| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Qingdi Quentin Li, Rebecca X Lee, Huasheng Liang, Yuhua Zhon. Anticancer activity of β-Elemene and its synthetic analogs in human malignant brain tumor cells. Anticancer research. vol 33. issue 1. 2013-05-30. PMID:23267129. |
furthermore, β-elemene increased caspase-3/7/10 activity, up-regulated protein expression of bax, and down-regulated the one of bcl-2, bcl-xl, and of x-linked inhibitor of apoptosis (xiap) in the cells, suggesting that apoptotic signaling pathways are involved in the responses triggered by β-elemene. |
2013-05-30 |
2023-08-12 |
human |
| Dong-Mei Zhang, Jun-Shan Liu, Ming-Kuen Tang, Anita Yiu, Hui-hui Cao, Lei Jiang, Judy Yuet-Wa Chan, Hai-Yan Tian, Kwok-Pui Fung, Wen-Cai Y. Bufotalin from Venenum Bufonis inhibits growth of multidrug resistant HepG2 cells through G2/M cell cycle arrest and apoptosis. European journal of pharmacology. vol 692. issue 1-3. 2013-05-29. PMID:22841670. |
bufotalin treatment also induced apoptosis which was accompanied by decrease in mitochondrial membrane potential, increases in intracellular calcium level and reactive oxygen species production, activations of caspase-9 and -3, cleavage of poly adp-ribose polymerase (parp) as well as changes in the expressions of bcl-2 and bax. |
2013-05-29 |
2023-08-12 |
Not clear |
| Yang Xu, Chunsun Li, Qing Tian, Yanqin Li, Zhen Yang, Zhixin Liang, Liangan Che. Suppression of lung cancer metastasis-related protein 1 promotes apoptosis in lung cancer cells. International journal of molecular medicine. vol 30. issue 6. 2013-05-28. PMID:23076562. |
in conclusion, lcmr1 suppresses apoptosis in lung cancer cells and this effect is associated with multiple apoptosis-related proteins, including p53, bax and mcl-1. |
2013-05-28 |
2023-08-12 |
human |
| Christian Seitz, Manuela Hugle, Silvia Cristofanon, Aurélie Tchoghandjian, Simone Fuld. The dual PI3K/mTOR inhibitor NVP-BEZ235 and chloroquine synergize to trigger apoptosis via mitochondrial-lysosomal cross-talk. International journal of cancer. vol 132. issue 11. 2013-05-28. PMID:23151917. |
in combination, bez235 and cq cooperate to trigger lmp, bax activation, loss of mitochondrial membrane potential (mmp) and caspase-dependent apoptosis. |
2013-05-28 |
2023-08-12 |
Not clear |
| Sha Yi, Yan Chen, Lu Wen, Lijing Yang, Guohui Cu. Downregulation of nucleoporin 88 and 214 induced by oridonin may protect OCIM2 acute erythroleukemia cells from apoptosis through regulation of nucleocytoplasmic transport of NF-κB. International journal of molecular medicine. vol 30. issue 4. 2013-05-24. PMID:22824908. |
these results also indicated that oridonin induced ocim2 cell apoptosis, associated with p65 and bax, while activating caspases-9, -6 and -3. |
2013-05-24 |
2023-08-12 |
human |
| Elliott M McMillan, Drew A Graham, James W E Rush, Joe Quadrilater. Decreased DNA fragmentation and apoptotic signaling in soleus muscle of hypertensive rats following 6 weeks of treadmill training. Journal of applied physiology (Bethesda, Md. : 1985). vol 113. issue 7. 2013-05-23. PMID:22858629. |
consistent with our previous work we found that soleus muscle of hypertensive animals had significantly higher dna fragmentation (a hallmark of apoptosis), elevated proapoptotic factors (bax, caspase-3 activity), and lower antiapoptotic proteins (apoptosis repressor with caspase recruitment domain, bcl-2, x-linked inhibitor of apoptosis protein) compared with normotensive rats. |
2013-05-23 |
2023-08-12 |
rat |
| Hye Young Park, Gi-Young Kim, Taeg Kyu Kwon, Hye Jin Hwang, Nam Deuk Kim, Young Hyun Yoo, Yung Hyun Cho. Apoptosis induction of human leukemia U937 cells by 7,8-dihydroxyflavone hydrate through modulation of the Bcl-2 family of proteins and the MAPKs signaling pathway. Mutation research. vol 751. issue 2. 2013-05-23. PMID:23262352. |
the increase in apoptosis was also associated with proteolytic activation of caspases, bid cleavage, insertion of pro-apoptotic bax into the mitochondria and release of cytochrome c from mitochondria to cytosol. |
2013-05-23 |
2023-08-12 |
human |
| Rawad Hodeify, Judit Megyesi, Adel Tarcsafalvi, Hossam I Mustafa, Nang San Hti Lar Seng, Peter M Pric. Gender differences control the susceptibility to ER stress-induced acute kidney injury. American journal of physiology. Renal physiology. vol 304. issue 7. 2013-05-23. PMID:23364800. |
similarly, the induction of apoptosis was higher in tunicamycin-treated male mice, as measured by the activation of bax and caspase-3. |
2013-05-23 |
2023-08-12 |
mouse |
| b' L Leanza, M Zoratti, E Gulbins, I Szab\\xc3\\xb. Induction of apoptosis in macrophages via Kv1.3 and Kv1.5 potassium channels. Current medicinal chemistry. vol 19. issue 31. 2013-05-22. PMID:22856664.' |
mutation of bax at lysine 128 (baxk128e) abrogates its inhibitory effects on mtkv1.3 and prevents apoptosis. |
2013-05-22 |
2023-08-12 |
mouse |
| Jayant S Londhe, Thomas P A Devasagayam, L Yeap Foo, Padma Shastry, Saroj S Ghaskadb. Geraniin and amariin, ellagitannins from Phyllanthus amarus, protect liver cells against ethanol induced cytotoxicity. Fitoterapia. vol 83. issue 8. 2013-05-22. PMID:22982332. |
poly (adp-ribose) polymerase (parp), bax and bcl2 were checked to assess the induction of apoptosis using western blots. |
2013-05-22 |
2023-08-12 |
mouse |
| Yang Yu, Si-Miao Fan, Yuan-Chao Ye, Shin-Ichi Tashiro, Satoshi Onodera, Takashi Ikejim. The tyrphostin AG1478 augments oridonin-induced A431 cell apoptosis by blockage of JNK MAPK and enhancement of oxidative stress. Free radical research. vol 46. issue 11. 2013-05-21. PMID:22881126. |
inhibition of egfraugmented oridonin-induced a431 cell apoptosis, while the changes of expression of downstream proteins, bcl-2, bcl-xl, bax, cytochrome c, pro-caspase-3, fas, fadd and pro-caspase-8 suggested that both the intrinsic and extrinsic apoptotic pathways are involved in these processes. |
2013-05-21 |
2023-08-12 |
human |
| Paramasivan Poornima, Robin Sheeba Quency, Viswandha Vijaya Padm. Neferine induces reactive oxygen species mediated intrinsic pathway of apoptosis in HepG2 cells. Food chemistry. vol 136. issue 2. 2013-05-21. PMID:23122111. |
our data further indicate reduction of Δψm and increased [ca(2+)](i) during apoptosis induction by neferine with increased expression of apoptotic proteins such as bax, bad, cleaved forms of caspase 3, caspase 9 and parp, with the downregulation of anti-apoptotic protein bcl2 in hepg2 cells. |
2013-05-21 |
2023-08-12 |
Not clear |
| Na Zhang, Li-Yan Zhang, Yan Zhang, Qing Ji, Jin-Hong Wang, Rui-Zhe Qi, Jing Xu, Wei-Ping Yuan, Tao Cheng, Ying-Dai Ga. [Effects of DAPT on biological activity of hematopoietic stem cells in mice]. Zhongguo shi yan xue ye xue za zhi. vol 20. issue 3. 2013-05-16. PMID:22739182. |
the results indicated that the mrna expression of the cell cycle related-genes cdk1, cdk2, cdk4, cdk6, p27 in lin(-) c-kit(+)sca-1(+) marked cells increased (p < 0.05), the expression of p18, p21 decreased (p < 0.05), the expression of the apoptosis related-genes bcl-2, bcl-xl, bax, p53, puma in lin(-) c-kit(+)sca-1(+) marked cells increased (p < 0.05), the expression of bim decreased (p < 0.05), the expression of mcl-1 had not changed (p > 0.05) after treatment with dapt 1 µmol/l for 5 d. the changes of cell cycle of lin(-)c-kit(+)sca-1(+) marked cells in bone marrow had no statistical significance after treatment with dapt 1 µmol/l for 5 d, cd34(-)lin(-)c-kit(+)sca-1(+) marked cells in bone marrow at g(0) phase decreased and at g(1) phase increased after treatment with dapt 1 µmol/l for 5 d (p < 0.05); the apoptotic fractions of lin(-) c-kit(+) sca-1(+) marked cells and cd34(-)lin(-)c-kit(+)sca-1(+) marked cells in bone marrow increased after treatment with dapt 1 µmol/l for 5 d (p < 0.05). |
2013-05-16 |
2023-08-12 |
mouse |
| Xun Lei, Zhongyu Kong, Caiwen Fan, Shijiang Yi, Qiu Xiang, Qianghe Li. [Effects of EGCG on the nasopharyngeal carcinoma cell line CNE-2 and the expression of related gene]. Lin chuang er bi yan hou tou jing wai ke za zhi = Journal of clinical otorhinolaryngology, head, and neck surgery. vol 26. issue 15. 2013-05-16. PMID:23167183. |
to study the effects of epigallocatechin-3-gallate (egcg) on proliferation and apoptosis of nasopharyngeal carcinoma cne-2 cell line and analyze the expression of bcl-2, bax and caspase-3 in the cell line which treated with egcg. |
2013-05-16 |
2023-08-12 |
Not clear |
| Martin Koch, Michaela L Krieger, Daniel Stölting, Norbert Brenner, Manfred Beier, Ulrich Jaehde, Michael Wiese, Hans-Dieter Royer, Gerd Benda. Overcoming chemotherapy resistance of ovarian cancer cells by liposomal cisplatin: molecular mechanisms unveiled by gene expression profiling. Biochemical pharmacology. vol 85. issue 8. 2013-05-16. PMID:23396090. |
the free drug induced expression of essential genes of the intrinsic (mitochondrial) apoptosis pathway (bax, bid, casp9) most likely through p38mapk activation. |
2013-05-16 |
2023-08-12 |
Not clear |
| Ignacio Bejarano, Javier Espino, David González-Flores, Javier G Casado, Pedro C Redondo, Juan A Rosado, Carmen Barriga, José A Pariente, Ana B Rodrígue. Role of Calcium Signals on Hydrogen Peroxide-Induced Apoptosis in Human Myeloid HL-60 Cells. International journal of biomedical science : IJBS. vol 5. issue 3. 2013-05-16. PMID:23675144. |
furthermore, coimmunoprecipitation experiments showed active bax was bound to bid, which regulates bid activity and promotes apoptosis. |
2013-05-16 |
2023-08-12 |
human |
| Muralidharan Suganthi, Gopalakrishnan Sangeetha, Govindaraj Gayathri, Bhaskaran Ravi Sanka. Biphasic dose-dependent effect of lithium chloride on survival of human hormone-dependent breast cancer cells (MCF-7). Biological trace element research. vol 150. issue 1-3. 2013-05-14. PMID:23054864. |
the results showed breast cancer cells respond in a diverse manner to licl, i.e., at lower concentrations (1, 5, and 10 mm), licl induces cell survival by inhibiting apoptosis through regulation of gsk-3β, caspase-2, bax, and cleaved caspase-7 and by activating anti-apoptotic proteins (akt, β-catenin, bcl-2, and cyclin d1). |
2013-05-14 |
2023-08-12 |
human |
| Xinwei Li, Yanfei Han, Yuan Guan, Liang Zhang, Chongsheng Bai, Yanfei L. Aluminum induces osteoblast apoptosis through the oxidative stress-mediated JNK signaling pathway. Biological trace element research. vol 150. issue 1-3. 2013-05-14. PMID:23065425. |
the pro-apoptotic genes (caspase 3, caspase 9, bax, and factor-related apoptosis ligand) were significantly increased. |
2013-05-14 |
2023-08-12 |
Not clear |
| Ruizhao Li, Li Zhang, Wei Shi, Bin Zhang, Xinling Liang, Shuangxin Liu, Wenjian Wan. NFAT2 mediates high glucose-induced glomerular podocyte apoptosis through increased Bax expression. Experimental cell research. vol 319. issue 7. 2013-05-14. PMID:23340267. |
nfat2 mediates high glucose-induced glomerular podocyte apoptosis through increased bax expression. |
2013-05-14 |
2023-08-12 |
Not clear |
| Ariele Viacava Follis, Jerry E Chipuk, John C Fisher, Mi-Kyung Yun, Christy R Grace, Amanda Nourse, Katherine Baran, Li Ou, Lie Min, Stephen W White, Douglas R Green, Richard W Kriwack. PUMA binding induces partial unfolding within BCL-xL to disrupt p53 binding and promote apoptosis. Nature chemical biology. vol 9. issue 3. 2013-05-14. PMID:23340338. |
puma, unique among bh3-only proteins, disrupts the interaction between cytosolic p53 and bcl-xl, allowing p53 to promote apoptosis via direct activation of the bcl-2 effector molecules bax and bak. |
2013-05-14 |
2023-08-12 |
Not clear |