| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Yong Jiang, Dian-Wei Liu, Xiang-Yang Han, Ya-Nan Dong, Jun Gao, Bin Du, Lei Meng, Jian-Guo Sh. Neuroprotective effects of anti-tumor necrosis factor-alpha antibody on apoptosis following subarachnoid hemorrhage in a rat model. Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia. vol 19. issue 6. 2012-09-20. PMID:22516550. |
interestingly, we found increased expression of bax, but not caspase-3, in the prefrontal cortex, which indicates different molecular mechanisms of apoptosis in distinct brain regions. |
2012-09-20 |
2023-08-12 |
rat |
| Zu-An Zhu, Zheng-Qiu Zhu, Hong-Xing Cai, Ying Li. Reversion of multidrug resistance by SKI-II in SGC7901/DDP cells and exploration of underlying mechanisms. Asian Pacific journal of cancer prevention : APJCP. vol 13. issue 2. 2012-09-20. PMID:22524836. |
then cell growth, apoptosis, micro- morphological changes, and expression of sphk1, p-gp, nf-kb, bcl-2 and bax were assessed by mtt assay, flow cytometry, electron microscopy, immunocytochemistry and western blot assay respectively. |
2012-09-20 |
2023-08-12 |
Not clear |
| Chao Lin, Xin-yu Zhao, Lei Li, Huan-yi Liu, Kang Cao, Yang Wan, Xin-yu Liu, Chun-lai Nie, Lei Liu, Ai-ping Tong, Hong-xin Deng, Jiong Li, Zhu Yuan, Yu-quan We. NOXA-induced alterations in the Bax/Smac axis enhance sensitivity of ovarian cancer cells to cisplatin. PloS one. vol 7. issue 5. 2012-09-19. PMID:22590594. |
furthermore, gene silencing of bax or smac significantly attenuated noxa and/or cisplatin-induced apoptosis in chemosensitive a2780s cells, whereas overexpression of bax or addition of smac-n7 peptide significantly increased noxa and/or cisplatin-induced apoptosis in chemoresistant skov3 cells. |
2012-09-19 |
2023-08-12 |
Not clear |
| Duan Mengxi, Yuan Hong, Wang Nan, Li Shijun, Jiang Yanme. Effect of short hairpin RNA of Bcl-xL gene on biological behaviors of HepG-2 cells. Medical oncology (Northwood, London, England). vol 29. issue 2. 2012-09-18. PMID:21533603. |
cell apoptosis and bcl-2 and bax expression were detected by flow cytometry. |
2012-09-18 |
2023-08-12 |
Not clear |
| Yan Yu, Liang Zhou, Miao Sun, Ting Zhou, Kaiyin Zhong, Hecheng Wang, Yi Liu, Xinying Liu, Ruizhong Xiao, Jia Ge, Pengfei Tu, Dong Sheng Fan, Yuan Lan, Chen Hui, Dehua Chu. Xylocoside G reduces amyloid-β induced neurotoxicity by inhibiting NF-κB signaling pathway in neuronal cells. Journal of Alzheimer's disease : JAD. vol 30. issue 2. 2012-09-18. PMID:22430528. |
in addition, pretreatment with xg countered the effect of aβ on bax and bcl-2 expression and repressed aβ-induced caspase-3 activation, suggesting that the neuroprotective effect of xg is associated with apoptosis regulation. |
2012-09-18 |
2023-08-12 |
Not clear |
| Juliana P Vago, Camila R C Nogueira, Luciana P Tavares, Frederico M Soriani, Fernando Lopes, Remo C Russo, Vanessa Pinho, Mauro M Teixeira, Lirlândia P Sous. Annexin A1 modulates natural and glucocorticoid-induced resolution of inflammation by enhancing neutrophil apoptosis. Journal of leukocyte biology. vol 92. issue 2. 2012-09-17. PMID:22493082. |
mechanistically, resolution of neutrophilic inflammation was linked to cell apoptosis with activation of bax and caspase-3 and inhibition of survival pathways mcl-1, erk1/2, and nf-κb. |
2012-09-17 |
2023-08-12 |
mouse |
| Ying Zheng, Sarit Lilo, Patricio Mena, James B Blisk. YopJ-induced caspase-1 activation in Yersinia-infected macrophages: independent of apoptosis, linked to necrosis, dispensable for innate host defense. PloS one. vol 7. issue 4. 2012-09-17. PMID:22563435. |
in addition, cytotoxicity and il-1β secretion were not reduced in the presence of a caspase-8 inhibitor, or in b-cell lymphoma 2 (bcl-2)-associated x protein (bax)/bcl-2 homologous antagonist/killer (bak) knockout macrophages, showing that yopj(kim)-mediated cell death and caspase-1 activation occur independent of mitochondrial-directed apoptosis. |
2012-09-17 |
2023-08-12 |
mouse |
| Chang-Hai Zhao, Han-Qiang Liu, Rui Cao, Ai-Ling Ji, Lei Zhang, Feng Wang, Rui-Hua Yan. Effects of dietary fish oil on learning function and apoptosis of hippocampal pyramidal neurons in streptozotocin-diabetic rats. Brain research. vol 1457. 2012-09-13. PMID:22542021. |
diabetes increased the expression of bax and caspase-3, which led the apoptosis of the ca1 pyramidal neurons, and further contributed to the deficits in learning and memory processing. |
2012-09-13 |
2023-08-12 |
rat |
| F Ke, A Voss, J B Kerr, L A O'Reilly, L Tai, N Echeverry, P Bouillet, A Strasser, T Kaufman. BCL-2 family member BOK is widely expressed but its loss has only minimal impact in mice. Cell death and differentiation. vol 19. issue 6. 2012-09-10. PMID:22281706. |
bok/mtd was discovered as a protein that binds to the anti-apoptotic bcl-2 family member mcl-1 and shares extensive amino-acid sequence similarity to bax and bak, which are essential for the effector phase of apoptosis. |
2012-09-10 |
2023-08-12 |
mouse |
| K F Huang, G D Zhang, Y Q Huang, Y Dia. Wogonin induces apoptosis and down-regulates survivin in human breast cancer MCF-7 cells by modulating PI3K-AKT pathway. International immunopharmacology. vol 12. issue 2. 2012-09-07. PMID:22182776. |
wogonin-induced apoptosis was accompanied by a significant decrease of the bcl-2 and survivin and increase of bax and p53. |
2012-09-07 |
2023-08-12 |
human |
| Zhangjian Huang, Junjie Fu, Ling Liu, Yijun Sun, Yisheng Lai, Hui Ji, Edward E Knaus, Jide Tian, Yihua Zhan. Glycosylated diazeniumdiolate-based oleanolic acid derivatives: synthesis, in vitro and in vivo biological evaluation as anti-human hepatocellular carcinoma agents. Organic & biomolecular chemistry. vol 10. issue 19. 2012-09-07. PMID:22473516. |
furthermore, 6 induced hcc cell apoptosis, which was accompanied by lower mitochondrial membrane potentials and bcl2 expression, but with higher cytochrome c release, bax, caspase 3 and 9 expression activities in hcc cells. |
2012-09-07 |
2023-08-12 |
mouse |
| Brahmasani Sambasiva Rao, Yelisetti Uma Mahesh, Katari Venu Charan, Komjeti Suman, Nithya Sekhar, Sisinthy Shivaj. Effect of vitrification on meiotic maturation and expression of genes in immature goat cumulus oocyte complexes. Cryobiology. vol 64. issue 3. 2012-09-06. PMID:22280956. |
the aim of the study was to evaluate meiotic maturation, and expression of genes coding for oocyte secreted factors (gdf9, bmp15, tgfbr1, and bpr2) and apoptosis (bcl2, bax and p53) after vitrification of immature goat cumulus oocyte complexes (cocs) and in vitro maturation. |
2012-09-06 |
2023-08-12 |
Not clear |
| Erin E Perrone, Enjae Jung, Elise Breed, Jessica A Dominguez, Zhe Liang, Andrew T Clark, W Michael Dunne, Eileen M Burd, Craig M Coopersmit. Mechanisms of methicillin-resistant Staphylococcus aureus pneumonia-induced intestinal epithelial apoptosis. Shock (Augusta, Ga.). vol 38. issue 1. 2012-09-06. PMID:22592747. |
methicillin-resistant s. aureus-induced intestinal apoptosis was associated with an increase in the expression of the proapoptotic proteins bid and bax and the antiapoptotic protein bcl-xl in the mitochondrial pathway. |
2012-09-06 |
2023-08-12 |
mouse |
| Evripidis Gavathiotis, Denis E Reyna, Joseph A Bellairs, Elizaveta S Leshchiner, Loren D Walensk. Direct and selective small-molecule activation of proapoptotic BAX. Nature chemical biology. vol 8. issue 7. 2012-09-06. PMID:22634637. |
we recently identified a geographically distinct bh3-binding groove that mediates direct bax activation, suggesting a new strategy for inducing apoptosis by flipping bax's 'on switch'. |
2012-09-06 |
2023-08-12 |
Not clear |
| C Wang, R J Youl. Predominant requirement of Bax for apoptosis in HCT116 cells is determined by Mcl-1's inhibitory effect on Bak. Oncogene. vol 31. issue 26. 2012-09-05. PMID:22056880. |
predominant requirement of bax for apoptosis in hct116 cells is determined by mcl-1's inhibitory effect on bak. |
2012-09-05 |
2023-08-12 |
human |
| C Wang, R J Youl. Predominant requirement of Bax for apoptosis in HCT116 cells is determined by Mcl-1's inhibitory effect on Bak. Oncogene. vol 31. issue 26. 2012-09-05. PMID:22056880. |
although bax and bak seem to have redundant roles in apoptosis, accumulating evidence also suggests that they might not be interchangeable under certain conditions, at least in some human cell lines. |
2012-09-05 |
2023-08-12 |
human |
| C Wang, R J Youl. Predominant requirement of Bax for apoptosis in HCT116 cells is determined by Mcl-1's inhibitory effect on Bak. Oncogene. vol 31. issue 26. 2012-09-05. PMID:22056880. |
in addition, bax deficiency only provides partial protection against camptothecin and cisplatin-induced apoptosis and no protection against killing by puma or abt-737 plus noxa overexpression. |
2012-09-05 |
2023-08-12 |
human |
| Zesong Wang, Xuhui Ma, Li Fan, Won Jong Rhee, Tai Hyun Park, Liang Zhao, Wen-Song Ta. Understanding the mechanistic roles of 30Kc6 gene in apoptosis and specific productivity in antibody-producing Chinese hamster ovary cells. Applied microbiology and biotechnology. vol 94. issue 5. 2012-09-05. PMID:22367610. |
it was observed that the bax translocation from cytosol to mitochondria and the cytochrome c (cyt c) release from mitochondrial intermembrane space to cytosol were repressed, which resulted in a decrease in the activation of apoptosis executioner, caspase-3. |
2012-09-05 |
2023-08-12 |
Not clear |
| Zesong Wang, Xuhui Ma, Li Fan, Won Jong Rhee, Tai Hyun Park, Liang Zhao, Wen-Song Ta. Understanding the mechanistic roles of 30Kc6 gene in apoptosis and specific productivity in antibody-producing Chinese hamster ovary cells. Applied microbiology and biotechnology. vol 94. issue 5. 2012-09-05. PMID:22367610. |
in conclusion, 30kc6 expression inhibited apoptosis by repressing the bax translocation, which down-regulated the downstream cascade responses including cyt c release and caspase-3 activation. |
2012-09-05 |
2023-08-12 |
Not clear |
| Qiu-jie Zhao, Yan-bo Yu, Xiu-li Zuo, Yan-yan Dong, Yan-qing L. Milk fat globule-epidermal growth factor 8 is decreased in intestinal epithelium of ulcerative colitis patients and thereby causes increased apoptosis and impaired wound healing. Molecular medicine (Cambridge, Mass.). vol 18. 2012-09-04. PMID:22204000. |
mfg-e8 knockdown could promote apoptosis in intestinal epithelial cell lines, accompanied by a decrease in level of the antiapoptotic protein b-cell lymphoma 2 (bcl-2) and induction of the proapoptotic protein bcl2-associated protein x (bax). |
2012-09-04 |
2023-08-12 |
human |