| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| V V Kolobov, Z I Storozheva, M A Gruden, V V Sherstne. Regional features of the expression of genes involved in neurogenesis and apoptosis in the brain of adult rats. Bulletin of experimental biology and medicine. vol 153. issue 5. 2013-03-12. PMID:23113275. |
the expression of mrna of genes involved in neurogenesis and apoptosis (apaf1, ascl1, bax, bcl2, casp3, casp8, casp9, dffb, myh10, naip2, napa, notch2, numb, pura, s100a6, tnf) in the prefrontal cortex, hippocampus, and cerebellum was studied in adult rats. |
2013-03-12 |
2023-08-12 |
rat |
| Xiu Dong, Jian-Chun Li, Yuan-Yuan Jiang, Ming-Yu Xia, Shin-Ichi Tashiro, Satoshi Onodera, Takashi Ikejim. p38-NF-κB-promoted mitochondria-associated apoptosis and G2/M cell cycle arrest in norcantharidin-treated HeLa cells. Journal of Asian natural products research. vol 14. issue 11. 2013-03-12. PMID:23281704. |
nctd-induced mitochondria-associated apoptosis was concomitant with the collapse of mitochondrial membrane potential (ΔΨ(m)), translocation of bax, down-regulation of bcl-2 expression, and release of cytochrome c. nctd-led g2/m cell-cycle arrest was associated with the up-regulated p21 and p-cdc25c expression and the down-regulated cyclin b and cdc2 expression. |
2013-03-12 |
2023-08-12 |
human |
| Chao Feng, Li-Ying Zhou, Ting Yu, Gang Xu, Hong-Lei Tian, Jin-Jie Xu, Hong-Xi Xu, Kathy Qian Lu. A new anticancer compound, oblongifolin C, inhibits tumor growth and promotes apoptosis in HeLa cells through Bax activation. International journal of cancer. vol 131. issue 6. 2013-03-11. PMID:22116711. |
a new anticancer compound, oblongifolin c, inhibits tumor growth and promotes apoptosis in hela cells through bax activation. |
2013-03-11 |
2023-08-12 |
mouse |
| Chao Feng, Li-Ying Zhou, Ting Yu, Gang Xu, Hong-Lei Tian, Jin-Jie Xu, Hong-Xi Xu, Kathy Qian Lu. A new anticancer compound, oblongifolin C, inhibits tumor growth and promotes apoptosis in HeLa cells through Bax activation. International journal of cancer. vol 131. issue 6. 2013-03-11. PMID:22116711. |
our results showed that oc induced a caspase-dependent apoptosis by triggering a series of events in hela cells including bax translocation, cytochrome c release, caspase-3 activation, chromosome fragmentation followed by caspase-8 activation, bid cleavage and eventually cell death. |
2013-03-11 |
2023-08-12 |
mouse |
| Wei-jun Mai, Peng Liu, Weina Wan. Characterization of the tilapia p53 gene and its role in chemical-induced apoptosis. Biotechnology letters. vol 34. issue 10. 2013-03-08. PMID:22714278. |
in addition, atm, p53 and bax proteins, associated with dna damage responses and apoptosis, were all upregulated in tilapia liver after treatment with the stress inducers etoposide and cdcl(2). |
2013-03-08 |
2023-08-12 |
rabbit |
| Emiko Sano, Shinnya Tashiro, Hisashi Tadakuma, Toshiaki Takei, Takuya Ueda, Kouhei Tsumot. Type 1 IFN inhibits the growth factor deprived apoptosis of cultured human aortic endothelial cells and protects the cells from chemically induced oxidative cytotoxicity. Journal of cellular biochemistry. vol 113. issue 12. 2013-03-08. PMID:22821369. |
it was considered that ifn-β inhibits the executive late stage apoptosis from the results of annexin-v-fitc/pi double staining and the inhibition of caspase-3 activity, and that the anti-apoptotic effect might be owing to the direct inhibition of the apoptotic pathway mediated by p53 from the transient down-regulation of bax mrna expression. |
2013-03-08 |
2023-08-12 |
human |
| Seung Bin Park, Jong Woon Bae, Jong Min Kim, Seung Gee Lee, Myoungseok Ha. Antiproliferative and apoptotic effect of epigallocatechin-3-gallate on Ishikawa cells is accompanied by sex steroid receptor downregulation. International journal of molecular medicine. vol 30. issue 5. 2013-03-07. PMID:22923012. |
the apoptosis was measured by annexin v-pi staining and real-time analysis of bcl-2, bax and caspase genes. |
2013-03-07 |
2023-08-12 |
human |
| Seung Bin Park, Jong Woon Bae, Jong Min Kim, Seung Gee Lee, Myoungseok Ha. Antiproliferative and apoptotic effect of epigallocatechin-3-gallate on Ishikawa cells is accompanied by sex steroid receptor downregulation. International journal of molecular medicine. vol 30. issue 5. 2013-03-07. PMID:22923012. |
this compound interfered with akt activation and mapk signals, and increased apoptosis signals leading to a controlled caspases, bcl-2, bax genes and protein expression. |
2013-03-07 |
2023-08-12 |
human |
| Chun-Hung Chen, Sz-Jie Chen, Chin-Chuan Su, Cheng-Chieh Yen, To-Jung Tseng, Tzyy-Rong Jinn, Feng-Cheng Tang, Kuo-Liang Chen, Yi-Chang Su, kuan-I Lee, Dong-Zong Hung, Chun-Fa Huan. Chloroacetic acid induced neuronal cells death through oxidative stress-mediated p38-MAPK activation pathway regulated mitochondria-dependent apoptotic signals. Toxicology. vol 303. 2013-03-07. PMID:23103613. |
ca also increased the number of sub-g1 hypodiploid cells; increased mitochondrial dysfunction (loss of mmp, cytochrome c release, and accompanied by bcl-2 and mcl-1 down-regulation and bax up-regulation), and activated the caspase cascades activations, which displayed features of mitochondria-dependent apoptosis pathway. |
2013-03-07 |
2023-08-12 |
Not clear |
| Arwa S Kathiria, William L Neumann, Jennifer Rhees, Erin Hotchkiss, Yulan Cheng, Robert M Genta, Stephen J Meltzer, Rhonda F Souza, Arianne L Theis. Prohibitin attenuates colitis-associated tumorigenesis in mice by modulating p53 and STAT3 apoptotic responses. Cancer research. vol 72. issue 22. 2013-03-05. PMID:22869582. |
tg mice exhibited decreased susceptibility in a manner associated with increased apoptosis, p53, bax, and bad expression plus decreased bcl-xl and bcl-2 expression. |
2013-03-05 |
2023-08-12 |
mouse |
| Peng Wang, Jin Wang, Hui Jian. [Human hepatocarcinoma cell apoptosis induced by toosendanin through mitochondria-dependent pathway]. Zhongguo Zhong xi yi jie he za zhi Zhongguo Zhongxiyi jiehe zazhi = Chinese journal of integrated traditional and Western medicine. vol 31. issue 2. 2013-03-04. PMID:21425578. |
to explore the effects of toosendanin in inducing apoptosis of human hepatocarcinoma cell line smmc-7721 and hep3b, and its influence on the related genes, bcl-2, bax and fas. |
2013-03-04 |
2023-08-12 |
human |
| Qing-Sheng Yu, Hong-Liang Yu, Jin-Fang Pa. [Effect of qihuang decoction on mRNA expressions of Bcl-2, Bax, and Caspase-3, 9 in intestinal mucosa epithelium of ischemia/reperfusion injured rats]. Zhongguo Zhong xi yi jie he za zhi Zhongguo Zhongxiyi jiehe zazhi = Chinese journal of integrated traditional and Western medicine. vol 31. issue 2. 2013-03-04. PMID:21425579. |
to observe the effect of qihuang decoction (qhd) on mrna expression of apoptosis genes bcl-2, bax, and signal transduction molecules caspase-3, 9 in intestinal mucosa epithelium of ischemia/ reperfusion (i/r) injured rats. |
2013-03-04 |
2023-08-12 |
rat |
| T Kodama, H Hikita, T Kawaguchi, M Shigekawa, S Shimizu, Y Hayashi, W Li, T Miyagi, A Hosui, T Tatsumi, T Kanto, N Hiramatsu, K Kiyomizu, S Tadokoro, Y Tomiyama, N Hayashi, T Takehar. Mcl-1 and Bcl-xL regulate Bak/Bax-dependent apoptosis of the megakaryocytic lineage at multistages. Cell death and differentiation. vol 19. issue 11. 2013-03-04. PMID:22790873. |
all these phenotypes were fully restored if bak and bax, downstream apoptosis executioners, were also deficient. |
2013-03-04 |
2023-08-12 |
mouse |
| Xiaodong Song, Meirong Wang, Lixia Zhang, Jinjin Zhang, Xiuwen Wang, Wenbo Liu, Xinbin Gu, Changjun L. Changes in cell ultrastructure and inhibition of JAK1/STAT3 signaling pathway in CBRH-7919 cells with astaxanthin. Toxicology mechanisms and methods. vol 22. issue 9. 2013-03-04. PMID:22889354. |
cell apoptosis was evaluated and the expressions of jak1, stat3, non-metastasis23-1 (nm23-1), and apoptotic gene like b-cell lymphoma/leukemia-2 (bcl-2), b-cell lymphoma-extra large (bcl-xl), proto-oncogene proteins c myc (c-myc) and bcl-2- associated x (bax) were also examined. |
2013-03-04 |
2023-08-12 |
rat |
| Rong-Huai Zhang, Jian-Yuan Gao, Hai-Tao Guo, Glenda I Scott, Anna R Eason, Xiao-Ming Wang, Jun Re. Inhibition of CYP2E1 attenuates chronic alcohol intake-induced myocardial contractile dysfunction and apoptosis. Biochimica et biophysica acta. vol 1832. issue 1. 2013-03-04. PMID:22967841. |
western blot analysis was used to evaluate cyp2e1, heme oxygenase-1 (ho-1), inos, the intracellular ca(2+) regulatory proteins sarco(endo)plasmic reticulum ca(2+)-atpase, na(+)ca(2+) exchanger and phospholamban, pro-apoptotic protein cleaved caspase-3, bax, c-jun-nh(2)-terminal kinase (jnk) and apoptosis signal-regulating kinase (ask-1). |
2013-03-04 |
2023-08-12 |
mouse |
| Chi-Chien Niu, Song-Shu Lin, Li-Jen Yuan, Lih-Huei Chen, I-Chun Wang, Tsung-Ting Tsai, Po-Liang Lai, Wen-Jer Che. Hyperbaric oxygen treatment suppresses MAPK signaling and mitochondrial apoptotic pathway in degenerated human intervertebral disc cells. Journal of orthopaedic research : official publication of the Orthopaedic Research Society. vol 31. issue 2. 2013-02-28. PMID:22886767. |
hbo up-regulated the ratio of bcl-2 to bax expression and reduced the activity of caspases 9 and 3 but not of caspase 8, indicating a selective effect over the mitochondrial apoptosis pathway in degenerated npcs. |
2013-02-28 |
2023-08-12 |
human |
| Uwe Schlattner, Malgorzata Tokarska-Schlattner, Sacnicte Ramirez, Yulia Y Tyurina, Andrew A Amoscato, Dariush Mohammadyani, Zhentai Huang, Jianfei Jiang, Naveena Yanamala, Amal Seffouh, Mathieu Boissan, Raquel F Epand, Richard M Epand, Judith Klein-Seetharaman, Marie-Lise Lacombe, Valerian E Kaga. Dual function of mitochondrial Nm23-H4 protein in phosphotransfer and intermembrane lipid transfer: a cardiolipin-dependent switch. The Journal of biological chemistry. vol 288. issue 1. 2013-02-28. PMID:23150663. |
hela cells expressing the wild-type enzyme showed increased accumulation of bax in mitochondria and were sensitized to rotenone-induced apoptosis as revealed by stimulated release of cytochrome c into the cytosol, elevated caspase 3/7 activity, and increased annexin v binding. |
2013-02-28 |
2023-08-12 |
rat |
| Junhe Ma, Frank Edlich, Guillermo A Bermejo, Kristi L Norris, Richard J Youle, Nico Tjandr. Structural mechanism of Bax inhibition by cytomegalovirus protein vMIA. Proceedings of the National Academy of Sciences of the United States of America. vol 109. issue 51. 2013-02-28. PMID:23213219. |
the human protein bax sits at a critical regulatory junction of apoptosis, or programmed cell death. |
2013-02-28 |
2023-08-12 |
human |
| Junhe Ma, Frank Edlich, Guillermo A Bermejo, Kristi L Norris, Richard J Youle, Nico Tjandr. Structural mechanism of Bax inhibition by cytomegalovirus protein vMIA. Proceedings of the National Academy of Sciences of the United States of America. vol 109. issue 51. 2013-02-28. PMID:23213219. |
such is the case of human cytomegalovirus, the replication of which hinges on vmia (viral mitochondria-localized inhibitor of apoptosis), a virus-encoded protein with a unique, albeit poorly understood antiapoptotic activity by which it binds and recruits bax to mitochondria. |
2013-02-28 |
2023-08-12 |
human |
| Junhe Ma, Frank Edlich, Guillermo A Bermejo, Kristi L Norris, Richard J Youle, Nico Tjandr. Structural mechanism of Bax inhibition by cytomegalovirus protein vMIA. Proceedings of the National Academy of Sciences of the United States of America. vol 109. issue 51. 2013-02-28. PMID:23213219. |
mutants that disrupt key intermolecular interactions disfavor vmia's mitochondrial recruitment of bax, and increase cytochrome c release upon apoptosis induction. |
2013-02-28 |
2023-08-12 |
human |