| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Tsung-Ying Yang, Gee-Chen Chang, Kun-Chieh Chen, Hsiao-Wen Hung, Kuo-Hsuan Hsu, Chi-Hao Wu, Gwo-Tarng Sheu, Shih-Lan Hs. Pemetrexed induces both intrinsic and extrinsic apoptosis through ataxia telangiectasia mutated/p53-dependent and -independent signaling pathways. Molecular carcinogenesis. vol 52. issue 3. 2013-04-12. PMID:22086658. |
the molecular events of pemetrexed-mediated apoptosis was associated with the activation of ataxia telangiectasia mutated (atm)/p53-dependent and -independent signaling pathways, which promoted intrinsic and extrinsic apoptosis by upregulating bax, puma, fas, dr4, and dr5 and activating the caspase signaling cascade. |
2013-04-12 |
2023-08-12 |
Not clear |
| Fang Wang, Min Liu, Xin Li, Hua Tan. MiR-214 reduces cell survival and enhances cisplatin-induced cytotoxicity via down-regulation of Bcl2l2 in cervical cancer cells. FEBS letters. vol 587. issue 5. 2013-04-12. PMID:23337879. |
further analysis reveals that apoptosis induced by mir-214 is correlated with increased expression of bax, caspase-9, caspase-8 and caspase-3. |
2013-04-12 |
2023-08-12 |
Not clear |
| Ram Prasad, Santosh K Katiya. Bioactive phytochemical proanthocyanidins inhibit growth of head and neck squamous cell carcinoma cells by targeting multiple signaling molecules. PloS one. vol 7. issue 9. 2013-04-10. PMID:23050025. |
gsps significantly (p<0.05-0.001) increased apoptosis of scc1 and osc19 cells with induction of bax, reduced expression of bcl-2, and activation of caspase-3. |
2013-04-10 |
2023-08-12 |
mouse |
| Maria Kaparou, Despoina Choumerianou, Chrysoula Perdikogianni, Georgia Martimianaki, Maria Kalmanti, Eftichia Stiakak. Enhanced levels of the apoptotic BAX/BCL-2 ratio in children with acute lymphoblastic leukemia and high-risk features. Genetics and molecular biology. vol 36. issue 1. 2013-04-10. PMID:23569402. |
the aim of this study was to examine the expression of key molecules related to apoptosis (bcl-2, bax, fas, fas-l) in children with acute lymphoblastic leukemia (all). |
2013-04-10 |
2023-08-12 |
Not clear |
| Ji-Ae Shin, Ji-Youn Jung, Mi Heon Ryu, Stephen Safe, Sung-Dae Ch. Mithramycin A inhibits myeloid cell leukemia-1 to induce apoptosis in oral squamous cell carcinomas and tumor xenograft through activation of Bax and oligomerization. Molecular pharmacology. vol 83. issue 1. 2013-04-09. PMID:23019217. |
mithramycin a inhibits myeloid cell leukemia-1 to induce apoptosis in oral squamous cell carcinomas and tumor xenograft through activation of bax and oligomerization. |
2013-04-09 |
2023-08-12 |
human |
| Ji-Ae Shin, Ji-Youn Jung, Mi Heon Ryu, Stephen Safe, Sung-Dae Ch. Mithramycin A inhibits myeloid cell leukemia-1 to induce apoptosis in oral squamous cell carcinomas and tumor xenograft through activation of Bax and oligomerization. Molecular pharmacology. vol 83. issue 1. 2013-04-09. PMID:23019217. |
mith also suppressed tumor growth in vivo and induced apoptosis in tumor by also regulating expression of mcl-1 and bax proteins. |
2013-04-09 |
2023-08-12 |
human |
| Xiang Gao, BiLan Wang, XiaWei Wei, Ke Men, Fengjin Zheng, Yingfeng Zhou, Yu Zheng, MaLing Gou, Meijuan Huang, Gang Guo, Ning Huang, ZhiYong Qian, Yuquan We. Anticancer effect and mechanism of polymer micelle-encapsulated quercetin on ovarian cancer. Nanoscale. vol 4. issue 22. 2013-04-09. PMID:23044718. |
mcl-1 downregulation, bcl-2 downregulation, bax upregulation and mitochondrial transmembrane potential change were observed, suggesting that quercetin may induce apoptosis of a2780s cells through the mitochondrial apoptotic pathway. |
2013-04-09 |
2023-08-12 |
Not clear |
| Yanwu Liu, Lingjuan Wang, Yaoping Wu, Changwei Lv, Xinkui Li, Xiaorui Cao, Min Yang, Dapeng Feng, Zhuojing Lu. Pterostilbene exerts antitumor activity against human osteosarcoma cells by inhibiting the JAK2/STAT3 signaling pathway. Toxicology. vol 304. 2013-04-08. PMID:23313376. |
pte also down-regulated the expression of stat3 target genes, including the anti-apoptotic proteins bcl-xl and mcl-1, leading to the up-regulation of mitochondrial apoptosis pathway-related proteins (bax, bak, cytosolic cytochrome c, and cleaved caspase3) and cyclin-dependent kinase inhibitors such as p21 and p27. |
2013-04-08 |
2023-08-12 |
human |
| Daniela Verzola, Annamaria Famà, Barbara Villaggio, Maia Di Rocco, Alchiede Simonato, Elena D'Amato, Fabio Gianiorio, Giacomo Garibott. Lysine triggers apoptosis through a NADPH oxidase-dependent mechanism in human renal tubular cells. Journal of inherited metabolic disease. vol 35. issue 6. 2013-04-05. PMID:22403019. |
overloading hk-2 with lysine levels reproducing those observed in urine of patients affected by lpi (10 mm) increased apoptosis (+30%; p < 0.01 vs.c), as well as bax and apaf-1 expressions (+30-50% p < 0.05), while downregulated bcl-2 (-40% p < 0.05). |
2013-04-05 |
2023-08-12 |
human |
| Shaojing Li, Chuanhong Wu, Li Zhu, Jian Gao, Jing Fang, Defeng Li, Meihong Fu, Rixin Liang, Lan Wang, Ming Cheng, Hongjun Yan. By improving regional cortical blood flow, attenuating mitochondrial dysfunction and sequential apoptosis galangin acts as a potential neuroprotective agent after acute ischemic stroke. Molecules (Basel, Switzerland). vol 17. issue 11. 2013-04-05. PMID:23143152. |
western blot analysis revealed that galangin also inhibited apoptosis in a dose-dependent manner concomitant with the up-regulation of bcl-2 expression, down-regulation of bax expression and the bax/bcl-2 ratio, a reduction in cytochrome c release from the mitochondria to the cytosol, the reduced expression of activated caspase-3 and the cleavage of poly(adp-ribose) polymerase (parp). |
2013-04-05 |
2023-08-12 |
rat |
| George G Chen, Jackie Leung, Nian Ci Liang, Li Li, Kefeng Wu, Ursula P F Chan, Billy C S Leung, Mingyue Li, Jing Du, Yi Feng Deng, Xianling Gong, Yingnian Lv, Ernest C W Chak, Paul B S La. Ent-11α-hydroxy-15-oxo-kaur-16-en-19-oic-acid inhibits hepatocellular carcinoma in vitro and in vivo via stabilizing IkBα. Investigational new drugs. vol 30. issue 6. 2013-04-04. PMID:22227815. |
it induces apoptosis in hcc cells via inhibiting nf-kb, leading to the decrease of bcl-2 but the increase of bax and bak. |
2013-04-04 |
2023-08-12 |
mouse |
| Grethe Skretting, Nina Iversen, Christiane F Myklebust, Anders E Dahm, Per Morten Sandse. Overexpression of tissue factor pathway inhibitor in CHO-K1 cells results in increased activation of NF-κB and apoptosis mediated by a caspase-3 independent pathway. Molecular biology reports. vol 39. issue 12. 2013-04-04. PMID:22932941. |
this was accompanied by downregulation of bcl-xl, elevated levels of bax, and increased translocation of the apoptosis initiating factor. |
2013-04-04 |
2023-08-12 |
Not clear |
| In Hee Kim, Sang Wook Kim, Seong Hun Kim, Seung Ok Lee, Soo Teik Lee, Dae Ghon Kim, Mi Jin Lee, Woo Hyun Par. Parthenolide-induced apoptosis of hepatic stellate cells and anti-fibrotic effects in an in vivo rat model. Experimental & molecular medicine. vol 44. issue 7. 2013-04-03. PMID:22581380. |
pt increased the expression of bax proteins during apoptosis, but decreased the expression of bcl-2 and bcl-x(l) proteins. |
2013-04-03 |
2023-08-12 |
rat |
| Himanshu Vashistha, Pravin C Singhal, Ashwani Malhotra, Mohammad Husain, Peter Mathieson, Moin A Saleem, Cyril Kuriakose, Surya Seshan, Anna Wilk, Luis Delvalle, Francesca Peruzzi, Marco Giorgio, Pier Giuseppe Pelicci, Oliver Smithies, Hyung-Suk Kim, Masao Kakoki, Krzysztof Reiss, Leonard G Megg. Null mutations at the p66 and bradykinin 2 receptor loci induce divergent phenotypes in the diabetic kidney. American journal of physiology. Renal physiology. vol 303. issue 12. 2013-04-02. PMID:23019230. |
experiments with cultured podocytes revealed previously unrecognized cross talk between p66 and the redox-sensitive transcription factor p53 that controls hyperglycemia-induced ros metabolism, transcription of p53 target genes (angiotensinogen, angiotensin ii type-1 receptor, and bax), angiotensin ii generation, and apoptosis. |
2013-04-02 |
2023-08-12 |
mouse |
| Gaurav Kumar, Pooja Tajpara, Girish Mar. Dietary turmeric post-treatment decreases DMBA-induced hamster buccal pouch tumor growth by altering cell proliferation and apoptosis-related markers. Journal of environmental pathology, toxicology and oncology : official organ of the International Society for Environmental Toxicology and Cancer. vol 31. issue 4. 2013-04-02. PMID:23394443. |
when compared to hamsters bearing tumors that remained on the control diet, the buccal pouches of hamsters bearing tumors receiving turmeric showed the following results: (1) decreased cell proliferation (diminished pcna, cyclin d1, and bcl-2) and pcna labelling index, (2) enhanced apoptosis (increased bax, caspase-3, caspase-9, and cytochrome c, and decreased survivin) and apoptotic index, (3) decreased inflammation (decreased cox-2), and (4) decreased mapk activation (p-erk and p-p38). |
2013-04-02 |
2023-08-12 |
Not clear |
| Min Sung Kim, Sung Soo Kim, Nam Jin Yoo, Sug Hyung Le. Rare somatic mutation of pro-apoptotic BAX and BAK genes in common human cancers. Tumori. vol 98. issue 6. 2013-03-29. PMID:23389372. |
bax and bak are both pro-apoptotic bcl-2 proteins and are essential for the pathway of intrinsic apoptosis. |
2013-03-29 |
2023-08-12 |
human |
| Chien-Hang Ni, Po-Yuan Chen, Hsu-Feng Lu, Jai-Sing Yang, Hui-Ying Huang, Shin-Hwar Wu, Siu-Wan Ip, Chin-Tung Wu, Su-Yin Chiang, Jaung-Geng Lin, W Gibson Wood, Jing-Gung Chun. Chrysophanol-induced necrotic-like cell death through an impaired mitochondrial ATP synthesis in Hep3B human liver cancer cells. Archives of pharmacal research. vol 35. issue 5. 2013-03-28. PMID:22644856. |
no effects were observed on known protein regulators of apoptosis such as bax and bcl-2. |
2013-03-28 |
2023-08-12 |
human |
| Mi-Yeon Cho, Su-Young Park, Sumin Park, Yong Rok Lee, Mi-Kyoung Kwak, Jung-Ae Ki. Effects of geranyl-phloroacetophenone on the induction of apoptosis and chemosensitization of adriamycin-resistant MCF-7 human breast cancer cells. Archives of pharmacal research. vol 35. issue 5. 2013-03-28. PMID:22644859. |
in adriamycin-resistant mcf-7 human breast cancer (mcf-7/adr) cells, which express a mutant form of p53, 3-gap induced significant apoptosis, which was accompanied by no change in p53 transcriptional activity, but an increase in bax expression, cyt c release, and activation of caspase-9, 7, and 3. |
2013-03-28 |
2023-08-12 |
human |
| Sang-Won Hong, Kyung Hee Jung, Hee-Seung Lee, Myung-Joo Choi, Mi Kwon Son, Hong-Mei Zheng, Soon-Sun Hon. SB365 inhibits angiogenesis and induces apoptosis of hepatocellular carcinoma through modulation of PI3K/Akt/mTOR signaling pathway. Cancer science. vol 103. issue 11. 2013-03-28. PMID:22909393. |
sb365 strongly suppressed the growth of hcc cells in a dose-dependent manner and induced apoptosis by increasing the proportion of sub g1 apoptotic cells from 8% to 21% through induction of expression of bax and cleaved caspase-3. |
2013-03-28 |
2023-08-12 |
mouse |
| Chieh-Lin Jerry Teng, Chang-Tze Ricky Yu, Wen-Li Hwang, Jia-Rong Tsai, Hsiang-Chun Liu, Guang-Yuh Hwang, Shih-Lan Hs. Effector mechanisms of sunitinib-induced G1 cell cycle arrest, differentiation, and apoptosis in human acute myeloid leukaemia HL60 and KG-1 cells. Annals of hematology. vol 92. issue 3. 2013-03-28. PMID:23180436. |
furthermore, sunitinib increased pro-apoptotic molecule expression (bax, bak, puma, fas, fasl, dr4, and dr5) and decreased anti-apoptotic molecule expression (bcl-2 and mcl-1), resulting in caspase-2, caspase-3, caspase-8, and caspase-9 activation and both death receptor and mitochondria-dependent apoptosis. |
2013-03-28 |
2023-08-12 |
human |