| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| P Bonvini, E Zorzi, L Mussolin, M Pillon, C Romualdi, M Peron, E S G d'Amore, L Lamant, A Rosole. Consequences of heat shock protein 72 (Hsp72) expression and activity on stress-induced apoptosis in CD30+ NPM-ALK+ anaplastic large-cell lymphomas. Leukemia. vol 26. issue 6. 2012-08-07. PMID:22289917. |
different from other hsps, hsp72 prevents cell injury, bax activation and death by apoptosis in alk(+) cells, acting both upstream and downstream of mitochondria. |
2012-08-07 |
2023-08-12 |
Not clear |
| Qingjuan Shang, Dianliang Zhang, Chunbao Guo, Qiu Lin, Zhenhua Guo, Chun Den. Potential synergism of Bim with p53 in mice with Myc‑induced lymphoma in a mouse lymphoma model. Molecular medicine reports. vol 5. issue 6. 2012-08-07. PMID:22446994. |
thus, myc-induced apoptotic signals through bim and p53 must bifurcate to activate bax, suggesting that the activation of bim and p53 significantly contribute to apoptosis. |
2012-08-07 |
2023-08-12 |
mouse |
| Jian Duo, Guo-Guang Ying, Guo-Wen Wang, Li Zhan. Quercetin inhibits human breast cancer cell proliferation and induces apoptosis via Bcl-2 and Bax regulation. Molecular medicine reports. vol 5. issue 6. 2012-08-07. PMID:22447039. |
quercetin inhibits human breast cancer cell proliferation and induces apoptosis via bcl-2 and bax regulation. |
2012-08-07 |
2023-08-12 |
human |
| Thangaiyan Radhiga, Chellam Rajamanickam, Arjunan Sundaresan, Muthukrishnan Ezhumalai, Kodukkur Viswanathan Pugalend. Effect of ursolic acid treatment on apoptosis and DNA damage in isoproterenol-induced myocardial infarction. Biochimie. vol 94. issue 5. 2012-08-03. PMID:22289617. |
ua influenced decreased dna fragmentation and an apoptosis by upregulation of anti-apoptotic proteins such as bcl-2, bcl-xl and down-regulation of bax, caspase-3, -8 and -9, cytochrome c, tnf-α, fas through mitochondrial pathway. |
2012-08-03 |
2023-08-12 |
rat |
| Zi-Rong Yang, Meng Liu, Xiu-Lan Peng, Xiao-Fei Lei, Ji-Xiang Zhang, Wei-Guo Don. Noscapine induces mitochondria-mediated apoptosis in human colon cancer cells in vivo and in vitro. Biochemical and biophysical research communications. vol 421. issue 3. 2012-08-03. PMID:22546556. |
this cytotoxicity was reflected by cell cycle arrest at g(2)/m and subsequent apoptosis, as indicated by increased chromatin condensation and fragmentation, the upregulation of bax and cytochrome c (cyt-c), the downregulation of survivin and bcl-2, and the activation of caspase-3 and caspase-9. |
2012-08-03 |
2023-08-12 |
mouse |
| Najeeb Ullah, Muhammad Imran Naseer, Ikram Ullah, Hae Young Lee, Phil Ok Koh, Myeong Ok Ki. Protective effect of pyruvate against ethanol-induced apoptotic neurodegeneration in the developing rat brain. Neuropharmacology. vol 61. issue 8. 2012-08-01. PMID:21803053. |
after 4h, a single dose of ethanol induced upregulation of bax, release of mitochondrial cytochrome-c into the cytosol, activation of caspase-3 and cleavage of poly (adp-ribose) polymerase (parp-1), all of which promote apoptosis. |
2012-08-01 |
2023-08-12 |
rat |
| Takafumi Sai, Fuko Matsuda, Yasufumi Goto, Akihisa Maeda, Miki Sugimoto, Hong-Mei Gao, Abul Khair Mohammad Ahan Kabir, Jun-You Li, Noboru Manab. Effect of RNA interference of BID and BAX mRNAs on apoptosis in granulosa cell-derived KGN cells. The Journal of reproduction and development. vol 58. issue 1. 2012-07-31. PMID:22052011. |
effect of rna interference of bid and bax mrnas on apoptosis in granulosa cell-derived kgn cells. |
2012-07-31 |
2023-08-12 |
human |
| Takafumi Sai, Fuko Matsuda, Yasufumi Goto, Akihisa Maeda, Miki Sugimoto, Hong-Mei Gao, Abul Khair Mohammad Ahan Kabir, Jun-You Li, Noboru Manab. Effect of RNA interference of BID and BAX mRNAs on apoptosis in granulosa cell-derived KGN cells. The Journal of reproduction and development. vol 58. issue 1. 2012-07-31. PMID:22052011. |
in mitochondrion-dependent type ii apoptosis, bh3-interacting domain death agonist (bid) and bcl-2-associated x protein (bax) promote death ligand and receptor-mediated cell death. |
2012-07-31 |
2023-08-12 |
human |
| Takafumi Sai, Fuko Matsuda, Yasufumi Goto, Akihisa Maeda, Miki Sugimoto, Hong-Mei Gao, Abul Khair Mohammad Ahan Kabir, Jun-You Li, Noboru Manab. Effect of RNA interference of BID and BAX mRNAs on apoptosis in granulosa cell-derived KGN cells. The Journal of reproduction and development. vol 58. issue 1. 2012-07-31. PMID:22052011. |
in the present study, to confirm the pro-apoptotic activity of bid and bax in granulosa cells, we examined the effect of rna interference of bid or bax on apoptosis using a human ovarian granulosa tumor cell line, kgn. |
2012-07-31 |
2023-08-12 |
human |
| Takafumi Sai, Fuko Matsuda, Yasufumi Goto, Akihisa Maeda, Miki Sugimoto, Hong-Mei Gao, Abul Khair Mohammad Ahan Kabir, Jun-You Li, Noboru Manab. Effect of RNA interference of BID and BAX mRNAs on apoptosis in granulosa cell-derived KGN cells. The Journal of reproduction and development. vol 58. issue 1. 2012-07-31. PMID:22052011. |
these results suggest that bid and bax act as signal-transducing factors in mitochondrion-dependent type ii apoptosis. |
2012-07-31 |
2023-08-12 |
human |
| Tae Myoung Kim, Sang-Kyung Shin, Tae-Wang Kim, So-Young Youm, Dae Joong Kim, Byeongwoo Ah. Elm tree bark extract inhibits HepG2 hepatic cancer cell growth via pro-apoptotic activity. Journal of veterinary science. vol 13. issue 1. 2012-07-31. PMID:22437530. |
pro-apoptotic activity was promoted via the mitochondrial pathway of apoptosis, as demonstrated by the activation of pro-apoptotic proteins bax, caspase-9, caspase-3, and poly (adp-ribose) polymerase as well as the down-regulation of the anti-apoptotic protein bcl-2. |
2012-07-31 |
2023-08-12 |
human |
| Su-Xia Shao, Lei Zhang, Hong-Xia Chen, Yan Liu, Jin-Ping Zhang, Wei Chen, Guo-Yu Xu. Diazoxide pretreatment enhances L6 skeletal myoblast survival and inhibits apoptosis induced by hydrogen peroxide. Anatomical record (Hoboken, N.J. : 2007). vol 295. issue 4. 2012-07-30. PMID:22262406. |
compared with control group, h(2)o(2) treatment caused cell damage, increased lactate dehydrogenase release, cell apoptosis, and bax gene expression, while reduced cell proliferation and decreased bcl-2 expression. |
2012-07-30 |
2023-08-12 |
Not clear |
| Su-Xia Shao, Lei Zhang, Hong-Xia Chen, Yan Liu, Jin-Ping Zhang, Wei Chen, Guo-Yu Xu. Diazoxide pretreatment enhances L6 skeletal myoblast survival and inhibits apoptosis induced by hydrogen peroxide. Anatomical record (Hoboken, N.J. : 2007). vol 295. issue 4. 2012-07-30. PMID:22262406. |
dz pretreatment may protect cells from damage induced by h(2)o(2) and reduce cell apoptosis by increasing bcl-2 and decreasing bax expression. |
2012-07-30 |
2023-08-12 |
Not clear |
| Y-P Xia, R-L Dai, Y-N Li, L Mao, Y-M Xue, Q-W He, M Huang, Y Huang, Y-W Mei, B H. The protective effect of sonic hedgehog is mediated by the phosphoinositide [corrected] 3-kinase/AKT/Bcl-2 pathway in cultured rat astrocytes under oxidative stress. Neuroscience. vol 209. 2012-07-30. PMID:22402346. |
blocking shh or phosphoinositide 3-kinases (pi3-k)/akt signaling pathway with cyclopamine or ly294002 decreased the survival rate of astrocytes, induced cell apoptosis, upregulated the expression of bax, and downregulated the expression of bcl-2. |
2012-07-30 |
2023-08-12 |
rat |
| Rosanna Di Paola, Daniela Impellizzeri, Agata Torre, Emanuela Mazzon, Alessandro Cappellani, Caterina Faggio, Emanuela Esposito, Francesca Trischitta, Salvatore Cuzzocre. Effects of palmitoylethanolamide on intestinal injury and inflammation caused by ischemia-reperfusion in mice. Journal of leukocyte biology. vol 91. issue 6. 2012-07-30. PMID:22469754. |
in this study, we demonstrated that the administration of pea, 5 min before reperfusion, significantly reduced all of the parameters involved during inflammation, such as proinflammatory cytokine production (tnf-α, il-1β), adhesion molecules (icam-1, p-selectin) expression, nf-κb expression, and apoptosis (bax, bcl-2, tunel assay) activation. |
2012-07-30 |
2023-08-12 |
mouse |
| Sai Ma, Le-qun Shan, Yu-hong Xiao, Fang Li, Li Huang, Lijuan Shen, Ji-hua Che. The cytotoxicity of methacryloxylethyl cetyl ammonium chloride, a cationic antibacterial monomer, is related to oxidative stress and the intrinsic mitochondrial apoptotic pathway. Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas. vol 44. issue 11. 2012-07-27. PMID:22002093. |
dmae-cb may cause apoptosis by disturbing the expression of bcl-2 and bax, reducing the mitochondrial potential and inducing release of cytochrome c. taken together, these findings suggest that the toxicity of the antibacterial monomer dmae-cb is associated with ros production, mitochondrial dysfunction, cell cycle disturbance, and cell apoptosis/necrosis. |
2012-07-27 |
2023-08-12 |
mouse |
| Yan Zhou, Xianshu Tan, Wenjuan Kuang, Litao Liu, Lihong Wa. Erythromycin ameliorates cigarette-smoke-induced emphysema and inflammation in rats. Translational research : the journal of laboratory and clinical medicine. vol 159. issue 6. 2012-07-27. PMID:22633097. |
erythromycin protected significantly against the alveolar enlargement levels (p = 0.0017), reduced the pathologic apoptosis (p = 0.0023) related with bcl-2 (p = 0.0002) and bax (p = 0.0002), and inhibited the expressions of matrix metalloproteinase (mmp)-9 (p = 0.0019) and timp-1 protein (p = 0.04) and the mmp-9/timp-1 ratio (p = 0.0002) in the lungs of cs-induced emphysema in rats. |
2012-07-27 |
2023-08-12 |
rat |
| Xi Chen, Jianshu Wang, Qizhi Qin, Ying Jiang, Guangtao Yang, Kaimin Rao, Qian Wang, Wei Xiong, Jing Yua. Mono-2-ethylhexyl phthalate induced loss of mitochondrial membrane potential and activation of Caspase3 in HepG2 cells. Environmental toxicology and pharmacology. vol 33. issue 3. 2012-07-26. PMID:22387354. |
the increase in the bax to bcl-2 ratio suggests that bcl-2 family involved in the control of mehp-induced apoptosis in these two cell types. |
2012-07-26 |
2023-08-12 |
Not clear |
| Ali A Alshatwi, Gowhar Shafi, Tarique N Hasan, Amal A Al-Hazzani, Mohammed A Alsaif, Mohammed A Alfawaz, K Y Lei, Anjana Munsh. Apoptosis-mediated inhibition of human breast cancer cell proliferation by lemon citrus extract. Asian Pacific journal of cancer prevention : APJCP. vol 12. issue 6. 2012-07-23. PMID:22126498. |
additionally, the expression of a pro-apoptotic gene, bax, was increased, and the expression of an anti-apoptotic gene, bcl-2, was decreased by le extract treatment, resulting in a shift in the bax:bcl-2 ratio to one that favored apoptosis. |
2012-07-23 |
2023-08-12 |
human |
| Annika Müer, Tim Overkamp, Bernd Gillissen, Antje Richter, Thomas Pretzsch, Ana Milojkovic, Bernd Dörken, Peter T Daniel, Philipp Hemmat. p14(ARF)-induced apoptosis in p53 protein-deficient cells is mediated by BH3-only protein-independent derepression of Bak protein through down-regulation of Mcl-1 and Bcl-xL proteins. The Journal of biological chemistry. vol 287. issue 21. 2012-07-23. PMID:22354970. |
although forced expression of bak markedly sensitizes toward p14(arf)-induced apoptosis, re-expression of bax has no effect. |
2012-07-23 |
2023-08-12 |
Not clear |