| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Yang Liu, Luwei Zhang, Hong Zhang, Bin Liu, Zhenhua Wu, Weiping Zhao, Zhenhua Wan. Exogenous melatonin modulates apoptosis in the mouse brain induced by high-LET carbon ion irradiation. Journal of pineal research. vol 52. issue 1. 2012-06-18. PMID:21812816. |
in irradiated mice, a significant rise in oxidative stress and apoptosis (tunel positive) was accompanied by activated expression of bax, cytochrome c, caspase-3, and decreased ΔΨm level. |
2012-06-18 |
2023-08-12 |
mouse |
| Philipp Baumann, Laura Schneider, Sonja Mandl-Weber, Fuat Oduncu, Ralf Schmidmaie. Simultaneous targeting of PI3K and mTOR with NVP-BGT226 is highly effective in multiple myeloma. Anti-cancer drugs. vol 23. issue 1. 2012-06-18. PMID:21959532. |
induction of apoptosis was accompanied by upregulation of proapoptotic bim and a moderate upregulation of mcl-1 and bad and a downregulation of bcl-2, bax and bcl-xl. |
2012-06-18 |
2023-08-12 |
Not clear |
| Tracey S Hanks, Katherine A Gaus. Pleomorphic adenoma gene-like 2 regulates expression of the p53 family member, p73, and induces cell cycle block and apoptosis in human promonocytic U937 cells. Apoptosis : an international journal on programmed cell death. vol 17. issue 3. 2012-06-18. PMID:22076304. |
there was significant increase in the p53 homologue, p73, with plagl2 expression, and consistent with mechanisms of p73-regulated cell cycle control and apoptosis, there was increased expression of known p73 target genes p21, dr5, trail, and bax. |
2012-06-18 |
2023-08-12 |
human |
| Nathaniel Edward Bennett Saidu, Sergio Valente, Emilie Bana, Gilbert Kirsch, Denyse Bagrel, Mathias Montenar. Coumarin polysulfides inhibit cell growth and induce apoptosis in HCT116 colon cancer cells. Bioorganic & medicinal chemistry. vol 20. issue 4. 2012-06-18. PMID:22264758. |
a decrease in bcl-2 level, and increase in the level of bax, cytochrome c release into the cytosol, cleavage of caspase 3/7and parp suggested that coumarin polysulfides induced the intrinsic pathway of apoptosis. |
2012-06-18 |
2023-08-12 |
Not clear |
| Guanghui Wang, Xiaoyu Guo, Haifeng Chen, Ting Lin, Yang Xu, Quancheng Chen, Jie Liu, Jinzhang Zeng, Xiao-Kun Zhang, Xinsheng Ya. A resveratrol analog, phoyunbene B, induces G2/M cell cycle arrest and apoptosis in HepG2 liver cancer cells. Bioorganic & medicinal chemistry letters. vol 22. issue 5. 2012-06-18. PMID:22326393. |
induction of g2/m phase cell cycle arrest by pyb was associated with its up-regulation of cyclin b1, while its induction of apoptosis was accompanied with its down-regulation of bcl-2 and up-regulation of bax. |
2012-06-18 |
2023-08-12 |
Not clear |
| Tai-Long Pan, Pei-Wen Wang, Yann-Lii Leu, Tung-Ho Wu, Tian-Shung W. Inhibitory effects of Scutellaria baicalensis extract on hepatic stellate cells through inducing G2/M cell cycle arrest and activating ERK-dependent apoptosis via Bax and caspase pathway. Journal of ethnopharmacology. vol 139. issue 3. 2012-06-13. PMID:22210104. |
inhibitory effects of scutellaria baicalensis extract on hepatic stellate cells through inducing g2/m cell cycle arrest and activating erk-dependent apoptosis via bax and caspase pathway. |
2012-06-13 |
2023-08-12 |
Not clear |
| Eun-Ryeong Hahm, Shivendra V Sing. Bim contributes to phenethyl isothiocyanate-induced apoptosis in breast cancer cells. Molecular carcinogenesis. vol 51. issue 6. 2012-06-12. PMID:21739479. |
on the other hand, a non-tumorigenic human mammary epithelial cell line (mcf-10a) was significantly more resistant to peitc-induced apoptosis compared with bri-jm04 despite induction of bax and puma due to concomitant overexpression of anti-apoptotic proteins, including bcl-xl, bcl-2, and mcl-1. |
2012-06-12 |
2023-08-12 |
mouse |
| Sandra Vogel, Nina Raulf, Stephanie Bregenhorn, Martin L Biniossek, Ulrich Maurer, Peter Czabotar, Christoph Borne. Cytosolic Bax: does it require binding proteins to keep its pro-apoptotic activity in check? The Journal of biological chemistry. vol 287. issue 12. 2012-06-12. PMID:22277657. |
however, this protein could not be validated as a crucial inhibitory bax binding partner as its over- or underexpression did not show any apoptosis defects. |
2012-06-12 |
2023-08-12 |
Not clear |
| Xue Shao, Zhengtao Hu, Chunyan Hu, Qian Bu, Guangyan Yan, Pengchi Deng, Lei Lv, Dan Wu, Yi Deng, Jinxuan Zhao, Ruiming Zhu, Yan Li, Hongyu Li, Youzhi Xu, Hanshuo Yang, Yinglan Zhao, Xiaobo Ce. Taurine protects methamphetamine-induced developmental angiogenesis defect through antioxidant mechanism. Toxicology and applied pharmacology. vol 260. issue 3. 2012-06-12. PMID:22426360. |
dysregulations of nf-κb, p-erk as well as bax, which reflect apoptosis, cell cycle arrest and oxidative stress in vascular endothelium, were blocked by taurine. |
2012-06-12 |
2023-08-12 |
human |
| S-C DU, Q-M Ge, N Lin, Y Dong, Q S. ROS-mediated lipopolysaccharide-induced apoptosis in INS-1 cells by modulation of Bcl-2 and Bax. Cellular and molecular biology (Noisy-le-Grand, France). vol 58 Suppl. 2012-06-12. PMID:22455982. |
ros-mediated lipopolysaccharide-induced apoptosis in ins-1 cells by modulation of bcl-2 and bax. |
2012-06-12 |
2023-08-12 |
rat |
| Min Wang, Shuo Chen, Shuai Wang, Defeng Sun, Jian Chen, Yanqing Li, Wei Han, Xiaoyun Yang, Hai-Qing Ga. Effects of phytochemicals sulforaphane on uridine diphosphate-glucuronosyltransferase expression as well as cell-cycle arrest and apoptosis in human colon cancer Caco-2 cells. The Chinese journal of physiology. vol 55. issue 2. 2012-06-12. PMID:22559738. |
75 μm, sfn caused g1/g2 cell cycle arrest and induced apoptosis possibly through reducing anti-apoptotic bcl-2 expression and increasing apoptosis-inducing bax expression in caco-2 cells. |
2012-06-12 |
2023-08-12 |
human |
| Yan Zhang, Guoquan Zhang, Laura R Hendrix, Vernon L Tesh, James E Samue. Coxiella burnetii induces apoptosis during early stage infection via a caspase-independent pathway in human monocytic THP-1 cells. PloS one. vol 7. issue 1. 2012-06-11. PMID:22303462. |
these data suggest that nmii infection induced caspase-independent apoptosis through a mechanism involving cytochrome c release, cytosol-to-mitochondrial translocation of bax and nuclear translocation of aif in thp-1 monocytes. |
2012-06-11 |
2023-08-12 |
human |
| Yuquan Lin, Ti Wen, Xianyi Meng, Zhenzhou Wu, Liqing Zhao, Puyue Wang, Zhangyong Hong, Zhinan Yi. The mouse Mageb18 gene encodes a ubiquitously expressed type I MAGE protein and regulates cell proliferation and apoptosis in melanoma B16-F0 cells. The Biochemical journal. vol 443. issue 3. 2012-06-08. PMID:22332604. |
finally, we demonstrate that knockdown of mageb18 inhibits the growth of b16-f0 cells and induces apoptosis, which correlates with increased levels of tp53 (tumour protein 53), p21, bax and caspase 3. |
2012-06-08 |
2023-08-12 |
mouse |
| You Song, Brit Salbu, Lene Sørlie Heier, Hans-Christian Teien, Ole-Christian Lind, Deborah Oughton, Karina Petersen, Bjørn Olav Rosseland, Lindis Skipperud, Knut Erik Tollefse. Early stress responses in Atlantic salmon (Salmo salar) exposed to environmentally relevant concentrations of uranium. Aquatic toxicology (Amsterdam, Netherlands). vol 112-113. 2012-06-08. PMID:22366426. |
the hepatic transcriptional level of 12 biomarker genes from four stress-response categories, including oxidative stress (γ-glutamyl cysteine synthetase (gcs), glutathione reductase (gr), glutathione peroxidase (gpx)), dna damage and repair (p53, cyclin-dependent kinase inhibitor 1 (p21), growth arrest and dna damage-inducible gene gamma (gadd45g), proliferating cell nuclear antigen (pcna), rad51), apoptosis (bcl2-associated x protein (bax), bcl-x, caspase 6a,) and protein degradation (ubiquitin) were evaluated by quantitative real-time polymerase chain reaction (q-rtpcr). |
2012-06-08 |
2023-08-12 |
Not clear |
| Weiwei Zhang, Xiaoping Wang, Tongsheng Che. Resveratrol induces apoptosis via a Bak-mediated intrinsic pathway in human lung adenocarcinoma cells. Cellular signalling. vol 24. issue 5. 2012-06-06. PMID:22245142. |
rv treatment remarkably induced the activation of bak but not bax, and silencing bak but not bax by shrna almost completely prevented rv-induced cell death, mitochondrial dysfunction and also largely prevented rv-induced aif release, demonstrating the preferential engagement of bak but not bax during rv-induced apoptosis. |
2012-06-06 |
2023-08-12 |
human |
| Bashir M Rezk, Tadashi Yoshida, Laura Semprun-Prieto, Yusuke Higashi, Sergiy Sukhanov, Patrice Delafontain. Angiotensin II infusion induces marked diaphragmatic skeletal muscle atrophy. PloS one. vol 7. issue 1. 2012-06-04. PMID:22276172. |
expression of the e3 ubiquitin ligases atrogin-1 and muscle ring finger-1 (murf-1) and of the pro-apoptotic factor bax was increased after 24 h of ang ii infusion (4.4±0.3 fold, 3.1±0.5 fold and 1.6±0.2 fold, respectively, compared to sham infused control) suggesting increased muscle protein degradation and apoptosis. |
2012-06-04 |
2023-08-12 |
mouse |
| Jonathan M Gall, Zhiyong Wang, Marc Liesa, Anthony Molina, Andrea Havasi, John H Schwartz, Orian Shirihai, Steven C Borkan, Ramon G B Bonegi. Role of mitofusin 2 in the renal stress response. PloS one. vol 7. issue 1. 2012-06-04. PMID:22292091. |
despite similar stress-induced bax 6a7 epitope exposure in mfn2 deficient and control cells, mfn2 deficiency significantly increased mitochondrial bax accumulation and was associated with greater release of both apoptosis inducing factor and cytochrome c. in conclusion, mfn2 deficiency in the kidney causes mitochondrial fragmentation but does not affect kidney or tubular function during development or under non-stress conditions. |
2012-06-04 |
2023-08-12 |
mouse |
| Chuan-Rong Chen, Yong-Hui Xia, Shu-Yan Yao, Qing Zhang, Ying Wang, Zhao-Ning J. Virosecurinine induces apoptosis by affecting Bcl-2 and Bax expression in human colon cancer SW480 cells. Die Pharmazie. vol 67. issue 4. 2012-06-04. PMID:22570942. |
virosecurinine induces apoptosis by affecting bcl-2 and bax expression in human colon cancer sw480 cells. |
2012-06-04 |
2023-08-12 |
human |
| Chuan-Rong Chen, Yong-Hui Xia, Shu-Yan Yao, Qing Zhang, Ying Wang, Zhao-Ning J. Virosecurinine induces apoptosis by affecting Bcl-2 and Bax expression in human colon cancer SW480 cells. Die Pharmazie. vol 67. issue 4. 2012-06-04. PMID:22570942. |
hence, we suggest that virosecurinine induced apoptosis in sw480 cells by affecting the expression of bcl-2 and bax. |
2012-06-04 |
2023-08-12 |
human |
| Yuan-Yuan Hua, Xiao-Shu Wang, Yu Zhang, Chen-Guo Yao, Xi-Ming Zhang, Zheng-Ai Xion. Intense picosecond pulsed electric fields induce apoptosis through a mitochondrial-mediated pathway in HeLa cells. Molecular medicine reports. vol 5. issue 4. 2012-06-01. PMID:22307872. |
in addition, activation of caspase-3, caspase-9, upregulation of bax, p53 and downregulation of bcl-2 were observed in hela cells also indicating apoptosis. |
2012-06-01 |
2023-08-12 |
Not clear |