| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Phullara B Shelat, Leigh D Plant, Janice C Wang, Elizabeth Lee, Jeremy D Mark. The membrane-active tri-block copolymer pluronic F-68 profoundly rescues rat hippocampal neurons from oxygen-glucose deprivation-induced death through early inhibition of apoptosis. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 33. issue 30. 2013-10-17. PMID:23884935. |
however, f-68 treatment prevented phosphatidylserine externalization, caspase activation, loss of mitochondrial membrane potential, and bax translocation to mitochondria, indicating that f-68 alters apoptotic mechanisms early in the intrinsic pathway of apoptosis. |
2013-10-17 |
2023-08-12 |
rat |
| Rong-hui Tu, Li Chen, Guo-qiang Zhong, Zhi-yu Zeng, Qing-jie Li, Yan He, Yan He, Jin-yi L. [The effect of mitochondrial oxidative stress and the expression of Bcl-2 and Bax proteins on cardiomyocyte apoptosis during hypoxia postconditioning]. Zhonghua xin xue guan bing za zhi. vol 40. issue 6. 2013-09-30. PMID:22943649. |
[the effect of mitochondrial oxidative stress and the expression of bcl-2 and bax proteins on cardiomyocyte apoptosis during hypoxia postconditioning]. |
2013-09-30 |
2023-08-12 |
Not clear |
| Rong-hui Tu, Li Chen, Guo-qiang Zhong, Zhi-yu Zeng, Qing-jie Li, Yan He, Yan He, Jin-yi L. [The effect of mitochondrial oxidative stress and the expression of Bcl-2 and Bax proteins on cardiomyocyte apoptosis during hypoxia postconditioning]. Zhonghua xin xue guan bing za zhi. vol 40. issue 6. 2013-09-30. PMID:22943649. |
to investigate mitochondrial oxidative stress on cardiomyocyte apoptosis and the expression of bcl-2 and bax proteins in cardiac sarcolemma and mitochondria after application of hypoxia postconditioning and free radical scavengers. |
2013-09-30 |
2023-08-12 |
Not clear |
| Justin T Schwartz, Sarmistha Bandyopadhyay, Scott D Kobayashi, Jenna McCracken, Adeline R Whitney, Frank R Deleo, Lee-Ann H Alle. Francisella tularensis alters human neutrophil gene expression: insights into the molecular basis of delayed neutrophil apoptosis. Journal of innate immunity. vol 5. issue 2. 2013-09-30. PMID:22986450. |
moreover, we demonstrate that the x-linked inhibitor of apoptosis protein remained abundant in polymorphonuclear leukocytes over 48 h of lvs infection, whereas bax mrna and protein were progressively downregulated. |
2013-09-30 |
2023-08-12 |
human |
| D Faccenda, C H Tan, A Seraphim, M R Duchen, M Campanell. IF1 limits the apoptotic-signalling cascade by preventing mitochondrial remodelling. Cell death and differentiation. vol 20. issue 5. 2013-09-30. PMID:23348567. |
we show that the progression of apoptosis engages an amplification pathway mediated by: (i) cyt c-dependent release of er ca(2+), (ii) ca(2+)-dependent recruitment of the gtpase dynamin-related protein 1 (drp1), (iii) bax insertion into the outer mitochondrial membrane and (iv) further release of cyt c. this pathway is accelerated by suppression of if1 and delayed by its overexpression. |
2013-09-30 |
2023-08-12 |
human |
| R Peng, J-S Tong, H Li, B Yue, F Zou, J Yu, L Zhan. Targeting Bax interaction sites reveals that only homo-oligomerization sites are essential for its activation. Cell death and differentiation. vol 20. issue 5. 2013-09-30. PMID:23392123. |
bax is a proapoptotic bcl-2 family member that has a central role in the initiation of mitochondria-dependent apoptosis. |
2013-09-30 |
2023-08-12 |
Not clear |
| R Peng, J-S Tong, H Li, B Yue, F Zou, J Yu, L Zhan. Targeting Bax interaction sites reveals that only homo-oligomerization sites are essential for its activation. Cell death and differentiation. vol 20. issue 5. 2013-09-30. PMID:23392123. |
however, the mechanism of bax activation during apoptosis remains unsettled. |
2013-09-30 |
2023-08-12 |
Not clear |
| R Peng, J-S Tong, H Li, B Yue, F Zou, J Yu, L Zhan. Targeting Bax interaction sites reveals that only homo-oligomerization sites are essential for its activation. Cell death and differentiation. vol 20. issue 5. 2013-09-30. PMID:23392123. |
bax-mediated apoptosis was intact upon knock-in (ki) of k21e and d33a, which were shown to block the interaction of bax with bh3-only activators. |
2013-09-30 |
2023-08-12 |
Not clear |
| R Peng, J-S Tong, H Li, B Yue, F Zou, J Yu, L Zhan. Targeting Bax interaction sites reveals that only homo-oligomerization sites are essential for its activation. Cell death and differentiation. vol 20. issue 5. 2013-09-30. PMID:23392123. |
apoptosis was partially reduced by ki of d68r, which impairs the interaction of bax with prosurvival members, and s184v, a constitutively mitochondria-targeting mutant. |
2013-09-30 |
2023-08-12 |
Not clear |
| R Peng, J-S Tong, H Li, B Yue, F Zou, J Yu, L Zhan. Targeting Bax interaction sites reveals that only homo-oligomerization sites are essential for its activation. Cell death and differentiation. vol 20. issue 5. 2013-09-30. PMID:23392123. |
in contrast, apoptosis was largely suppressed by ki of l70a/d71a, which blocks homo-oligomerization of bax and its binding to prosurvival bcl-2 family proteins. |
2013-09-30 |
2023-08-12 |
Not clear |
| R Peng, J-S Tong, H Li, B Yue, F Zou, J Yu, L Zhan. Targeting Bax interaction sites reveals that only homo-oligomerization sites are essential for its activation. Cell death and differentiation. vol 20. issue 5. 2013-09-30. PMID:23392123. |
we therefore postulate that critical interaction sites yet to be identified, or mechanisms other than protein-protein interactions, need to be pursued to delineate the mechanism of bax activation during apoptosis. |
2013-09-30 |
2023-08-12 |
Not clear |
| Yan Song, Xin Sun, Wei-Liang Bai, Wen-Yue J. Antitumor effects of Dasatinib on laryngeal squamous cell carcinoma in vivo and in vitro. European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery. vol 270. issue 4. 2013-09-30. PMID:23404469. |
measuring the modulation of regulators in the cell cycle, apoptosis and signal transductions by western blot analysis showed that the effect of dasatinib was due to suppression of the expression of bax, bcl-2, caspase-3, and caspase-8. |
2013-09-30 |
2023-08-12 |
mouse |
| Parviz Deyhimi, Payam Tavakol. Study of apoptosis in oral pemphigus vulgaris using immunohistochemical marker Bax and TUNEL technique. Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology. vol 42. issue 5. 2013-09-27. PMID:23186378. |
study of apoptosis in oral pemphigus vulgaris using immunohistochemical marker bax and tunel technique. |
2013-09-27 |
2023-08-12 |
Not clear |
| Monika Katharina Guenther, Ulrike Graab, Simone Fuld. Synthetic lethal interaction between PI3K/Akt/mTOR and Ras/MEK/ERK pathway inhibition in rhabdomyosarcoma. Cancer letters. vol 337. issue 2. 2013-09-27. PMID:23684925. |
consistently, pi103/uo126 cotreatment cooperates to trigger bax activation, loss of mitochondrial membrane potential, caspase activation and caspase-dependent apoptosis. |
2013-09-27 |
2023-08-12 |
Not clear |
| Lin-xi Wang, Yan-ping Wang, Xiao-ying Liu, Liang Liu, Li-jing Wang, Wen-jia Chen, Xiao-hong Liu, Li-bin Li. [Dexamethasone-induced apoptosis of murine MIN6 pancreatic beta-cells and its effect on AKT phosphorylation]. Yao xue xue bao = Acta pharmaceutica Sinica. vol 44. issue 11. 2013-09-26. PMID:21355321. |
the results indicated that after exposure to dexamethasone at a concentration ranging from 50-800 nmol x l(-1) for 48 h, the percentage of cell apoptosis was significantly increased with the concentration over 100 nmol x l(-1) of dexamethasone; after exposure to dexamethasone (100 nmol x l(-1)) for 72 h, the activity of caspase-3 increased significantly; after exposure to dexamethasone at a concentration ranging from 50-800 nmol x l(-1) for 48 h, the expression of cyt-c increased, bcl-2 and akt phosphorylation decreased while bax and t-akt remained unchanged. |
2013-09-26 |
2023-08-12 |
Not clear |
| M M Pereira, N R B Raposo, R Brayner, E M Teixeira, V Oliveira, C C R Quintão, L S A Camargo, L H C Mattoso, H M Brandã. Cytotoxicity and expression of genes involved in the cellular stress response and apoptosis in mammalian fibroblast exposed to cotton cellulose nanofibers. Nanotechnology. vol 24. issue 7. 2013-09-26. PMID:23358497. |
cell viability was analyzed by flow cytometry assay and gene expression of biomarkers focused on cell stress response such as heat shock protein 70.1 (hsp70.1) and peroxiredoxin 1 (prdx1) and apoptosis as b-cell leukemia (bcl-2) and bcl-2 associated x protein (bax) by rt-pcr assay. |
2013-09-26 |
2023-08-12 |
Not clear |
| Yafang Wang, Lili Liu, Xiangqiang Liu, Hui Zhang, Jiaming Liu, Bin Feng, Yulong Shang, Lin Zhou, Kaichun Wu, Yongzhan Nie, Hongbo Zhang, Daiming Fa. Shugoshin1 enhances multidrug resistance of gastric cancer cells by regulating MRP1, Bcl-2, and Bax genes. Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine. vol 34. issue 4. 2013-09-26. PMID:23564482. |
additionally, we confirmed that sgo1 increased capacity of cells to enable adriamycin (adr) efflux and inhibit drug-induced apoptosis by regulating mrp 1, bcl-2, and bax genes so as to confer a mdr phenotype to gc cells. |
2013-09-26 |
2023-08-12 |
Not clear |
| Ying Liu, Zu-an Zhu, Shang-Nuan Zhang, Jie Mou, Lei Liu, Tao Cui, Dong-Sheng Pe. Combinational effect of PPARγ agonist and RXR agonist on the growth of SGC7901 gastric carcinoma cells in vitro. Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine. vol 34. issue 4. 2013-09-26. PMID:23605322. |
then, the cell growth, apoptosis, morphological changes, and the expression of pparγ, rxrγ, bcl-2, and bax were detected by mtt assay, flow cytometry, he staining, immunocytochemistry staining, and western blot assay, respectively. |
2013-09-26 |
2023-08-12 |
Not clear |
| Baobiao Zhuo, Rong Wang, Yiyu Yin, Hongwei Zhang, Tongsheng Ma, Fengli Liu, Hui Cao, Yingchun Sh. Adenovirus arming human IL-24 inhibits neuroblastoma cell proliferation in vitro and xenograft tumor growth in vivo. Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine. vol 34. issue 4. 2013-09-26. PMID:23609032. |
to further explore the molecular mechanism by which ad-il24 induced apoptosis in sh-sy5y tumor cells, we found that ad-il24 increased the expression of bax and promoted the activation of caspase-3, while decreasing bcl-2 levels. |
2013-09-26 |
2023-08-12 |
mouse |
| Jesus A F Tresguerres, Roman Kireev, Katherine Forman, Sara Cuesta, Ana F Tresguerres, Elena Var. Effect of chronic melatonin administration on several physiological parameters from old Wistar rats and SAMP8 mice. Current aging science. vol 5. issue 3. 2013-09-24. PMID:23387890. |
after treatment, the expression of inflammatory mediators (tumor necrosis factor-α, interleukin 1 and 10, nfκbp50 and nfκbp52), apoptosis markers (bad, bax, and bcl2), and parameters related to oxidative stress (heme oxygenases 1 and 2, endothelial and inducible nitric oxide synthases) were determined in the heart. |
2013-09-24 |
2023-08-12 |
mouse |