| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Behnam Kamalidehghan, Fatemeh Ahmadipour, Mohamed Ibrahim Noordi. DNA fragmentation is not associated with apoptosis in zerumbone-induced HepG2 cells. Iranian biomedical journal. vol 16. issue 4. 2013-06-21. PMID:23183623. |
to furthur confirm the induction of apoptosis, the protein of zerumbone-induced hepg2 cells using western-blotting indicated a low and high expression of bcl2 and bax proteins, respectively. |
2013-06-21 |
2023-08-12 |
human |
| Aiping Zhang, Richard L Hildreth, Anamaris M Colberg-Pole. Human cytomegalovirus inhibits apoptosis by proteasome-mediated degradation of Bax at endoplasmic reticulum-mitochondrion contacts. Journal of virology. vol 87. issue 10. 2013-06-21. PMID:23487455. |
human cytomegalovirus inhibits apoptosis by proteasome-mediated degradation of bax at endoplasmic reticulum-mitochondrion contacts. |
2013-06-21 |
2023-08-12 |
human |
| Li-Na Xu, Bi-Nan Lu, Ming-Ming Hu, You-Wei Xu, Xu Han, Yan Qi, Jin-Yong Pen. Mechanisms involved in the cytotoxic effects of berberine on human colon cancer HCT-8 cells. Biocell : official journal of the Sociedades Latinoamericanas de Microscopia Electronica ... et. al. vol 36. issue 3. 2013-06-20. PMID:23682426. |
decrease of bcl-2 and increase of bax in mrna and/or protein expressions showed that the bcl-2 family proteins were involved in berberine-induced apoptosis. |
2013-06-20 |
2023-08-12 |
human |
| Nathan D Roe, Jun Re. Oxidative activation of Ca(2+)/calmodulin-activated kinase II mediates ER stress-induced cardiac dysfunction and apoptosis. American journal of physiology. Heart and circulatory physiology. vol 304. issue 6. 2013-06-19. PMID:23316062. |
echocardiographic assessment revealed that tunicamycin elicited cardiac remodeling (enlarged end-systolic diameter without affecting diastolic and ventricular wall thickness), depressed fractional shortening, ejection fraction, and cardiomyocyte contractile capacity, intracellular ca(2+) mishandling, accumulation of reactive oxygen species (superoxide production and nadph oxidase p47phox level), camkii oxidation, and apoptosis (evidenced by bax, bcl-2/bax ratio, and tunel staining), the effects of which were obliterated by catalase. |
2013-06-19 |
2023-08-12 |
mouse |
| Jia-He Wang, Ke Zhang, Hui-Yan Niu, Lin-Hua Shu, Dong-Mei Yue, Dong- Yang Li, Ping H. Jolkinolide B from Euphorbia fischeriana Steud induces in human leukemic cells apoptosis via JAK2/STAT3 pathways. International journal of clinical pharmacology and therapeutics. vol 51. issue 3. 2013-06-18. PMID:23253949. |
taken together, our study for the first time suggests that jolkinolide b is able to enhance apoptosis of human leukemic hl-60 and thp-1 cells, at least in part, through downregulation of jak2/stat3 and bcl-2, and upregulation of bax and cytosolic cytochrome c. moreover, the triggering of caspase-3, -8, and -9 activation mediated apoptotic induction. |
2013-06-18 |
2023-08-12 |
human |
| Kahkashan Rashid, Joydeep Das, Parames C Si. Taurine ameliorate alloxan induced oxidative stress and intrinsic apoptotic pathway in the hepatic tissue of diabetic rats. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association. vol 51. 2013-06-17. PMID:23092809. |
studies on the mechanism of apoptosis showed that alx accelerated the markers of mitochondrial dependent apoptotic pathway (enhanced cytochrome c release in cytosol from mitochondria, altered the expression of bax, bcl-2, apaf-1, caspase-9, caspase-3). |
2013-06-17 |
2023-08-12 |
rat |
| Kazim Husain, Barbara A Centeno, Dung-Tsa Chen, William J Fulp, Marta Perez, Guo Zhang Lee, Noreen Luetteke, Sunil R Hingorani, Said M Sebti, Mokenge P Malaf. Prolonged survival and delayed progression of pancreatic intraepithelial neoplasia in LSL-KrasG12D/+;Pdx-1-Cre mice by vitamin E δ-tocotrienol. Carcinogenesis. vol 34. issue 4. 2013-06-17. PMID:23302291. |
δ-tocotrienol also induced biomarkers of apoptosis such as bax and activated caspase 3 along with an increase in plasma levels of ck18. |
2013-06-17 |
2023-08-12 |
mouse |
| V H Tran, R Bartolo, D Westphal, A Alsop, G Dewson, R M Kluc. Bak apoptotic function is not directly regulated by phosphorylation. Cell death & disease. vol 4. 2013-06-17. PMID:23303126. |
during apoptosis, bak and bax permeabilize the mitochondrial outer membrane by undergoing major conformational change and oligomerization. |
2013-06-17 |
2023-08-12 |
Not clear |
| A Berger, S-A Quast, M Plötz, A Kammermeier, J Eberl. Sensitization of melanoma cells for TRAIL-induced apoptosis by BMS-345541 correlates with altered phosphorylation and activation of Bax. Cell death & disease. vol 4. 2013-06-17. PMID:23348591. |
sensitization of melanoma cells for trail-induced apoptosis by bms-345541 correlates with altered phosphorylation and activation of bax. |
2013-06-17 |
2023-08-12 |
Not clear |
| Y Liu, H Cheng, Y Zhou, Y Zhu, R Bian, Y Chen, C Li, Q Ma, Q Zheng, Y Zhang, H Jin, X Wang, Q Chen, D Zh. Myostatin induces mitochondrial metabolic alteration and typical apoptosis in cancer cells. Cell death & disease. vol 4. 2013-06-17. PMID:23412387. |
myostatin promoted the translocation of bax from cytosol to mitochondria, and knockdown of vdac1 inhibited myostatin-induced bax translocation and apoptosis. |
2013-06-17 |
2023-08-12 |
Not clear |
| D M Monsalve, T Merced, I F Fernández, S Blanco, M Vázquez-Cedeira, P A Laz. Human VRK2 modulates apoptosis by interaction with Bcl-xL and regulation of BAX gene expression. Cell death & disease. vol 4. 2013-06-17. PMID:23449449. |
human vrk2 modulates apoptosis by interaction with bcl-xl and regulation of bax gene expression. |
2013-06-17 |
2023-08-12 |
human |
| D M Monsalve, T Merced, I F Fernández, S Blanco, M Vázquez-Cedeira, P A Laz. Human VRK2 modulates apoptosis by interaction with Bcl-xL and regulation of BAX gene expression. Cell death & disease. vol 4. 2013-06-17. PMID:23449449. |
vrk2a does not compete with bax for interaction with bcl-xl, and these proteins can form a complex that reduces apoptosis. |
2013-06-17 |
2023-08-12 |
human |
| T Zhou, G Li, B Cao, L Liu, Q Cheng, H Kong, C Shan, X Huang, J Chen, N Ga. Downregulation of Mcl-1 through inhibition of translation contributes to benzyl isothiocyanate-induced cell cycle arrest and apoptosis in human leukemia cells. Cell death & disease. vol 4. 2013-06-17. PMID:23449451. |
exposure of jurkat cells to bitc resulted in dose- and time-dependent increase in apoptosis, caspase activation, cytochrome c release, nuclear apoptosis-inducing factor (aif) accumulation, bcl2-associated x protein (bax) translocation, and myeloid cell leukemia-1 (mcl-1) downregulation. |
2013-06-17 |
2023-08-12 |
mouse |
| Shuli Xie, Mingguang Zhu, Guoyue Lv, Qiang Zhang, Guangyi Wan. The role of RhoC in the proliferation and apoptosis of hepatocellular carcinoma cells. Medical oncology (Northwood, London, England). vol 29. issue 3. 2013-06-14. PMID:21674277. |
knockdown of rhoc expression in bel-7402 cells also significantly increased the percentage of cells in the g0/g1 phase, cellular apoptosis, and expression of p21, p16, and bax. |
2013-06-14 |
2023-08-12 |
human |
| Anuradha Sehrawat, Julie A Arlotti, Akira Murakami, Shivendra V Sing. Zerumbone causes Bax- and Bak-mediated apoptosis in human breast cancer cells and inhibits orthotopic xenograft growth in vivo. Breast cancer research and treatment. vol 136. issue 2. 2013-06-14. PMID:23053663. |
on the other hand, the sv40 immortalized mouse embryonic fibroblasts derived from bax and bak double knockout mice were significantly more resistant to zer-induced apoptosis. |
2013-06-14 |
2023-08-12 |
mouse |
| Biyun Ching, Xiu L Chen, Jing H A Yong, Jonathan M Wilson, Kum C Hiong, Eugene W L Sim, Wai P Wong, Siew H Lam, Shit F Chew, Yuen K I. Increases in apoptosis, caspase activity and expression of p53 and bax, and the transition between two types of mitochondrion-rich cells, in the gills of the climbing perch, Anabas testudineus, during a progressive acclimation from freshwater to seawater. Frontiers in physiology. vol 4. 2013-06-14. PMID:23760020. |
increases in apoptosis, caspase activity and expression of p53 and bax, and the transition between two types of mitochondrion-rich cells, in the gills of the climbing perch, anabas testudineus, during a progressive acclimation from freshwater to seawater. |
2013-06-14 |
2023-08-12 |
Not clear |
| R Gallo, M Natale, F Vendrame, U Boggi, F Filipponi, P Marchetti, F Laghi Pasini, F Dott. In vitro effects of mycophenolic acid on survival, function, and gene expression of pancreatic beta-cells. Acta diabetologica. vol 49 Suppl 1. 2013-06-13. PMID:22249339. |
consequently, we evaluated the viability, the induction of apoptosis, the glucose-stimulated insulin secretion, and the expression of β-cell function genes (isl1, pax6, glut-2, glucokinase) and apoptosis-related genes (bax and bcl2). |
2013-06-13 |
2023-08-12 |
mouse |
| R K Srivastava, Q Rahman, M P Kashyap, A K Singh, G Jain, S Jahan, M Lohani, M Lantow, A B Pan. Nano-titanium dioxide induces genotoxicity and apoptosis in human lung cancer cell line, A549. Human & experimental toxicology. vol 32. issue 2. 2013-06-13. PMID:23111874. |
apoptosis was confirmed by the formation of apoptotic bodies and altered expression (messenger rna (mrna) and protein) of markers such as p(53), p(21), bax, bcl(2) and cleaved caspase-3. |
2013-06-13 |
2023-08-12 |
human |
| Gyöngyi N Kiss, Sue-Chin Lee, James I Fells, Jianxiong Liu, William J Valentine, Yuko Fujiwara, Karin Emmons Thompson, Charles R Yates, Balázs Sümegi, Gabor Tigy. Mitigation of radiation injury by selective stimulation of the LPA(2) receptor. Biochimica et biophysica acta. vol 1831. issue 1. 2013-06-12. PMID:23127512. |
our findings suggest that by specifically activating lpa(2) receptors gri977143 activates the erk1/2 prosurvival pathway, effectively reduces bax translocation to the mitochondrion, attenuates the activation of initiator and effector caspases, reduces dna fragmentation, and inhibits parp-1 cleavage associated with γ-irradiation-induced apoptosis. |
2013-06-12 |
2023-08-12 |
mouse |
| L Masuelli, M Benvenuto, M Fantini, L Marzocchella, P Sacchetti, E Di Stefano, I Tresoldi, V Izzi, R Bernardini, C Palumbo, M Mattei, F Lista, F Galvano, A Modesti, R Be. Curcumin induces apoptosis in breast cancer cell lines and delays the growth of mammary tumors in neu transgenic mice. Journal of biological regulators and homeostatic agents. vol 27. issue 1. 2013-06-12. PMID:23489691. |
the activation of apoptosis was confirmed by parp-1 cleavage and by the increased ratio between the pro-apoptotic bax and the anti-apoptotic bcl-2 protein. |
2013-06-12 |
2023-08-12 |
mouse |