| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Jiaxing Song, Qun Chen, Da Xin. Enhanced apoptotic effects by downregulating Mcl-1: evidence for the improvement of photodynamic therapy with Celecoxib. Experimental cell research. vol 319. issue 10. 2013-07-19. PMID:23524145. |
silencing mcl-1 sensitizes tumor cells to pdt-induced apoptosis, and ectopic expression of mcl-1 significantly delays bax translocation to mitochondria and inhibits caspase-3 activity following pdt. |
2013-07-19 |
2023-08-12 |
Not clear |
| Yoshimi Shionome, Li Yan, Song Liu, Toshiaki Saeki, Toru Ouch. Integrity of p53 associated pathways determines induction of apoptosis of tumor cells resistant to Aurora-A kinase inhibitors. PloS one. vol 8. issue 1. 2013-07-17. PMID:23383195. |
in this study, we investigated the roles of genes involved in p53 pathway (p53, puma, p21, bax, and chk2) in response to aurora-a inhibitors, vx680 and mk-8745, and explored whether chemoresistant tumor cells would further undergo apoptosis with other therapeutic agents. |
2013-07-17 |
2023-08-12 |
mouse |
| Hye Hyeon Lee, Cheol Park, Jin-Woo Jeong, Min Jeong Kim, Min Jeong Seo, Byoung Won Kang, Jeong Uck Park, Gi-Young Kim, Byung Tae Choi, Yung Hyun Choi, Yong Kee Jeon. Apoptosis induction of human prostate carcinoma cells by cordycepin through reactive oxygen species‑mediated mitochondrial death pathway. International journal of oncology. vol 42. issue 3. 2013-07-16. PMID:23292300. |
in addition, cordycepin treatment resulted in an increase of the bax/bcl-2 (or bcl-xl) ratio, downregulation of inhibitor of apoptosis protein (iap) family members, bax conformational changes, and release of cytochrome c from the mitochondria to the cytosol. |
2013-07-16 |
2023-08-12 |
human |
| Séverine Hamann, Sylviane Métrailler, Daniel F Schorderet, Sandra Cotte. Analysis of the cytoprotective role of α-crystallins in cell survival and implication of the αA-crystallin C-terminal extension domain in preventing Bax-induced apoptosis. PloS one. vol 8. issue 2. 2013-07-15. PMID:23383327. |
in the rpe65⁻/⁻ mouse model of leber's congenital amaurosis, we previously observed decreased expression of αa- and αb-crystallins during disease progression, which was correlated with bax pro-death activity and photoreceptor apoptosis. |
2013-07-15 |
2023-08-12 |
mouse |
| Séverine Hamann, Sylviane Métrailler, Daniel F Schorderet, Sandra Cotte. Analysis of the cytoprotective role of α-crystallins in cell survival and implication of the αA-crystallin C-terminal extension domain in preventing Bax-induced apoptosis. PloS one. vol 8. issue 2. 2013-07-15. PMID:23383327. |
in the present study, we demonstrated that α-crystallins interacted with pro-apoptotic bax and displayed cytoprotective action against bax-triggered apoptosis, as assessed by tunel and caspase assays. |
2013-07-15 |
2023-08-12 |
mouse |
| Jinghua Yang, Qiufang Liu, Shengwen Wu, Qi Xi, Yuan Ca. Effects of lanthanum chloride on glutamate level, intracellular calcium concentration and caspases expression in the rat hippocampus. Biometals : an international journal on the role of metal ions in biology, biochemistry, and medicine. vol 26. issue 1. 2013-07-12. PMID:23097080. |
these results indicate that lacl(3) increases glutamate level, [ca(2+)](i) and ratio of bax and bcl-2 expression, which cause excessive apoptosis by the mitochondrial and endoplasmic reticulum stress-induced pathway, and thus neuronal damages in the hippocampus. |
2013-07-12 |
2023-08-12 |
rat |
| Hayley Furlong, Carmel Mothersill, Fiona M Lyng, Orla How. Apoptosis is signalled early by low doses of ionising radiation in a radiation-induced bystander effect. Mutation research. vol 741-742. 2013-07-11. PMID:23454491. |
the data generated consolidated the role of apoptosis following direct ir exposure for all doses and time points as pro-apoptotic genes such as bax and jnk as well as initiator caspase 7 and effector caspase 3 and 9 were up-regulated. |
2013-07-11 |
2023-08-12 |
Not clear |
| Marion Piedfer, Sandrine Bouchet, Ruoping Tang, Christian Billard, Daniel Dauzonne, Brigitte Bauvoi. p70S6 kinase is a target of the novel proteasome inhibitor 3,3'-diamino-4'-methoxyflavone during apoptosis in human myeloid tumor cells. Biochimica et biophysica acta. vol 1833. issue 6. 2013-07-11. PMID:23481040. |
accordingly, dd1 failed to induce p70s6k cleavage, bax stimulation and apoptosis in k562 cells resistant to bortezomib. |
2013-07-11 |
2023-08-12 |
human |
| Marion Piedfer, Sandrine Bouchet, Ruoping Tang, Christian Billard, Daniel Dauzonne, Brigitte Bauvoi. p70S6 kinase is a target of the novel proteasome inhibitor 3,3'-diamino-4'-methoxyflavone during apoptosis in human myeloid tumor cells. Biochimica et biophysica acta. vol 1833. issue 6. 2013-07-11. PMID:23481040. |
these results indicate that dd1 has the potential to eradicate aml cells and support a critical role for bax and p70s6k in dd1-mediated proteasome inhibition and apoptosis of leukemia cells. |
2013-07-11 |
2023-08-12 |
human |
| Cindy Gallerne, Alexandre Prola, Christophe Lemair. Hsp90 inhibition by PU-H71 induces apoptosis through endoplasmic reticulum stress and mitochondrial pathway in cancer cells and overcomes the resistance conferred by Bcl-2. Biochimica et biophysica acta. vol 1833. issue 6. 2013-07-11. PMID:23485394. |
this study investigated the mechanism of apoptosis induced by the purine-scaffold hsp90 inhibitor pu-h71 in different human cancer cell lines and examined the role of bcl-2 and bax in this process. |
2013-07-11 |
2023-08-12 |
human |
| Cindy Gallerne, Alexandre Prola, Christophe Lemair. Hsp90 inhibition by PU-H71 induces apoptosis through endoplasmic reticulum stress and mitochondrial pathway in cancer cells and overcomes the resistance conferred by Bcl-2. Biochimica et biophysica acta. vol 1833. issue 6. 2013-07-11. PMID:23485394. |
apoptosis was executed through the mitochondrial pathway as shown by down-regulation of bcl-2, up-regulation and activation of bax, permeabilization of mitochondrial membranes, release of cytochrome c and activation of caspases. |
2013-07-11 |
2023-08-12 |
human |
| Wei Zhang, Hongqi Feng, Yanhui Gao, Liyan Sun, Jing Wang, Yuanyuan Li, Cheng Wang, Lijun Zhao, Xinxin Hu, Huixin Sun, Yudan Wei, Dianjun Su. Role of pigment epithelium-derived factor (PEDF) in arsenic-induced cell apoptosis of liver and brain in a rat model. Biological trace element research. vol 151. issue 2. 2013-07-10. PMID:23229538. |
therefore, we thought pedf played a role in cell apoptosis of liver and brain which induced by sodium arsenite exposure, and the results also demonstrated that bax and bcl-2 might be two key targets in the action of pedf. |
2013-07-10 |
2023-08-12 |
human |
| Rong Li, Li Cai, Xue-feng Xie, Lei Peng, Ting-ni Wu, Jun L. 7,3'-dimethoxy hesperetin inhibits inflammation by inducing synovial apoptosis in rats with adjuvant-induced arthritis. Immunopharmacology and immunotoxicology. vol 35. issue 1. 2013-07-09. PMID:22978269. |
mechanisms of this effect are partly related to induction of synovial apoptosis through modulation of bcl-2 and bax expression. |
2013-07-09 |
2023-08-12 |
rat |
| Yu-Jiao Li, Qi Yang, Kun Zhang, Yan-Yan Guo, Xu-Bo Li, Le Yang, Ming-Gao Zhao, Yu-Mei W. Cytisine confers neuronal protection against excitotoxic injury by down-regulating GluN2B-containing NMDA receptors. Neurotoxicology. vol 34. 2013-07-09. PMID:23022271. |
cyt significantly inhibited the neuronal apoptosis induced by nmda exposure by reversing intracellular ca(2+) overload and balancing bcl-2 and bax expression levels. |
2013-07-09 |
2023-08-12 |
Not clear |
| Lu Zhang, HongJuan Jing, LiuQing Cui, HuanQing Li, Bo Zhou, GuangZhou Zhou, Fang Da. 3,4-Dimethoxystilbene, a resveratrol derivative with anti-angiogenic effect, induces both macroautophagy and apoptosis in endothelial cells. Journal of cellular biochemistry. vol 114. issue 3. 2013-07-09. PMID:23059970. |
our results showed that 3,4-dms exerted its anti-angiogenic effect likely through induction of endothelial cell apoptosis via a pathway involving p53, bax, cytochrome c, and caspase proteases. |
2013-07-09 |
2023-08-12 |
Not clear |
| Yu Chen, Jinshu Ma, Fang Wang, Jie Hu, Ai Cui, Chengguo Wei, Qing Yang, Fan L. Amygdalin induces apoptosis in human cervical cancer cell line HeLa cells. Immunopharmacology and immunotoxicology. vol 35. issue 1. 2013-07-09. PMID:23137229. |
further studies indicated that antiapoptotic protein bcl-2 was downregulated whereas proapoptotic bax protein was upregulated in the amygdalin-treated hela cells implying involvement of the intrinsic pathway of apoptosis. |
2013-07-09 |
2023-08-12 |
human |
| Hyou-Ju Jin, Xiao-Liang Xie, Ji-Ming Ye, Chun-Guang L. TanshinoneIIA and cryptotanshinone protect against hypoxia-induced mitochondrial apoptosis in H9c2 cells. PloS one. vol 8. issue 1. 2013-07-09. PMID:23341883. |
chronic hypoxia caused a significant increase in hypoxia inducible factor 1α expression and the cell late apoptosis rate, which was accompanied with an increase in caspase 3 activity, cytochrome c release, mitochondria membrane potential and expression of pro-apoptosis proteins (bax and bak). |
2013-07-09 |
2023-08-12 |
Not clear |
| Vivek Kumar, Vinay K Tripathi, Abhishek K Singh, Mohathshim Lohani, Mohammed Kuddu. Trans-resveratrol restores the damages induced by organophosphate pesticide-monocrotophos in neuronal cells. Toxicology international. vol 20. issue 1. 2013-07-08. PMID:23833438. |
restoration of markers such as cytochrome c, bax, bcl-2 and caspase-3 also confirms the effectiveness of rv against mcp-induced, mitochondria-mediated apoptosis in pc12 cells. |
2013-07-08 |
2023-08-12 |
rat |
| Shao-Jung Lo, Li-Ching Fan, Yow-Fu Tsai, Kuo-Yang Lin, Hsiao-Ling Huang, Tong-Hong Wang, Hsuan Liu, Tse-Chin Chen, Shiu-Fen Huang, Chee-Jen Chang, Yu-Jr Lin, Benjamin Yat-Ming Yung, Sen-Yung Hsie. A novel interaction of nucleophosmin with BCL2-associated X protein regulating death evasion and drug sensitivity in human hepatoma cells. Hepatology (Baltimore, Md.). vol 57. issue 5. 2013-07-05. PMID:23258611. |
bax was translocated to cytoplasm in cells with relatively high npm level, or accumulated in the mitochondria in cells with relatively low npm level and undergoing apoptosis. |
2013-07-05 |
2023-08-12 |
human |
| Eun-Seok Park, Jun Chul Kang, Do-Hyun Kang, Yong Chang Jang, Kyu Yang Yi, Hun-Jong Chung, Jong Seok Park, Bokyung Kim, Zhong-Ping Feng, Hwa-Sup Shi. 5-AIQ inhibits H2O2-induced apoptosis through reactive oxygen species scavenging and Akt/GSK-3β signaling pathway in H9c2 cardiomyocytes. Toxicology and applied pharmacology. vol 268. issue 1. 2013-07-05. PMID:23352507. |
in addition, inhibiting the akt/gsk-3β pathway by ly294002 significantly attenuated the 5-aiq-mediated decrease in cleaved caspase-3 and bax activation and h9c2 cell apoptosis induction. |
2013-07-05 |
2023-08-12 |
Not clear |