| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Yanwen Fang, Xiaofen Mo, Yi Luo, Yi L. BAX gene over-expression via nucleofection to induce apoptosis in human lens epithelial cells. Experimental biology and medicine (Maywood, N.J.). vol 237. issue 9. 2012-11-29. PMID:22946090. |
bax gene over-expression via nucleofection to induce apoptosis in human lens epithelial cells. |
2012-11-29 |
2023-08-12 |
human |
| Sharifah S Syed Alwi, Breeze E Cavell, Alison Donlevy, Graham Packha. Differential induction of apoptosis in human breast cancer cell lines by phenethyl isothiocyanate, a glutathione depleting agent. Cell stress & chaperones. vol 17. issue 5. 2012-11-27. PMID:22351438. |
whereas peitc readily induced apoptosis in mda-mb-231 cells (associated with rapid activation of caspases 9 and 3, and decreased expression of bax), mcf7 cells were relatively resistant to the apoptosis promoting effects of peitc. |
2012-11-27 |
2023-08-12 |
human |
| Yongkun Sun, Kumiko Takahashi, Toshiyuki Hosokawa, Takeshi Saito, Masaaki Kurasak. Diethyl phthalate enhances apoptosis induced by serum deprivation in PC12 cells. Basic & clinical pharmacology & toxicology. vol 111. issue 2. 2012-11-26. PMID:22348465. |
in this study, to examine the mechanism of diethyl phthalate toxicity to cells, the effects of diethyl phthalate on apoptosis in a pc12 cell system were investigated by assaying apoptotic factors such as caspase-3, bax, cytochrome c and dna damage. |
2012-11-26 |
2023-08-12 |
Not clear |
| Kathrin Sabine Ellesat, Tor Fredrik Holth, Marcin Włodzimierz Wojewodzic, Ketil Hyllan. Atorvastatin up-regulate toxicologically relevant genes in rainbow trout gills. Ecotoxicology (London, England). vol 21. issue 7. 2012-11-26. PMID:22555812. |
genes involved in membrane transport (pgp, mrp1), oxidative stress response (sod, mt), apoptosis (bax) and biotransformation (sult2b) were differentially expressed whereas the expression of genes involved in cholesterol biosynthesis (hmgr, fdps) or peroxisomal proliferation (ppar) were not affected. |
2012-11-26 |
2023-08-12 |
Not clear |
| Hye-Min Park, Shang-Jin Kim, Jin-Shang Kim, Hyung-Sub Kan. Reactive oxygen species mediated ginsenoside Rg3- and Rh2-induced apoptosis in hepatoma cells through mitochondrial signaling pathways. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association. vol 50. issue 8. 2012-11-26. PMID:22634290. |
in the mitochondria-mediated apoptosis pathway, krg, grg3 and grh2 have the ability to stimulate the release of mitochondrial cytochrome c, activation of caspase-3 and bax protein, inhibition of bcl-2 protein and production of intracellular reactive oxygen species in hep3b cells. |
2012-11-26 |
2023-08-12 |
human |
| Luciana Rabelo, Norberto Monteiro, Raphael Serquiz, Paula Santos, Ruth Oliveira, Adeliana Oliveira, Hugo Rocha, Ana Heloneida Morais, Adriana Uchoa, Elizeu Santo. A lactose-binding lectin from the marine sponge Cinachyrella apion (Cal) induces cell death in human cervical adenocarcinoma cells. Marine drugs. vol 10. issue 4. 2012-11-26. PMID:22690140. |
results showed that lectin probably induces cell death by apoptosis activation by pro-apoptotic protein bax, promoting mitochondrial membrane permeabilization, cell cycle arrest in s phase and acting as both dependent and/or independent of caspases pathway. |
2012-11-26 |
2023-08-12 |
human |
| Daniela Impellizzeri, Emanuela Mazzon, Irene Paterniti, Emanuela Esposito, Salvatore Cuzzocre. Effect of fasudil, a selective inhibitor of Rho kinase activity, in the secondary injury associated with the experimental model of spinal cord trauma. The Journal of pharmacology and experimental therapeutics. vol 343. issue 1. 2012-11-26. PMID:22733360. |
the treatment with fasudil significantly decreased 1) histological damage; 2) motor recovery; 3) nuclear factor-κb (nf-κb) expression; 4) rok activity; 5) inflammasome activation (caspase-1 and nod-like receptor family, pyrin domain-containing 3 expression); 6) production of proinflammatory cytokine such as tumor necrosis factor and interleukin-1β (il-1β); 7) neutrophil infiltration; 8) nitrotyrosine and poly-adp-ribose formation; 9) glial fibrillary acidic protein expression; 10) apoptosis (terminal deoxynucleotidyl transferase dutp nick-end labeling staining, fas ligand expression, and bax and bcl-2 expression); and 11) mitogen-activated protein kinase activation (phospho-extracellular signal-regulated kinase and phospho-c-jun nh(2)-terminal kinase expression). |
2012-11-26 |
2023-08-12 |
mouse |
| Chaoqing Huang, Xiaoguang Chen, Baolin Guo, Wenhua Huang, Ting Shen, Xinguang Sun, Peigen Xiao, Qing Zho. Induction of apoptosis by Icariside II through extrinsic and intrinsic signaling pathways in human breast cancer MCF7 cells. Bioscience, biotechnology, and biochemistry. vol 76. issue 7. 2012-11-26. PMID:22785466. |
icas also increased the expression of bax and biml without affecting the expression status of bcl-2 and bid, suggesting that the apoptosis induced by icas was related to bcl-2 family protein regulation. |
2012-11-26 |
2023-08-12 |
human |
| Zhang Yuan, Chen Long, Tang Junming, Liu Qihuan, Zhang Youshun, Zou Cha. Quercetin-induced apoptosis of HL-60 cells by reducing PI3K/Akt. Molecular biology reports. vol 39. issue 7. 2012-11-23. PMID:22555976. |
hl-60 leukemia cell lines was treated with different dose quercetin, the proliferation activity of leukemia cells was assessed by mtt method; the morphological changes of apoptosis of hl-60 cells, including nuclear condensation and dna fragmentation, were observed by hoechst 33258 fluorescence staining, the apoptosis rate and caspase 2,3 activation were assessed by flow cytometry, and the cell signal pathway including phosphatidylinositol 3-kinase (pi3k), phosphorylated protein kinase b (pakt), bcl-2, bax were detected by western blotting. |
2012-11-23 |
2023-08-12 |
Not clear |
| Zhang Yuan, Chen Long, Tang Junming, Liu Qihuan, Zhang Youshun, Zou Cha. Quercetin-induced apoptosis of HL-60 cells by reducing PI3K/Akt. Molecular biology reports. vol 39. issue 7. 2012-11-23. PMID:22555976. |
quercetin caused leukemia cells apoptosis by decreasing the protein expression of pi3k and bax, the inhibitory phosphorylation of akt, the decreased levels of bcl-2 protein and increased activations of caspase-2 and -3, and increased poly(adp-ribose) polymerase cleavage. |
2012-11-23 |
2023-08-12 |
Not clear |
| Yanhong Lv, Ming Fang, Jinhua Zheng, Bing Yang, Haixia Li, Zhong Xiuzigao, Wei Song, Yan Chen, Wenwu Ca. Low-intensity ultrasound combined with 5-aminolevulinic acid administration in the treatment of human tongue squamous carcinoma. Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology. vol 30. issue 2. 2012-11-20. PMID:22739213. |
the process initially damaged mitochondria, activated pro-apoptotic factors bax and cytochrome c and suppressed the anti-apoptotic factor bcl-2, activated caspase-3 to executed apoptosis through mitochondrial signaling pathway. |
2012-11-20 |
2023-08-12 |
mouse |
| Yuri Kim, Jina Kim, Seung-Min Lee, Hyun Ah Lee, Seolhyun Park, Yesl Kim, Jung-Hyun Ki. Chemopreventive effects of Rubus coreanus Miquel on prostate cancer. Bioscience, biotechnology, and biochemistry. vol 76. issue 4. 2012-11-19. PMID:22484941. |
eur also induced mitochondrial-mediated apoptosis in prostate cancer cells by reducing bcl-2 and bcl-(x)l levels, but increased bax levels. |
2012-11-19 |
2023-08-12 |
Not clear |
| Lin Wang, Haiyan Xing, Zheng Tian, Leiwen Peng, Yan Li, Kejing Tang, Qing Rao, Min Wang, Jianxiang Wan. iASPPsv antagonizes apoptosis induced by chemotherapeutic agents in MCF-7 cells and mouse thymocytes. Biochemical and biophysical research communications. vol 424. issue 3. 2012-11-19. PMID:22766503. |
iasppsv also down-regulated proapoptotic genes (bax, puma and noxa) expression to inhibit apoptosis caused by vp-16. |
2012-11-19 |
2023-08-12 |
mouse |
| N I Grineva, E A Duchovenskay, A M Timofeev, T V Akhlynina, L P Gerasimova, T V Borovkova, D A Schmarov, N G Sarycheva, N M Naydenova, A R Gavrichkova, L Y Kolosova, T I Kolosheynova, L G Kovalev. Gene Expression upon Proliferation and Differentiation of Hematopoietic Cells with Ph Chromosome ex vivo. Acta naturae. vol 4. issue 3. 2012-11-19. PMID:23150808. |
the genesp53, mdm2, p21, c-myc,bcr/abl, bcr, bcl2, bax, and gapdh participate in the regulation of cell proliferation and differentiation, apoptosis and cell distribution for the cell cycle ex vivo in the ph(+)cells of chronic myeloid leukemia containing the ph chromosome andbcr/abloncogene. |
2012-11-19 |
2023-08-12 |
Not clear |
| Xiao Wen Mao, James D Crapo, Daila S Gridle. Mitochondrial oxidative stress-induced apoptosis and radioprotection in proton-irradiated rat retina. Radiation research. vol 178. issue 3. 2012-11-16. PMID:22780102. |
proton irradiation was delivered to the same eye at doses of 1 or 4 gy and assays were done at 6 h. levels of bax, bcl-2 and sod2 proteins were evaluated by western blot and caspase-3 immunohistochemistry was performed to confirm the occurrence of apoptosis. |
2012-11-16 |
2023-08-12 |
rat |
| Xiao Wen Mao, James D Crapo, Daila S Gridle. Mitochondrial oxidative stress-induced apoptosis and radioprotection in proton-irradiated rat retina. Radiation research. vol 178. issue 3. 2012-11-16. PMID:22780102. |
in addition, irradiation caused changes in various proteins involved in apoptosis (caspase-3, bax and bcl2). |
2012-11-16 |
2023-08-12 |
rat |
| Salik Hussain, Faris Al-Nsour, Annette B Rice, Jamie Marshburn, Brenda Yingling, Zhaoxia Ji, Jeffrey I Zink, Nigel J Walker, Stavros Garantzioti. Cerium dioxide nanoparticles induce apoptosis and autophagy in human peripheral blood monocytes. ACS nano. vol 6. issue 7. 2012-11-13. PMID:22717232. |
ceo(2) np exposure leads to decrease in cell viability, and treated cells exhibit characteristic hallmarks of apoptosis (activation of bax, loss of mitochondrial membrane potential, dna fragmentation). |
2012-11-13 |
2023-08-12 |
human |
| Y-L Sun, J Zhang, Z-G Ping, C-Q Wang, Y-F Sun, L Chen, X-Y Li, C-J Li, X-L Zhu, Z Liu, W Zhang, X Zho. Relationship between apoptosis and proliferation in granulosa and theca cells of cystic follicles in sows. Reproduction in domestic animals = Zuchthygiene. vol 47. issue 4. 2012-11-09. PMID:22023076. |
apoptotic frequencies were examined by tunel assay and the expression of apoptosis regulators (xiap, bax, bc1-2 and caspase-3) by immunohistochemistry, western blotting and real-time quantitative pcr; cell proliferation activity was evaluated by pcna immunohistochemistry and proliferation of in vitro cultured granulosa and theca cells. |
2012-11-09 |
2023-08-12 |
Not clear |
| Y-L Sun, J Zhang, Z-G Ping, C-Q Wang, Y-F Sun, L Chen, X-Y Li, C-J Li, X-L Zhu, Z Liu, W Zhang, X Zho. Relationship between apoptosis and proliferation in granulosa and theca cells of cystic follicles in sows. Reproduction in domestic animals = Zuchthygiene. vol 47. issue 4. 2012-11-09. PMID:22023076. |
low frequency of apoptosis might be associated with decreased amounts of apoptotic-related factors (bax and caspase-3) and increased amounts of anti-apoptotic factors (xiap and bcl-2) in cystic follicles. |
2012-11-09 |
2023-08-12 |
Not clear |
| Rong Hui Du, Jiang Tao Cui, Ting Wang, Ai Hua Zhang, Ren Xiang Ta. Trichothecin induces apoptosis of HepG2 cells via caspase-9 mediated activation of the mitochondrial death pathway. Toxicon : official journal of the International Society on Toxinology. vol 59. issue 1. 2012-11-08. PMID:22118979. |
in consistence with the elevated apoptosis rate, expression of anti-apoptotic protein bcl-2 was diminished and expression of proapoptotic protein bax was enhanced at mrna levels. |
2012-11-08 |
2023-08-12 |
human |