| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Foxiao Qiao, Daiying Zuo, Haifeng Wang, Zengqiang Li, Huan Qi, Weige Zhang, Yingliang W. DAT-230, a Novel Microtubule Inhibitor, Induced Aberrant Mitosis and Apoptosis in SGC-7901 Cells. Biological & pharmaceutical bulletin. vol 36. issue 2. 2013-08-05. PMID:23370351. |
mitochondria pathway participated in apoptosis after g2/m arrest in sgc-7901 cells treated with dat-230, which was characterized by dna fragmentation, cleavage of poly(adp-ribose) polymerase (parp), activation of caspase-3 and caspase-9, changes of bcl-2 and bax expression, decrease of mitochondrial membrane potential and release of cytochrome c from mitochondria. |
2013-08-05 |
2023-08-12 |
mouse |
| Wen-jing Du, Jing-cheng Dong, Cui Ca. [Effects of icariin on Bcl-2 and Bax protein expressions and eosinophils apoptosis in bronchial asthmatic mice]. Zhongguo Zhong xi yi jie he za zhi Zhongguo Zhongxiyi jiehe zazhi = Chinese journal of integrated traditional and Western medicine. vol 31. issue 9. 2013-08-01. PMID:22013806. |
[effects of icariin on bcl-2 and bax protein expressions and eosinophils apoptosis in bronchial asthmatic mice]. |
2013-08-01 |
2023-08-12 |
mouse |
| Wen-jing Du, Jing-cheng Dong, Cui Ca. [Effects of icariin on Bcl-2 and Bax protein expressions and eosinophils apoptosis in bronchial asthmatic mice]. Zhongguo Zhong xi yi jie he za zhi Zhongguo Zhongxiyi jiehe zazhi = Chinese journal of integrated traditional and Western medicine. vol 31. issue 9. 2013-08-01. PMID:22013806. |
to study the effects of icariin on bcl-2 and bax protein expressions and eosinophils apoptosis in bronchial asthmatic mice. |
2013-08-01 |
2023-08-12 |
mouse |
| Dong-Mei Zhang, Jun-Shan Liu, Li-Juan Deng, Min-Feng Chen, Anita Yiu, Hui-Hui Cao, Hai-Yan Tian, Kwok-Pui Fung, Hiroshi Kurihara, Jing-Xuan Pan, Wen-Cai Y. Arenobufagin, a natural bufadienolide from toad venom, induces apoptosis and autophagy in human hepatocellular carcinoma cells through inhibition of PI3K/Akt/mTOR pathway. Carcinogenesis. vol 34. issue 6. 2013-08-01. PMID:23393227. |
we found that arenobufagin induced mitochondria-mediated apoptosis in hcc cells, with decreasing mitochondrial potential, as well as increasing bax/bcl-2 expression ratio, bax translocation from cytosol to mitochondria. |
2013-08-01 |
2023-08-12 |
human |
| Suganya Sekaran, Selvakumar Kandaswamy, Krishnamoorthy Gunasekaran, Elumalai Perumal, Fariya Yasmine Afsar Basha, Balasakthi Janani Madhan Mohan, Arunakaran Jagadeesa. Protective role of quercetin on polychlorinated biphenyls (Aroclor-1254) induced oxidative stress and apoptosis in liver of adult male rats. Journal of biochemical and molecular toxicology. vol 26. issue 12. 2013-07-30. PMID:23281070. |
whereas simultaneous treatment with quercetin normalized all the biochemical parameters, consequently it inhibited apoptosis mediated by aroclor-1254 by downregulating aryl hydrocarbon receptor, p53 and apoptotic protein (bax, caspase-9, caspase-3) and upregulating the antiapoptotic protein (bcl-2) expression patterns; thereby, quercetin reduces alteration in hepatocellular morphology. |
2013-07-30 |
2023-08-12 |
rat |
| Zakir Khan, Prakash S Bise. Oncoapoptotic signaling and deregulated target genes in cancers: special reference to oral cancer. Biochimica et biophysica acta. vol 1836. issue 1. 2013-07-30. PMID:23602834. |
bax and bh-3 family, fas, tnf-r, and caspases), and the genes encoding key transcription factors or elements for signal transduction leading to cell growth and apoptosis. |
2013-07-30 |
2023-08-12 |
human |
| N Liman, E Alan, G K Bayram, K Gürbula. Expression of survivin, Bcl-2 and Bax proteins in the domestic cat (Felis catus) endometrium during the oestrus cycle. Reproduction in domestic animals = Zuchthygiene. vol 48. issue 1. 2013-07-29. PMID:22471444. |
to clarify the regulation of apoptosis in the cat endometrium during the normal oestrus cycle, the expressions of the apoptosis-related proteins (bcl-2 and bax) and their correlation to the inhibitor of apoptosis protein survivin were analysed using immunohistochemistry. |
2013-07-29 |
2023-08-12 |
cat |
| N Liman, E Alan, G K Bayram, K Gürbula. Expression of survivin, Bcl-2 and Bax proteins in the domestic cat (Felis catus) endometrium during the oestrus cycle. Reproduction in domestic animals = Zuchthygiene. vol 48. issue 1. 2013-07-29. PMID:22471444. |
the overall results suggest that survivin, bax and bcl-2 proteins may cooperatively contribute to cell apoptosis and cell proliferation in the cat uterus during the oestrus cycle. |
2013-07-29 |
2023-08-12 |
cat |
| Zhao Yang, Wei Eric Wang, Qian Zhan. CIAPIN1 siRNA inhibits proliferation, migration and promotes apoptosis of VSMCs by regulating Bcl-2 and Bax. Current neurovascular research. vol 10. issue 1. 2013-07-29. PMID:23151078. |
ciapin1 sirna inhibits proliferation, migration and promotes apoptosis of vsmcs by regulating bcl-2 and bax. |
2013-07-29 |
2023-08-12 |
human |
| Zhao Yang, Wei Eric Wang, Qian Zhan. CIAPIN1 siRNA inhibits proliferation, migration and promotes apoptosis of VSMCs by regulating Bcl-2 and Bax. Current neurovascular research. vol 10. issue 1. 2013-07-29. PMID:23151078. |
the results demonstrated that ciapin1 sirna inhibited proliferation, migration and promotes apoptosis of vsmcs by regulating bcl-2 and bax. |
2013-07-29 |
2023-08-12 |
human |
| Narin Liman, Emel Ala. The process of apoptosis in a holocrine gland as shown by the avian uropygial gland. Anatomical record (Hoboken, N.J. : 2007). vol 296. issue 3. 2013-07-29. PMID:23362229. |
this study was designed to elucidate the presence of apoptosis and the localization of apoptosis-related bax and survivin proteins and proliferating cell nuclear antigen (pcna) within the chicken uropygial gland, a specialized holocrine secretory gland. |
2013-07-29 |
2023-08-12 |
chicken |
| Mao-Chun Xu, Hai-Ming Shi, Xiu-Fang Gao, Hao Wan. Salidroside attenuates myocardial ischemia-reperfusion injury via PI3K/Akt signaling pathway. Journal of Asian natural products research. vol 15. issue 3. 2013-07-29. PMID:23418859. |
the results showed that intracoronary injection of salidroside at the onset of reperfusion markedly reduced the apoptosis of cardiomyocytes, significantly increasing bcl-2 and p-akt proteins expressions and decreasing bax and caspase-3 expressions in the hearts subjected to ischemia followed by 120-min reperfusion. |
2013-07-29 |
2023-08-12 |
rabbit |
| Rahul Bhowmick, Umesh Chandra Halder, Shiladitya Chattopadhyay, Mukti Kant Nayak, Mamta Chawla-Sarka. Rotavirus-encoded nonstructural protein 1 modulates cellular apoptotic machinery by targeting tumor suppressor protein p53. Journal of virology. vol 87. issue 12. 2013-07-29. PMID:23576507. |
degradation of p53 during initial stages of infection inhibited apoptosis, as the proapoptotic genes puma and bax were downregulated. |
2013-07-29 |
2023-08-12 |
Not clear |
| b' Bal\\xc3\\xa1zs B\\xc3\\xb6rzs\\xc3\\xb6nyi, Csaba Demendi, J\\xc3\\xa1nos Rig\\xc3\\xb3, Imre Szentp\\xc3\\xa9teri, Attila Rab, J\\xc3\\xb3zsef G\\xc3\\xa1bor Jo\\xc3\\xb. The regulation of apoptosis in intrauterine growth restriction: a study of Bcl-2 and Bax gene expression in human placenta. The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians. vol 26. issue 4. 2013-07-22. PMID:23038985.' |
the regulation of apoptosis in intrauterine growth restriction: a study of bcl-2 and bax gene expression in human placenta. |
2013-07-22 |
2023-08-12 |
human |
| Tânia Mara Fischer Günther, Maicon Roberto Kviecinski, Carla Cristine Baron, Karina Bettega Felipe, Mirelle Sifroni Farias, Fabiana Ourique da Silva, Nádia Cristina Falcão Bücker, Claus Tröger Pich, Eduardo Antonio Ferreira, Danilo Wilhelm Filho, Julien Verrax, Pedro Buc Calderon, Rozangela Curi Pedros. Sodium orthovanadate associated with pharmacological doses of ascorbate causes an increased generation of ROS in tumor cells that inhibits proliferation and triggers apoptosis. Biochemical and biophysical research communications. vol 430. issue 3. 2013-07-22. PMID:23261463. |
apoptosis induced by orthovanadate and ascorbate is closer related to inhibition on bcl-xl and activation of bax. |
2013-07-22 |
2023-08-12 |
mouse |
| Fang Wang, Ting Li, Bin Zhang, Hong Li, Qiong Wu, Li Yang, Yongzhan Nie, Kaichun Wu, Yongquan Shi, Daiming Fa. MicroRNA-19a/b regulates multidrug resistance in human gastric cancer cells by targeting PTEN. Biochemical and biophysical research communications. vol 434. issue 3. 2013-07-22. PMID:23603256. |
we further confirmed that mir-19a/b accelerated the adr efflux of gastric cancer cells by increasing the levels of mdr1 and p-gp and that mir-19a/b suppressed drug-induced apoptosis by regulating bcl-2 and bax. |
2013-07-22 |
2023-08-12 |
human |
| Jiaxing Song, Qun Chen, Da Xin. Enhanced apoptotic effects by downregulating Mcl-1: evidence for the improvement of photodynamic therapy with Celecoxib. Experimental cell research. vol 319. issue 10. 2013-07-19. PMID:23524145. |
silencing mcl-1 sensitizes tumor cells to pdt-induced apoptosis, and ectopic expression of mcl-1 significantly delays bax translocation to mitochondria and inhibits caspase-3 activity following pdt. |
2013-07-19 |
2023-08-12 |
Not clear |
| Yoshimi Shionome, Li Yan, Song Liu, Toshiaki Saeki, Toru Ouch. Integrity of p53 associated pathways determines induction of apoptosis of tumor cells resistant to Aurora-A kinase inhibitors. PloS one. vol 8. issue 1. 2013-07-17. PMID:23383195. |
in this study, we investigated the roles of genes involved in p53 pathway (p53, puma, p21, bax, and chk2) in response to aurora-a inhibitors, vx680 and mk-8745, and explored whether chemoresistant tumor cells would further undergo apoptosis with other therapeutic agents. |
2013-07-17 |
2023-08-12 |
mouse |
| Hye Hyeon Lee, Cheol Park, Jin-Woo Jeong, Min Jeong Kim, Min Jeong Seo, Byoung Won Kang, Jeong Uck Park, Gi-Young Kim, Byung Tae Choi, Yung Hyun Choi, Yong Kee Jeon. Apoptosis induction of human prostate carcinoma cells by cordycepin through reactive oxygen species‑mediated mitochondrial death pathway. International journal of oncology. vol 42. issue 3. 2013-07-16. PMID:23292300. |
in addition, cordycepin treatment resulted in an increase of the bax/bcl-2 (or bcl-xl) ratio, downregulation of inhibitor of apoptosis protein (iap) family members, bax conformational changes, and release of cytochrome c from the mitochondria to the cytosol. |
2013-07-16 |
2023-08-12 |
human |
| Séverine Hamann, Sylviane Métrailler, Daniel F Schorderet, Sandra Cotte. Analysis of the cytoprotective role of α-crystallins in cell survival and implication of the αA-crystallin C-terminal extension domain in preventing Bax-induced apoptosis. PloS one. vol 8. issue 2. 2013-07-15. PMID:23383327. |
in the rpe65⁻/⁻ mouse model of leber's congenital amaurosis, we previously observed decreased expression of αa- and αb-crystallins during disease progression, which was correlated with bax pro-death activity and photoreceptor apoptosis. |
2013-07-15 |
2023-08-12 |
mouse |