| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Wei Li, Yanqi Chu, Lan Zhang, Linlin Yin, Lin L. Ginsenoside Rg1 prevents SK-N-SH neuroblastoma cell apoptosis induced by supernatant from Aβ1-40-stimulated THP-1 monocytes. Brain research bulletin. vol 88. issue 5. 2013-04-25. PMID:22617143. |
incubation of sk-n-sh cells with cell-free supernatant from aβ(1-40) (125nm)-treated thp-1 monocytes for 24 h significantly increased lactate dehydrogenase (ldh) release, cell apoptosis, bax and caspase-3 expression in sk-n-sh cells. |
2013-04-25 |
2023-08-12 |
Not clear |
| Wei Li, Yanqi Chu, Lan Zhang, Linlin Yin, Lin L. Ginsenoside Rg1 prevents SK-N-SH neuroblastoma cell apoptosis induced by supernatant from Aβ1-40-stimulated THP-1 monocytes. Brain research bulletin. vol 88. issue 5. 2013-04-25. PMID:22617143. |
ldh release, cell apoptosis, bax and caspase-3 expression in sk-n-sh cells were significantly decreased when cultured with cell-free supernatant from aβ(1-40)-stimulated thp-1 monocytes that were pretreated with grg1. |
2013-04-25 |
2023-08-12 |
Not clear |
| Peng Xiu, Xuesong Dong, Xiaofeng Dong, Zongzhen Xu, Huaqiang Zhu, Feng Liu, Zheng Wei, Bo Zhai, Jagat R Kanwar, Hongchi Jiang, Jie Li, Xueying Su. Secretory clusterin contributes to oxaliplatin resistance by activating Akt pathway in hepatocellular carcinoma. Cancer science. vol 104. issue 3. 2013-04-25. PMID:23279642. |
overexpression of sclu abrogated oxa-induced inhibition of cell growth and cell apoptosis, but depletion of sclu synergized with oxa to inhibit cell growth and enhance cell apoptosis, by regulating proteins involved in mitochondrial apoptosis pathways, such as bcl-2, bax, bcl-xl and caspase-9, and affecting phosphorylation of akt and gsk-3β. |
2013-04-25 |
2023-08-12 |
mouse |
| Huanjie Yang, Ying Wang, Vino T Cheryan, Wenjuan Wu, Cindy Qiuzhi Cui, Lisa A Polin, Harvey I Pass, Q Ping Dou, Arun K Rishi, Anil Wal. Withaferin A inhibits the proteasome activity in mesothelioma in vitro and in vivo. PloS one. vol 7. issue 8. 2013-04-23. PMID:22912669. |
wa suppression of mpm growth also involved elevated apoptosis as evidenced by activation of pro-apoptotic p38 stress activated protein kinase (sapk) and caspase-3, elevated levels of pro-apoptotic bax protein and cleavage of poly-(adp-ribose)-polymerase (parp). |
2013-04-23 |
2023-08-12 |
Not clear |
| Ana-Maria Rosca, Camelia Matei, Emanuel Dragan, Alexandrina Burlac. Cardiomyocyte apoptosis in ischaemia-reperfusion due to the exogenous oxidants at the time of reperfusion. Cell biology international. vol 36. issue 12. 2013-04-23. PMID:22994946. |
in contrast, 25-oh-cholesterol promoted cmc apoptosis by a caspase 3-dependent mechanism that involved the transcriptional activation of the pro-apoptotic protein, bax and post-translational degradation of the anti-apoptotic protein, bcl-2. |
2013-04-23 |
2023-08-12 |
Not clear |
| Zhaocal Li, Yong Huang, Feng Dong, Wei Li, Li Ding, Gaoshui Yu, Dan Xu, Yuanyuan Yang, Xingang Xu, Dewen Ton. Swainsonine promotes apoptosis in human oesophageal squamous cell carcinoma cells in vitro and in vivo through activation of mitochondrial pathway. Journal of biosciences. vol 37. issue 6. 2013-04-23. PMID:23151791. |
further results showed that swainsonine treatment up-regulated bax, downregulated bcl-2 expression, triggered bax translocation to mitochondria, destructed mitochondria integrity and activated mitochondria-mediated apoptotic pathway, followed by the release of cytochrome c, which in turn activated caspase-9 and caspase-3, promoted the cleavage of parp, resulting in eca-109 cell apoptosis. |
2013-04-23 |
2023-08-12 |
mouse |
| Deepak Bhatia, Roslin J Thoppil, Animesh Mandal, Karishma A Samtani, Altaf S Darvesh, Anupam Bishaye. Pomegranate Bioactive Constituents Suppress Cell Proliferation and Induce Apoptosis in an Experimental Model of Hepatocellular Carcinoma: Role of Wnt/ β -Catenin Signaling Pathway. Evidence-based complementary and alternative medicine : eCAM. vol 2013. 2013-04-23. PMID:23606879. |
pe substantially induced apoptosis by upregulating proapoptotic protein bax and downregulating antiapoptotic protein bcl-2. |
2013-04-23 |
2023-08-12 |
rat |
| Maria Rosaria Romano, Francesca Biagioni, Gianluca Besozzi, Albino Carrizzo, Carmine Vecchione, Francesco Fornai, Marcello Diego Logran. Effects of bevacizumab on neuronal viability of retinal ganglion cells in rats. Brain research. vol 1478. 2013-04-18. PMID:23046588. |
rgcs apoptosis after multiple treatments was demonstrated to occur by tunel, annexin v and bax assays. |
2013-04-18 |
2023-08-12 |
rat |
| Long Zhang, Qing Ji, Zhen-Hua Ni, Jian Su. Prohibitin induces apoptosis in BGC823 gastric cancer cells through the mitochondrial pathway. Asian Pacific journal of cancer prevention : APJCP. vol 13. issue 8. 2013-04-18. PMID:23098474. |
cell proliferation, cell cycling, apoptosis, bax, bcl-2 and cyt.c protein expression and the activation of caspase-3,9 were assessed after 48 h. over-expression of phb gene in bgc823 cells resulted in slow cell growth, cell arrest in g2 phase, and an increased apoptosis ratio while the opposite was found for phb under-expressing cells. |
2013-04-18 |
2023-08-12 |
Not clear |
| Jingyan Xu, Min Zhou, Jian Ouyang, Jing Wang, Qiguo Zhang, Yong Xu, Yueyi Xu, Qian Zhang, Xihui Xu, Hui Zen. Gambogic acid induces mitochondria-dependent apoptosis by modulation of Bcl-2 and Bax in mantle cell lymphoma JeKo-1 cells. Chinese journal of cancer research = Chung-kuo yen cheng yen chiu. vol 25. issue 2. 2013-04-18. PMID:23592899. |
gambogic acid induces mitochondria-dependent apoptosis by modulation of bcl-2 and bax in mantle cell lymphoma jeko-1 cells. |
2013-04-18 |
2023-08-12 |
human |
| Kyu-Sung Choi, Ji Yeon Kim, Seo-Kyung Lim, Yong Won Choi, Young Hwa Kim, So Young Kang, Tae Jun Park, In Kyoung Li. TIS21(/BTG2/PC3) accelerates the repair of DNA double strand breaks by enhancing Mre11 methylation and blocking damage signal transfer to the Chk2(T68)-p53(S20) pathway. DNA repair. vol 11. issue 12. 2013-04-17. PMID:23089312. |
the loss of chk2 activation after etoposide treatment reduced apoptosis in the cells by downregulating the expression of e2f1 and bax. |
2013-04-17 |
2023-08-12 |
mouse |
| Nan You, Weihui Liu, Tao Wang, Ru Ji, Xing Wang, Zhenbing Gong, Kefeng Dou, Kaishan Ta. Swainsonine inhibits growth and potentiates the cytotoxic effect of paclitaxel in hepatocellular carcinoma in vitro and in vivo. Oncology reports. vol 28. issue 6. 2013-04-16. PMID:22993037. |
furthermore, swainsonine enhanced the apoptosis of mhcc97-h cells with the induction of the upregulation of bax and the downregulation of bcl-2, whereas the expressionof fas and fas-l remained almost unchanged. |
2013-04-16 |
2023-08-12 |
human |
| Daniel R Premkumar, Esther P Jane, Naomi R Agostino, Joseph D DiDomenico, Ian F Pollac. Bortezomib-induced sensitization of malignant human glioma cells to vorinostat-induced apoptosis depends on reactive oxygen species production, mitochondrial dysfunction, Noxa upregulation, Mcl-1 cleavage, and DNA damage. Molecular carcinogenesis. vol 52. issue 2. 2013-04-15. PMID:22086447. |
our results also revealed that combination of bortezomib with vorinostat enhanced apoptosis by increasing mcl-1 cleavage, noxa upregulation, bak and bax activation, and cytochrome c release. |
2013-04-15 |
2023-08-12 |
human |
| Aidin Molouki, Khatijah Yusof. NDV-induced apoptosis in absence of Bax; evidence of involvement of apoptotic proteins upstream of mitochondria. Virology journal. vol 9. 2013-04-15. PMID:22935147. |
ndv-induced apoptosis in absence of bax; evidence of involvement of apoptotic proteins upstream of mitochondria. |
2013-04-15 |
2023-08-12 |
Not clear |
| Aidin Molouki, Khatijah Yusof. NDV-induced apoptosis in absence of Bax; evidence of involvement of apoptotic proteins upstream of mitochondria. Virology journal. vol 9. 2013-04-15. PMID:22935147. |
recently it was shown that following infection of hela cells with newcastle disease virus (ndv), the matrix (m) protein binds to bax and subsequently the intrinsic pathway of apoptosis is activated. |
2013-04-15 |
2023-08-12 |
Not clear |
| Mohamed Rahmani, Mandy Mayo Aust, Elisa Attkisson, David C Williams, Andrea Ferreira-Gonzalez, Steven Gran. Dual inhibition of Bcl-2 and Bcl-xL strikingly enhances PI3K inhibition-induced apoptosis in human myeloid leukemia cells through a GSK3- and Bim-dependent mechanism. Cancer research. vol 73. issue 4. 2013-04-15. PMID:23243017. |
bax, bak, or bim (bcl2l11) knockdown or mcl-1 overexpression significantly diminished regimen-induced apoptosis. |
2013-04-15 |
2023-08-12 |
human |
| Mohamed Rahmani, Mandy Mayo Aust, Elisa Attkisson, David C Williams, Andrea Ferreira-Gonzalez, Steven Gran. Dual inhibition of Bcl-2 and Bcl-xL strikingly enhances PI3K inhibition-induced apoptosis in human myeloid leukemia cells through a GSK3- and Bim-dependent mechanism. Cancer research. vol 73. issue 4. 2013-04-15. PMID:23243017. |
together, these findings suggest that antileukemic synergism between pi3k/akt/mtor inhibitors and bh3 mimetics involves multiple mechanisms, including mcl-1 downregulation, release of bim from bcl-2/bcl-xl as well as bak and bax from mcl-1/bcl-2/bcl-xl, and gsk3α/β, culminating in bax/bak activation and apoptosis. |
2013-04-15 |
2023-08-12 |
human |
| Haijun Wang, Hongyang Zhao, Youfan Ye, Nanxiang Xiong, Junhong Huang, Dongxiao Yao, Yin Shen, Xintong Zha. Focal cerebral ischemia induces Alzheimer's disease-like pathological change in rats. Journal of Huazhong University of Science and Technology. Medical sciences = Hua zhong ke ji da xue xue bao. Yi xue Ying De wen ban = Huazhong keji daxue xuebao. Yixue Yingdewen ban. vol 30. issue 1. 2013-04-12. PMID:20155452. |
the changes in the tau protein phosphorylation and expression of bcl-2, and bax in rat parietal cortex neurons after focal cerebral ischemia-reperfusion (i/r) were explored, and the relationship between the tau protein phosphorylation and the expression of bax or apoptosis was clarified in order to elucidate the relationship between cerebral infarction and alzheimer's disease. |
2013-04-12 |
2023-08-12 |
rat |
| Haijun Wang, Hongyang Zhao, Youfan Ye, Nanxiang Xiong, Junhong Huang, Dongxiao Yao, Yin Shen, Xintong Zha. Focal cerebral ischemia induces Alzheimer's disease-like pathological change in rats. Journal of Huazhong University of Science and Technology. Medical sciences = Hua zhong ke ji da xue xue bao. Yi xue Ying De wen ban = Huazhong keji daxue xuebao. Yixue Yingdewen ban. vol 30. issue 1. 2013-04-12. PMID:20155452. |
the relationship between the tau protein phosphorylation and the expression of bax, or apoptosis was examined by tunel method and double-labeling immunofluorenscence method. |
2013-04-12 |
2023-08-12 |
rat |
| Haijun Wang, Hongyang Zhao, Youfan Ye, Nanxiang Xiong, Junhong Huang, Dongxiao Yao, Yin Shen, Xintong Zha. Focal cerebral ischemia induces Alzheimer's disease-like pathological change in rats. Journal of Huazhong University of Science and Technology. Medical sciences = Hua zhong ke ji da xue xue bao. Yi xue Ying De wen ban = Huazhong keji daxue xuebao. Yixue Yingdewen ban. vol 30. issue 1. 2013-04-12. PMID:20155452. |
neuronal apoptosis, bax expression and the tau protein hyperphosphorylation were co-localized. |
2013-04-12 |
2023-08-12 |
rat |