| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Jingbo Sun, Jing Shen, Zhengbo Shao, Yuanhang Yang, Donglai Wu, Xuemei Zhou, Huiping Yua. Annexin 1 protects against apoptosis induced by serum deprivation in transformed rat retinal ganglion cells. Molecular biology reports. vol 39. issue 5. 2012-07-12. PMID:22189540. |
ac2-26 attenuated the apoptosis resulting from serum deprivation of rgc-5 in a concentration-dependent manner, decreased caspase 3 and bax levels and produced an increase of bcl-2 in cell lysates. |
2012-07-12 |
2023-08-12 |
rat |
| Adele Chimento, Rosa Sirianni, Ivan Casaburi, Carmen Ruggiero, Marcello Maggiolini, Sebastiano Andò, Vincenzo Pezz. 17β-Estradiol activates GPER- and ESR1-dependent pathways inducing apoptosis in GC-2 cells, a mouse spermatocyte-derived cell line. Molecular and cellular endocrinology. vol 355. issue 1. 2012-07-11. PMID:22306083. |
in fact, in gc-2 cells we observed that esr1 and gper activation caused rapid erk and c-jun phosphorylation, bax up-regulation, events associated with apoptosis. |
2012-07-11 |
2023-08-12 |
mouse |
| A Kunwar, S Jayakumar, A K Srivastava, K I Priyadarsin. Dimethoxycurcumin-induced cell death in human breast carcinoma MCF7 cells: evidence for pro-oxidant activity, mitochondrial dysfunction, and apoptosis. Archives of toxicology. vol 86. issue 4. 2012-07-10. PMID:22119759. |
the s-phase arrest and apoptosis could also be correlated with the changes in the expressions of cell cycle proteins like p53, p21, cdk4, and cyclin-d1 and apoptotic markers like bax and bcl-2. |
2012-07-10 |
2023-08-12 |
human |
| Theres Lindgren, Torgny Stigbrand, Katrine Riklund, Lennart Johansson, David Eriksso. Gene expression profiling in MOLT-4 cells during gamma-radiation-induced apoptosis. Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine. vol 33. issue 3. 2012-07-09. PMID:22322922. |
from 3 to 24 h post-irradiation, a significant fraction of the genes with altered expression were found to be involved in cell cycle checkpoints and their regulation (cdkn1a), dna repair (gadd45a, ddb2, xpc), apoptosis induction (dr5, fasr, apo-2l, bax), and t-cell activation/proliferation (cd70, ox40l). |
2012-07-09 |
2023-08-12 |
Not clear |
| Matthew C Poling, Joshua Kim, Sangeeta Dhamija, Alexander S Kauffma. Development, sex steroid regulation, and phenotypic characterization of RFamide-related peptide (Rfrp) gene expression and RFamide receptors in the mouse hypothalamus. Endocrinology. vol 153. issue 4. 2012-07-09. PMID:22355072. |
using bax knockout mice, we determined that the dramatic developmental decrease in le rfrp cells is not due primarily to bax-dependent apoptosis. |
2012-07-09 |
2023-08-12 |
mouse |
| Nitika Paudel, Sathish Sadagopan, Sayan Chakraborty, Grzegorz Sarek, Päivi M Ojala, Bala Chandra. Kaposi's sarcoma-associated herpesvirus latency-associated nuclear antigen interacts with multifunctional angiogenin to utilize its antiapoptotic functions. Journal of virology. vol 86. issue 11. 2012-07-09. PMID:22438557. |
silencing ang or inhibiting its nuclear translocation resulted in decreased nuclear lana-1 and ang levels, decreased interactions between ang-lana-1, ang-p53, and lana-1-p53, the induction of p53, p21, and bax proteins, the increased cytoplasmic localization of p53, the downregulation of bcl-2, the increased cleavage of caspase-3, and the apoptosis of cells. |
2012-07-09 |
2023-08-12 |
Not clear |
| Jui-Ling Hsu, Yunn-Fang Ho, Tsai-Kun Li, Ching-Shih Chen, Lih-Ching Hsu, Jih-Hwa Gu. Rottlerin potentiates camptothecin-induced cytotoxicity in human hormone refractory prostate cancers through increased formation and stabilization of topoisomerase I-DNA cleavage complexes in a PKCδ-independent pathway. Biochemical pharmacology. vol 84. issue 1. 2012-07-09. PMID:22490701. |
the combinatory treatment of camptothecin and rottlerin induced conformational change and activation of bax and formation of truncated bad, suggesting the contribution of mitochondria stress to apoptosis. |
2012-07-09 |
2023-08-12 |
human |
| Jui-Ling Hsu, Yunn-Fang Ho, Tsai-Kun Li, Ching-Shih Chen, Lih-Ching Hsu, Jih-Hwa Gu. Rottlerin potentiates camptothecin-induced cytotoxicity in human hormone refractory prostate cancers through increased formation and stabilization of topoisomerase I-DNA cleavage complexes in a PKCδ-independent pathway. Biochemical pharmacology. vol 84. issue 1. 2012-07-09. PMID:22490701. |
subsequently, mitochondria-involved apoptosis is triggered through bax activation and truncated bad formation. |
2012-07-09 |
2023-08-12 |
human |
| Russell S Whelan, Klitos Konstantinidis, An-Chi Wei, Yun Chen, Denis E Reyna, Saurabh Jha, Ying Yang, John W Calvert, Tullia Lindsten, Craig B Thompson, Michael T Crow, Evripidis Gavathiotis, Gerald W Dorn, Brian O'Rourke, Richard N Kitsi. Bax regulates primary necrosis through mitochondrial dynamics. Proceedings of the National Academy of Sciences of the United States of America. vol 109. issue 17. 2012-07-09. PMID:22493254. |
bcl-2 proteins bax and bak are the principal activators of momp and apoptosis. |
2012-07-09 |
2023-08-12 |
mouse |
| Russell S Whelan, Klitos Konstantinidis, An-Chi Wei, Yun Chen, Denis E Reyna, Saurabh Jha, Ying Yang, John W Calvert, Tullia Lindsten, Craig B Thompson, Michael T Crow, Evripidis Gavathiotis, Gerald W Dorn, Brian O'Rourke, Richard N Kitsi. Bax regulates primary necrosis through mitochondrial dynamics. Proceedings of the National Academy of Sciences of the United States of America. vol 109. issue 17. 2012-07-09. PMID:22493254. |
reconstitution of these cells or mitochondria with wild-type bax, or an oligomerization-deficient mutant that cannot support momp and apoptosis, restores mptp opening and necrosis, implicating distinct mechanisms for bax-regulated necrosis and apoptosis. |
2012-07-09 |
2023-08-12 |
mouse |
| Yu Tang, Qinghua Jia, Ping Ma, Fujun Li, Tongde Lv, Xiaoqin H. [The effects of lead exposure on primary cultured hippocampus neurons apoptosis and the expressions of Bcl-2, Bax, p53 and NOS1]. Wei sheng yan jiu = Journal of hygiene research. vol 39. issue 2. 2012-07-06. PMID:20459046. |
[the effects of lead exposure on primary cultured hippocampus neurons apoptosis and the expressions of bcl-2, bax, p53 and nos1]. |
2012-07-06 |
2023-08-12 |
Not clear |
| Shan Jin, Chao-Liu Da. Attenuation of reperfusion-induced hepatocyte apoptosis is associated with reversed bcl-2/bax ratio in hemi-hepatic artery-preserved portal occlusion. The Journal of surgical research. vol 174. issue 2. 2012-07-06. PMID:21324399. |
this study aimed to examine the hepatocyte apoptosis in a hepatic blood inflow occlusion rat model without hemi-hepatic arterial control and its association with the expressions of the apoptosis-regulating genes bcl-2 and bax. |
2012-07-06 |
2023-08-12 |
rat |
| Shu-Fen Liou, Jong-Hau Hsu, Jyh-Chong Liang, Hung-Jen Ke, Ing-Jun Chen, Jiunn-Ren Wu, Jwu-Lai Ye. San-Huang-Xie-Xin-Tang protects cardiomyocytes against hypoxia/reoxygenation injury via inhibition of oxidative stress-induced apoptosis. Journal of natural medicines. vol 66. issue 2. 2012-07-05. PMID:21979292. |
in addition, shxt and baicalin also inhibited hypoxia- or h/r-induced apoptosis, with associated decreased bax protein, increased bcl-2 protein, and decreased caspase-3 activity. |
2012-07-05 |
2023-08-12 |
rat |
| Guoqi Zhu, Xuncui Wang, Shengbing Wu, Qinglin L. Involvement of activation of PI3K/Akt pathway in the protective effects of puerarin against MPP+-induced human neuroblastoma SH-SY5Y cell death. Neurochemistry international. vol 60. issue 4. 2012-07-05. PMID:22265823. |
we further demonstrated that puerarin protected against mpp(+)-induced p53 nuclear accumulation, puma (p53-upregulated mediator of apoptosis) and bax expression and caspase-3-dependent programmed cell death (pcd). |
2012-07-05 |
2023-08-12 |
human |
| Xiao-Feng Song, Hao Ren, Arne Andreasen, Jesper Skovhus Thomsen, Xiao-Yue Zha. Expression of Bcl-2 and Bax in mouse renal tubules during kidney development. PloS one. vol 7. issue 2. 2012-07-05. PMID:22389723. |
bcl-2 and bax play an important role in apoptosis regulation, as well as in cell adhesion and migration during kidney morphogenesis, which is structurally and functionally related to mitochondria. |
2012-07-05 |
2023-08-12 |
mouse |
| S P Garrison, D C Phillips, J R Jeffers, J E Chipuk, M J Parsons, J E Rehg, J T Opferman, D R Green, G P Zambett. Genetically defining the mechanism of Puma- and Bim-induced apoptosis. Cell death and differentiation. vol 19. issue 4. 2012-07-03. PMID:22015606. |
biochemical analyses demonstrated an essential role for either puma or bim to activate bax, thereby leading to mitochondrial outer membrane permeability, cytochrome c release and apoptosis. |
2012-07-03 |
2023-08-12 |
mouse |
| G Dewson, S Ma, P Frederick, C Hockings, I Tan, T Kratina, R M Kluc. Bax dimerizes via a symmetric BH3:groove interface during apoptosis. Cell death and differentiation. vol 19. issue 4. 2012-07-03. PMID:22015607. |
bax dimerizes via a symmetric bh3:groove interface during apoptosis. |
2012-07-03 |
2023-08-12 |
Not clear |
| G Dewson, S Ma, P Frederick, C Hockings, I Tan, T Kratina, R M Kluc. Bax dimerizes via a symmetric BH3:groove interface during apoptosis. Cell death and differentiation. vol 19. issue 4. 2012-07-03. PMID:22015607. |
we also found that a population of bax:bak heterodimers generated during apoptosis formed via a bh3:groove interaction, further demonstrating that bax and bak oligomerize via similar mechanisms. |
2012-07-03 |
2023-08-12 |
Not clear |
| Shu-Chun Hsu, Chien-Chih Yu, Jai-Sing Yang, Kuang-Chi Lai, Shin-Hwar Wu, Jen-Jyh Lin, Jehn-Hwa Kuo, Su-Tso Yang, Ching-Che Huang, Sheng-Chu Kuo, Jing-Gung Chun. A novel synthetic 2-(3-methoxyphenyl)-6,7-methylenedioxoquinolin-4-one arrests the G2/M phase arrest via Cdc25c and induces apoptosis through caspase- and mitochondria-dependent pathways in TSGH8301 human bladder cancer cells. International journal of oncology. vol 40. issue 3. 2012-07-03. PMID:22021033. |
mmeq promoted the levels of caspase-3, caspase-8, caspase-9, bax, bcl-xs, decreased the levels of bcl-2 and bid and then led to dysfunction of ΔΨm, following the releases of cytochrome c, aif and endo g from mitochondria to cytosol and nuclei, and finally caused cell apoptosis. |
2012-07-03 |
2023-08-12 |
human |
| Chunle Zhang, Lingjun Liu, Yang Yu, Bin Chen, Chengwei Tang, Xiao L. Antitumor effects of ginsenoside Rg3 on human hepatocellular carcinoma cells. Molecular medicine reports. vol 5. issue 5. 2012-07-03. PMID:22366885. |
flow cytometry experiments were carried out to investigate the effect of rg3 on cell apoptosis after the cells had been treated with rg3 (50 and 100 µg/ml) for 24 and 48 h. the expression levels of caspase-3, bax and bcl-2 in rg3-treated cells (100 µg/ml, 48 h), as well as normal cells were detected through real-time pcr experiments. |
2012-07-03 |
2023-08-12 |
human |