadarsini, Prabukumar Anitha, Krishnan Ramalingam, Ramasamy Sakthivel, Gempuraj Purushothaman, Abhishek Kumar Singh, Devarajan Karunagaran, Siddavaram Nagin. Nimbolide, a neem limonoid abrogates canonical NF-κB and Wnt signaling to induce caspase-dependent apoptosis in human hepatocarcinoma (HepG2) cells. European journal of pharmacology. vol 681. issue 1-3. 2012-07-20. PMID:22327045. |
the objective of this study was to investigate the effect of nimbolide, a neem derived tetranortriterpenoid on nf-κb signaling and its downstream events - wnt/β-catenin activation and apoptosis evasion in human hepatocarcinoma (hepg2) cells by evaluating nf-κb family members (nf-κb-p50, p65, iκb-α, p-iκb-α, and ikkβ), members of wnt signaling (gsk-3β and β-catenin), and intrinsic apoptosis (bcl-2, bax, cytochrome c, smac/diablo, caspase-3, and caspase-9). |
2012-07-20 |
2023-08-12 |
human |
| Mi H Kwack, Moon K Kim, Jung C Kim, Young K Sun. Dickkopf 1 promotes regression of hair follicles. The Journal of investigative dermatology. vol 132. issue 6. 2012-07-17. PMID:22358062. |
moreover, we observed that rhdkk-1 blocks canonical wnt-mediated activation of β-catenin signaling and induces the proapoptotic protein bax, resulting in apoptosis in outer root sheath keratinocytes. |
2012-07-17 |
2023-08-12 |
mouse |
| Zhaocai Li, Xingang Xu, Yong Huang, Li Ding, Zhisheng Wang, Gaoshui Yu, Dan Xu, Wei Li, Dewen Ton. Swainsonine activates mitochondria-mediated apoptotic pathway in human lung cancer A549 cells and retards the growth of lung cancer xenografts. International journal of biological sciences. vol 8. issue 3. 2012-07-17. PMID:22393311. |
further studies showed that sw treatment up-regulated bax, down-regulated bcl-2 expression, promoted bax translocation to mitochondria, activated mitochondria-mediated apoptotic pathway, which in turn caused the release of cytochrome c, the activation of caspase-9 and caspase-3, and the cleavage of poly (adp-ribose) polymerase (parp), resulting in a549 cell apoptosis. |
2012-07-17 |
2023-08-12 |
mouse |
| Yan Sun, Yuan Lin, Hong Li, Jin Liu, Xiaohua Sheng, Wenchang Zhan. 2,5-Hexanedione induces human ovarian granulosa cell apoptosis through BCL-2, BAX, and CASPASE-3 signaling pathways. Archives of toxicology. vol 86. issue 2. 2012-07-16. PMID:21901545. |
2,5-hexanedione induces human ovarian granulosa cell apoptosis through bcl-2, bax, and caspase-3 signaling pathways. |
2012-07-16 |
2023-08-12 |
human |
| Yan Sun, Yuan Lin, Hong Li, Jin Liu, Xiaohua Sheng, Wenchang Zhan. 2,5-Hexanedione induces human ovarian granulosa cell apoptosis through BCL-2, BAX, and CASPASE-3 signaling pathways. Archives of toxicology. vol 86. issue 2. 2012-07-16. PMID:21901545. |
these results suggest that the mechanisms of 2,5-hd causing increased apoptosis in human ovarian granulosa cells might be through bcl-2, bax, and caspase-3 signaling pathways. |
2012-07-16 |
2023-08-12 |
human |
| Julia Donauer, Ilona Schreck, Urban Liebel, Carsten Weis. Role and interaction of p53, BAX and the stress-activated protein kinases p38 and JNK in benzo(a)pyrene-diolepoxide induced apoptosis in human colon carcinoma cells. Archives of toxicology. vol 86. issue 2. 2012-07-16. PMID:21983885. |
role and interaction of p53, bax and the stress-activated protein kinases p38 and jnk in benzo(a)pyrene-diolepoxide induced apoptosis in human colon carcinoma cells. |
2012-07-16 |
2023-08-12 |
human |
| Julia Donauer, Ilona Schreck, Urban Liebel, Carsten Weis. Role and interaction of p53, BAX and the stress-activated protein kinases p38 and JNK in benzo(a)pyrene-diolepoxide induced apoptosis in human colon carcinoma cells. Archives of toxicology. vol 86. issue 2. 2012-07-16. PMID:21983885. |
in addition, we identify bax as a novel and essential factor to trigger the intrinsic pathway of apoptosis in response to bpde. |
2012-07-16 |
2023-08-12 |
human |
| Gunasekaran Sivagami, Rajamanickam Vinothkumar, Roberta Bernini, Christo Paul Preethy, Anvarbatcha Riyasdeen, Mohammad Abdulkader Akbarsha, Venugopal Padmanaban Menon, Namasivayam Nalin. Role of hesperetin (a natural flavonoid) and its analogue on apoptosis in HT-29 human colon adenocarcinoma cell line--a comparative study. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association. vol 50. issue 3-4. 2012-07-16. PMID:22142698. |
results of western blot analysis of apoptosis associated genes revealed an increase in cytochrome c, bax, cleaved caspase-3 expression and a decrease in bcl-2 expression. |
2012-07-16 |
2023-08-12 |
human |
| Gunasekaran Sivagami, Rajamanickam Vinothkumar, Roberta Bernini, Christo Paul Preethy, Anvarbatcha Riyasdeen, Mohammad Abdulkader Akbarsha, Venugopal Padmanaban Menon, Namasivayam Nalin. Role of hesperetin (a natural flavonoid) and its analogue on apoptosis in HT-29 human colon adenocarcinoma cell line--a comparative study. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association. vol 50. issue 3-4. 2012-07-16. PMID:22142698. |
these findings indicate that hn and ha induce apoptosis on ht-29 via bax dependent mitochondrial pathway involving oxidant/antioxidant imbalance. |
2012-07-16 |
2023-08-12 |
human |
| Zhiwei Zhao, Jingjing Wang, Jingsheng Tang, Xinyu Liu, Qian Zhong, Fang Wang, Wenbin Hu, Zhu Yuan, Chunlai Nie, Yuquan We. JNK- and Akt-mediated Puma expression in the apoptosis of cisplatin-resistant ovarian cancer cells. The Biochemical journal. vol 444. issue 2. 2012-07-13. PMID:22394200. |
the reduction of puma expression inhibits bax activation and apoptosis. |
2012-07-13 |
2023-08-12 |
Not clear |