| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Yong Huang, Li Ding, Zhaocai Li, Meiling Dai, Xiaomin Zhao, Wei Li, Qian Du, Xingang Xu, Dewen Ton. Transmissible gastroenteritis virus infection induces cell apoptosis via activation of p53 signalling. The Journal of general virology. vol 94. issue Pt 8. 2013-09-24. PMID:23677787. |
blocking of p53 activation significantly inhibited the occurrence of apoptosis through suppressing the tgev-induced fasl expression, bcl-2 reduction, bax and cytochrome c redistribution, while inhibition of p38 activity moderately blocked apoptosis induction and partly attenuated the accumulation and activation of p53. |
2013-09-24 |
2023-08-12 |
Not clear |
| Ricardo Parrondo, Alicia de Las Pozas, Teresita Reiner, Carlos Perez-Stabl. ABT-737, a small molecule Bcl-2/Bcl-xL antagonist, increases antimitotic-mediated apoptosis in human prostate cancer cells. PeerJ. vol 1. 2013-09-23. PMID:24058878. |
knockdown of bax or bak in lncap indicates that abt-737-induced antimitotic enhancement of apoptosis is more dependent on the levels of bax than bak. |
2013-09-23 |
2023-08-12 |
human |
| Jiann-Horng Leu, Shin-Jen Lin, Jiun-Yan Huang, Tsan-Chi Chen, Chu-Fang L. A model for apoptotic interaction between white spot syndrome virus and shrimp. Fish & shellfish immunology. vol 34. issue 4. 2013-09-20. PMID:22683516. |
wssv also induces the expression of a shrimp anti-apoptosis protein, pm-fortilin, which can act on bax to inhibit mitochondria-triggered apoptosis. |
2013-09-20 |
2023-08-12 |
Not clear |
| Maria Grazia Bottone, Dal Bo Veronica, Valeria Maria Piccolini, Giovanni Bottiroli, Sandra Angelica De Pascali, Francesco Paolo Fanizzi, Graziella Bernocch. Developmental expression of cellular prion protein and apoptotic molecules in the rat cerebellum: effects of platinum compounds. Journal of chemical neuroanatomy. vol 46. issue 1-2. 2013-09-19. PMID:23017299. |
one day after administration (pd11), cispt markedly increased the apoptosis of the proliferating cells of the egl (external granular layer); at the same time, several apoptotic bodies with strong bax immunoreactivity were noticed. |
2013-09-19 |
2023-08-12 |
rat |
| Jin-Ha Lee, Sang-Won Lee, Seong-Ho Choi, Sun-Hun Kim, Won-Jae Kim, Ji-Yeon Jun. p38 MAP kinase and ERK play an important role in nitric oxide-induced apoptosis of the mouse embryonic stem cells. Toxicology in vitro : an international journal published in association with BIBRA. vol 27. issue 1. 2013-09-17. PMID:22878015. |
taken together, these results suggest that no-induced apoptosis in mes cells was mediated through p38 map kinase/erk signaling pathway by triggering caspases activation and bax translocation from the cytosol to the mitochondria. |
2013-09-17 |
2023-08-12 |
mouse |
| Young-hee Kim, Jung-rak Hong, Hyo-wook Gil, Ho-yeon Song, Sae-yong Hon. Mixtures of glyphosate and surfactant TN20 accelerate cell death via mitochondrial damage-induced apoptosis and necrosis. Toxicology in vitro : an international journal published in association with BIBRA. vol 27. issue 1. 2013-09-17. PMID:23099315. |
after exposure of rat h9c2 cells to glyphosate and tn-20 mixtures, following assays were performed: flow cytometry to determine the proportion of cells that underwent apoptosis and necrosis; western blotting to determine expression of mitochondrial proteins (bcl-2 and bax); immunological methods to evaluate translocation of cytochrome c; luminometric measurements to determine activity of caspases 3/7 and 9; and tetramethyl rhodamine methyl ester assay to measure mitochondrial membrane potentials. |
2013-09-17 |
2023-08-12 |
rat |
| Su-Ping Kong, Xin Zhang, Qi-Wen Ta. [Effects of electroacupuncture at "Jiaji" (EX-B 2) on myocardial apoptosis and the expression of Bcl-2 and Bax in rats with ischemia-reperfusion injury]. Zhongguo zhen jiu = Chinese acupuncture & moxibustion. vol 33. issue 6. 2013-09-17. PMID:23967644. |
[effects of electroacupuncture at "jiaji" (ex-b 2) on myocardial apoptosis and the expression of bcl-2 and bax in rats with ischemia-reperfusion injury]. |
2013-09-17 |
2023-08-12 |
rat |
| Miriam Cnop, Hindrik Mulder, Mariana Igoillo-Estev. Diabetes in Friedreich ataxia. Journal of neurochemistry. vol 126 Suppl 1. 2013-09-16. PMID:23859345. |
moreover, in the intrinsic pathway of apoptosis, pro-apoptotic signals converge on mitochondria, resulting in mitochondrial bax translocation, membrane permeabilization, cytochrome c release and caspase cleavage. |
2013-09-16 |
2023-08-12 |
Not clear |
| Ying-Cheng Chiang, Ming-Cheng Chang, Pao-Jen Chen, Meei-Maan Wu, Chang-Yao Hsieh, Wen-Fang Cheng, Chi-An Che. Epigenetic silencing of BLU through interfering apoptosis results in chemoresistance and poor prognosis of ovarian serous carcinoma patients. Endocrine-related cancer. vol 20. issue 2. 2013-09-13. PMID:23329649. |
in vitro studies have shown that blu could upregulate the expression of bax and enhance the effect of paclitaxel-induced apoptosis in ovarian cancer cells. |
2013-09-13 |
2023-08-12 |
Not clear |
| Ju-Hye Lee, Eun-Kyoung Oh, Hyun-Dong Cho, Jae-Yong Kim, Mi-Kyung Lee, Kwon-Il Se. Crude saponins from Platycodon grandiflorum induce apoptotic cell death in RC-58T/h/SA#4 prostate cancer cells through the activation of caspase cascades and apoptosis-inducing factor. Oncology reports. vol 29. issue 4. 2013-09-12. PMID:23443329. |
moreover, spg-induced apoptosis was associated with changes in caspase activity, the upregulation of the apoptotic protein, bax and the downregulation of the anti-apoptotic protein, bcl-2. |
2013-09-12 |
2023-08-12 |
Not clear |
| Peter Fleming, Marc Kvansakul, Valentina Voigt, Benjamin T Kile, Ruth M Kluck, David C S Huang, Mariapia A Degli-Esposti, Christopher E Andonio. MCMV-mediated inhibition of the pro-apoptotic Bak protein is required for optimal in vivo replication. PLoS pathogens. vol 9. issue 2. 2013-09-12. PMID:23468630. |
the bcl-2 family of proteins are the principle regulators of apoptosis, with two pro-apoptotic members, bax and bak, essential for apoptosis to proceed. |
2013-09-12 |
2023-08-12 |
mouse |
| Haiwei Mou, Zongmeng Li, Pengle Yao, Shu Zhuo, Wei Luan, Bo Deng, Lihua Qian, Mengmei Yang, Hong Mei, Yingying L. Knockdown of FAM3B triggers cell apoptosis through p53-dependent pathway. The international journal of biochemistry & cell biology. vol 45. issue 3. 2013-09-11. PMID:23246487. |
silencing p53 could almost completely reverse fam3b knockdown induced upregulation of bax, downregulation of bcl-2, cleavage of caspases-8, -9, -3, and apoptotic cell death, suggesting p53-dependent pathway plays critical roles in fam3b silencing induced apoptosis. |
2013-09-11 |
2023-08-12 |
mouse |
| Fen Yang, Xiao-Jun Qian, Wei Qin, Rong Deng, Xiao-Qi Wu, Juan Qin, Gong-Kan Feng, Xiao-Feng Zh. Dual phosphoinositide 3-kinase/mammalian target of rapamycin inhibitor NVP-BEZ235 has a therapeutic potential and sensitizes cisplatin in nasopharyngeal carcinoma. PloS one. vol 8. issue 3. 2013-09-11. PMID:23533654. |
in combination with nvp-bez235 and cddp, there was dramatic synergy in shrinking tumor volumes and inducing apoptosis through increasing noxa, bax and decreasing mcl-1, bcl-2. |
2013-09-11 |
2023-08-12 |
mouse |
| A Shukla, T M Mohapatra, A K Agrawal, D Parmar, K Set. Salsolinol induced apoptotic changes in neural stem cells: amelioration by neurotrophin support. Neurotoxicology. vol 35. 2013-09-10. PMID:23261589. |
morphological impairment, enhanced tunel positivity, cleaved caspase-3 and decreased bcl-2:bax suggested apoptosis. |
2013-09-10 |
2023-08-12 |
rat |
| Tatiane C Nogueira, Flavia M Paula, Olatz Villate, Maikel L Colli, Rodrigo F Moura, Daniel A Cunha, Lorella Marselli, Piero Marchetti, Miriam Cnop, Cécile Julier, Decio L Eiziri. GLIS3, a susceptibility gene for type 1 and type 2 diabetes, modulates pancreatic beta cell apoptosis via regulation of a splice variant of the BH3-only protein Bim. PLoS genetics. vol 9. issue 5. 2013-09-10. PMID:23737756. |
the increased cell death was due to activation of the intrinsic (mitochondrial) pathway of apoptosis, as indicated by cytochrome c release to the cytosol, bax translocation to the mitochondria and activation of caspases 9 and 3. |
2013-09-10 |
2023-08-12 |
human |
| Gregory R Bean, Yogesh Tengarai Ganesan, Yiyu Dong, Shugaku Takeda, Han Liu, Po M Chan, Yafen Huang, Lewis A Chodosh, Gerard P Zambetti, James J-D Hsieh, Emily H-Y Chen. PUMA and BIM are required for oncogene inactivation-induced apoptosis. Science signaling. vol 6. issue 268. 2013-09-09. PMID:23532334. |
the bh3 domain containing proteins bim and puma can directly activate the proapoptotic proteins bax and bak to permeabilize mitochondria, leading to caspase activation and apoptosis. |
2013-09-09 |
2023-08-12 |
mouse |
| Xiaolin Hu, Kankana Bardhan, Amy V Paschall, Dafeng Yang, Jennifer L Waller, Mary Anne Park, Asha Nayak-Kapoor, Thomas A Samuel, Scott I Abrams, Kebin Li. Deregulation of apoptotic factors Bcl-xL and Bax confers apoptotic resistance to myeloid-derived suppressor cells and contributes to their persistence in cancer. The Journal of biological chemistry. vol 288. issue 26. 2013-09-09. PMID:23677993. |
screening for changes of key apoptosis mediators downstream the fas receptor revealed that expression levels of irf8 and bax are diminished, whereas expression of bcl-xl is increased in tumor-induced mdscs. |
2013-09-09 |
2023-08-12 |
mouse |
| Xiaolin Hu, Kankana Bardhan, Amy V Paschall, Dafeng Yang, Jennifer L Waller, Mary Anne Park, Asha Nayak-Kapoor, Thomas A Samuel, Scott I Abrams, Kebin Li. Deregulation of apoptotic factors Bcl-xL and Bax confers apoptotic resistance to myeloid-derived suppressor cells and contributes to their persistence in cancer. The Journal of biological chemistry. vol 288. issue 26. 2013-09-09. PMID:23677993. |
our data thus determined that mdscs use down-regulation of irf8 to alter bax and bcl-xl expression to deregulate the fas-mediated apoptosis pathway to evade elimination by host ctls. |
2013-09-09 |
2023-08-12 |
mouse |
| Xu-Hua Ge, Guo-Ji Zhu, De-Qin Geng, Zhi-Jun Zhang, Chun-Feng Li. Erythropoietin attenuates 6-hydroxydopamine-induced apoptosis via glycogen synthase kinase 3β-mediated mitochondrial translocation of Bax in PC12 cells. Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology. vol 33. issue 6. 2013-09-05. PMID:22294054. |
erythropoietin attenuates 6-hydroxydopamine-induced apoptosis via glycogen synthase kinase 3β-mediated mitochondrial translocation of bax in pc12 cells. |
2013-09-05 |
2023-08-12 |
Not clear |
| Fan Guo, Huiwen Wang, Liya Li, Heng Zhou, Haidong Wei, Weilin Jin, Qiang Wang, Lize Xion. A novel domain of amino-Nogo-A protects HT22 cells exposed to oxygen glucose deprivation by inhibiting NADPH oxidase activity. Cellular and molecular neurobiology. vol 33. issue 3. 2013-09-04. PMID:23354671. |
the fusion protein also protected ht22 cells from apoptosis, suppressed overexpression of bax, and inhibited the reduction in bcl-2 expression. |
2013-09-04 |
2023-08-12 |
human |