| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Peter E Czabotar, Dana Westphal, Grant Dewson, Stephen Ma, Colin Hockings, W Douglas Fairlie, Erinna F Lee, Shenggen Yao, Adeline Y Robin, Brian J Smith, David C S Huang, Ruth M Kluck, Jerry M Adams, Peter M Colma. Bax crystal structures reveal how BH3 domains activate Bax and nucleate its oligomerization to induce apoptosis. Cell. vol 152. issue 3. 2013-03-28. PMID:23374347. |
bax crystal structures reveal how bh3 domains activate bax and nucleate its oligomerization to induce apoptosis. |
2013-03-28 |
2023-08-12 |
Not clear |
| Peter E Czabotar, Dana Westphal, Grant Dewson, Stephen Ma, Colin Hockings, W Douglas Fairlie, Erinna F Lee, Shenggen Yao, Adeline Y Robin, Brian J Smith, David C S Huang, Ruth M Kluck, Jerry M Adams, Peter M Colma. Bax crystal structures reveal how BH3 domains activate Bax and nucleate its oligomerization to induce apoptosis. Cell. vol 152. issue 3. 2013-03-28. PMID:23374347. |
in stressed cells, apoptosis ensues when bcl-2 family members bax or bak oligomerize and permeabilize the mitochondrial outer membrane. |
2013-03-28 |
2023-08-12 |
Not clear |
| Peter E Czabotar, Dana Westphal, Grant Dewson, Stephen Ma, Colin Hockings, W Douglas Fairlie, Erinna F Lee, Shenggen Yao, Adeline Y Robin, Brian J Smith, David C S Huang, Ruth M Kluck, Jerry M Adams, Peter M Colma. Bax crystal structures reveal how BH3 domains activate Bax and nucleate its oligomerization to induce apoptosis. Cell. vol 152. issue 3. 2013-03-28. PMID:23374347. |
our results thus define critical bax transitions toward apoptosis. |
2013-03-28 |
2023-08-12 |
Not clear |
| Zhenzhen Zhang, Tingmei Ye, Xueting Cai, Jie Yang, Wuguang Lu, Chunping Hu, Zhigang Wang, Xiaoning Wang, Peng Ca. 5,7-Dihydroxyflavone Enhances the Apoptosis-Inducing Potential of TRAIL in Human Tumor Cells via Regulation of Apoptosis-Related Proteins. Evidence-based complementary and alternative medicine : eCAM. vol 2013. 2013-03-28. PMID:23533482. |
5,7-dihydroxyflavone up-regulated the expression of pro-apoptotic protein bax, attenuated the expression of anti-apoptotic proteins bcl-2, mcl-1, and iaps, and reduced the phosphorylation levels of akt and stat3, weakening the anti-apoptotic signals thus facilitating the process of apoptosis. |
2013-03-28 |
2023-08-12 |
mouse |
| Tusty-Jiuan Hsieh, Pei-Chen Hsieh, Yi-Hong Tsai, Chia-Fang Wu, Chia-Chu Liu, Ming-Yen Lin, Ming-Tsang W. Melamine induces human renal proximal tubular cell injury via transforming growth factor-β and oxidative stress. Toxicological sciences : an official journal of the Society of Toxicology. vol 130. issue 1. 2013-03-27. PMID:22915474. |
the melamine-stimulated overexpression of tgf-β1 not only promotes fibronectin production but also leads to decreased antiapoptotic (bcl-2, bcl-xl)/proapoptotic (bad, bax) protein ratio, increased caspase-3 and caspase-9 activities, and eventually hk-2 cell apoptosis. |
2013-03-27 |
2023-08-12 |
human |
| Ali Osman Çeribaşı, Fatih Sakin, Gaffari Türk, Mustafa Sönmez, Ahmet Ateşşahi. Impact of ellagic acid on adriamycin-induced testicular histopathological lesions, apoptosis, lipid peroxidation and sperm damages. Experimental and toxicologic pathology : official journal of the Gesellschaft fur Toxikologische Pathologie. vol 64. issue 7-8. 2013-03-26. PMID:21295454. |
at the end of the 8-week treatment period, reproductive organ weights, epididymal sperm parameters, histopathological changes and apoptosis via bax and bcl-2 proteins, testicular tissue lipid peroxidation, and antioxidant enzyme activities, were investigated. |
2013-03-26 |
2023-08-12 |
rat |
| Andromachi Kotsafti, Fabio Farinati, Romilda Cardin, Umberto Cillo, Donato Nitti, Marina Bortolam. Autophagy and apoptosis-related genes in chronic liver disease and hepatocellular carcinoma. BMC gastroenterology. vol 12. 2013-03-25. PMID:22928777. |
in this study we evaluated the expression of beclin 1 (one of the main autophagocytic agents, which bridges autophagy, apoptosis and both differentiation), and both pro- (bad, bax) and anti-apoptotic (bcl-2, bcl-xl) factors in liver samples from patients with different stages of liver disease. |
2013-03-25 |
2023-08-12 |
Not clear |
| Jing Liu, Li Liu, Xiao-Feng Wang, Hui-Yun Teng, Na Yan. Antenatal supplementation of taurine for protection of fetal rat brain with intrauterine growth restriction from injury by reducing neuronal apoptosis. Neuropediatrics. vol 43. issue 5. 2013-03-25. PMID:22932950. |
neuronal apoptosis was detected using transferase-mediated dutp biotin nick end-labeling (tunel); the expression of bcl-2, bax, and caspase-3 mrna and proteins was detected by reverse transcription-polymerase chain reaction and immunohistochemistry. |
2013-03-25 |
2023-08-12 |
rat |
| Hangjun Zhang, Dandan Shao, Yingzhu Wu, Chenchen Cai, Ciming Hu, Xiaolu Shou, Bingru Dai, Binhui Ye, Mengdi Wang, Xiuying Ji. Apoptotic responses of Carassius auratus lymphocytes to nodularin exposure in vitro. Fish & shellfish immunology. vol 33. issue 6. 2013-03-25. PMID:22951228. |
the mechanism of apoptosis induced by nodularin was determined, and results showed that nodularin exposure caused a significant increase in intracellular reactive oxygen species (ros), loss of mitochondrial transmembrane potential in a dose-dependent manner, upregulation of intracellular ca²⁺, downregulation of bcl-2 and upregulation of bax expression at the mrna and protein levels, and activation of caspase-3 and caspase-9 without caspase-8. |
2013-03-25 |
2023-08-12 |
Not clear |
| Sang-Won Hong, Kyung Hee Jung, Myung-Joo Choi, Da Young Kim, Hee-Seung Lee, Hong-Mei Zheng, Guang Yong Li, Ibrahim M El-Deeb, Byung Sun Park, So Ha Lee, Soon-Sun Hon. Anticancer effects of KI-10F: a novel compound affecting apoptosis, angiogenesis and cell growth in colon cancer. International journal of oncology. vol 41. issue 5. 2013-03-22. PMID:22941304. |
apoptosis by ki-10f was confirmed by observation of an increase in the expression of cleaved caspase-3, caspase-8, caspase-9 and bax, and the decrease of bcl-2. |
2013-03-22 |
2023-08-12 |
mouse |
| Kaustuv Basu, Arijit Mukhopadhyay, Ilora Ghosh, Kasturi Datt. Nuclear morphology and c-Jun N-terminal kinase 1 expression differentiate serum-starved oxidative stress signalling from hydrogen peroxide-induced apoptosis in retinal neuronal cell line. Cell biology international. vol 36. issue 11. 2013-03-21. PMID:22775755. |
generation of excess intracellular ros, nuclear localization of bax and caspase 3 activation along with decrease of cellular viability, confirmed apoptosis induction in rgc-5 by 72 h serum starvation and 500 m h2o2 exposure for 1 h. nuclear swelling as supported by nuclear cytoplasmic ratio and conspicuous black spots with nuclear remodelling were observed only upon sfm, but not with h2o2 treatment. |
2013-03-21 |
2023-08-12 |
Not clear |
| Christiana Howard, Shixin Tao, Hai-Chun Yang, Agnes B Fogo, James R Woodgett, Raymond C Harris, Reena Ra. Specific deletion of glycogen synthase kinase-3β in the renal proximal tubule protects against acute nephrotoxic injury in mice. Kidney international. vol 82. issue 9. 2013-03-21. PMID:22785175. |
apoptosis, measured by tunel staining, bax activation, and caspase 3 cleavage, was reduced in the knockout mice. |
2013-03-21 |
2023-08-12 |
mouse |
| Yu-Zhen Liang, Le-Ping Feng, Ning Xia, Yue-Lian Yang, Mu-Xun Zhan. [High glucose lowers insulin receptor substrate 2 expression and induces apoptosis in mouse islet cells in vitro]. Nan fang yi ke da xue xue bao = Journal of Southern Medical University. vol 29. issue 7. 2013-03-20. PMID:19620044. |
to investigate the role of insulin receptor substrate 2 (irs2) and bax on mouse islet cell apoptosis in the presence of high glucose in vitro. |
2013-03-20 |
2023-08-12 |
mouse |
| Izumi Aoyama, Ken Yaegaki, Bogdan Calenic, Hisataka Ii, Nikolay Ishkitiev, Toshio Ima. The role of p53 in an apoptotic process caused by an oral malodorous compound in periodontal tissues: a review. Journal of breath research. vol 6. issue 1. 2013-03-19. PMID:22368256. |
h(2)s also increases the expression of bax, a primary response gene playing an important role in p53-mediated apoptosis, but maintains a lower expression of bcl-2, an anti-apoptotic factor, in osteoblasts. |
2013-03-19 |
2023-08-12 |
human |
| Jin Fan, Ning Zhang, Guoyong Yin, Zitao Zhang, Gang Cheng, Wenwu Qian, Hao Long, Weihua Ca. Edaravone protects cortical neurons from apoptosis by inhibiting the translocation of BAX and Increasing the interaction between 14-3-3 and p-BAD. The International journal of neuroscience. vol 122. issue 11. 2013-03-19. PMID:22757651. |
edaravone protects cortical neurons from apoptosis by inhibiting the translocation of bax and increasing the interaction between 14-3-3 and p-bad. |
2013-03-19 |
2023-08-12 |
Not clear |
| Jazir Haneef, Muraleedharan Parvathy, Parvathy M, Santhosh Kumar Thankayyan R, Hima Sithul, Sreeja Sreeharsha. Bax translocation mediated mitochondrial apoptosis and caspase dependent photosensitizing effect of Ficus religiosa on cancer cells. PloS one. vol 7. issue 7. 2013-03-19. PMID:22792212. |
bax translocation mediated mitochondrial apoptosis and caspase dependent photosensitizing effect of ficus religiosa on cancer cells. |
2013-03-19 |
2023-08-12 |
human |
| Jazir Haneef, Muraleedharan Parvathy, Parvathy M, Santhosh Kumar Thankayyan R, Hima Sithul, Sreeja Sreeharsha. Bax translocation mediated mitochondrial apoptosis and caspase dependent photosensitizing effect of Ficus religiosa on cancer cells. PloS one. vol 7. issue 7. 2013-03-19. PMID:22792212. |
to understand the role of bax in fae induced apoptosis, we employed a sensitive cell based platform of mcf-7 cells expressing bax-egfp. |
2013-03-19 |
2023-08-12 |
human |
| Jazir Haneef, Muraleedharan Parvathy, Parvathy M, Santhosh Kumar Thankayyan R, Hima Sithul, Sreeja Sreeharsha. Bax translocation mediated mitochondrial apoptosis and caspase dependent photosensitizing effect of Ficus religiosa on cancer cells. PloS one. vol 7. issue 7. 2013-03-19. PMID:22792212. |
fae induced dose and time dependent inhibition of cancer cell growth which was associated with bax translocation and mitochondria mediated apoptosis with the activation of caspase 9 dependent caspase cascade. |
2013-03-19 |
2023-08-12 |
human |
| Jie Ping, Ai-Mei Gao, Dan Xu, Rui-Wen Li, Hui Wan. [Therapeutic effect of indole-3-carbinol on pig serum-induced hepatic fibrosis in rats]. Yao xue xue bao = Acta pharmaceutica Sinica. vol 46. issue 8. 2013-03-18. PMID:22007515. |
apoptosis analysis showed that i3c significantly increased hsc-t6 apoptosis rate and the expressional ratio of bax to bcl-2. |
2013-03-18 |
2023-08-12 |
rat |
| Yan Wen, Prachi Wani, Lu Zhou, Tom Baer, Smruti Madan Phadnis, Renee A Reijo Pera, Bertha Che. Reprogramming of fibroblasts from older women with pelvic floor disorders alters cellular behavior associated with donor age. Stem cells translational medicine. vol 2. issue 2. 2013-03-14. PMID:23341439. |
there was no significant difference in expression of senescence and apoptosis markers (p21, p53, and bax) in ipscs derived from the younger subject compared with the older subject. |
2013-03-14 |
2023-08-12 |
human |