| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Jun Liao, Meigui Ke, Teng Xu, Lili Li. Electroacupuncture inhibits apoptosis in annulus fibrosis cells through suppression of the mitochondria-dependent pathway in a rat model of cervical intervertebral disc degradation. Genetics and molecular biology. vol 35. issue 3. 2012-10-12. PMID:23055810. |
tunel staining was measured to assess apoptosis in af cells, immunohistochemistry was used to examine bcl-2 and bax expression, colorimetric assays were used to determine caspase 9 and caspase 3 activities and rt-pcr and western blotting were used to assess the mrna and protein expression of crk and erk2. |
2012-10-12 |
2023-08-12 |
rat |
| Evagelos Giotakis, Ilias P Gomatos, Leonidas Alevizos, Leonidas Manolopoulos, Agapi Kataki, Dimitris Kandiloros, Vassilis G Gorgoulis, Katerina Tsimaratou, Manousos M Konstantoulakis, Ioannis Yiotaki. Apoptotic and proliferative status in HPV (+) and HPV (-) inverted papilloma patients. Correlation with local recurrence and clinicopathological variables. Pathology, research and practice. vol 208. issue 6. 2012-10-11. PMID:22560505. |
immunohistochemistry for pcna, bax, cytochrome c and caspase-8 and flow cytometry for the detection of apoptosis, necrosis and ki67 expression were performed. |
2012-10-11 |
2023-08-12 |
Not clear |
| Evagelos Giotakis, Ilias P Gomatos, Leonidas Alevizos, Leonidas Manolopoulos, Agapi Kataki, Dimitris Kandiloros, Vassilis G Gorgoulis, Katerina Tsimaratou, Manousos M Konstantoulakis, Ioannis Yiotaki. Apoptotic and proliferative status in HPV (+) and HPV (-) inverted papilloma patients. Correlation with local recurrence and clinicopathological variables. Pathology, research and practice. vol 208. issue 6. 2012-10-11. PMID:22560505. |
increased pcna and ki67 and decreased bax and caspase-8 expression indicate that cell proliferation is increased while apoptosis is inhibited in ip, explaining its biological behavior. |
2012-10-11 |
2023-08-12 |
Not clear |
| Franziska Busch, Ali Mobasheri, Parviz Shayan, Ralf Stahlmann, Mehdi Shakibae. Sirt-1 is required for the inhibition of apoptosis and inflammatory responses in human tenocytes. The Journal of biological chemistry. vol 287. issue 31. 2012-10-11. PMID:22689577. |
transient transfection of tenocytes with aso against sirt-1 induced expression of bax and other proteins involved in apoptosis (cleaved caspase-3 and poly(adp-ribose)polymerase), acetylation of tumor suppressor p53, and mitochondrial degradation. |
2012-10-11 |
2023-08-12 |
human |
| Xiaokui Yang, Jiandong Wang, Ying Zhou, Yamei Wang, Shuyu Wang, Weiyuan Zhan. Hsp70 promotes chemoresistance by blocking Bax mitochondrial translocation in ovarian cancer cells. Cancer letters. vol 321. issue 2. 2012-10-09. PMID:22281241. |
bax translocation to mitochondria is required for mitochondrial protein release and cisplatin-induced apoptosis in human ovarian cancer cells. |
2012-10-09 |
2023-08-12 |
human |
| Li Wang, Chao Sun, Zhen-Hua Wang, Guang-Qin Gu. Mechanism of apoptotosis induced by ortho-topolin riboside in human hepatoma cell line SMMC-7721. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association. vol 50. issue 6. 2012-10-09. PMID:22465833. |
after otr treatment, up-regulation of the protein levels of pro-apoptotic bax and the down-regulation of the anti-apoptotic proteins, bcl-2 and bcl-xl was observed, leading to the loss of mitochondrial membrane potential, the release of cytochrome c from the mitochondria into the cytosol, the downstream activation of caspase-9 and caspase-3, as well as the cleavage of poly adp-ribose-polymerase (parp), the effect of apoptosis could be blocked by the pan-specific caspase inhibitor z-vad-fmk and caspase-9-specific inhibitor z-lehd-fmk. |
2012-10-09 |
2023-08-12 |
human |
| Kyung Hee Chang, Abel Sanchez-Aguilera, Shuhong Shen, Amitava Sengupta, Malav N Madhu, Ashley M Ficker, Susan K Dunn, Ashley M Kuenzi, Jorden L Arnett, Rebecca A Santho, Xabier Agirre, John P Perentesis, Michael W Deininger, Yi Zheng, Xose R Bustelo, David A Williams, Jose A Cancela. Vav3 collaborates with p190-BCR-ABL in lymphoid progenitor leukemogenesis, proliferation, and survival. Blood. vol 120. issue 4. 2012-10-09. PMID:22692505. |
vav3 deficiency induces apoptosis of murine and human leukemic lymphoid progenitors, decreases the activation of rho gtpase family members and p21-activated kinase, and is associated with increased bad phosphorylation and up-regulation of bax, bak, and bik. |
2012-10-09 |
2023-08-12 |
human |
| Mi-Ae Lyu, Lan V Pham, Bokyung Sung, Archito T Tamayo, Kwang Seok Ahn, Walter N Hittelman, Lawrence H Cheung, John W Marks, Min-Jeong Cho, Richard J Ford, Bharat B Aggarwal, Michael G Rosenblu. The therapeutic effects of rGel/BLyS fusion toxin in in vitro and in vivo models of mantle cell lymphoma. Biochemical pharmacology. vol 84. issue 4. 2012-10-08. PMID:22687624. |
combination treatment resulted in a synergistic growth inhibition, down-regulation of nf-κb dna-binding activity, inhibition of cyclin d1, bcl-x(l), p-akt, akt, p-mtor, and p-bad, up-regulation of bax, and induction of cellular apoptosis. |
2012-10-08 |
2023-08-12 |
mouse |
| Xue-Jiao Yang, Hui-Yuan Lu, Zi-Yin Li, Qian Bian, Liang-Lin Qiu, Zhong Li, Qizhan Liu, Jianmin Li, Xinru Wang, Shou-Lin Wan. Cytochrome P450 2A13 mediates aflatoxin B1-induced cytotoxicity and apoptosis in human bronchial epithelial cells. Toxicology. vol 300. issue 3. 2012-10-05. PMID:22743290. |
the increased expression of pro-apoptotic proteins, such as c-parp, c-caspase-3, and bax, and decreased expression of anti-apoptotic proteins, such as caspase-3, bcl-2, and p-bad further confirmed the data of afb(1)-induced cytotoxicity and apoptosis. |
2012-10-05 |
2023-08-12 |
human |
| Xiao-Peng Zhang, Feng Liu, Wei Wan. Regulation of the DNA damage response by p53 cofactors. Biophysical journal. vol 102. issue 10. 2012-10-04. PMID:22677378. |
if the damage is beyond repair, hzf is effectively degraded, and activated e2f1 induces aspp, which promotes the expression of bax to trigger apoptosis. |
2012-10-04 |
2023-08-12 |
Not clear |
| Jie Chen, Xiaoyan Liu, Jie Zhang, Yueran Zha. Targeting HMGB1 inhibits ovarian cancer growth and metastasis by lentivirus-mediated RNA interference. Journal of cellular physiology. vol 227. issue 11. 2012-10-03. PMID:22331597. |
furthermore, knockdown of hmgb1 induced ovarian cancer cell apoptosis, which was mediated by increased expression of bax and decreased expression of bcl-2. |
2012-10-03 |
2023-08-12 |
Not clear |
| A R Gottschalk, L H Boise, Z N Oltvai, M A Accavitti, S J Korsmeyer, J Quintáns, C B Thompso. The ability of Bcl-x(L) and Bcl-2 to prevent apoptosis can be differentially regulated. Cell death and differentiation. vol 3. issue 1. 2012-10-02. PMID:17180062. |
although bax overexpression can inhibit bcl-2 from prolonging cell survival upon growth factor withdrawal, bax overexpression did not inhibit bcl-x(l) from preventing apoptosis in this cell line. |
2012-10-02 |
2023-08-12 |
Not clear |
| K K Khanna, T Wie, Q Song, S R Burrows, D J Moss, S Krajewski, J C Reed, M F Lavi. Expression of p53, bcl-2, bax, bcl-x2 and c-myc in radiation-induced apoptosis in Burkitt's lymphoma cells. Cell death and differentiation. vol 3. issue 3. 2012-10-02. PMID:17180100. |
expression of p53, bcl-2, bax, bcl-x2 and c-myc in radiation-induced apoptosis in burkitt's lymphoma cells. |
2012-10-02 |
2023-08-12 |
human |
| K K Khanna, T Wie, Q Song, S R Burrows, D J Moss, S Krajewski, J C Reed, M F Lavi. Expression of p53, bcl-2, bax, bcl-x2 and c-myc in radiation-induced apoptosis in Burkitt's lymphoma cells. Cell death and differentiation. vol 3. issue 3. 2012-10-02. PMID:17180100. |
when these lines were analysed for bax and bcl-x(l) expression again no correlation was observed with susceptibility or resistance to apoptosis. |
2012-10-02 |
2023-08-12 |
human |
| K K Khanna, T Wie, Q Song, S R Burrows, D J Moss, S Krajewski, J C Reed, M F Lavi. Expression of p53, bcl-2, bax, bcl-x2 and c-myc in radiation-induced apoptosis in Burkitt's lymphoma cells. Cell death and differentiation. vol 3. issue 3. 2012-10-02. PMID:17180100. |
thus the status of p53, c-myc, bcl-2, bcl-x(l) and bax is not sufficiently informative in bl lines to predict susceptibility to radiation-induced apoptosis. |
2012-10-02 |
2023-08-12 |
human |
| M A Vogelbaum, J X Tong, R Higashikubo, D H Gutmann, K M Ric. Transfection of C6 glioma cells with the bax gene and increased sensitivity to treatment with cytosine arabinoside. Neurosurgical focus. vol 3. issue 5. 2012-10-02. PMID:17206779. |
genes known to be involved in the regulation of apoptosis include members of the bcl-2 gene family, such as inhibitors of apoptosis (bcl-2 and bcl-xl) and promotors of apoptosis (bax). |
2012-10-02 |
2023-08-12 |
rat |
| M A Vogelbaum, J X Tong, R Higashikubo, D H Gutmann, K M Ric. Transfection of C6 glioma cells with the bax gene and increased sensitivity to treatment with cytosine arabinoside. Neurosurgical focus. vol 3. issue 5. 2012-10-02. PMID:17206779. |
overexpression of the bax gene resulted in a decreased growth rate (average doubling time of 32.96 hours compared with 22.49 hours for untransfected c6, and 23.11 hours for clones transfected with pcdna3 only), which may be caused, in part, by an increased rate of spontaneous apoptosis (0.77 +/- 0.15% compared with 0.42 +/- 0.08% for the vector-only transfected c6 cell line; p = 0.038, two-tailed student's t-test). |
2012-10-02 |
2023-08-12 |
rat |
| M A Vogelbaum, J X Tong, R Higashikubo, D H Gutmann, K M Ric. Transfection of C6 glioma cells with the bax gene and increased sensitivity to treatment with cytosine arabinoside. Neurosurgical focus. vol 3. issue 5. 2012-10-02. PMID:17206779. |
treatment with 1 microm of cytosine arabinoside (ara-c) resulted in significantly more cells undergoing apoptosis in the cell line overexpressing bax than in the vector-only control cell line (23.57 +/- 2.6% compared with 5.3 +/- 0.7% terminal deoxynucleotidyl transferase--mediated biotinylated--deoxyuridine triphosphate nick-end labeling technique-positive cells; p = 0.007). |
2012-10-02 |
2023-08-12 |
rat |
| Mo Zheng, Lingxiao Xing, Hongyong Guo, Ying Li, Changzai Fan, Xianghong Zhang, Weili Ya. Study of the Effects of 50Hz Homogeneous Magnetic Field on Expression of Bax, Bcl-2 and Caspase-3 of SNU Cells In Vitro. Conference proceedings : ... Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual Conference. vol 2005. 2012-10-02. PMID:17281333. |
we concluded that possible mechanisms of apoptosis of snu cells after 50hz homogeneous ferromagnetic field (0.097t) treatment may be up-regulating the expression of bax and caspase-3, dowm-regulating the expression of bcl-2. |
2012-10-02 |
2023-08-12 |
human |
| O Csuka, E Remenár, K Koronczay, Z Doleschall, G Német. Predictive value of p53, Bcl2 and bax in the radiotherapy of head and neck cancer. Pathology oncology research : POR. vol 3. issue 3. 2012-10-02. PMID:18470731. |
the apoptosis is modulated by p53, bcl2 and bax proteins. |
2012-10-02 |
2023-08-12 |
Not clear |