| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Lei Sun, Tongsheng Chen, Xiaoping Wang, Yun Chen, Xunbin We. Bufalin Induces Reactive Oxygen Species Dependent Bax Translocation and Apoptosis in ASTC-a-1 Cells. Evidence-based complementary and alternative medicine : eCAM. vol 2011. 2012-08-23. PMID:19592481. |
bufalin induces reactive oxygen species dependent bax translocation and apoptosis in astc-a-1 cells. |
2012-08-23 |
2023-08-12 |
human |
| Lei Sun, Tongsheng Chen, Xiaoping Wang, Yun Chen, Xunbin We. Bufalin Induces Reactive Oxygen Species Dependent Bax Translocation and Apoptosis in ASTC-a-1 Cells. Evidence-based complementary and alternative medicine : eCAM. vol 2011. 2012-08-23. PMID:19592481. |
in this study, we used the confocal fluorescence microscopy (cfm) to monitor the spatio-temporal dynamics of reactive oxygen species (ros) production, bax translocation and caspase-3 activation during bufalin-induced apoptosis in living human lung adenocarcinoma (astc-a-1) cells. |
2012-08-23 |
2023-08-12 |
human |
| Lei Sun, Tongsheng Chen, Xiaoping Wang, Yun Chen, Xunbin We. Bufalin Induces Reactive Oxygen Species Dependent Bax Translocation and Apoptosis in ASTC-a-1 Cells. Evidence-based complementary and alternative medicine : eCAM. vol 2011. 2012-08-23. PMID:19592481. |
treatment with the antioxidant n-acetyl-cysteine (nac), a ros scavenger, inhibited ros generation and bax translocation and led to a significant protection against bufalin-induced apoptosis. |
2012-08-23 |
2023-08-12 |
human |
| Lei Sun, Tongsheng Chen, Xiaoping Wang, Yun Chen, Xunbin We. Bufalin Induces Reactive Oxygen Species Dependent Bax Translocation and Apoptosis in ASTC-a-1 Cells. Evidence-based complementary and alternative medicine : eCAM. vol 2011. 2012-08-23. PMID:19592481. |
taken together, bufalin induced ros-mediated bax translocation, mitochondrial permeability transition and caspase-3 activation, implying that bufalin induced apoptosis via ros-dependent mitochondrial death pathway in astc-a-1 cells. |
2012-08-23 |
2023-08-12 |
human |
| Weilin Wang, Jianju Lu, Feng Zhu, Jianfeng Wei, Changku Jia, Yuanbiao Zhang, Lin Zhou, Haiyang Xie, Shusen Zhen. Pro-apoptotic and anti-proliferative effects of mitofusin-2 via Bax signaling in hepatocellular carcinoma cells. Medical oncology (Northwood, London, England). vol 29. issue 1. 2012-08-23. PMID:21190094. |
our results show that the mfn2 gene is a potential tumor suppressor target that may significantly promote apoptosis via bax and may inhibit proliferation in hcc cells. |
2012-08-23 |
2023-08-12 |
Not clear |
| Helle Evi Simovart, Andres Arend, Jüri Lieberg, Marina Aunapu. Associations of NF-kappaB and bax with apoptosis in varicose veins of women of different age groups. International journal of vascular medicine. vol 2011. 2012-08-23. PMID:22121486. |
associations of nf-kappab and bax with apoptosis in varicose veins of women of different age groups. |
2012-08-23 |
2023-08-12 |
Not clear |
| Helle Evi Simovart, Andres Arend, Jüri Lieberg, Marina Aunapu. Associations of NF-kappaB and bax with apoptosis in varicose veins of women of different age groups. International journal of vascular medicine. vol 2011. 2012-08-23. PMID:22121486. |
apoptosis was determined by the tunel method, nf-kappab and bax expression by immunohistochemistry. |
2012-08-23 |
2023-08-12 |
Not clear |
| Muhammad Khan, Bo Yu, Azhar Rasul, Ali Al Shawi, Fei Yi, Hong Yang, Tonghui M. Jaceosidin Induces Apoptosis in U87 Glioblastoma Cells through G2/M Phase Arrest. Evidence-based complementary and alternative medicine : eCAM. vol 2012. 2012-08-23. PMID:22216058. |
furthermore, our study revealed that induction of apoptosis was associated with cell cycle arrest at g2/m phase, upregulation of p53 and bax, decrease in mitochondrial membrane potential, release of cytochrome c, and activation of caspase 3. |
2012-08-23 |
2023-08-12 |
Not clear |
| Jennifer Law, Victor C Yu, Shairaz Baks. Modulator of Apoptosis 1: A Highly Regulated RASSF1A-Interacting BH3-Like Protein. Molecular biology international. vol 2012. 2012-08-23. PMID:22745908. |
moap-1 is a downstream effector of rassf1a that promotes bax activation and cell death and is highly regulated during apoptosis. |
2012-08-23 |
2023-08-12 |
human |
| Muhammad Khan, Bin Zheng, Fei Yi, Azhar Rasul, Zhuyi Gu, Ting Li, Hongwen Gao, Javed Iqbal Qazi, Hong Yang, Tonghui M. Pseudolaric Acid B induces caspase-dependent and caspase-independent apoptosis in u87 glioblastoma cells. Evidence-based complementary and alternative medicine : eCAM. vol 2012. 2012-08-23. PMID:22778780. |
further mechanistic study demonstrated that plab induced caspase-dependent apoptosis via upregulation of p53, increased level of proapoptotic protein bax, decreased level of antiapoptotic protein bcl-2, release of cytochrome c from mitochondria, activation of caspase-3 and proteolytic cleavage of poly (adp-ribose) polymerase (parp) and caspase-independent apoptosis through apoptosis inducing factor (aif). |
2012-08-23 |
2023-08-12 |
mouse |
| Venkat R Katkoori, Catalina Suarez-Cuervo, Chandrakumar Shanmugam, Nirag C Jhala, Tom Callens, Ludwine Messiaen, James Posey, Harvey L Bumpers, Sreelatha Meleth, William E Grizzle, Upender Mann. Bax expression is a candidate prognostic and predictive marker of colorectal cancer. Journal of gastrointestinal oncology. vol 1. issue 2. 2012-08-23. PMID:22811811. |
since the anti-tumor activity of 5-fluorouracil (5-fu) is due to induction of apoptosis, we assessed the value of expression of key apoptotic molecules (bax, bcl-2 and p53) in predicting the efficacy of 5-fu therapy for colorectal adenocarcinomas (crcs). |
2012-08-23 |
2023-08-12 |
Not clear |
| L S Howard, A Crosby, P Vaughan, A Sobolewski, M Southwood, M L Foster, E R Chilvers, N W Morrel. Distinct responses to hypoxia in subpopulations of distal pulmonary artery cells contribute to pulmonary vascular remodeling in emphysema. Pulmonary circulation. vol 2. issue 2. 2012-08-23. PMID:22837865. |
hypoxia induced apoptosis in pasmc(norm) (as assessed by tunel) and mrna expression of bax and bcl-2, and induced proliferation in pasmc(hyp) (as assessed by (3)h-thymidine incorporation). |
2012-08-23 |
2023-08-12 |
human |
| J Zhao, S Z Wang, X F Tang, N Liu, D Zhao, Z Y Ma. Analysis of thermochemotherapy-induced apoptosis and the protein expressions of Bcl-2 and Bax in maxillofacial squamous cell carcinomas. Medical oncology (Northwood, London, England). vol 28 Suppl 1. 2012-08-22. PMID:21104343. |
analysis of thermochemotherapy-induced apoptosis and the protein expressions of bcl-2 and bax in maxillofacial squamous cell carcinomas. |
2012-08-22 |
2023-08-12 |
Not clear |
| J Zhao, S Z Wang, X F Tang, N Liu, D Zhao, Z Y Ma. Analysis of thermochemotherapy-induced apoptosis and the protein expressions of Bcl-2 and Bax in maxillofacial squamous cell carcinomas. Medical oncology (Northwood, London, England). vol 28 Suppl 1. 2012-08-22. PMID:21104343. |
the aim of this study is to investigate the relationship between thermochemotherapy-induced apoptosis and the expressions of the bcl-2 and bax proteins in maxillofacial squamous cell carcinomas. |
2012-08-22 |
2023-08-12 |
Not clear |
| J Zhao, S Z Wang, X F Tang, N Liu, D Zhao, Z Y Ma. Analysis of thermochemotherapy-induced apoptosis and the protein expressions of Bcl-2 and Bax in maxillofacial squamous cell carcinomas. Medical oncology (Northwood, London, England). vol 28 Suppl 1. 2012-08-22. PMID:21104343. |
the terminal deoxynucleotidyl transferase-mediated deoxyuridine triphosphate-biotin nick-end labeling method was used to assess the apoptosis in the carcinoma cells, and immunohistochemistry was performed using the streptavidin-peroxidase method to determine the expression levels of the bcl-2 and bax proteins, and quantitative analysis was employed. |
2012-08-22 |
2023-08-12 |
Not clear |
| J Zhao, S Z Wang, X F Tang, N Liu, D Zhao, Z Y Ma. Analysis of thermochemotherapy-induced apoptosis and the protein expressions of Bcl-2 and Bax in maxillofacial squamous cell carcinomas. Medical oncology (Northwood, London, England). vol 28 Suppl 1. 2012-08-22. PMID:21104343. |
thermochemotherapy induces apoptosis in maxillofacial squamous cell carcinoma cells by downregulating the protein expression of bcl-2 and upregulating that of bax. |
2012-08-22 |
2023-08-12 |
Not clear |
| Li Zhou, Xin-Yun Xu, Yue-Bin Ke, Li-Ping Ding, Xue-Yu Li, Yu-Feng Li. [Pathological analysis and mRNA expression of apoptosis genes in rat kidney tissue after subacute melamine treatment]. Zhonghua lao dong wei sheng zhi ye bing za zhi = Zhonghua laodong weisheng zhiyebing zazhi = Chinese journal of industrial hygiene and occupational diseases. vol 28. issue 10. 2012-08-20. PMID:21126425. |
to investigate pathological changes and mrna expression of apoptosis genes bcl-2, bax and caspase-3 in rat kidney tissue after rats are administrated with melamine for 28 days. |
2012-08-20 |
2023-08-12 |
rat |
| Maria Chomova, Zuzana Tatarkova, Dusan Dobrota, Peter Raca. Ischemia-induced inhibition of mitochondrial complex I in rat brain: effect of permeabilization method and electron acceptor. Neurochemical research. vol 37. issue 5. 2012-08-20. PMID:22219133. |
add to this, initialization of p53 mitochondrial apoptosis through p53, bax, bcl-x(l) proteins and a possible involvement of grim-19, the ci structural subunit, in apoptotic processes were also studied. |
2012-08-20 |
2023-08-12 |
rat |
| Mi-Ae Lyu, Lawrence H Cheung, Walter N Hittelman, Yuying Liu, John W Marks, Min-Jeong Cho, Michael G Rosenblu. Bax345/BLyS: a novel, completely human fusion protein targeting malignant B cells and delivering a unique mitochondrial toxin. Cancer letters. vol 322. issue 2. 2012-08-20. PMID:22388102. |
specific delivery of bax(345)/blys to malignant b cells drove cells into apoptosis by mitochondrial dysfunction and treatment of cells with bax(345)/blys induced down-regulation of mcl-1, x-iap, and survivin. |
2012-08-20 |
2023-08-12 |
human |
| Li-Hua Shang, Chun-Mei Li, Zhao-Yang Yang, De-Hai Che, Jing-Yan Cao, Yan Y. Luffa echinata Roxb. induces human colon cancer cell (HT-29) death by triggering the mitochondrial apoptosis pathway. Molecules (Basel, Switzerland). vol 17. issue 5. 2012-08-20. PMID:22592084. |
furthermore, the ratio of mitochondria-dependent apoptosis genes (bax and bcl-2) was sharply increased from 1.6 to 54.1. |
2012-08-20 |
2023-08-12 |
human |