| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Eloi Montanez, Esra Karaköse, Denise Tischner, Andreas Villunger, Reinhard Fässle. PINCH-1 promotes Bcl-2-dependent survival signalling and inhibits JNK-mediated apoptosis in the primitive endoderm. Journal of cell science. vol 125. issue Pt 21. 2013-06-10. PMID:22946061. |
chemical inhibition of jnk attenuated apoptosis of pre cells but failed to reduce bax activity. |
2013-06-10 |
2023-08-12 |
Not clear |
| Yunyi Liu, Wei Wang, Bin Fang, Fengyun Ma, Qian Zheng, Pengyi Deng, Shasha Zhao, Mingjie Chen, Guangxiao Yang, Guangyuan H. Anti-tumor effect of germacrone on human hepatoma cell lines through inducing G2/M cell cycle arrest and promoting apoptosis. European journal of pharmacology. vol 698. issue 1-3. 2013-06-10. PMID:23117090. |
hoechst 33258 and annexin v/pi staining results showed that the total cell number in apoptosis associated with a dose-dependent up-regulation of bax and down-regulation of bcl-2/bcl-xl was increased. |
2013-06-10 |
2023-08-12 |
human |
| Xin Zhao, So-Young Kim, Kun-Young Par. Bamboo salt has in vitro anticancer activity in HCT-116 cells and exerts anti-metastatic effects in vivo. Journal of medicinal food. vol 16. issue 1. 2013-06-10. PMID:23256441. |
bamboo salt (9×) significantly induced apoptosis in cancer cells (p<.05) by upregulating bax, caspase-9, and caspase-3, and downregulating bcl-2. |
2013-06-10 |
2023-08-12 |
mouse |
| Meng-Shiou Lee, Jung Chao, Jiin-Cherng Yen, Li-Wei Lin, Fan-Shiu Tsai, Ming-Tsuen Hsieh, Wen-Huang Peng, Hao-Yuan Chen. Schizandrin protects primary rat cortical cell cultures from glutamate-induced apoptosis by inhibiting activation of the MAPK family and the mitochondria dependent pathway. Molecules (Basel, Switzerland). vol 18. issue 1. 2013-06-10. PMID:23271470. |
glutamate (10 μm) administered for 24 h decreased the expression of bcl-2 and bcl-x(l) protein, whereas increased the expression of bax, bak, apoptosis inducing factor (aif), endonuclease g (nodo g) and endoplasmic reticulum (er) stress of caspase-12. |
2013-06-10 |
2023-08-12 |
rat |
| Fu-Xin Wang, An-Jun Deng, Ming Li, Jin-Feng Wei, Hai-Lin Qin, Ai-Ping Wan. (3S)-1,2,3,4-Tetrahydro-β-carboline-3-carboxylic acid from Cichorium endivia. L induces apoptosis of human colorectal cancer HCT-8 cells. Molecules (Basel, Switzerland). vol 18. issue 1. 2013-06-10. PMID:23275050. |
the compound 1-induced apoptosis in hct-8 cells was accompanied by the loss of mitochondrial membrane potential, the activation of caspase-3, caspase-8 and caspase-9, the up-regulation of bax and the down-regulation of bcl-2. |
2013-06-10 |
2023-08-12 |
human |
| Ritesh K Shukla, Ashutosh Kumar, Deepak Gurbani, Alok K Pandey, Shashi Singh, Alok Dhawa. TiO(2) nanoparticles induce oxidative DNA damage and apoptosis in human liver cells. Nanotoxicology. vol 7. issue 1. 2013-06-07. PMID:22047016. |
furthermore, immunoblot analysis revealed an increased expression of p53, bax, cyto-c, apaf-1, caspase-9 and caspase-3 and decreased the level of bcl-2 thereby indicating that apoptosis induced by tio(2) nps occurs via the caspase-dependent pathway. |
2013-06-07 |
2023-08-12 |
human |
| Guorui Dou, Parameswaran G Sreekumar, Christine Spee, Shikun He, Stephen J Ryan, Ram Kannan, David R Hinto. Deficiency of αB crystallin augments ER stress-induced apoptosis by enhancing mitochondrial dysfunction. Free radical biology & medicine. vol 53. issue 5. 2013-06-07. PMID:22781655. |
overexpression of αb crystallin protects rpe cells from er stress-induced apoptosis by attenuating increases in bax, chop, mitochondrial permeability transition, and cleaved caspase 3. |
2013-06-07 |
2023-08-12 |
mouse |
| Mei-Yi Li, Yan-Bo Zhang, Huan Zuo, Li-Li Liu, Jing-Zhong Ni. [Protective effect of pretreatment of Salvia miltiorrhiza Bunge. f. alba plasma against oxygen-glucose deprivation-induced injury of cultured rat hippocampal neurons by inhibiting apoptosis]. Sheng li xue bao : [Acta physiologica Sinica]. vol 64. issue 1. 2013-06-06. PMID:22348959. |
these results suggest that pharmacological pretreatment of blood plasma containing middle and high dose sma could raise viability and inhibit apoptosis of ogd-injured hippocampal neurons by up-regulating the expression of bcl-2 and down-regulating the expression of bax. |
2013-06-06 |
2023-08-12 |
rat |
| Wenbin Liu, Chengchao Sho. Mycoplasma hyorhinis and Mycoplasma fermentans induce cell apoptosis and changes in gene expression profiles of 32D cells. Biological research. vol 44. issue 4. 2013-06-06. PMID:22446603. |
apoptosis related proteins bcl-2, bid and p53 were down-regulated, fas was up-regulated and bax was dysregulated in mycoplasma-infected 32d cells. |
2013-06-06 |
2023-08-12 |
human |
| Motarab Hossain, Naren L Banik, Swapan K Ra. Synergistic anti-cancer mechanisms of curcumin and paclitaxel for growth inhibition of human brain tumor stem cells and LN18 and U138MG cells. Neurochemistry international. vol 61. issue 7. 2013-06-05. PMID:22910273. |
apoptosis required activation of caspase-8, cleavage of bid to tbid, increase in bax:bcl-2 ratio, and mitochondrial release of cytochrome c, smac, and apoptosis-inducing factor (aif). |
2013-06-05 |
2023-08-12 |
human |
| Lilia Espada, Nathalie Meo-Evoli, Patricia Sancho, Sebastian Real, Isabel Fabregat, Santiago Ambrosio, Albert Taule. ROS production is essential for the apoptotic function of E2F1 in pheochromocytoma and neuroblastoma cell lines. PloS one. vol 7. issue 12. 2013-06-03. PMID:23251571. |
ros accumulation followed e2f1 induction and treatment with the antioxidant n-acetylcysteine, inhibited e2f1-induced bax translocation to mitochondria and subsequent apoptosis. |
2013-06-03 |
2023-08-12 |
Not clear |
| Gamal Badr, Mohamed K Al-Sadoon, Mostafa A Abdel-Maksoud, Danny M Rabah, Ahmed M El-Ton. Cellular and molecular mechanisms underlie the anti-tumor activities exerted by Walterinnesia aegyptia venom combined with silica nanoparticles against multiple myeloma cancer cell types. PloS one. vol 7. issue 12. 2013-06-03. PMID:23251606. |
monitoring the expression of b-cell ccl/lymphoma 2 (bcl-2) family members and their role in apoptosis induction after treatment with wev or wev+np revealed that the combination of wev with np robustly decreased the expression of the anti-apoptotic effectors bcl-2, bcl(xl) and mcl-1; conversely increased the expression of the pro-apoptotic effectors bak, bax and bim; and altered the mitochondrial membrane potential in mm cells. |
2013-06-03 |
2023-08-12 |
Not clear |
| Patchara Ngok-Ngam, Piyajit Watcharasit, Apinya Thiantanawat, Jutamaad Satayaviva. Pharmacological inhibition of GSK3 attenuates DNA damage-induced apoptosis via reduction of p53 mitochondrial translocation and Bax oligomerization in neuroblastoma SH-SY5Y cells. Cellular & molecular biology letters. vol 18. issue 1. 2013-05-31. PMID:23161404. |
pharmacological inhibition of gsk3 attenuates dna damage-induced apoptosis via reduction of p53 mitochondrial translocation and bax oligomerization in neuroblastoma sh-sy5y cells. |
2013-05-31 |
2023-08-12 |
Not clear |
| S Cristofanon, S Fuld. ABT-737 promotes tBid mitochondrial accumulation to enhance TRAIL-induced apoptosis in glioblastoma cells. Cell death & disease. vol 3. 2013-05-31. PMID:23190604. |
of note, knockdown of bid significantly decreases abt-737- and trail-mediated bax activation and apoptosis. |
2013-05-31 |
2023-08-12 |
Not clear |
| I Paul, A D Chacko, I Stasik, S Busacca, N Crawford, F McCoy, N McTavish, B Wilson, M Barr, K J O'Byrne, D B Longley, D A Fennel. Acquired differential regulation of caspase-8 in cisplatin-resistant non-small-cell lung cancer. Cell death & disease. vol 3. 2013-05-31. PMID:23254292. |
although bcl-2-associated x protein (bax) and bcl-2 antagonist killer (bak) are critical regulators of the mitochondrial apoptosis pathway, their requirement has not been robustly established in relation to cisplatin. |
2013-05-31 |
2023-08-12 |
Not clear |
| I Paul, A D Chacko, I Stasik, S Busacca, N Crawford, F McCoy, N McTavish, B Wilson, M Barr, K J O'Byrne, D B Longley, D A Fennel. Acquired differential regulation of caspase-8 in cisplatin-resistant non-small-cell lung cancer. Cell death & disease. vol 3. 2013-05-31. PMID:23254292. |
here, we show that cisplatin can efficiently bypass mitochondrial apoptosis block caused by loss of bax and bak, via activation of the extrinsic death receptor pathway in some model cell lines. |
2013-05-31 |
2023-08-12 |
Not clear |
| Soumya Chatterjee, Gunjan Biswas, Swarnendu Chandra, Goutam Kumar Saha, Krishnendu Achary. Apoptogenic effects of Tricholoma giganteum on Ehrlich's ascites carcinoma cell. Bioprocess and biosystems engineering. vol 36. issue 1. 2013-05-30. PMID:22684905. |
pro-apoptotic gene bax was up-regulated during p53-mediated apoptosis. |
2013-05-30 |
2023-08-12 |
Not clear |
| Alexandra Jaeger, Jana Baake, Dieter G Weiss, Ralf Kriehube. Glycogen synthase kinase-3beta regulates differentiation-induced apoptosis of human neural progenitor cells. International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience. vol 31. issue 1. 2013-05-30. PMID:23085082. |
treatment of differentiating cells with sb216763 induced a significant dephosphorylation of gsk-3beta at serine 9 accompanied by a significant decrease of apoptosis of about 0.7±0.03% and reduced activation of caspase-3 as well as bax and parp cleavage during the first 12h of differentiation compared to untreated, differentiating cells. |
2013-05-30 |
2023-08-12 |
human |
| Alexandra Jaeger, Jana Baake, Dieter G Weiss, Ralf Kriehube. Glycogen synthase kinase-3beta regulates differentiation-induced apoptosis of human neural progenitor cells. International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience. vol 31. issue 1. 2013-05-30. PMID:23085082. |
we assume that gsk-3beta drives neural progenitor cell apoptosis by direct interaction with pro-apoptotic bax or by indirect influence on the canonical wnt/beta-catenin target gene transcription. |
2013-05-30 |
2023-08-12 |
human |
| Jian Zuo, Caifeng Bi, Yuhua Fan, Daniela Buac, Chiara Nardon, Kenyon G Daniel, Q Ping Do. Cellular and computational studies of proteasome inhibition and apoptosis induction in human cancer cells by amino acid Schiff base-copper complexes. Journal of inorganic biochemistry. vol 118. 2013-05-30. PMID:23142973. |
the complexes c1 and c3, but not their counterparts c2 and c4, inhibit the chymotrypsin-like activity of purified 20s proteasome and human cancer cellular 26s proteasome, cause accumulation of proteasome target proteins bax and iκb-α, and induce growth inhibition and apoptosis in concentration- and time-dependent manners. |
2013-05-30 |
2023-08-12 |
human |