| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Jong-Lyel Roh, Jung Ho Ko, Soo Jin Moon, Chang Hwan Ryu, Jun Young Choi, Wayne M Koc. The p53-reactivating small-molecule RITA enhances cisplatin-induced cytotoxicity and apoptosis in head and neck cancer. Cancer letters. vol 325. issue 1. 2013-01-16. PMID:22634494. |
rita promoted apoptosis in association with upregulation of p21, bax, and cleaved caspase-3; notably, the apoptotic response was blocked by pifithrin-α, demonstrating its p53 dependence. |
2013-01-16 |
2023-08-12 |
Not clear |
| Hui Tian, Baofu Zhang, JieHui Di, Guan Jiang, FeiFei Chen, HuiZhong Li, LianTao Li, DongSheng Pei, JunNian Zhen. Keap1: one stone kills three birds Nrf2, IKKβ and Bcl-2/Bcl-xL. Cancer letters. vol 325. issue 1. 2013-01-16. PMID:22743616. |
keap1 led to the repression and destabilization of bcl-2, decreased bcl-2:bax heterodimers and facilitated cancer cells apoptosis. |
2013-01-16 |
2023-08-12 |
Not clear |
| Junghyun Kim, Chan-Sik Kim, Eunjin Sohn, Yun Mi Lee, Kyuhyung Jo, Jin Sook Ki. KIOM-79 protects AGE-induced retinal pericyte apoptosis via inhibition of NF-kappaB activation in vitro and in vivo. PloS one. vol 7. issue 8. 2013-01-16. PMID:22916281. |
kiom-79 strongly inhibited pericyte apoptosis, nf-κb activation and the expression of pro-apoptotic bax and tumor necrosis factor-α. |
2013-01-16 |
2023-08-12 |
rat |
| J F N Pinto Rodrigues, C T Fujiyama Oshima, A P Ribeiro Paiotti, M Franco, S S Miki Ihara, D A Ribeir. Expression of apoptosis regulatory proteins p53, bcl-2 and bax in recurrent aphthous ulceration. Journal of the European Academy of Dermatology and Venereology : JEADV. vol 26. issue 10. 2013-01-15. PMID:22092434. |
expression of apoptosis regulatory proteins p53, bcl-2 and bax in recurrent aphthous ulceration. |
2013-01-15 |
2023-08-12 |
Not clear |
| Min-Xia Zhu, Bing Ran, Zhi-Qiang Feng, Qiang-Wen Pa. [Effects of Rb1 and Rg1 on the expression of Bcl-2, Bax in apoptosis of HK-2 cells induced by the serum of kidney ischemia/reperfusion]. Zhongguo ying yong sheng li xue za zhi = Zhongguo yingyong shenglixue zazhi = Chinese journal of applied physiology. vol 25. issue 4. 2013-01-14. PMID:21158042. |
[effects of rb1 and rg1 on the expression of bcl-2, bax in apoptosis of hk-2 cells induced by the serum of kidney ischemia/reperfusion]. |
2013-01-14 |
2023-08-12 |
Not clear |
| Min-Xia Zhu, Bing Ran, Zhi-Qiang Feng, Qiang-Wen Pa. [Effects of Rb1 and Rg1 on the expression of Bcl-2, Bax in apoptosis of HK-2 cells induced by the serum of kidney ischemia/reperfusion]. Zhongguo ying yong sheng li xue za zhi = Zhongguo yingyong shenglixue zazhi = Chinese journal of applied physiology. vol 25. issue 4. 2013-01-14. PMID:21158042. |
to explore effects of ginsenosides (rb1, rg1) on the expression of bcl-2, bax in the serum of kidney ischemia/reperfusion inducing apoptosis of hk-2 cells. |
2013-01-14 |
2023-08-12 |
Not clear |
| Musiliyu A Musa, Veera L D Badisa, Lekan M Latinwo, Tyise A Patterson, Marcia A Owen. Coumarin-based benzopyranone derivatives induced apoptosis in human lung (A549) cancer cells. Anticancer research. vol 32. issue 10. 2013-01-14. PMID:23060547. |
western blotting demonstrated that compound 5 induced apoptosis and caused cell death in the a549 cell line via an increase (up-regulation) in bax protein expression (pro-apoptotic pathway) and a slight decrease (down-regulation) in bcl-2 protein expression (anti-apoptotic pathway) after 6 h of treatment. |
2013-01-14 |
2023-08-12 |
human |
| Jie Zhao, Lin-ping Wang, Ji-sheng Nie, Qiao Ni. [Effects of benzo(a)pyrene on apoptosis of neuronal cells and expression of Bcl-2 and Bax proteins in rat brain tissue]. Zhonghua lao dong wei sheng zhi ye bing za zhi = Zhonghua laodong weisheng zhiyebing zazhi = Chinese journal of industrial hygiene and occupational diseases. vol 29. issue 11. 2013-01-07. PMID:22357517. |
[effects of benzo(a)pyrene on apoptosis of neuronal cells and expression of bcl-2 and bax proteins in rat brain tissue]. |
2013-01-07 |
2023-08-12 |
rat |
| Jie Zhao, Lin-ping Wang, Ji-sheng Nie, Qiao Ni. [Effects of benzo(a)pyrene on apoptosis of neuronal cells and expression of Bcl-2 and Bax proteins in rat brain tissue]. Zhonghua lao dong wei sheng zhi ye bing za zhi = Zhonghua laodong weisheng zhiyebing zazhi = Chinese journal of industrial hygiene and occupational diseases. vol 29. issue 11. 2013-01-07. PMID:22357517. |
to observe the effects of benzo(a)pyrene (bap) on apoptosis of neuronal cells and expression of bcl-2 and bax proteins and to explore the mechanism of neurotoxicity induced by bap in rats. |
2013-01-07 |
2023-08-12 |
rat |
| Qian Wei, Yu Qiang Sun, Jin Zhan. Exendin-4, a glucagon-like peptide-1 receptor agonist, inhibits cell apoptosis induced by lipotoxicity in pancreatic β-cell line. Peptides. vol 37. issue 1. 2013-01-07. PMID:22776329. |
exendin-4 also inhibited the mitochondrial pathway of apoptosis and down-regulated bax in min6 cells. |
2013-01-07 |
2023-08-12 |
Not clear |
| Tao Shen, Li Zhang, Yan-Yan Wang, Pei-Hong Fan, Xiao-Ning Wang, Zhao-Min Lin, Hong-Xiang Lo. Steroids from Commiphora mukul display antiproliferative effect against human prostate cancer PC3 cells via induction of apoptosis. Bioorganic & medicinal chemistry letters. vol 22. issue 14. 2013-01-04. PMID:22687747. |
further study showed that 2 was able to enforce the pc3 cell cycle arrest in the g2/m phase, and induce the apoptosis of pc3 cells by activation of bax, caspases 3 and 9, and by inhibition of bcl-2. |
2013-01-04 |
2023-08-12 |
human |
| Alessandro Didonna, Joshua Sussman, Federico Benetti, Giuseppe Legnam. The role of Bax and caspase-3 in doppel-induced apoptosis of cerebellar granule cells. Prion. vol 6. issue 3. 2013-01-02. PMID:22561161. |
the role of bax and caspase-3 in doppel-induced apoptosis of cerebellar granule cells. |
2013-01-02 |
2023-08-12 |
mouse |
| Alessandro Didonna, Joshua Sussman, Federico Benetti, Giuseppe Legnam. The role of Bax and caspase-3 in doppel-induced apoptosis of cerebellar granule cells. Prion. vol 6. issue 3. 2013-01-02. PMID:22561161. |
when primary neuronal cultures from bax-deficient mice were incubated with dpl, no apoptosis was observed, suggesting an important role of bax in triggering neurodegeneration. |
2013-01-02 |
2023-08-12 |
mouse |
| Alessandro Didonna, Joshua Sussman, Federico Benetti, Giuseppe Legnam. The role of Bax and caspase-3 in doppel-induced apoptosis of cerebellar granule cells. Prion. vol 6. issue 3. 2013-01-02. PMID:22561161. |
together, our findings raise the possibility that bax and caspase-3 feature in dpl-mediated apoptosis. |
2013-01-02 |
2023-08-12 |
mouse |
| Xuan Li, Xiao-Ling Zhang, Gang Shen, Guo-Hua Tan. Effects of tensile forces on serum deprivation-induced osteoblast apoptosis: expression analysis of caspases, Bcl-2, and Bax. Chinese medical journal. vol 125. issue 14. 2013-01-02. PMID:22882941. |
effects of tensile forces on serum deprivation-induced osteoblast apoptosis: expression analysis of caspases, bcl-2, and bax. |
2013-01-02 |
2023-08-12 |
Not clear |
| Xuan Li, Xiao-Ling Zhang, Gang Shen, Guo-Hua Tan. Effects of tensile forces on serum deprivation-induced osteoblast apoptosis: expression analysis of caspases, Bcl-2, and Bax. Chinese medical journal. vol 125. issue 14. 2013-01-02. PMID:22882941. |
the purpose of this study was to investigate the effects of tensile forces on osteoblast apoptosis and the related mechanism by analyzing the expression of caspases, bcl-2, and bax. |
2013-01-02 |
2023-08-12 |
Not clear |
| Huda H Al-Khalaf, Siti-Faujiah Hendrayani, Abdelilah Aboussekhr. ATR controls the p21(WAF1/Cip1) protein up-regulation and apoptosis in response to low UV fluences. Molecular carcinogenesis. vol 51. issue 12. 2012-12-26. PMID:21976111. |
furthermore, we present evidence that atr inhibits apoptosis in response to low fluences of uv light, through inhibiting the cleavage of caspase 3 and parp as well as the repression of the proapoptotic proteins bax and bak. |
2012-12-26 |
2023-08-12 |
human |
| Mitali Pandey, Parminder Kaur, Sanjeev Shukla, Ata Abbas, Pingfu Fu, Sanjay Gupt. Plant flavone apigenin inhibits HDAC and remodels chromatin to induce growth arrest and apoptosis in human prostate cancer cells: in vitro and in vivo study. Molecular carcinogenesis. vol 51. issue 12. 2012-12-26. PMID:22006862. |
furthermore, apigenin intake caused a significant decrease in bcl2 expression with concomitant increase in bax, shifting the bax/bcl2 ratio in favor of apoptosis. |
2012-12-26 |
2023-08-12 |
mouse |
| Aditya Sunkaria, Willayat Yousuf Wani, Deep Raj Sharma, Kiran Dip Gil. Dichlorvos exposure results in activation induced apoptotic cell death in primary rat microglia. Chemical research in toxicology. vol 25. issue 8. 2012-12-26. PMID:22817663. |
the dna fragmentation pattern of dichlorvos treated microglia along with increased expression of bax in mitochondria, cytochrome c release from mitochondria, and caspase-3 activation led us to assume that microglia were undergoing apoptosis. |
2012-12-26 |
2023-08-12 |
rat |
| Derek G Southwell, Mercedes F Paredes, Rui P Galvao, Daniel L Jones, Robert C Froemke, Joy Y Sebe, Clara Alfaro-Cervello, Yunshuo Tang, Jose M Garcia-Verdugo, John L Rubenstein, Scott C Baraban, Arturo Alvarez-Buyll. Intrinsically determined cell death of developing cortical interneurons. Nature. vol 491. issue 7422. 2012-12-26. PMID:23041929. |
we found that 40% of developing cortical interneurons were eliminated through bax (bcl-2-associated x)-dependent apoptosis during postnatal life. |
2012-12-26 |
2023-08-12 |
mouse |