| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Ling Zhang, Liting Jia, Shihong Cui, Ying Shi, Aimin Chang, Peng Wang, Zhan Zhan. AP-2α-dependent regulation of Bcl-2/Bax expression affects apoptosis in the trophoblast. Journal of molecular histology. vol 43. issue 6. 2013-05-03. PMID:22886241. |
ap-2α regulates expression of bcl-2 and bax and apoptosis in bewo cells. |
2013-05-03 |
2023-08-12 |
human |
| Ling Zhang, Liting Jia, Shihong Cui, Ying Shi, Aimin Chang, Peng Wang, Zhan Zhan. AP-2α-dependent regulation of Bcl-2/Bax expression affects apoptosis in the trophoblast. Journal of molecular histology. vol 43. issue 6. 2013-05-03. PMID:22886241. |
these results suggest that ap-2α-mediated regulation of bcl-2 and bax regulation influences apoptosis which in turn leads to the pathogenesis of preeclampsia. |
2013-05-03 |
2023-08-12 |
human |
| Mohammed O Altonsy, Tito N Habib, Simon C Andrew. Diallyl disulfide-induced apoptosis in a breast-cancer cell line (MCF-7) may be caused by inhibition of histone deacetylation. Nutrition and cancer. vol 64. issue 8. 2013-05-03. PMID:23163853. |
further studies revealed that dads modulates the cellular levels of bax, bcl-2, bcl-xl, and bcl-w in a dose-dependent manner, suggesting the involvement of bcl-2 family proteins in dads induced apoptosis. |
2013-05-03 |
2023-08-12 |
Not clear |
| Te Liu, Dingzhu Shen, Sanli Xing, Jiulin Chen, Zhihua Yu, Jian Wang, Beiling Wu, Huiying Chi, Hongbin Zhao, Zhenzhen Liang, Chuan Che. Attenuation of exogenous angiotensin II stress-induced damage and apoptosis in human vascular endothelial cells via microRNA-155 expression. International journal of molecular medicine. vol 31. issue 1. 2013-05-03. PMID:23174997. |
when huvecs were cultured in medium containing ang ii at the half maximal inhibitory concentration (68.94 ng/µl) for 24 h, qrt-pcr and western blotting showed that expression of the apoptosis inhibitor bcl-2 in the huvec-ang ii group was markedly lower than that in controls, but apoptosis-promoting factors (bax, cytochrome c, caspases-9 and -3) were not. |
2013-05-03 |
2023-08-12 |
human |
| E V Kaigorodova, N V Ryazantseva, V V Novitskii, A N Maroshkina, M V Belkin. Effects of HSP27 chaperone on THP-1 tumor cell apoptosis. Bulletin of experimental biology and medicine. vol 154. issue 1. 2013-05-03. PMID:23330095. |
chaperone hsp27 acted as apoptosis inhibitor in thp-1 tumor cells modulating the proportion of antiapoptotic (bcl-2) and proapoptotic (bax and bad) proteins. |
2013-05-03 |
2023-08-12 |
Not clear |
| Guangsheng Du, Jiagao Lv, Li He, Yexin M. Influence of silencing soluble epoxide hydrolase with RNA interference on cardiomyocytes apoptosis induced by doxorubicin. Journal of Huazhong University of Science and Technology. Medical sciences = Hua zhong ke ji da xue xue bao. Yi xue Ying De wen ban = Huazhong keji daxue xuebao. Yixue Yingdewen ban. vol 31. issue 3. 2013-05-02. PMID:21671172. |
as compared with the control group, the apoptosis rate of cardiomyocytes in three dox-treated groups was obviously increased, the expression levels of bax increased, and those of bcl-2 decreased (p<0.01). |
2013-05-02 |
2023-08-12 |
Not clear |
| Guangsheng Du, Jiagao Lv, Li He, Yexin M. Influence of silencing soluble epoxide hydrolase with RNA interference on cardiomyocytes apoptosis induced by doxorubicin. Journal of Huazhong University of Science and Technology. Medical sciences = Hua zhong ke ji da xue xue bao. Yi xue Ying De wen ban = Huazhong keji daxue xuebao. Yixue Yingdewen ban. vol 31. issue 3. 2013-05-02. PMID:21671172. |
however, the expression levels of bax were decreased, those of bcl-2 increased and the apoptosis rate of cardiomyocytes obviously decreased in eh-r+dox group when compared with those in the dox group and the pcn+dox group (p<0.01 for each). |
2013-05-02 |
2023-08-12 |
Not clear |
| Fan Yang, Luo Zhuo, Sunnassee Ananda, Tingyi Sun, Shangxun Li, Liang Li. Role of reactive oxygen species in triptolide-induced apoptosis of renal tubular cells and renal injury in rats. Journal of Huazhong University of Science and Technology. Medical sciences = Hua zhong ke ji da xue xue bao. Yi xue Ying De wen ban = Huazhong keji daxue xuebao. Yixue Yingdewen ban. vol 31. issue 3. 2013-05-02. PMID:21671174. |
the results showed that triptolide treatment promoted the generation of a great amount of ros, up-regulated the expression of bax, bid, bad, fas and fasl at both protein and mrna levels, as well as the ratio of bax to bcl-2, and caused the apoptosis of renal tubular cells and renal injury. |
2013-05-02 |
2023-08-12 |
rat |
| Hui Tian, Liantao Li, Baofu Zhang, Jiehui Di, Feifei Chen, Huizhong Li, Junjie Liu, Dongsheng Pei, Junnian Zhen. Critical role of lysine 123 in the ubiquitin-mediated degradation of MDA-7/IL-24. Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research. vol 32. issue 12. 2013-05-02. PMID:23078624. |
in addition, k123r mutant tilted the balance between antiapoptotic protein bcl-2 and proapoptotic protein bax, which subsequently induced the cleavage of caspase signaling cascade and initiated cell apoptosis. |
2013-05-02 |
2023-08-12 |
Not clear |
| Akira Endo, Hirotaka Koizumi, Makiko Takahashi, Tomohiro Tamura, Shinobu Tatsunami, Yoshiyuki Watanabe, Masayuki Takag. A significant imbalance in mitosis versus apoptosis accelerates the growth rate of sessile serrated adenoma/polyps. Virchows Archiv : an international journal of pathology. vol 462. issue 2. 2013-05-02. PMID:23292000. |
we suggest that other complex mechanisms may act synergistically with bax, bim, or bad deficiency to regulate apoptosis suppression in ssa/ps. |
2013-05-02 |
2023-08-12 |
Not clear |
| Qiqiang Tang, Ruodong Han, Han Xiao, Jilong Shen, Qingli Luo, Jun L. Neuroprotective effects of tanshinone IIA and/or tetramethylpyrazine in cerebral ischemic injury in vivo and in vitro. Brain research. vol 1488. 2013-05-01. PMID:23063715. |
apoptosis factors (bax, bcl-2, caspase-3, and trmp-7) were analyzed using western blot and immunohistochemistry. |
2013-05-01 |
2023-08-12 |
rat |
| Shao-Bin Cheng, Li-Chen Wu, Yun-Chih Hsieh, Chi-Hao Wu, Yu-Ju Chan, Li-Hsun Chang, Chieh-Ming J Chang, Shih-Lan Hsu, Chieh-Lin Teng, Chun-Chi W. Supercritical carbon dioxide extraction of aromatic turmerone from Curcuma longa Linn. induces apoptosis through reactive oxygen species-triggered intrinsic and extrinsic pathways in human hepatocellular carcinoma HepG2 cells. Journal of agricultural and food chemistry. vol 60. issue 38. 2013-04-30. PMID:22946656. |
ar-turmerone-induced apoptosis, confirmed by increased annexin v binding and dna fragmentation, was accompanied by reactive oxygen species (ros) production, mitochondrial membrane potential dissipation, increased bax and p53 up-regulated modulator of apoptosis (puma) levels, bax mitochondrial translocation, cytochrome c release, fas and death receptor 4 (dr4) augmentation, and caspase-3, -8, and -9 activation. |
2013-04-30 |
2023-08-12 |
human |
| Shao-Bin Cheng, Li-Chen Wu, Yun-Chih Hsieh, Chi-Hao Wu, Yu-Ju Chan, Li-Hsun Chang, Chieh-Ming J Chang, Shih-Lan Hsu, Chieh-Lin Teng, Chun-Chi W. Supercritical carbon dioxide extraction of aromatic turmerone from Curcuma longa Linn. induces apoptosis through reactive oxygen species-triggered intrinsic and extrinsic pathways in human hepatocellular carcinoma HepG2 cells. Journal of agricultural and food chemistry. vol 60. issue 38. 2013-04-30. PMID:22946656. |
exposure to caspase inhibitors, fas-antagonistic antibody, dr4 antagonist, and furosemide (a blocker of bax translocation) effectively abolished ar-turmerone-triggered apoptosis. |
2013-04-30 |
2023-08-12 |
human |
| Shao-Bin Cheng, Li-Chen Wu, Yun-Chih Hsieh, Chi-Hao Wu, Yu-Ju Chan, Li-Hsun Chang, Chieh-Ming J Chang, Shih-Lan Hsu, Chieh-Lin Teng, Chun-Chi W. Supercritical carbon dioxide extraction of aromatic turmerone from Curcuma longa Linn. induces apoptosis through reactive oxygen species-triggered intrinsic and extrinsic pathways in human hepatocellular carcinoma HepG2 cells. Journal of agricultural and food chemistry. vol 60. issue 38. 2013-04-30. PMID:22946656. |
moreover, ar-turmerone stimulated c-jun n-terminal kinase (jnk) and extracellular signal-related kinase (erk) phosphorylation and activation; treatment with jnk and erk inhibitors markedly reduced puma, bax, fas, and dr4 levels and reduced apoptosis but not ros generation. |
2013-04-30 |
2023-08-12 |
human |
| Shao-Bin Cheng, Li-Chen Wu, Yun-Chih Hsieh, Chi-Hao Wu, Yu-Ju Chan, Li-Hsun Chang, Chieh-Ming J Chang, Shih-Lan Hsu, Chieh-Lin Teng, Chun-Chi W. Supercritical carbon dioxide extraction of aromatic turmerone from Curcuma longa Linn. induces apoptosis through reactive oxygen species-triggered intrinsic and extrinsic pathways in human hepatocellular carcinoma HepG2 cells. Journal of agricultural and food chemistry. vol 60. issue 38. 2013-04-30. PMID:22946656. |
furthermore, antioxidants attenuated ar-turmerone-mediated ros production; mitochondrial dysfunction; jnk and erk activation; puma, bax, fas, and dr4 expression; and apoptosis. |
2013-04-30 |
2023-08-12 |
human |
| Lindsay C Spender, Matthew J Carter, Darren I O'Brien, Louise J Clark, Jian Yu, Ewa M Michalak, Lina Happo, Mark S Cragg, Gareth J Inma. Transforming growth factor-β directly induces p53-up-regulated modulator of apoptosis (PUMA) during the rapid induction of apoptosis in myc-driven B-cell lymphomas. The Journal of biological chemistry. vol 288. issue 7. 2013-04-29. PMID:23243310. |
previously we demonstrated that tgf-β-mediated cell death in bl cells is regulated via the mitochondrial intrinsic apoptosis pathway, which is dependent on the activation of bax and/or bak. |
2013-04-29 |
2023-08-12 |
human |
| Laura Vela, Oscar Gonzalo, Javier Naval, Isabel Marz. Direct interaction of Bax and Bak proteins with Bcl-2 homology domain 3 (BH3)-only proteins in living cells revealed by fluorescence complementation. The Journal of biological chemistry. vol 288. issue 7. 2013-04-29. PMID:23283967. |
the key event in the mitochondrial pathway of apoptosis is the activation of bax and bak by bh3-only proteins through a molecular mechanism that is still a matter of debate. |
2013-04-29 |
2023-08-12 |
Not clear |
| Laura Vela, Oscar Gonzalo, Javier Naval, Isabel Marz. Direct interaction of Bax and Bak proteins with Bcl-2 homology domain 3 (BH3)-only proteins in living cells revealed by fluorescence complementation. The Journal of biological chemistry. vol 288. issue 7. 2013-04-29. PMID:23283967. |
we also found a direct interaction between bim, puma, or noxa with either bax or bak during apoptosis induction. |
2013-04-29 |
2023-08-12 |
Not clear |
| Laura Vela, Oscar Gonzalo, Javier Naval, Isabel Marz. Direct interaction of Bax and Bak proteins with Bcl-2 homology domain 3 (BH3)-only proteins in living cells revealed by fluorescence complementation. The Journal of biological chemistry. vol 288. issue 7. 2013-04-29. PMID:23283967. |
these results reveal the ability of main bh3-only proteins to directly activate bax and bak in living cells and suggest that a complex network of interactions regulate the function of bcl-2 family members during apoptosis. |
2013-04-29 |
2023-08-12 |
Not clear |
| Aysegul Cort, Mujgan Timur, Evrim Dursun, Ertan Kucuksayan, Mutay Aslan, Tomris Ozbe. Effects of N-acetylcystein on bleomycin-induced apoptosis in malignant testicular germ cell tumors. Journal of physiology and biochemistry. vol 68. issue 4. 2013-04-25. PMID:22562160. |
we determined the cytotoxic effect of bleomycin and h(2)o(2) on nccit cells and measured apoptosis markers such as caspase-3, caspase-8, and caspase-9 activities and bcl-2, bax, and cytochrome c (cyt-c) levels in nccit cells incubated with bleomycin, h(2)o(2), and/or nac. |
2013-04-25 |
2023-08-12 |
human |