| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Xia Li, Lei Liu, Defang Meng, Dandan Wang, Jiyun Zhang, Dongyan Shi, Huiqing Liu, Huji Xu, Liwei Lu, Lingyun Su. Enhanced apoptosis and senescence of bone-marrow-derived mesenchymal stem cells in patients with systemic lupus erythematosus. Stem cells and development. vol 21. issue 13. 2013-01-23. PMID:22375903. |
when bmscs were induced to apoptosis by tumor necrosis factor-α (tnf-α) stimulation in vitro, the bax and caspase 8 expression in sle bmscs was significantly increased at mrna levels. |
2013-01-23 |
2023-08-12 |
Not clear |
| Chien-Chih Yu, Fang-Yu Ko, Chun-Shu Yu, Chin-Chung Lin, Yi-Ping Huang, Jai-Sing Yang, Jing-Pin Lin, Jing-Gung Chun. Norcantharidin triggers cell death and DNA damage through S-phase arrest and ROS-modulated apoptotic pathways in TSGH 8301 human urinary bladder carcinoma cells. International journal of oncology. vol 41. issue 3. 2013-01-23. PMID:22684608. |
western blotting indicated that nctd upregulated fas, fasl, bax, bid, cytochrome c, caspase-3, -8 and -9 that led to the induction of apoptosis through the fas extrinsic pathway. |
2013-01-23 |
2023-08-12 |
human |
| Juthika Kundu, S M Riajul Wahab, Joydeb Kumar Kundu, Yoon-La Choi, Ozgur Cem Erkin, Hun Seok Lee, Sang Gyu Park, Young Kee Shi. Tob1 induces apoptosis and inhibits proliferation, migration and invasion of gastric cancer cells by activating Smad4 and inhibiting β‑catenin signaling. International journal of oncology. vol 41. issue 3. 2013-01-23. PMID:22710759. |
the overexpression of tob1 induced apoptosis in mkn28 and ags cells, which was associated with sub-g1 arrest, activation of caspase-3, induction of bax, inhibition of bcl-2 and cleavage of poly (adp-ribose) polymerase (parp). |
2013-01-23 |
2023-08-12 |
human |
| Henriette Kauntz, Souad Bousserouel, Francine Gosse, Jacques Marescaux, Francis Rau. Silibinin, a natural flavonoid, modulates the early expression of chemoprevention biomarkers in a preclinical model of colon carcinogenesis. International journal of oncology. vol 41. issue 3. 2013-01-23. PMID:22735354. |
mechanisms involved in silibinin-induced apoptosis included the downregulation of the anti-apoptotic protein bcl-2 and upregulation of the pro-apoptotic protein bax, inverting the bcl-2/bax ratio to <1. |
2013-01-23 |
2023-08-12 |
human |
| Yan Sun, Xiaoping Zhao, Yuting Yao, Xinyi Qi, Yaozong Yuan, Yu H. Connexin 43 interacts with Bax to regulate apoptosis of pancreatic cancer through a gap junction-independent pathway. International journal of oncology. vol 41. issue 3. 2013-01-23. PMID:22736223. |
connexin 43 interacts with bax to regulate apoptosis of pancreatic cancer through a gap junction-independent pathway. |
2013-01-23 |
2023-08-12 |
Not clear |
| Yan Sun, Xiaoping Zhao, Yuting Yao, Xinyi Qi, Yaozong Yuan, Yu H. Connexin 43 interacts with Bax to regulate apoptosis of pancreatic cancer through a gap junction-independent pathway. International journal of oncology. vol 41. issue 3. 2013-01-23. PMID:22736223. |
in the context of apoptosis, cx43 translocated to the mitochondria, where it interacted with bax to initiate the mitochondrial apoptotic pathway. |
2013-01-23 |
2023-08-12 |
Not clear |
| Jin-Nyoung Ho, Ho-Geun Yoon, Chang-Soo Park, Sunoh Kim, Woojin Jun, Ryowon Choue, Jeongmin Le. Isothiocyanates ameliorate the symptom of heart dysfunction and mortality in a murine AIDS model by inhibiting apoptosis in the left ventricle. Journal of medicinal food. vol 15. issue 9. 2013-01-22. PMID:22925072. |
furthermore, certain itcs may have the potential to improve aids-related heart dysfunction due to their inhibition of apoptosis by decreasing inos and bax expression through suppression of nf-κb. |
2013-01-22 |
2023-08-12 |
mouse |
| Suren A Tatulian, Pranav Garg, Kathleen N Nemec, Bo Chen, Annette R Khale. Molecular basis for membrane pore formation by Bax protein carboxyl terminus. Biochemistry. vol 51. issue 46. 2013-01-22. PMID:23110300. |
bax protein plays a key role in mitochondrial membrane permeabilization and cytochrome c release upon apoptosis. |
2013-01-22 |
2023-08-12 |
Not clear |
| Lili Yu, Zehua Wan. Effects of Livin gene RNA interference on apoptosis of cervical cancer HeLa cells and enhanced sensitivity to cisplatin. Journal of Huazhong University of Science and Technology. Medical sciences = Hua zhong ke ji da xue xue bao. Yi xue Ying De wen ban = Huazhong keji daxue xuebao. Yixue Yingdewen ban. vol 29. issue 5. 2013-01-18. PMID:19821098. |
the recombinant plasmids pgenesil-1-birc71 and pgenesil-1-birc72 were transfected into hela cells and cisplatin was added with different concentrations in order to study the inhibitory effects of livin gene, increase the apoptosis induced by cisplatin, and detect the expression of bcl-2, bax, caspase-3, and survivin genes. |
2013-01-18 |
2023-08-12 |
Not clear |
| Lili Yu, Zehua Wan. Effects of Livin gene RNA interference on apoptosis of cervical cancer HeLa cells and enhanced sensitivity to cisplatin. Journal of Huazhong University of Science and Technology. Medical sciences = Hua zhong ke ji da xue xue bao. Yi xue Ying De wen ban = Huazhong keji daxue xuebao. Yixue Yingdewen ban. vol 29. issue 5. 2013-01-18. PMID:19821098. |
it was concluded that shrna expression vector targeting livin gene could inhibit the expression of livin gene in hela cells and enhance the apoptosis induced by cisplatin, which was related to the decreased expression of bcl-2 and activation of bax and caspase-3. |
2013-01-18 |
2023-08-12 |
Not clear |
| Xianghong Wang, Liling Li, Bo Wang, Jinyi Xian. Effects of ursolic acid on the proliferation and apoptosis of human ovarian cancer cells. Journal of Huazhong University of Science and Technology. Medical sciences = Hua zhong ke ji da xue xue bao. Yi xue Ying De wen ban = Huazhong keji daxue xuebao. Yixue Yingdewen ban. vol 29. issue 6. 2013-01-18. PMID:20037823. |
moreover, the apoptosis was found in the caov3 cells exposed to ua; the bax expression was increased and the bcl-2 expression decreased. |
2013-01-18 |
2023-08-12 |
human |
| Xianghong Wang, Liling Li, Bo Wang, Jinyi Xian. Effects of ursolic acid on the proliferation and apoptosis of human ovarian cancer cells. Journal of Huazhong University of Science and Technology. Medical sciences = Hua zhong ke ji da xue xue bao. Yi xue Ying De wen ban = Huazhong keji daxue xuebao. Yixue Yingdewen ban. vol 29. issue 6. 2013-01-18. PMID:20037823. |
and it can also induce the apoptosis of the caov3 cells by up-regulating the bax expression and down-regulating the bcl-2 expression. |
2013-01-18 |
2023-08-12 |
human |
| F Wilfling, A Weber, S Potthoff, F-N Vögtle, C Meisinger, S A Paschen, G Häcke. BH3-only proteins are tail-anchored in the outer mitochondrial membrane and can initiate the activation of Bax. Cell death and differentiation. vol 19. issue 8. 2013-01-18. PMID:22343714. |
during mitochondrial apoptosis, pro-apoptotic bh3-only proteins cause the translocation of cytosolic bcl-2-associated x protein (bax) to the outer mitochondrial membrane (omm) where it is activated to release cytochrome c from the mitochondrial intermembrane space, but the mechanism is under dispute. |
2013-01-18 |
2023-08-12 |
mouse |
| F Wilfling, A Weber, S Potthoff, F-N Vögtle, C Meisinger, S A Paschen, G Häcke. BH3-only proteins are tail-anchored in the outer mitochondrial membrane and can initiate the activation of Bax. Cell death and differentiation. vol 19. issue 8. 2013-01-18. PMID:22343714. |
the bh3-only proteins bcl-2-interacting mediator of cell death (bim), tbid and p53-upregulated modulator of apoptosis sensitised isolated mitochondria from bax/bcl-2 homologous antagonist/killer-deficient fibroblasts to cytochrome c-release by recombinant, extramitochondrial bax. |
2013-01-18 |
2023-08-12 |
mouse |
| L Cipa. Novel nonclassical antifolate, 2-[N-(2´-Hydroxyethyl)amino]methyl-3H-quinazolin-4-one, with a potent antineoplastic activity toward leukemia cells. Neoplasma. vol 59. issue 6. 2013-01-18. PMID:22862178. |
heamq-induced apoptosis was accompanied with up-regulation of the protein expression of bax and down-regulation of the protein expression of bcl-2, mcl-1, xiap, and survivin, resulting in cytochrome c release and activation of caspases. |
2013-01-18 |
2023-08-12 |
mouse |
| L Cipa. Novel nonclassical antifolate, 2-[N-(2´-Hydroxyethyl)amino]methyl-3H-quinazolin-4-one, with a potent antineoplastic activity toward leukemia cells. Neoplasma. vol 59. issue 6. 2013-01-18. PMID:22862178. |
inhibitors of jnk (sp600125) and p38 mapk (sb203580) suppressed heamq-induced apoptosis and g2/m phase arrest, attenuated the activation of bax, and blocked down-regulation of bcl-2, xiap and survivin in heamq-treated u937 cells. |
2013-01-18 |
2023-08-12 |
mouse |
| Juan I Barrasa, Angélica Santiago-Gómez, Nieves Olmo, María Antonia Lizarbe, Javier Turna. Resistance to butyrate impairs bile acid-induced apoptosis in human colon adenocarcinoma cells via up-regulation of Bcl-2 and inactivation of Bax. Biochimica et biophysica acta. vol 1823. issue 12. 2013-01-18. PMID:22917577. |
resistance to butyrate impairs bile acid-induced apoptosis in human colon adenocarcinoma cells via up-regulation of bcl-2 and inactivation of bax. |
2013-01-18 |
2023-08-12 |
human |
| Juan I Barrasa, Angélica Santiago-Gómez, Nieves Olmo, María Antonia Lizarbe, Javier Turna. Resistance to butyrate impairs bile acid-induced apoptosis in human colon adenocarcinoma cells via up-regulation of Bcl-2 and inactivation of Bax. Biochimica et biophysica acta. vol 1823. issue 12. 2013-01-18. PMID:22917577. |
moreover, butyrate-resistant cells show higher bcl-2 levels that confer resistance to bile acid-induced apoptosis sequestering bax and avoiding bax-dependent pore formation in the mitochondria. |
2013-01-18 |
2023-08-12 |
human |
| Sankar Ramachandran, Mahitosh Manda. Induction of apoptosis of azurin synthesized from P. aeruginosa MTCC 2453 against Dalton's lymphoma ascites model. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 65. issue 7. 2013-01-17. PMID:22000294. |
further, the cause of apoptosis was revealed by western blot which showed the reduction in the ratio of bcl-2 and bax protein expression, the activation of caspases-3 through the release of cytochrome c in dl cells. |
2013-01-17 |
2023-08-12 |
mouse |
| Birsen Caki. Bax induces activation of the unfolded protein response by inducing HAC1 mRNA splicing in Saccharomyces cerevisiae. Yeast (Chichester, England). vol 29. issue 9. 2013-01-17. PMID:22903551. |
bax, a multidomain pro-apoptotic bcl-2 protein, localizes to the endoplasmic reticulum (er), where it regulates er stress-induced apoptosis. |
2013-01-17 |
2023-08-12 |
Not clear |