| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Y-M Wu, R Jin, L Yang, J Zhang, Q Yang, Y-Y Guo, X-B Li, S-B Liu, X-X Luo, M-G Zha. Phosphatidylinositol 3 kinase/protein kinase B is responsible for the protection of paeoniflorin upon H₂O₂-induced neural progenitor cell injury. Neuroscience. vol 240. 2013-11-13. PMID:23485815. |
pf pretreatment also inhibited npc apoptosis induced by h₂o₂ by reversing the decreased level of procaspase-3 and balancing bcl-2 and bax expression. |
2013-11-13 |
2023-08-12 |
Not clear |
| Hai-Mei Zhao, Xiao-Ying Huang, Feng Zhou, Wen-Ting Tong, Pan-Ting Wan, Min-Fang Huang, Qing Ye, Duan-Yong Li. Si Shen Wan Inhibits mRNA Expression of Apoptosis-Related Molecules in p38 MAPK Signal Pathway in Mice with Colitis. Evidence-based complementary and alternative medicine : eCAM. vol 2013. 2013-11-13. PMID:24223057. |
compared with colitis mice without treatment, ssw alleviated colonic mucosal injuries and decreased apoptosis rate of colonic epithelial cell, while the mrna expressions of p38 mapk, p53, caspase-3, c-jun, c-fos, bax, and tnf- α were decreased in the colonic mucosa in colitis mice treated with ssw, and bcl-2 mrna and the ratio of bcl-2/bax were increased. |
2013-11-13 |
2023-08-12 |
mouse |
| Azim Hossain, Faisal F Y Radwan, Bently P Doonan, Jason M God, Lixia Zhang, P Darwin Bell, Azizul Haqu. A possible cross-talk between autophagy and apoptosis in generating an immune response in melanoma. Apoptosis : an international journal on programmed cell death. vol 17. issue 10. 2013-11-12. PMID:22847295. |
annexin v staining and flow cytometry showed that ga-dm treatment induced apoptosis of melanoma cells, which was supported by a detection of increased bax proteins, co-localization and elevation of apaf-1 and cytochrome c, and a subsequent cleavage of caspases 9 and 3. |
2013-11-12 |
2023-08-12 |
Not clear |
| Siyamak Ebrahimi Nigjeh, Fatimah Md Yusoff, Noorjahan Banu Mohamed Alitheen, Mehdi Rasoli, Yeap Swee Keong, Abdul Rahman bin Oma. Cytotoxic effect of ethanol extract of microalga, Chaetoceros calcitrans, and its mechanisms in inducing apoptosis in human breast cancer cell line. BioMed research international. vol 2013. 2013-11-12. PMID:23509778. |
based on gexp study, eec induced apoptosis on mcf-7 cells via modulation of cdk2, mdm2, p21cip1, cyclin a2, bax and bcl-2. |
2013-11-12 |
2023-08-12 |
human |
| Sandra Oramas-Royo, Concepción Torrejón, Irene Cuadrado, Rita Hernández-Molina, Sonsoles Hortelano, Ana Estévez-Braun, Beatriz de Las Hera. Synthesis and cytotoxic activity of metallic complexes of lawsone. Bioorganic & medicinal chemistry. vol 21. issue 9. 2013-11-12. PMID:23545136. |
compound 4 induced apoptosis by a mechanism that involves the activation of caspases 3, 8 and 9 and modulation of apoptotic-related proteins such as bax, bad, and p53. |
2013-11-12 |
2023-08-12 |
mouse |
| Aysegul Cort, Mujgan Timur, Evrim Ozdemir, Tomris Ozbe. Effects of curcumin on bleomycin-induced apoptosis in human malignant testicular germ cells. Journal of physiology and biochemistry. vol 69. issue 2. 2013-11-08. PMID:23001851. |
we measured apoptosis markers such as caspase-3, caspase-8, and caspase-9 activities and bcl-2, bax, and cyt-c levels in nccit cells incubated with curcumin (5 μm), bleomycin (120 μg/ml), bleomycin + curcumin, h2o2 (35 μm), and h2o2 + curcumin for 72 h. curcumin, bleomycin, and h2o2 caused apoptosis indicated as increases in caspase-3, caspase-8, and caspase-9 activities and bax and cytoplasmic cyt-c levels and a decrease in bcl-2 level. |
2013-11-08 |
2023-08-12 |
human |
| Yu-Fang He, Min-Lun Nan, Jia-Ming Sun, Zhao-Jie Meng, Wei Li, Ming Zhan. Design, synthesis and cytotoxicity of cell death mechanism of rotundic acid derivatives. Bioorganic & medicinal chemistry letters. vol 23. issue 9. 2013-11-08. PMID:23558236. |
the results indicated that compound 4 could induce apoptosis through increasing protein expression of cleaved caspase-3 and bax, and decreasing protein expression of bcl-2. |
2013-11-08 |
2023-08-12 |
human |
| Chun-Chi Wu, Tzu-Hsiu Chen, Bing-Lan Liu, Li-Chen Wu, Yung-Ching Chen, Yew-Min Tzeng, Shih-Lan Hs. Destruxin B Isolated from Entomopathogenic Fungus Metarhizium anisopliae Induces Apoptosis via a Bcl-2 Family-Dependent Mitochondrial Pathway in Human Nonsmall Cell Lung Cancer Cells. Evidence-based complementary and alternative medicine : eCAM. vol 2013. 2013-11-08. PMID:24204395. |
knockdown of bax by shrna effectively attenuated destruxin-b-triggered apoptosis in a549 cells. |
2013-11-08 |
2023-08-12 |
human |
| Jie Qiu, Xiao-Yu Zhou, Xiao-Guang Zhou, Rui Cheng, Hai-Ying Liu, Yong L. Neuroprotective effects of microRNA-210 against oxygen-glucose deprivation through inhibition of apoptosis in PC12 cells. Molecular medicine reports. vol 7. issue 6. 2013-11-07. PMID:23591709. |
furthermore, mir-210 suppressed cell apoptosis by inhibiting caspase activity and by regulating the balance between bcl-2 and bax levels. |
2013-11-07 |
2023-08-12 |
Not clear |
| Ying Wang, Shao-Lin Xu, Ya-Zhen Wu, Mei-Sheng Zhao, Wen-Jing Xu, Hai-Yan Yang, Yu-Xin L. Simvastatin induces caspase-dependent apoptosis and activates P53 in OCM-1 cells. Experimental eye research. vol 113. 2013-11-07. PMID:23727160. |
in addition, simvastatin resulted in an increase in levels of reactive oxygen species (ros) in ocm-1 cells and simvastatin significantly triggered apoptosis in ocm-1 cells, which was characterized by increased chromatin condensation, activation of caspase-9 and cleaved-caspase-3, increased expression mitochondrion-related apoptosis protein of p53, bax and decreased expression of bcl2 and iaspp. |
2013-11-07 |
2023-08-12 |
Not clear |
| Chuan Sun, Xiao-Xin Li, Xiang-Jun He, Qi Zhang, Yong Ta. Neuroprotective effect of minocycline in a rat model of branch retinal vein occlusion. Experimental eye research. vol 113. 2013-11-07. PMID:23748101. |
the expressional levels of apoptosis related genes (bax, bcl-2) and inflammation related genes (il-1 β, tnf α, mcp-1 and ccr2) were measured by real-time pcr, the results showed that minocycline treatment upregulated bcl-2 expression and inhibits tnf α expression since early stage of brvo. |
2013-11-07 |
2023-08-12 |
rat |
| Yao-Li Chen, Meng-Yi Yan, Su-Yu Chien, Shou-Jen Kuo, Dar-Ren Chen, Chun-Yuan Cheng, Chin-Cheng S. Sann-Joong-Kuey-Jian-Tang inhibits hepatocellular carcinoma Hep-G2 cell proliferation by increasing TNF-α, Caspase-8, Caspase- 3 and Bax but by decreasing TCTP and Mcl-1 expression in vitro. Molecular medicine reports. vol 7. issue 5. 2013-11-05. PMID:23525225. |
one of the molecular mechanisms responsible for this may be the increased fas, tnf-α, caspase-8, caspase- 3 and bax expression; another mechanism may be via decreasing tctp and mcl-1 expression in order to induce apoptosis. |
2013-11-05 |
2023-08-12 |
human |
| Sangeeta Mehta, Rakhee Chhetra, Radhika Srinivasan, Suresh C Sharma, Digambar Behera, Sujata Ghos. Potential importance of Maackia amurensis agglutinin in non-small cell lung cancer. Biological chemistry. vol 394. issue 7. 2013-11-05. PMID:23612596. |
the mechanism of this lectin-induced apoptosis involved downregulation of bcl-xl, upregulation of bax, release of cytochrome c and activation of procaspase-3. |
2013-11-05 |
2023-08-12 |
Not clear |
| Abul Azad, Alan Store. BAK multimerization for apoptosis, but not bid binding, is inhibited by negatively charged residue in the BAK hydrophobic groove. Molecular cancer. vol 12. 2013-11-05. PMID:23782464. |
bcl-2 family proteins bak and bax orchestrate outer mitochondrial membrane permeabilization (momp) during apoptosis by forming pores in the membrane to release apoptogenic factors that commits a cell to death. |
2013-11-05 |
2023-08-12 |
Not clear |
| Kumudha Balakrishnan, Sumesh Aggarwal, William Wierda, Varsha Gandh. Bax and Bak are required for apogossypolone, a BH3-mimetic, induced apoptosis in chronic lymphocytic leukemia cells. Leukemia & lymphoma. vol 54. issue 5. 2013-11-04. PMID:22866921. |
bax and bak are required for apogossypolone, a bh3-mimetic, induced apoptosis in chronic lymphocytic leukemia cells. |
2013-11-04 |
2023-08-12 |
Not clear |
| Chin-Chung Lin, Ya-Ju Chuang, Chien-Chih Yu, Jai-Sing Yang, Chi-Cheng Lu, Jo-Hua Chiang, Jing-Pin Lin, Nou-Ying Tang, An-Cheng Huang, Jing-Gung Chun. Apigenin induces apoptosis through mitochondrial dysfunction in U-2 OS human osteosarcoma cells and inhibits osteosarcoma xenograft tumor growth in vivo. Journal of agricultural and food chemistry. vol 60. issue 45. 2013-11-04. PMID:23066961. |
apigenin effectively induced apoptosis through the activations of caspase-3, -8, -9, and bax and promoted the release of aif in u-2 os cells. |
2013-11-04 |
2023-08-12 |
mouse |
| Xi Lan, Yong-Zhong Wu, Yong Wang, Fu-Rong Wu, Chun-Bao Zang, Chuan Tang, Shu Cao, Shao-Lin L. CD133 silencing inhibits stemness properties and enhances chemoradiosensitivity in CD133-positive liver cancer stem cells. International journal of molecular medicine. vol 31. issue 2. 2013-11-04. PMID:23233126. |
knockdown of cd133 reduced g0/g1 phase cells and increased cellular apoptosis via modulation of bcl-2 and bax. |
2013-11-04 |
2023-08-12 |
mouse |
| Changjun Jia, Chaoliu Dai, Xianmin Bu, Songlin Peng, Feng Xu, Yongqing Xu, Yang Zha. Co-administration of prostaglandin E1 with somatostatin attenuates acute liver damage after massive hepatectomy in rats via inhibition of inflammatory responses, apoptosis and endoplasmic reticulum stress. International journal of molecular medicine. vol 31. issue 2. 2013-11-04. PMID:23242071. |
in addition, apoptosis was inhibited via upregulation of bcl-2 and downregulation of bax and caspase-3 in drug treatment groups. |
2013-11-04 |
2023-08-12 |
rat |
| Aisha Shamas-Din, Scott Bindner, Weijia Zhu, Yehudit Zaltsman, Clinton Campbell, Atan Gross, Brian Leber, David W Andrews, Cécile Fradi. tBid undergoes multiple conformational changes at the membrane required for Bax activation. The Journal of biological chemistry. vol 288. issue 30. 2013-11-04. PMID:23744079. |
bid is a bcl-2 family protein that promotes apoptosis by activating bax and eliciting mitochondrial outer membrane permeabilization (momp). |
2013-11-04 |
2023-08-12 |
Not clear |
| Ruizan Shi, Hongwei Peng, Xiangfei Yuan, Xiuli Zhang, Yanjun Zhang, Dongmei Fan, Xuyi Liu, Dongsheng Xion. Down-regulation of c-fos by shRNA sensitizes adriamycin-resistant MCF-7/ADR cells to chemotherapeutic agents via P-glycoprotein inhibition and apoptosis augmentation. Journal of cellular biochemistry. vol 114. issue 8. 2013-11-01. PMID:23494858. |
further results proved that c-fos down-regulation in mcf-7/adr cells resulted in decreased p-gp expression and activity, enhanced apoptosis, and altered expression of apoptosis-associated proteins (i.e., bax, bcl-2, p53, and puma). |
2013-11-01 |
2023-08-12 |
human |