| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Junhe Ma, Frank Edlich, Guillermo A Bermejo, Kristi L Norris, Richard J Youle, Nico Tjandr. Structural mechanism of Bax inhibition by cytomegalovirus protein vMIA. Proceedings of the National Academy of Sciences of the United States of America. vol 109. issue 51. 2013-02-28. PMID:23213219. |
the structure suggests that by stabilizing key elements in bax needed to unravel for its mom insertion and oligomerization, vmia prevents these important steps in apoptosis. |
2013-02-28 |
2023-08-12 |
human |
| Ruma Sarkar, Sutapa Mukherjee, Jaydip Biswas, Madhumita Ro. Sulphoraphane, a naturally occurring isothiocyanate induces apoptosis in breast cancer cells by targeting heat shock proteins. Biochemical and biophysical research communications. vol 427. issue 1. 2013-02-27. PMID:22975350. |
it was furthermore investigated whether modulation of hsps and hsf1 could induce apoptosis in these cells by altering the expressions of p53, p21 and some apoptotic proteins like bcl-2, bax, bid, bad, apaf-1 and aif. |
2013-02-27 |
2023-08-12 |
human |
| Akbar Ahmad, Tiziana Genovese, Daniela Impellizzeri, Rosalia Crupi, Enrico Velardi, Angela Marino, Emanuela Esposito, Salvatore Cuzzocre. Reduction of ischemic brain injury by administration of palmitoylethanolamide after transient middle cerebral artery occlusion in rats. Brain research. vol 1477. 2013-02-27. PMID:23046519. |
pea-mediated improvements in tissues histology shown by reduction of lesion size and improvement in apoptosis level (assayed by bax and bcl-2) further support the efficacy of pea therapy. |
2013-02-27 |
2023-08-12 |
mouse |
| Tal Koppelmann, Yulia Pollak, Jorge Mogilner, Jacob Bejar, Arnold G Coran, Igor Sukhotni. Reversal of severe methotrexate-induced intestinal damage using enteral n-3 fatty acids. The British journal of nutrition. vol 109. issue 1. 2013-02-26. PMID:22456439. |
a significant decrease in enterocyte apoptosis in the ileum of mtx-n-3 pufa rats (v. mtx) was accompanied by decreased bax mrna and protein expression and increased bcl2 mrna levels. |
2013-02-26 |
2023-08-12 |
rat |
| Mehran Mohseni, Ehsan Mihandoost, Alireza Shirazi, Zargham Sepehrizadeh, Javad Tavakkoly Bazzaz, Mahmoud Ghazi-khansar. Melatonin may play a role in modulation of bax and bcl-2 expression levels to protect rat peripheral blood lymphocytes from gamma irradiation-induced apoptosis. Mutation research. vol 738-739. 2013-02-26. PMID:22982225. |
melatonin may play a role in modulation of bax and bcl-2 expression levels to protect rat peripheral blood lymphocytes from gamma irradiation-induced apoptosis. |
2013-02-26 |
2023-08-12 |
rat |
| Mehran Mohseni, Ehsan Mihandoost, Alireza Shirazi, Zargham Sepehrizadeh, Javad Tavakkoly Bazzaz, Mahmoud Ghazi-khansar. Melatonin may play a role in modulation of bax and bcl-2 expression levels to protect rat peripheral blood lymphocytes from gamma irradiation-induced apoptosis. Mutation research. vol 738-739. 2013-02-26. PMID:22982225. |
this reduced apoptosis by melatonin was related to the downregulation of bax, upregulation of bcl-2, and therefore reduction of bax/bcl-2 ratio. |
2013-02-26 |
2023-08-12 |
rat |
| Mehran Mohseni, Ehsan Mihandoost, Alireza Shirazi, Zargham Sepehrizadeh, Javad Tavakkoly Bazzaz, Mahmoud Ghazi-khansar. Melatonin may play a role in modulation of bax and bcl-2 expression levels to protect rat peripheral blood lymphocytes from gamma irradiation-induced apoptosis. Mutation research. vol 738-739. 2013-02-26. PMID:22982225. |
our results suggest that melatonin in these doses may provide modulation of bax and bcl-2 expression as well as bax/bcl-2 ratio to protect rat peripheral blood lymphocytes from gamma irradiation-induced apoptosis. |
2013-02-26 |
2023-08-12 |
rat |
| Fu-Shun Yu, An-Cheng Huang, Jai-Sing Yang, Chun-Shu Yu, Chi-Cheng Lu, Jo-Hua Chiang, Chang-Fang Chiu, Jing-Gung Chun. Safrole induces cell death in human tongue squamous cancer SCC-4 cells through mitochondria-dependent caspase activation cascade apoptotic signaling pathways. Environmental toxicology. vol 27. issue 7. 2013-02-25. PMID:21591240. |
safrole-induced apoptosis was accompanied with up-regulation of the protein expression of bax and bid and down-regulation of the protein levels of bcl-2 (up-regulation of the ratio of bax/bcl-2), resulting in cytochrome c release, promoted apaf-1 level and sequential activation of caspase-9 and caspase-3 in a time-dependent manner. |
2013-02-25 |
2023-08-12 |
human |
| Saurabh Chattopadhyay, Volker Fensterl, Ying Zhang, Manoj Veleeparambil, Michifumi Yamashita, Ganes C Se. Role of interferon regulatory factor 3-mediated apoptosis in the establishment and maintenance of persistent infection by Sendai virus. Journal of virology. vol 87. issue 1. 2013-02-25. PMID:23077293. |
the key proapoptotic protein in this pathway is interferon regulatory factor 3 (irf-3), which upon activation by virus infection binds bax, translocates it to mitochondria, and triggers apoptosis. |
2013-02-25 |
2023-08-12 |
mouse |
| Zhi-Yan Sui, Han-Jung Chae, Guang-Biao Huang, Tong Zhao, Sushma Shrestha Muna, Young-Chul Chun. Effects of chronic mild stress in female bax inhibitor-1-gene knockout mice. Clinical psychopharmacology and neuroscience : the official scientific journal of the Korean College of Neuropsychopharmacology. vol 10. issue 3. 2013-02-25. PMID:23430888. |
the anti-apoptotic protein bax inhibitor-1 (bi-1) is a regulator of apoptosis linked to endoplasmic reticulum (er) stress, and bi-1(-/-) mice exhibit increased sensitivity to tissue damage. |
2013-02-25 |
2023-08-12 |
mouse |
| Bonglee Kim, Sun-Hee Kim, Soo-Jin Jeong, Eun Jung Sohn, Ji Hoon Jung, Min Ho Lee, Sung-Hoon Ki. Brazilin induces apoptosis and G2/M arrest via inactivation of histone deacetylase in multiple myeloma U266 cells. Journal of agricultural and food chemistry. vol 60. issue 39. 2013-02-22. PMID:22967175. |
additionally, brazilin significantly increased the number of sub-g1 cell population and terminal deoxynucleotidyl transferase dutp nick end labeling (tunel)-positive cells undergoing apoptosis and also activated caspase-3 and regulated the expression of bcl-2 family proteins, including bax, bcl-x(l), and bcl-2 in u266 cells, indicating that brazilin induces apoptosis through the mitochondria-dependent pathway. |
2013-02-22 |
2023-08-12 |
human |
| Seyin Zou, Nuo Cao, Du Cheng, Rongqin Zheng, Jin Wang, Kangshun Zhu, Xintao Shua. Enhanced apoptosis of ovarian cancer cells via nanocarrier-mediated codelivery of siRNA and doxorubicin. International journal of nanomedicine. vol 7. 2013-02-21. PMID:22888237. |
upon the codelivery of sirna, targeting the bcl-2 gene, and dox, using the folate-targeted nanocarrier, dox-induced apoptosis in the skov-3 cells overexpressing folate receptor was significantly enhanced through a mechanism of downregulating the antiapoptotic protein bcl-2, while simultaneously upregulating the proapoptotic protein bax. |
2013-02-21 |
2023-08-12 |
Not clear |
| Meng Zhang, Li-Ping Liu, Yuling Chen, Xiao-ying Tian, Jian Qin, Dongmei Wang, Zhi Li, Sui-Lin M. Wogonin induces apoptosis in RPMI 8226, a human myeloma cell line, by downregulating phospho-Akt and overexpressing Bax. Life sciences. vol 92. issue 1. 2013-02-21. PMID:23142241. |
wogonin induces apoptosis in rpmi 8226, a human myeloma cell line, by downregulating phospho-akt and overexpressing bax. |
2013-02-21 |
2023-08-12 |
human |
| Basant Kumar Thakur, Tino Dittrich, Prakash Chandra, Annette Becker, Wolfgang Kuehnau, Jan-Henning Klusmann, Dirk Reinhardt, Karl Welt. Involvement of p53 in the cytotoxic activity of the NAMPT inhibitor FK866 in myeloid leukemic cells. International journal of cancer. vol 132. issue 4. 2013-02-20. PMID:22815158. |
further, knockdown of p53 attenuated the effects of fk866 on apoptosis and cell cycle arrest, which was partly associated with decreased expression of p21 and bax. |
2013-02-20 |
2023-08-12 |
Not clear |
| Tzu-Rong Su, Feng-Jen Tsai, Jen-Jie Lin, Han Hsiang Huang, Chien-Chih Chiu, Jui-Hsin Su, Ya-Ting Yang, Jeff Yi-Fu Chen, Bing-Sang Wong, Yu-Jen W. Induction of apoptosis by 11-dehydrosinulariolide via mitochondrial dysregulation and ER stress pathways in human melanoma cells. Marine drugs. vol 10. issue 8. 2013-02-20. PMID:23015779. |
it was found that the apoptosis induced by 11-dehydrosinulariolide is relevant to mitochondrial-mediated apoptosis via caspase-dependent pathways, elucidated by loss of mitochondrial membrane potential (∆Ψm), release of cytochrome c, activation of caspase-3/-9 and bax as well as suppression of bcl-2/bcl-xl. |
2013-02-20 |
2023-08-12 |
human |
| Shun X Ren, Alfred S L Cheng, Ka F To, Joanna H M Tong, May S Li, Jing Shen, Jin Shen, Clover C M Wong, Lin Zhang, Ruby L Y Chan, Xiao J Wang, Simon S M Ng, Lawrence C M Chiu, Victor E Marquez, Richard L Gallo, Francis K L Chan, Jun Yu, Joseph J Y Sung, William K K Wu, Chi H Ch. Host immune defense peptide LL-37 activates caspase-independent apoptosis and suppresses colon cancer. Cancer research. vol 72. issue 24. 2013-02-20. PMID:23100468. |
correspondingly, colonic mucosa of cathelicidin-deficient mice exhibited reduced expression of p53, bax, and bak and increased expression of bcl-2 together with a lower basal level of apoptosis. |
2013-02-20 |
2023-08-12 |
mouse |
| Hong-Xia Wang, Dong-Mei Zhang, Xiang-Jun Zeng, Jing Mu, Hui Yang, Ling-Qiao Lu, Li-Ke Zhan. Upregulation of cytochrome P450 2J3/11,12-epoxyeicosatrienoic acid inhibits apoptosis in neonatal rat cardiomyocytes by a caspase-dependent pathway. Cytokine. vol 60. issue 2. 2013-02-19. PMID:22717287. |
we proposed that upregulation of cyp2j3/11,12-eet during ipost induces cardioprotection by inhibiting cardiomyocyte apoptosis and that multiple apoptotic signals, including changes in mitochondrial membrane potential (mmp) and mitochondrial permeability transition pore (mptp) opening, mitochondrial cytochrome c leakage, caspase-3 levels, and levels of protective kinases such as bcl-2 and bax, are involved in the process. |
2013-02-19 |
2023-08-12 |
rat |
| Yu-xiao Liu, Jun-li Tai, Guo-qing Li, Zhi-wen Zhang, Jing-hui Xue, Hong-sheng Liu, Heng Zhu, Ji-de Cheng, Yuan-Ling Liu, An-ming Li, Yi Zhan. Exposure to 1950-MHz TD-SCDMA electromagnetic fields affects the apoptosis of astrocytes via caspase-3-dependent pathway. PloS one. vol 7. issue 8. 2013-02-19. PMID:22870319. |
moreover, caspase-3, a hallmark of apoptosis, was highlighted in astrocytes after 48 h of emf exposure, accompanied by a significantly increased expression of bax and reduced level of bcl-2. |
2013-02-19 |
2023-08-12 |
human |
| Yu-xiao Liu, Jun-li Tai, Guo-qing Li, Zhi-wen Zhang, Jing-hui Xue, Hong-sheng Liu, Heng Zhu, Ji-de Cheng, Yuan-Ling Liu, An-ming Li, Yi Zhan. Exposure to 1950-MHz TD-SCDMA electromagnetic fields affects the apoptosis of astrocytes via caspase-3-dependent pathway. PloS one. vol 7. issue 8. 2013-02-19. PMID:22870319. |
therefore, our results implied that exposure to the emf of 1950-mhz td-scdma may not promote the tumor formation, but continuous exposure damaged the mitochondria of astrocytes and induce apoptosis through a caspase-3-dependent pathway with the involvement of bax and bcl-2. |
2013-02-19 |
2023-08-12 |
human |
| Huiying Luo, He Su, Xiaopeng Wang, Lijuan Wang, Juan L. N-Succinyl-chitosan nanoparticles induced mitochondria-dependent apoptosis in K562. Molecular and cellular probes. vol 26. issue 4. 2013-02-15. PMID:22465598. |
here, by western blot we revealed that apoptosis induced by nscnp was associated with accumulation of cytochrome c in cytosol and elevating expression of apoptosis-promoted protein bax while depressing expression of apoptosis-restrained protein bcl-2 in time- and dose-dependence. |
2013-02-15 |
2023-08-12 |
Not clear |