| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Choo-Aun Neoh, Robert Y-L Wang, Zhong-Hao Din, Jui-Hsin Su, Yu-Kuei Chen, Feng-Jen Tsai, Shun-Hsiang Weng, Yu-Jen W. Induction of apoptosis by sinulariolide from soft coral through mitochondrial-related and p38MAPK pathways on human bladder carcinoma cells. Marine drugs. vol 10. issue 12. 2013-05-13. PMID:23249971. |
also, the sinulariolide-induced apoptosis is related to the mitochondrial-mediated apoptosis via caspase-dependent pathways, elucidated by the loss of mitochondrial membrane potential, release of cytochrome c, activation of caspase-3/-9, bax and bad, as well as suppression of bcl-2/bcl-xl/mcl-1. |
2013-05-13 |
2023-08-12 |
human |
| Dora Moon, Denise McCormack, Debbie McDonald, David McFadde. Pterostilbene induces mitochondrially derived apoptosis in breast cancer cells in vitro. The Journal of surgical research. vol 180. issue 2. 2013-05-10. PMID:22572619. |
high levels of bcl-2-associated x protein (bax) in tumor cells have been found to promote apoptosis and sensitize cells to anti-cancer therapies. |
2013-05-10 |
2023-08-12 |
Not clear |
| Elżbieta Płuciennik, Magdalena Nowakowska, Wioletta I Wujcicka, Anna Sitkiewicz, Bernarda Kazanowska, Elżbieta Zielińska, Andrzej K Bednare. Genetic alterations of WWOX in Wilms' tumor are involved in its carcinogenesis. Oncology reports. vol 28. issue 4. 2013-05-09. PMID:22842668. |
we evaluated the correlation between expression of wwox and genes involved in proliferation (ki67), apoptosis (bcl2, bax), signal transduction (erbb4, erbb2, egfr), cell cycle (ccne1, ccnd1), cell adhesion (cdh1) and transcription (tp73) using real-time rt-pcr in 23 tumor samples. |
2013-05-09 |
2023-08-12 |
Not clear |
| Yaodong Zhao, Zhengyi Li, Weihua Sheng, Jingchen Miao, Jicheng Yan. Adenovirus-mediated ING4/IL-24 double tumor suppressor gene co-transfer enhances antitumor activity in human breast cancer cells. Oncology reports. vol 28. issue 4. 2013-05-09. PMID:22842937. |
our results showed that the bicistronic adenovirus-mediated ing4 and il-24 co-expression induced additive growth suppression and apoptosis as well as an overlapping effect on the upregulation of p21, p27 and bax, and the downregulation of bcl-2 and survivin in mda-mb‑231 human breast cancer cells in vitro or in vivo. |
2013-05-09 |
2023-08-12 |
mouse |
| Lu Yue, Ying Wang, Huamao Wang, Huiping Gao, Jun Liang, Aihua Sui, Jinyu Xiang, Fang Zhou, Congcong Xu, Wenwen Zhao, Wanhua Liang, Ruyong Ya. Inhibition of hepatocellular carcinoma cell growth by an anti-insulin-like growth factor-I receptor monoclonal antibody. Oncology reports. vol 28. issue 4. 2013-05-09. PMID:22895605. |
additionally, we observed a moderate increase in apoptosis as demonstrated by detection of changes in the expression of the pro-apoptotic and anti-apoptotic proteins bax and bcl-2 after 4f2 treatment. |
2013-05-09 |
2023-08-12 |
Not clear |
| Tuo Wang, Yan Xue, Maode Wang, Qiang Su. Silencing of the hTERT gene through RNA interference induces apoptosis via bax/bcl-2 in human glioma cells. Oncology reports. vol 28. issue 4. 2013-05-09. PMID:22895663. |
we found that the silencing of the htert gene in t98g cells significantly decreased cell proliferation and telomerase activity, increased the number of cells in g1 phase and decreased the number of cells in s phase, and induced apoptosis via decreasing the protein level of bcl-2 and c-myc and increasing the protein levels of bax and p53. |
2013-05-09 |
2023-08-12 |
human |
| Xia Ren, Cui-Ling Li, Heng-Xiao Wang, Pei-E Wen, Chang-Jin Yuan, Yan-Mei Li, Guo-Sheng Jian. [Molecular mechanism of HL-60 cell apoptosis induced by baicalin]. Zhongguo shi yan xue ye xue za zhi. vol 20. issue 4. 2013-05-09. PMID:22931640. |
cell apoptosis in early stage could be detected, the expression of caspase-3, caspase-9 and bax mrna was obviously up-regulated, while the bcl-2 expression down-regulated, and accordingly bcl-2/bax ratio decreased. |
2013-05-09 |
2023-08-12 |
Not clear |
| Najat Abbassi, Hakima Chicha, El Mostapha Rakib, Abdellah Hannioui, Mdaghri Alaoui, Abdelouahed Hajjaji, Detlef Geffken, Cinzia Aiello, Rosaria Gangemi, Camillo Rosano, Maurizio Vial. Synthesis, antiproliferative and apoptotic activities of N-(6(4)-indazolyl)-benzenesulfonamide derivatives as potential anticancer agents. European journal of medicinal chemistry. vol 57. 2013-05-09. PMID:23072738. |
moreover, these indazoles were able to trigger apoptosis through the upregulation of the typical apoptosis markers p53 and bax. |
2013-05-09 |
2023-08-12 |
human |
| Juan-Hua Quan, Guang-Ho Cha, Wei Zhou, Jia-Qi Chu, Yoshifumi Nishikawa, Young-Ha Le. Involvement of PI 3 kinase/Akt-dependent Bad phosphorylation in Toxoplasma gondii-mediated inhibition of host cell apoptosis. Experimental parasitology. vol 133. issue 4. 2013-05-09. PMID:23333591. |
furthermore, thp-1 cells pretreated with these pi3k inhibitors showed reduced phosphorylation of bad in a dose-dependent manner and subsequently failed to inhibit the bax translocation, also these cells also failed to overcome the t. gondii-imposed inhibition of host cell apoptosis. |
2013-05-09 |
2023-08-12 |
Not clear |
| H Ben Chedly, P Lacasse, P-G Marnet, M Boutinau. The decrease in milk yield during once daily milking is due to regulation of synthetic activity rather than apoptosis of mammary epithelial cells in goats. Animal : an international journal of animal bioscience. vol 7. issue 1. 2013-05-07. PMID:23031579. |
tunel (terminal deoxynucleotidyl transferase-mediated dutp-biotin nick end labelling) staining of mammary gland biopsies did not show any increase in cell apoptosis after 2 and 16 days of odm (0.8% and 1%, respectively) despite upregulation of bax mrna levels in milk mec. |
2013-05-07 |
2023-08-12 |
Not clear |
| Saeid Shirali, Mahmoud Aghaei, Mahdi Shabani, Mojtaba Fathi, Majid Sohrabi, Marzieh Moeinifar. Adenosine induces cell cycle arrest and apoptosis via cyclinD1/Cdk4 and Bcl-2/Bax pathways in human ovarian cancer cell line OVCAR-3. Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine. vol 34. issue 2. 2013-05-07. PMID:23345014. |
cell cycle analysis, propidium iodide and annexin v staining, caspase-3 activity assay, cyclind1, cdk4, bcl-2 and bax protein expressions were assessed to detect apoptosis. |
2013-05-07 |
2023-08-12 |
human |
| Yasuo Onishi, Teruya Kawamoto, Takeshi Ueha, Kenta Kishimoto, Hitomi Hara, Naomasa Fukase, Mitsunori Toda, Risa Harada, Masaya Minoda, Yoshitada Sakai, Masahiko Miwa, Masahiro Kurosaka, Toshihiro Akisu. Transcutaneous application of carbon dioxide (CO2) induces mitochondrial apoptosis in human malignant fibrous histiocytoma in vivo. PloS one. vol 7. issue 11. 2013-05-06. PMID:23166610. |
we also evaluated the expression of mitochondrial apoptosis related proteins, such as caspases, cytochorome c and bax, by immunoblot analysis. |
2013-05-06 |
2023-08-12 |
human |
| Yasuo Onishi, Teruya Kawamoto, Takeshi Ueha, Kenta Kishimoto, Hitomi Hara, Naomasa Fukase, Mitsunori Toda, Risa Harada, Masaya Minoda, Yoshitada Sakai, Masahiko Miwa, Masahiro Kurosaka, Toshihiro Akisu. Transcutaneous application of carbon dioxide (CO2) induces mitochondrial apoptosis in human malignant fibrous histiocytoma in vivo. PloS one. vol 7. issue 11. 2013-05-06. PMID:23166610. |
we also observed an enrichment of cytochrome c in the cytoplasmic fraction and bax protein in the mitochondrial fraction of co(2) treated tumors, highlighting the involvement of mitochondria in apoptosis. |
2013-05-06 |
2023-08-12 |
human |
| Ting Li, Linlin Zeng, Wei Gao, Mei-Zhen Cui, Xueqi Fu, Xuemin X. PSAP induces a unique Apaf-1 and Smac-dependent mitochondrial apoptotic pathway independent of Bcl-2 family proteins. Biochimica et biophysica acta. vol 1832. issue 3. 2013-05-06. PMID:23207240. |
however, interestingly, our data demonstrate that overexpression of bcl-2 and bcl-xl did not protect cells from psap-induced apoptosis, and that knockdown of bid, bax, and bak had no effect on psap-induced cytochrome c and smac release, indicating that psap-induced apoptosis is not regulated by bcl-2 family proteins. |
2013-05-06 |
2023-08-12 |
Not clear |
| b' Mojca Tajnik, Mojca Stra\\xc5\\xbei\\xc5\\xa1ar, Metka Volav\\xc5\\xa1ek, Emanuela Bo\\xc5\\xa1tjan\\xc4\\x8di\\xc4\\x8d, Damjan Glava\\xc4\\x8. BBC3 is down-regulated with increased tumor size independently of p53 expression in head and neck cancer. Cancer biomarkers : section A of Disease markers. vol 11. issue 5. 2013-05-06. PMID:23220852.' |
in order to confirm the model of bbc3-mediated apoptosis, we used immunohistochemistry to determine the expression of apoptotic proteins p53, p63, bcl-2 and bax. |
2013-05-06 |
2023-08-12 |
Not clear |
| Xiao-Jing Zou, Le Yang, Shang-Long Ya. Endoplasmic reticulum stress and C/EBP homologous protein-induced Bax translocation are involved in angiotensin II-induced apoptosis in cultured neonatal rat cardiomyocytes. Experimental biology and medicine (Maywood, N.J.). vol 237. issue 11. 2013-05-06. PMID:23239445. |
endoplasmic reticulum stress and c/ebp homologous protein-induced bax translocation are involved in angiotensin ii-induced apoptosis in cultured neonatal rat cardiomyocytes. |
2013-05-06 |
2023-08-12 |
rat |
| Xiao-Jing Zou, Le Yang, Shang-Long Ya. Endoplasmic reticulum stress and C/EBP homologous protein-induced Bax translocation are involved in angiotensin II-induced apoptosis in cultured neonatal rat cardiomyocytes. Experimental biology and medicine (Maywood, N.J.). vol 237. issue 11. 2013-05-06. PMID:23239445. |
the aim of this study was to identify the roles and potential mechanisms of endoplasmic reticulum stress (er stress), proapoptotic transcription factor c/ebp homologous protein (chop) and bax in angiotensin ii (ang ii)-induced cardiomyocyte apoptosis. |
2013-05-06 |
2023-08-12 |
rat |
| Xiao-Jing Zou, Le Yang, Shang-Long Ya. Endoplasmic reticulum stress and C/EBP homologous protein-induced Bax translocation are involved in angiotensin II-induced apoptosis in cultured neonatal rat cardiomyocytes. Experimental biology and medicine (Maywood, N.J.). vol 237. issue 11. 2013-05-06. PMID:23239445. |
our results showed that ang ii-induced cardiomyocyte apoptosis was associated with the upregulations of bip and chop, bax translocation, mmp deplorization and cytochrome c release. |
2013-05-06 |
2023-08-12 |
rat |
| Xiao-Jing Zou, Le Yang, Shang-Long Ya. Endoplasmic reticulum stress and C/EBP homologous protein-induced Bax translocation are involved in angiotensin II-induced apoptosis in cultured neonatal rat cardiomyocytes. Experimental biology and medicine (Maywood, N.J.). vol 237. issue 11. 2013-05-06. PMID:23239445. |
from our results, ros, er stress and chop-mediated bax translocation may be involved in ang ii-induced cardiomyocyte apoptosis. |
2013-05-06 |
2023-08-12 |
rat |
| Ling Zhang, Liting Jia, Shihong Cui, Ying Shi, Aimin Chang, Peng Wang, Zhan Zhan. AP-2α-dependent regulation of Bcl-2/Bax expression affects apoptosis in the trophoblast. Journal of molecular histology. vol 43. issue 6. 2013-05-03. PMID:22886241. |
however, it is not clear whether ap-2α affects apoptosis in trophoblast cells and whether it regulates expression of apoptosis-related factors bcl-2 and bax. |
2013-05-03 |
2023-08-12 |
human |