| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Yong Guo, Qingqing Shan, Yuping Gong, Juan Lin, Xi Yang, Ruiqing Zho. Oridonin in combination with imatinib exerts synergetic anti-leukemia effect in Ph+ acute lymphoblastic leukemia cells in vitro by inhibiting activation of LYN/mTOR signaling pathway. Cancer biology & therapy. vol 13. issue 13. 2013-07-03. PMID:22895079. |
our results showed that oridonin inhibiting activations of lyn (one of src family kinases) and abl and their downstream akt/mtor, raf/mek/erk and stat5 pathways, downregulated bcl-2 but upregulated bax protein and then induced apoptosis in ph+ all cells. |
2013-07-03 |
2023-08-12 |
Not clear |
| Shuxian An, Xiujuan Zang, Weijie Yuan, Yifeng Zhuge, Qing Y. Neutrophil gelatinase-associated lipocalin (NGAL) may play a protective role against rats ischemia/reperfusion renal injury via inhibiting tubular epithelial cell apoptosis. Renal failure. vol 35. issue 1. 2013-07-02. PMID:23151253. |
serum creatinine (scr) and blood urea nitrogen (bun) were measured on automatic biochemistry analyzer; kidney sections were stained with hematoxylin-eosin; terminal dutp nick-labeling method was used to examine the apoptosis of tubular epithelial cells; cleaved caspase-3 and bax protein expression were detected by immunohistochemistry and western blot; real-time polymerase chain reaction was used to detect the expression of bax mrna. |
2013-07-02 |
2023-08-12 |
rat |
| Shuxian An, Xiujuan Zang, Weijie Yuan, Yifeng Zhuge, Qing Y. Neutrophil gelatinase-associated lipocalin (NGAL) may play a protective role against rats ischemia/reperfusion renal injury via inhibiting tubular epithelial cell apoptosis. Renal failure. vol 35. issue 1. 2013-07-02. PMID:23151253. |
rats with ngal displayed an attenuated renal damage and a decreased number of tubular epithelial cell apoptosis compared to the i/r + ns group (scr 63.400 ± 11.908 vs. 121.857 ± 17.151 μmol/l, bun 14.840 ± 2.868 vs. 28.557 ± 6.434 mmol/l, apoptosis cell number 7.800 ± 1.924 vs. 15.400 ± 3.049/high power field (hpf), p < 0.05), the values were lower in the control group (24.000 ± 3.829 μmol/l, 5.814 ± 1.961 mmol/l, 1.800 ± 0.837/hpf, p < 0.05) compared to two groups above; ngal-treated rats showed down-regulated cleaved caspase-3 protein (0.284 ± 0.066 vs. 0.409 ± 0.073, p < 0.05), bax protein (0.346 ± 0.055 vs. 0.443 ± 0.041, p < 0.05), bax mrna (1.423 ± 0.187 vs. 2.550 ± 0.217, p < 0.05) compared to i/r + ns group, but the values were higher in both of the two groups than those in the control group (cleaved caspase-3 protein 0.104 ± 0.029, bax protein 0.155 ± 0.027, bax mrna 1.000 ± 0.000, p < 0.05). |
2013-07-02 |
2023-08-12 |
rat |
| Shuxian An, Xiujuan Zang, Weijie Yuan, Yifeng Zhuge, Qing Y. Neutrophil gelatinase-associated lipocalin (NGAL) may play a protective role against rats ischemia/reperfusion renal injury via inhibiting tubular epithelial cell apoptosis. Renal failure. vol 35. issue 1. 2013-07-02. PMID:23151253. |
we supposed that exogenous ngal can inhibit the activation of caspase-3, reduce the expression of bax, and thus reduce renal tubular cell apoptosis and protect renal function in i/r injury rats. |
2013-07-02 |
2023-08-12 |
rat |
| Keren I Hilgendorf, Elizaveta S Leshchiner, Simona Nedelcu, Mindy A Maynard, Eliezer Calo, Alessandra Ianari, Loren D Walensky, Jacqueline A Lee. The retinoblastoma protein induces apoptosis directly at the mitochondria. Genes & development. vol 27. issue 9. 2013-07-02. PMID:23618872. |
together, these data establish a nontranscriptional role for prb in direct activation of bax and mitochondrial apoptosis in response to diverse stimuli, which is profoundly tumor-suppressive. |
2013-07-02 |
2023-08-12 |
human |
| Laura D Attardi, Julien Sag. RB goes mitochondrial. Genes & development. vol 27. issue 9. 2013-07-02. PMID:23651852. |
1003-1015) have identified a novel tumor suppressor function for rb independent of its role as a transcriptional regulator, in which rb directly activates the apoptosis regulator bax at the mitochondria to promote cell death. |
2013-07-02 |
2023-08-12 |
Not clear |
| Yuanxiang Jin, Xiuhong Pan, Limin Cao, Bufang Ma, Zhengwei F. Embryonic exposure to cis-bifenthrin enantioselectively induces the transcription of genes related to oxidative stress, apoptosis and immunotoxicity in zebrafish (Danio rerio). Fish & shellfish immunology. vol 34. issue 2. 2013-07-01. PMID:23261506. |
we observed that the mrna levels of the most genes related to oxidative stress, apoptosis and immunotoxicity including cu/zn-superoxide dismutase (cu/zn-sod), catalase (cat), p53, murine double minute 2 (mdm2), b-cell lymphoma/leukaemia-2 gene (bcl2), bcl2 associated x protein (bax), apoptotic protease activating factor-1 (apaf1), caspase 9 (cas9), caspase 3 (cas3), interleukin-1 beta (il-1β) and interleukin-8(il-8) were much higher in 1s-cis-bf treated group than those in cis-bf or 1r-cis-bf treated ones, suggesting that 1s-cis-bf has higher risk to induced oxidative stress, apoptosis and immunotoxicity than 1r-cis-bf in zebrafish. |
2013-07-01 |
2023-08-12 |
cat |
| Chunning Zheng, Wei Jia, Yong Tang, HuiLiang Zhao, Yingsheng Jiang, Shaochuan Su. Mesothelin regulates growth and apoptosis in pancreatic cancer cells through p53-dependent and -independent signal pathway. Journal of experimental & clinical cancer research : CR. vol 31. 2013-06-28. PMID:23034174. |
we observed that in the aspc-1 and capan-1cells with mt-p53, and capan-2 cells with wt-p53, shrna mediated sliencing of the mesothelin significantly increased puma and bax expression and caspase-3 activity, and decreased bcl-2 expression, followed by the reduced proliferation and colony forming capability and increased cell apoptosis. |
2013-06-28 |
2023-08-12 |
human |
| Casandra M Cartagena, Kara E Schmid, Katie L Phillips, Frank C Tortella, Jitendra R Dav. Changes in apoptotic mechanisms following penetrating ballistic-like brain injury. Journal of molecular neuroscience : MN. vol 49. issue 2. 2013-06-27. PMID:22684621. |
for the mitochondria-mediated apoptosis pathway, rqs of anti-apoptotic factors bcl2a1d and birc3 were upregulated while both bcl2 and bax were downregulated. |
2013-06-27 |
2023-08-12 |
Not clear |
| Diana Marklein, Ulrike Graab, Ivonne Naumann, Tiandong Yan, Rosalie Ridzewski, Frauke Nitzki, Albert Rosenberger, Kai Dittmann, Jürgen Wienands, Leszek Wojnowski, Simone Fulda, Heidi Hah. PI3K inhibition enhances doxorubicin-induced apoptosis in sarcoma cells. PloS one. vol 7. issue 12. 2013-06-27. PMID:23300809. |
instead, the combination treatment of dox plus pi103 activated bax, the mitochondrial apoptosis pathway, and caspase 3. |
2013-06-27 |
2023-08-12 |
mouse |
| Guang-Zhi Zeng, Jun-Ting Fan, Jun-Ju Xu, Yan Li, Ning-Hua Ta. Apoptosis induction and G2/M arrest of 2-methyl-1,3,6-trihydroxy-9,10-anthraquinone from Rubia yunnanensis in human cervical cancer Hela cells. Die Pharmazie. vol 68. issue 4. 2013-06-26. PMID:23700797. |
it caused the translocation of bax to the mitochondria and release of cytochrome c into the cytosol, which caused the cleavage of caspase and poly(adp-ribose) polymerase and finally triggered the apoptosis. |
2013-06-26 |
2023-08-12 |
human |
| Shunqin Zhu, Tai Li, Juan Tan, Xiaomin Yan, Dunke Zhang, Chunqin Zheng, Yibiao Chen, Zhonghuai Xiang, Hongjuan Cu. Bax is essential for death receptor-mediated apoptosis in human colon cancer cells. Cancer biotherapy & radiopharmaceuticals. vol 27. issue 9. 2013-06-25. PMID:23113596. |
bax is essential for death receptor-mediated apoptosis in human colon cancer cells. |
2013-06-25 |
2023-08-12 |
human |
| Shunqin Zhu, Tai Li, Juan Tan, Xiaomin Yan, Dunke Zhang, Chunqin Zheng, Yibiao Chen, Zhonghuai Xiang, Hongjuan Cu. Bax is essential for death receptor-mediated apoptosis in human colon cancer cells. Cancer biotherapy & radiopharmaceuticals. vol 27. issue 9. 2013-06-25. PMID:23113596. |
to demonstrate the role of bax in death receptor-induced apoptosis in the human colon cancer hct116 cells. |
2013-06-25 |
2023-08-12 |
human |
| Shunqin Zhu, Tai Li, Juan Tan, Xiaomin Yan, Dunke Zhang, Chunqin Zheng, Yibiao Chen, Zhonghuai Xiang, Hongjuan Cu. Bax is essential for death receptor-mediated apoptosis in human colon cancer cells. Cancer biotherapy & radiopharmaceuticals. vol 27. issue 9. 2013-06-25. PMID:23113596. |
although the p53 signaling pathway is totally intact in this system, the down-regulation of bax in hct116 cells is dramatically resistant to trail and failed to undergo apoptosis. |
2013-06-25 |
2023-08-12 |
human |
| Shunqin Zhu, Tai Li, Juan Tan, Xiaomin Yan, Dunke Zhang, Chunqin Zheng, Yibiao Chen, Zhonghuai Xiang, Hongjuan Cu. Bax is essential for death receptor-mediated apoptosis in human colon cancer cells. Cancer biotherapy & radiopharmaceuticals. vol 27. issue 9. 2013-06-25. PMID:23113596. |
however, the over-expression of bax can rescue the sensitivity of apoptosis induced by the death receptor. |
2013-06-25 |
2023-08-12 |
human |
| Shunqin Zhu, Tai Li, Juan Tan, Xiaomin Yan, Dunke Zhang, Chunqin Zheng, Yibiao Chen, Zhonghuai Xiang, Hongjuan Cu. Bax is essential for death receptor-mediated apoptosis in human colon cancer cells. Cancer biotherapy & radiopharmaceuticals. vol 27. issue 9. 2013-06-25. PMID:23113596. |
our study has revealed an essential role for bax in death receptor-induced apoptosis in the human colon cancer hct116 cells. |
2013-06-25 |
2023-08-12 |
human |
| Jing Xu, Hui-fang Wang, Wei Zhan. [Effect of K-ATP channel opener diazoxide on islet cell apoptosis and the expressions of apoptosis-related genes]. Nan fang yi ke da xue xue bao = Journal of Southern Medical University. vol 30. issue 7. 2013-06-24. PMID:20650802. |
to investigate the effect of potassium channel opener (diazoxide) on the islet cells apoptosis and bcl-2 and bax gene expressions in diabetic rats. |
2013-06-24 |
2023-08-12 |
rat |
| Wei Cui, Hengmin Cui, Xi Peng, Jing Fang, Zhicai Zuo, Xiaodong Liu, Bangyuan W. Dietary vanadium induces lymphocyte apoptosis in the bursa of Fabricius of broilers. Biological trace element research. vol 146. issue 1. 2013-06-24. PMID:21960355. |
lymphocyte apoptosis in the bursa induced by high levels of dietary vanadium is associated with mitochondrial injury and changes in levels of apoptogenic proteins, such as bcl-2, bax, and caspase-3. |
2013-06-24 |
2023-08-12 |
Not clear |
| F Todt, Z Cakir, F Reichenbach, R J Youle, F Edlic. The C-terminal helix of Bcl-x(L) mediates Bax retrotranslocation from the mitochondria. Cell death and differentiation. vol 20. issue 2. 2013-06-21. PMID:23079612. |
the proapoptotic bcl-2 protein bax can commit a cell to apoptosis by translocation from the cytosol to the mitochondria and permeabilization of the outer mitochondrial membrane. |
2013-06-21 |
2023-08-12 |
Not clear |
| F Todt, Z Cakir, F Reichenbach, R J Youle, F Edlic. The C-terminal helix of Bcl-x(L) mediates Bax retrotranslocation from the mitochondria. Cell death and differentiation. vol 20. issue 2. 2013-06-21. PMID:23079612. |
in healthy cells, mitochondrial bax does not permeabilize the outer mitochondrial membrane, but increases cell death after apoptosis induction. |
2013-06-21 |
2023-08-12 |
Not clear |