| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Tsung-Ho Ying, Chia-Wei Chen, Yu-Ping Hsiao, Sung-Jen Hung, Jing-Gung Chung, Jen-Hung Yan. Citric acid induces cell-cycle arrest and apoptosis of human immortalized keratinocyte cell line (HaCaT) via caspase- and mitochondrial-dependent signaling pathways. Anticancer research. vol 33. issue 10. 2013-12-09. PMID:24123010. |
citric acid increased the level of bcl-2-associated x protein (bax) and reduced the levels of b-cell lymphoma-2 (bcl-2), b-cell lymphoma-extra large (bcl-xl) and activated caspase-9 and caspase-3, which subsequently induced apoptosis via caspase-dependent and caspase-independent pathways. |
2013-12-09 |
2023-08-12 |
human |
| Xiao-Ling Chen, Shan-Sheng Huang, Kun Liu, Jie A. Modulatory action of endogenous and exogenous nitric oxide on survival of alveolar macrophages from normal and bleomycin-treated rats. Sheng li xue bao : [Acta physiologica Sinica]. vol 57. issue 5. 2013-12-05. PMID:16220201. |
it is concluded that no can induce the apoptosis of blm ams and normal ams; that bcl-2 and bax are implicated in no-induced apoptosis of normal ams, whereas they are not involved in that of blm ams, suggesting the differential molecular mechanisms underlying the no-induced apoptosis of normal ams and blm ams; and that endogenous no promotes proliferation of blm ams, which might be associated with down-regulation of bax. |
2013-12-05 |
2023-08-12 |
rat |
| Sirin Korulu, Aysegul Yildiz-Unal, Meral Yuksel, Arzu Karaba. Protein kinase C activation causes neurite retraction via cyclinD1 and p60-katanin increase in rat hippocampal neurons. The European journal of neuroscience. vol 37. issue 10. 2013-12-05. PMID:23489891. |
since up-regulation of cell cycle is associated with apoptosis in neurons, we also analysed changes in bax, bcl-2 early and parp (poly(adp-ribose)polymerase), caspase3 late apoptotic markers. |
2013-12-05 |
2023-08-12 |
rat |
| Jan Petrasek, Arvin Iracheta-Vellve, Timea Csak, Abhishek Satishchandran, Karen Kodys, Evelyn A Kurt-Jones, Katherine A Fitzgerald, Gyongyi Szab. STING-IRF3 pathway links endoplasmic reticulum stress with hepatocyte apoptosis in early alcoholic liver disease. Proceedings of the National Academy of Sciences of the United States of America. vol 110. issue 41. 2013-12-04. PMID:24052526. |
activated irf3 associated with the proapoptotic molecule bax [b-cell lymphoma 2 (bcl2)-associated x protein] and contributed to hepatocyte apoptosis. |
2013-12-04 |
2023-08-12 |
Not clear |
| Rakesh Kumar Gupta, Ayan Banerjee, Suajta Pathak, Chandresh Sharma, Neeta Sing. Induction of mitochondrial-mediated apoptosis by Morinda citrifolia (Noni) in human cervical cancer cells. Asian Pacific journal of cancer prevention : APJCP. vol 14. issue 1. 2013-12-03. PMID:23534730. |
the observed apoptosis appeared to be mediated particularly through the up-regulation of p53 and pro-apoptotic bax proteins, as well as down- regulation of the anti-apoptotic bcl-2, bcl-xl proteins and survivin. |
2013-12-03 |
2023-08-12 |
human |
| Yongfeng Zhou, Yanying Bi, Chunhui Yang, Jingbo Yang, Yu Jiang, Fanmin Meng, Bo Yu, Muhammad Khan, Tonghui Ma, Hong Yan. Magnolol induces apoptosis in MCF-7 human breast cancer cells through G2/M phase arrest and caspase-independent pathway. Die Pharmazie. vol 68. issue 9. 2013-12-03. PMID:24147344. |
further mechanistic studies revealed that induction of apoptosis is associated with cell cycle arrest at g2/m phase, increased generation of reactive oxygen species (ros), reduced mitochondrial membrane potential (mmp), release of cytochrome c (cyto c) and apoptosis inducing factor (aif) from mitochondria to cytosol, upregulation of bax, p21 and p53, and down-regulation of bcl-2, cyclin b1 and cyclin-dependent kinase 1 (cdk1). |
2013-12-03 |
2023-08-12 |
human |
| Rubén Ruiz-González, Pilar Acedo, David Sánchez-García, Santi Nonell, Magdalena Cañete, Juan Carlos Stockert, Angeles Villanuev. Efficient induction of apoptosis in HeLa cells by a novel cationic porphycene photosensitizer. European journal of medicinal chemistry. vol 63. 2013-11-27. PMID:23517729. |
after 18 h incubation with 0.5 μm py3meo-tbpo and subsequent red light irradiation (3.6 j/cm(2)), a high number of cells die by apoptosis, as evaluated by morphological alterations, immunofluorescent relocalization of bax from cytosol to mitochondria, and tunel assay. |
2013-11-27 |
2023-08-12 |
Not clear |
| Rubén Ruiz-González, Pilar Acedo, David Sánchez-García, Santi Nonell, Magdalena Cañete, Juan Carlos Stockert, Angeles Villanuev. Efficient induction of apoptosis in HeLa cells by a novel cationic porphycene photosensitizer. European journal of medicinal chemistry. vol 63. 2013-11-27. PMID:23517729. |
likewise, immunofluorescence techniques showed that cytochrome c is released from mitochondria into cytosol in cells undergoing apoptosis, which occurs immediately after relocation of bax in mitochondria. |
2013-11-27 |
2023-08-12 |
Not clear |
| Philipp Stahl, Volker Ruppert, Thomas Meyer, Jörg Schmidt, Marco A Campos, Ricardo T Gazzinelli, Bernhard Maisch, Ralph T Schwarz, Françoise Debierre-Grockieg. Trypomastigotes and amastigotes of Trypanosoma cruzi induce apoptosis and STAT3 activation in cardiomyocytes in vitro. Apoptosis : an international journal on programmed cell death. vol 18. issue 6. 2013-11-26. PMID:23435997. |
increase of apoptosis was associated with up-regulation of the apoptotic gene bax by trypomastigotes, while expression of the anti-apoptotic gene bcl-2 was down-regulated by amastigotes. |
2013-11-26 |
2023-08-12 |
rat |
| Ting Song, Zuguang Xue, Zhichao Zhang, Xiaoyun Shen, Xiangqian L. Pan-BH3 mimetic S1 exhibits broad-spectrum antitumour effects by cooperation between Bax and Bak. Basic & clinical pharmacology & toxicology. vol 113. issue 3. 2013-11-26. PMID:23557083. |
herein, different bcl-2 member expression cancer cell lines (nci-h345, mcf-7, smmc-7721 and hela) and cells deficient in bax and/or bak by shrna were used to unravel the cascade of events by which s1 promotes apoptosis compared with bcl-2/bcl-xl inhibitor abt-737. |
2013-11-26 |
2023-08-12 |
Not clear |
| Ting Song, Zuguang Xue, Zhichao Zhang, Xiaoyun Shen, Xiangqian L. Pan-BH3 mimetic S1 exhibits broad-spectrum antitumour effects by cooperation between Bax and Bak. Basic & clinical pharmacology & toxicology. vol 113. issue 3. 2013-11-26. PMID:23557083. |
moreover, the individual and combined roles of bax and bak in s1-induced apoptosis were revealed. |
2013-11-26 |
2023-08-12 |
Not clear |
| Ting Song, Zuguang Xue, Zhichao Zhang, Xiaoyun Shen, Xiangqian L. Pan-BH3 mimetic S1 exhibits broad-spectrum antitumour effects by cooperation between Bax and Bak. Basic & clinical pharmacology & toxicology. vol 113. issue 3. 2013-11-26. PMID:23557083. |
bak played a predominant role in either s1 or abt-737-induced apoptosis through the cooperation with bax on the formation of large oligomers on mitochondrial membrane. |
2013-11-26 |
2023-08-12 |
Not clear |
| Cailing Yang, Dapeng Wu, Jinling Jia, Dong Liu, Zhanguo Li, Chunxiao Zhang, Min Li, Yonghua Xi. DLC1 as a regulator of proliferation, invasion, cell cycle, and apoptosis in cutaneous squamous cell carcinoma. Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine. vol 34. issue 5. 2013-11-26. PMID:23625658. |
additionally, dlc1 overexpression induced apoptosis coupled with elevations of bax level and caspase-3 activity and decrease of bcl-2 level in a431 cells. |
2013-11-26 |
2023-08-12 |
Not clear |
| Marcus Wallgren, Martin Lidman, Anders Pedersen, Kristoffer Brännström, B Göran Karlsson, Gerhard Gröbne. Reconstitution of the anti-apoptotic Bcl-2 protein into lipid membranes and biophysical evidence for its detergent-driven association with the pro-apoptotic Bax protein. PloS one. vol 8. issue 4. 2013-11-26. PMID:23626686. |
the anti-apoptotic b-cell cll/lymphoma-2 (bcl-2) protein and its counterpart, the pro-apoptotic bcl-2-associated x protein (bax), are key players in the regulation of the mitochondrial pathway of apoptosis. |
2013-11-26 |
2023-08-12 |
human |
| Rohinton S Tarapore, Yizeng Yang, Jonathan P Kat. Restoring KLF5 in esophageal squamous cell cancer cells activates the JNK pathway leading to apoptosis and reduced cell survival. Neoplasia (New York, N.Y.). vol 15. issue 5. 2013-11-26. PMID:23633919. |
when klf5 was induced, escc cells demonstrated increased apoptosis and decreased viability, with up-regulation of the proapoptotic factor bax. |
2013-11-26 |
2023-08-12 |
human |
| Jinghua Yang, Qiufang Liu, Ming Qi, Shuai Lu, Shengwen Wu, Qi Xi, Yuan Ca. Lanthanum chloride promotes mitochondrial apoptotic pathway in primary cultured rat astrocytes. Environmental toxicology. vol 28. issue 9. 2013-11-25. PMID:21793157. |
(3) lacl3 treatment increased the ratio of pro-apoptotic bax and antiapoptotic bcl-2 proteins, which in turn broke the balance among pro-apoptotic and antiapoptotic bcl-2 family proteins, leading to astrocyte apoptosis. |
2013-11-25 |
2023-08-12 |
rat |
| Wen-Jun Gu, Hai-Lin Li. Induction of pancreatic cancer cell apoptosis, invasion, migration, and enhancement of chemotherapy sensitivity of gemcitabine, 5-FU, and oxaliplatin by hnRNP A2/B1 siRNA. Anti-cancer drugs. vol 24. issue 6. 2013-11-19. PMID:23525071. |
hnrnp a2/b1 sirna combined with gemcitabine, 5-fu and oxaliplatin significantly increased (p<0.01) apoptosis of pancreatic cancer cell lines sw1990 and bxpc-3, increased the expression level of bax mrna, decreased bcl-2 mrna and mdr1 mrna expression (p<0.01), and induced no change in p53, trail, and survivin mrna expression in sw1990. |
2013-11-19 |
2023-08-12 |
human |
| Hongping Yin, Chuanlong Guo, Ying Wang, Dan Liu, Yunbin Lv, Fengxia Lv, Zhaoxin L. Fengycin inhibits the growth of the human lung cancer cell line 95D through reactive oxygen species production and mitochondria-dependent apoptosis. Anti-cancer drugs. vol 24. issue 6. 2013-11-19. PMID:23552471. |
while investigating caspase activity and the expression of apoptosis-related proteins, fengycin was found to induce apoptosis in 95d cells through the mitochondrial pathway, evidenced by increased caspase activity, bax expression, and cytochrome c release into the cytoplasm, as well as decreased bcl-2 levels. |
2013-11-19 |
2023-08-12 |
mouse |
| Peng Zhao, Juanling Fu, Biyun Yao, Entan Hu, Yanchao Song, Lan Mi, Zhenning Li, Hongtao Zhang, Yongrui Jia, Shiliang Ma, Wen Chen, Zongcan Zho. Diethyl sulfate-induced cell cycle arrest and apoptosis in human bronchial epithelial 16HBE cells. Chemico-biological interactions. vol 205. issue 2. 2013-11-14. PMID:23830811. |
apoptosis related proteins measurement results revealed that des-induced apoptosis was concurrent with the increasing of bax and cleavage fragment caspase-3 and the decreasing of bcl-2 and full length procaspase-3. |
2013-11-14 |
2023-08-12 |
human |
| Sunil Kumar, Anup Singh Pathania, A K Saxena, R A Vishwakarma, Asif Ali, Shashi Bhusha. The anticancer potential of flavonoids isolated from the stem bark of Erythrina suberosa through induction of apoptosis and inhibition of STAT signaling pathway in human leukemia HL-60 cells. Chemico-biological interactions. vol 205. issue 2. 2013-11-14. PMID:23850732. |
mlf and aif induce apoptosis bodies formation, enhanced annexinv-fitc binding of the cells, increased sub-g0 cell fraction, loss of mitochondrial membrane potential (Δψm), release of cytochrome c, bax, activation of caspase-9, caspase-3 and parp (poly adp ribose polymers) cleavage in hl-60 cells. |
2013-11-14 |
2023-08-12 |
human |