| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Zhenran Wang, Wenjing Lu, Yang Li, Bo Tan. Alpinetin promotes Bax translocation, induces apoptosis through the mitochondrial pathway and arrests human gastric cancer cells at the G2/M phase. Molecular medicine reports. vol 7. issue 3. 2014-01-03. PMID:23254270. |
alpinetin promotes bax translocation, induces apoptosis through the mitochondrial pathway and arrests human gastric cancer cells at the g2/m phase. |
2014-01-03 |
2023-08-12 |
human |
| Zhenran Wang, Wenjing Lu, Yang Li, Bo Tan. Alpinetin promotes Bax translocation, induces apoptosis through the mitochondrial pathway and arrests human gastric cancer cells at the G2/M phase. Molecular medicine reports. vol 7. issue 3. 2014-01-03. PMID:23254270. |
bcl‑2‑associated x protein (bax) translocation is known to activate the mitochondrial‑dependent endogenous apoptosis pathway. |
2014-01-03 |
2023-08-12 |
human |
| Zhenran Wang, Wenjing Lu, Yang Li, Bo Tan. Alpinetin promotes Bax translocation, induces apoptosis through the mitochondrial pathway and arrests human gastric cancer cells at the G2/M phase. Molecular medicine reports. vol 7. issue 3. 2014-01-03. PMID:23254270. |
the aim of the current study was to investigate the roles of bax and the mitochondrial pathway during alpinetin‑induced gastric cancer cell apoptosis and the effects of alpinetin on the cell cycle. |
2014-01-03 |
2023-08-12 |
human |
| Chuan-Dong Wei, Yan Li, Hong-Yun Zheng, Yong-Qing Tong, Wen Da. Palmitate induces H9c2 cell apoptosis by increasing reactive oxygen species generation and activation of the ERK1/2 signaling pathway. Molecular medicine reports. vol 7. issue 3. 2014-01-03. PMID:23338747. |
in this model of treatment with palmitate, h9c2 cell apoptosis correlated with increased levels of p53 and bax expression and reduced levels of bcl-2 expression. |
2014-01-03 |
2023-08-12 |
Not clear |
| Cheng-Yen Huang, Tsung-Lang Chiu, Shou-Jen Kuo, Su-Yu Chien, Dar-Ren Chen, Chin-Cheng S. Tanshinone IIA inhibits the growth of pancreatic cancer BxPC‑3 cells by decreasing protein expression of TCTP, MCL‑1 and Bcl‑xL. Molecular medicine reports. vol 7. issue 3. 2014-01-03. PMID:23358553. |
these results indicate that tan‑iia may inhibit bxpc‑3 human pancreatic cancer cells through the induction of apoptosis by decreasing protein expression of tctp, mcl‑1 and bcl‑xl and increasing bax expression in vitro. |
2014-01-03 |
2023-08-12 |
human |
| Xia Ding, Fangshi Zhu, Yun Yang, Min L. Purification, antitumor activity in vitro of steroidal glycoalkaloids from black nightshade (Solanum nigrum L.). Food chemistry. vol 141. issue 2. 2014-01-03. PMID:23790901. |
the mechanism of action may be related to the decrease of mutation p53, the increase of the ratio of bax to bcl-2 and the activation of caspase-3 to induce apoptosis. |
2014-01-03 |
2023-08-12 |
Not clear |
| Guo-Hua Dai, Jing-Chang Sun, Dong-Mei Q. [Effects of rhynchophylla alkaloids on vascular adventitial fibroblast apoptosis and proliferation in the thoracic aorta of spontaneously hypertensive rats]. Zhongguo Zhong xi yi jie he za zhi Zhongguo Zhongxiyi jiehe zazhi = Chinese journal of integrated traditional and Western medicine. vol 32. issue 9. 2014-01-02. PMID:23185766. |
to study the effects of rhynchophylline, isorhynchophylline, and rhynchophylla alkaloids on the vascular adventitial fibroblasts (vaf) apoptosis and proliferation in thoracic aorta of spontaneously hypertensive rats (shr), and on the bcl-2, bax, c-fos, c-myc, laminin (ln), and fibronectin (fn). |
2014-01-02 |
2023-08-12 |
rat |
| Jaesook Roh, Woojin P. Regulation of follicle growth and apoptosis in cultured mouse ovaries by NGF and oxygen. Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology. vol 29. issue 6. 2014-01-02. PMID:23506274. |
under 20% oxygen, but not 1.5% or 5%, ngf decreased apoptosis in mouse ovaries by down-regulating the pro-apoptotic genes bax and p53. |
2014-01-02 |
2023-08-12 |
mouse |
| Silvia Ramírez-Peinado, Clara Lucía León-Annicchiarico, Javier Galindo-Moreno, Raffaella Iurlaro, Alfredo Caro-Maldonado, Jochen H M Prehn, Kevin M Ryan, Cristina Muñoz-Pined. Glucose-starved cells do not engage in prosurvival autophagy. The Journal of biological chemistry. vol 288. issue 42. 2013-12-31. PMID:24014036. |
glucose withdrawal induces cell death that can occur by apoptosis (in bax, bak-deficient mouse embryonic fibroblasts or hela cells) or by necrosis (in rh4 rhabdomyosarcoma cells). |
2013-12-31 |
2023-08-12 |
mouse |
| Peter Chrenek, Alexander V Makarevich, Andrej Balazi, Janka Fazekasová, Janka Schlarmannová, Barbora Matejovicová, Alexander V Sirotki. The effect of the cAMP analogue, dbcAMP, on proliferation and apoptosis of rabbit oviductal cells. Folia biologica. vol 61. issue 3-4. 2013-12-31. PMID:24279176. |
for this purpose, we compared the expression of markers of proliferation (pcna, cyclin b1) and apoptosis (bax and bcl-2) in the oviduct epithelial cells isolated from rabbits, whose ovarian and oviductal cycle was induced by gonadotropins alone or in combination with dbcamp (50 microg/animal) by using immunocytochemistry. |
2013-12-31 |
2023-08-12 |
rabbit |
| Peter Chrenek, Alexander V Makarevich, Andrej Balazi, Janka Fazekasová, Janka Schlarmannová, Barbora Matejovicová, Alexander V Sirotki. The effect of the cAMP analogue, dbcAMP, on proliferation and apoptosis of rabbit oviductal cells. Folia biologica. vol 61. issue 3-4. 2013-12-31. PMID:24279176. |
no influence of dbcamp administration on regulators and markers of apoptosis (pro-apoptotic - bax and anti-apoptotic - bcl-2) suggests that dbcamp is probably not involved in the control of apoptosis in rabbit oviduct epithelial cells. |
2013-12-31 |
2023-08-12 |
rabbit |
| Corey L Cusack, Vijay Swahari, W Hampton Henley, J Michael Ramsey, Mohanish Deshmuk. Distinct pathways mediate axon degeneration during apoptosis and axon-specific pruning. Nature communications. vol 4. 2013-12-30. PMID:23695670. |
both apoptosis and axon degeneration require bax and caspases. |
2013-12-30 |
2023-08-12 |
Not clear |
| Xudong Hu, Ligang Xing, Yang Jiao, Jiaying Xu, Xingwu Wang, Anqin Han, Jinming Y. BTG2 overexpression increases the radiosensitivity of breast cancer cells in vitro and in vivo. Oncology research. vol 20. issue 10. 2013-12-30. PMID:24308156. |
the mcf-7-btg2 cells were more susceptible to radiation-caused apoptosis with decreased cyclin b1, cyclin d1, ku70, fen-1, and xrcc1 protein expression as well as increased bax protein expression. |
2013-12-30 |
2023-08-12 |
human |
| Tongsheng Chen, Min Chen, Jingqin Che. Ionizing radiation potentiates dihydroartemisinin-induced apoptosis of A549 cells via a caspase-8-dependent pathway. PloS one. vol 8. issue 3. 2013-12-27. PMID:23536891. |
silencing of proapoptotic protein bax but not bak significantly inhibited dha-induced apoptosis in which bax but not bak was activated. |
2013-12-27 |
2023-08-12 |
human |
| Hideyuki Iwayama, Norishi Ued. Role of mitochondrial Bax, caspases, and MAPKs for ceramide-induced apoptosis in renal proximal tubular cells. Molecular and cellular biochemistry. vol 379. issue 1-2. 2013-12-27. PMID:23543151. |
role of mitochondrial bax, caspases, and mapks for ceramide-induced apoptosis in renal proximal tubular cells. |
2013-12-27 |
2023-08-12 |
Not clear |
| Hideyuki Iwayama, Norishi Ued. Role of mitochondrial Bax, caspases, and MAPKs for ceramide-induced apoptosis in renal proximal tubular cells. Molecular and cellular biochemistry. vol 379. issue 1-2. 2013-12-27. PMID:23543151. |
it remains elusive whether crosstalk exists among mitochondrial bax, caspases, and mitogen-activated protein kinases (mapks), and whether epidermal growth factor (egf), which may activate mapks, affects ceramide-induced apoptosis through the crosstalk in renal proximal tubular cells (rptcs). |
2013-12-27 |
2023-08-12 |
Not clear |
| Hideyuki Iwayama, Norishi Ued. Role of mitochondrial Bax, caspases, and MAPKs for ceramide-induced apoptosis in renal proximal tubular cells. Molecular and cellular biochemistry. vol 379. issue 1-2. 2013-12-27. PMID:23543151. |
effect of ceramide on expression of mitochondrial bax and phosphorylated (p)-erk, p38mapk and jnk, that of mapks inhibition, and of egf in the presence or absence of mapks inhibition on ceramide-induced apoptosis were examined in hk-2 cells. |
2013-12-27 |
2023-08-12 |
Not clear |
| Hideyuki Iwayama, Norishi Ued. Role of mitochondrial Bax, caspases, and MAPKs for ceramide-induced apoptosis in renal proximal tubular cells. Molecular and cellular biochemistry. vol 379. issue 1-2. 2013-12-27. PMID:23543151. |
apoptosis and expression of mitochondrial bax and p-mapks were measured by hoechst 33258 staining and western blotting. |
2013-12-27 |
2023-08-12 |
Not clear |
| Hideyuki Iwayama, Norishi Ued. Role of mitochondrial Bax, caspases, and MAPKs for ceramide-induced apoptosis in renal proximal tubular cells. Molecular and cellular biochemistry. vol 379. issue 1-2. 2013-12-27. PMID:23543151. |
c2-ceramide, but not dihydroc2-ceramide, inactive c2-ceramide, induced apoptosis at 24 h. c2-ceramide enhanced the mitochondrial bax expression at 1 h, which was peaked at 3-6 h and decreased at 24 h, but remained increased, compared to control. |
2013-12-27 |
2023-08-12 |
Not clear |
| Hideyuki Iwayama, Norishi Ued. Role of mitochondrial Bax, caspases, and MAPKs for ceramide-induced apoptosis in renal proximal tubular cells. Molecular and cellular biochemistry. vol 379. issue 1-2. 2013-12-27. PMID:23543151. |
egf, which enhanced the expression of p-erk and p-p38mapk but not p-jnk, ameliorated c2-ceramide-induced apoptosis without affecting mitochondrial bax. |
2013-12-27 |
2023-08-12 |
Not clear |