| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Ievgeniia Burlaka, Xiao Li Liu, Johan Rebetz, Ida Arvidsson, Liping Yang, Hjalmar Brismar, Diana Karpman, Anita Aperi. Ouabain protects against Shiga toxin-triggered apoptosis by reversing the imbalance between Bax and Bcl-xL. Journal of the American Society of Nephrology : JASN. vol 24. issue 9. 2013-11-01. PMID:23744887. |
ouabain protects against shiga toxin-triggered apoptosis by reversing the imbalance between bax and bcl-xl. |
2013-11-01 |
2023-08-12 |
mouse |
| Ievgeniia Burlaka, Xiao Li Liu, Johan Rebetz, Ida Arvidsson, Liping Yang, Hjalmar Brismar, Diana Karpman, Anita Aperi. Ouabain protects against Shiga toxin-triggered apoptosis by reversing the imbalance between Bax and Bcl-xL. Journal of the American Society of Nephrology : JASN. vol 24. issue 9. 2013-11-01. PMID:23744887. |
stx2 binds to the glycosphingolipid globotriaosylceramide receptor, expressed by renal epithelial cells, and triggers apoptosis by activating the apoptotic factor bax. |
2013-11-01 |
2023-08-12 |
mouse |
| Ievgeniia Burlaka, Xiao Li Liu, Johan Rebetz, Ida Arvidsson, Liping Yang, Hjalmar Brismar, Diana Karpman, Anita Aperi. Ouabain protects against Shiga toxin-triggered apoptosis by reversing the imbalance between Bax and Bcl-xL. Journal of the American Society of Nephrology : JASN. vol 24. issue 9. 2013-11-01. PMID:23744887. |
signaling via the ouabain/na,k-atpase/ip3r/nf-κb pathway increases expression of bcl-xl, an inhibitor of bax, suggesting that ouabain might protect renal cells from stx2-triggered apoptosis. |
2013-11-01 |
2023-08-12 |
mouse |
| Ievgeniia Burlaka, Xiao Li Liu, Johan Rebetz, Ida Arvidsson, Liping Yang, Hjalmar Brismar, Diana Karpman, Anita Aperi. Ouabain protects against Shiga toxin-triggered apoptosis by reversing the imbalance between Bax and Bcl-xL. Journal of the American Society of Nephrology : JASN. vol 24. issue 9. 2013-11-01. PMID:23744887. |
here, exposing rat proximal tubular cells to stx2 in vitro resulted in massive apoptosis, upregulation of the apoptotic factor bax, increased cleaved caspase-3, and downregulation of the survival factor bcl-xl; co-incubation with ouabain prevented all of these effects. |
2013-11-01 |
2023-08-12 |
mouse |
| Xuefei Hou, Yan Ding, Zheng Nie, Hui Li, Yuhong Tang, Hua Zhou, Li Chen, Yu Zhen. [Damage effects of chronic hypoxia on medulla oblongata associated with oxidative stress and cell apoptosis]. Sheng wu yi xue gong cheng xue za zhi = Journal of biomedical engineering = Shengwu yixue gongchengxue zazhi. vol 29. issue 4. 2013-10-31. PMID:23016425. |
nissl's staining was used to examine the niss bodies of neurons in medullary respiratory related nuclei, biochemistry methods were utilized to examine oxidant stress damage induced by chronic hypoxia on medulla oblongata through measuring malondialdehyde (mda) content and superoxide dismutase (sod) activity, and rt-pcr technique was used to study the influence of apoptosis induced by chronic hypoxia on medulla oblongata through analyzing the levels of bax mrna and bcl-2 mrna. |
2013-10-31 |
2023-08-12 |
rat |
| Ashish Dwivedi, Manish Kumar Pal, Amit Kumar Tripathi, Neera Yadav, Syed Faiz Mujtaba, M C Pant, Shio Kumar Singh, Durga Prasad Mishra, Ratan Singh Ray, B H Manjunatha Prabh. Role of type-II pathway in apoptotic cell death induction by photosensitized CDRI-97/78 under ambient exposure of UV-B. Toxicology letters. vol 222. issue 2. 2013-10-31. PMID:23769964. |
in conclusion, the study highlights ros mediated dna damage, lysosomal and mitochondrial destabilization via upregulation of bax and activation of caspase-3 which further leads to apoptosis. |
2013-10-31 |
2023-08-12 |
Not clear |
| Jinling Cao, Jianjie Chen, Jundong Wang, Ruhui Jia, Wenjuan Xue, Yongju Luo, Xi Ga. Effects of fluoride on liver apoptosis and Bcl-2, Bax protein expression in freshwater teleost, Cyprinus carpio. Chemosphere. vol 91. issue 8. 2013-10-30. PMID:23415306. |
effects of fluoride on liver apoptosis and bcl-2, bax protein expression in freshwater teleost, cyprinus carpio. |
2013-10-30 |
2023-08-12 |
Not clear |
| Jinling Cao, Jianjie Chen, Jundong Wang, Ruhui Jia, Wenjuan Xue, Yongju Luo, Xi Ga. Effects of fluoride on liver apoptosis and Bcl-2, Bax protein expression in freshwater teleost, Cyprinus carpio. Chemosphere. vol 91. issue 8. 2013-10-30. PMID:23415306. |
this study was conducted to evaluate oxidative stress, histopathological changes, apoptosis and bcl-2, bax expression in the livers of the common carp (cyprinus carpio) chronically exposed to fluoride. |
2013-10-30 |
2023-08-12 |
Not clear |
| Yuan Zhang, Sobia Iqbal, Michael F N O'Leary, Keir J Menzies, Ayesha Saleem, Shuzhe Ding, David A Hoo. Altered mitochondrial morphology and defective protein import reveal novel roles for Bax and/or Bak in skeletal muscle. American journal of physiology. Cell physiology. vol 305. issue 5. 2013-10-30. PMID:23784543. |
the function bax and/or bak in constituting a gateway for mitochondrial apoptosis in response to apoptotic stimuli has been unequivocally demonstrated. |
2013-10-30 |
2023-08-12 |
mouse |
| Ertan Kucuksayan, Aysegul Cort, Mujgan Timur, Evrim Ozdemir, Suleyman Gultekin Yucel, Tomris Ozbe. N-acetyl-L-cysteine inhibits bleomycin induced apoptosis in malignant testicular germ cell tumors. Journal of cellular biochemistry. vol 114. issue 7. 2013-10-29. PMID:23386420. |
we determined the cytotoxic effect of bleomycin on nt2 cells and measured apoptosis markers such as caspase-3, -8, -9 activities and bcl-2, bax, cyt-c, annexin v-ftic and pi levels in nt2 cells incubated with different agents for 24 h. early apoptosis was determined using facs assay. |
2013-10-29 |
2023-08-12 |
human |
| Lakkyong Hwang, In-Young Choi, Sung-Eun Kim, Il-Gyu Ko, Mal-Soon Shin, Chang-Ju Kim, Sang-Hoon Kim, Jun-Jang Jin, Jun-Young Chung, Jae-Woo Y. Dexmedetomidine ameliorates intracerebral hemorrhage-induced memory impairment by inhibiting apoptosis and enhancing brain-derived neurotrophic factor expression in the rat hippocampus. International journal of molecular medicine. vol 31. issue 5. 2013-10-29. PMID:23503673. |
terminal deoxynucleotidyl transferase‑mediated dutp nick end-labeling (tunel) assay, immunohistochemistry for caspase‑3, and western blot analysis for bcl‑2, bax, bid and caspase-3 expression were performed for the detection of apoptosis in the hippocampus. |
2013-10-29 |
2023-08-12 |
rat |
| Jung-Il Chae, Young-Joo Jeon, Jung-Hyun Shi. Downregulation of Sp1 is involved in honokiol-induced cell cycle arrest and apoptosis in human malignant pleural mesothelioma cells. Oncology reports. vol 29. issue 6. 2013-10-29. PMID:23525508. |
hnk reduced the transcriptional activity of sp1 regulatory proteins, including cyclin d1, mcl-1 and survivin, and, thus, induced apoptosis signaling pathways by increasing bax, reducing bid and bcl-xl and activating caspase-3 and parp in mesothelioma cells. |
2013-10-29 |
2023-08-12 |
human |
| Aiping Wang, Baochao Zhang, Jiandang Zhang, Wei Wu, Wei W. Embelin-induced brain glioma cell apoptosis and cell cycle arrest via the mitochondrial pathway. Oncology reports. vol 29. issue 6. 2013-10-29. PMID:23545899. |
additionally, embelin regulated the shifting of bax and bcl-2 to promote the mitochondrial release of cytochrome c, thus activating the caspase proteins to cause apoptosis. |
2013-10-29 |
2023-08-12 |
Not clear |
| Guo-Qing Bao, Bai-Yong Shen, Chun-Peng Pan, Ya-Jing Zhang, Min-Min Shi, Cheng-Hong Pen. Andrographolide causes apoptosis via inactivation of STAT3 and Akt and potentiates antitumor activity of gemcitabine in pancreatic cancer. Toxicology letters. vol 222. issue 1. 2013-10-29. PMID:23845849. |
interestingly, andro induces cell cycle arrest and apoptosis of pancreatic cancer cells by inhibiting stat3 and akt activation, upregulating the expression of p21(waf1) and bax, and downregulating the expression of cyclind1, cycline, survivin, x-iap and bcl-2. |
2013-10-29 |
2023-08-12 |
human |
| Ming-Yue Li, Nian Ci Liang, George G Che. Ent-11α-hydroxy-15-oxo-kaur-16-en-19-oic-acid induces apoptosis of human malignant cancer cells. Current drug targets. vol 13. issue 14. 2013-10-25. PMID:23140284. |
5f induces apoptosis of cancer cells by inhibiting nf-κb activation/induction, which leading to the decrease of bcl-2 but the increase of bax and bak. |
2013-10-25 |
2023-08-12 |
human |
| N Echeverry, D Bachmann, F Ke, A Strasser, H U Simon, T Kaufman. Intracellular localization of the BCL-2 family member BOK and functional implications. Cell death and differentiation. vol 20. issue 6. 2013-10-25. PMID:23429263. |
based on these results, we propose that major functions of bok are exerted at the golgi and er membranes and that bok induces apoptosis in a manner dependent on bax and bak. |
2013-10-25 |
2023-08-12 |
human |
| Wenchang Zhang, Lei Huang, Cancan Kong, Jin Liu, Lingfeng Luo, Huiling Huan. Apoptosis of rat ovarian granulosa cells by 2,5-hexanedione in vitro and its relevant gene expression. Journal of applied toxicology : JAT. vol 33. issue 7. 2013-10-24. PMID:22337490. |
in summary, our results indicate that hd can induce the apoptosis of ovarian granulosa cell, and the occurrence of apoptosis is related to inhibition of protein expression of nf-κb, activation of nf-κb, upregulation of mrna levels of fasl and bax, and downregulation of mrna levels of xiap and bcl-2. |
2013-10-24 |
2023-08-12 |
rat |
| Mi Hwa Park, You-Jin Jeon, Hak-Ju Kim, Ji Sook Ha. Effect of diphlorethohydroxycarmalol isolated from Ishige okamurae on apoptosis in 3 T3-L1 preadipocytes. Phytotherapy research : PTR. vol 27. issue 6. 2013-10-24. PMID:23007872. |
our findings indicate that the induction of apoptosis in 3 t3-l1 preadipocytes by dphc is mediated through the activation of caspase-3, bax, and caspase-9, and then through the cleavage of poly(adp-ribose) polymerase and the down-regulation of bcl-2. |
2013-10-24 |
2023-08-12 |
Not clear |
| Xin-Lan Lu, Jin Zeng, Yu-Le Chen, Peng-Mei He, Mai-Xia Wen, Mu-Dan Ren, Ya-Nan Hu, Gui-Fang Lu, Shui-Χiang H. Sinomenine hydrochloride inhibits human hepatocellular carcinoma cell growth in vitro and in vivo: involvement of cell cycle arrest and apoptosis induction. International journal of oncology. vol 42. issue 1. 2013-10-24. PMID:23165705. |
additionally, sh induced caspase‑dependent apoptosis, which involved the disruption of mitochondrial membrane potential, the increased release of cytochrome c and omi/htra2 from the mitochondria into the cytoplasm, the downregulation of bcl‑2 and the upregulation of bax, the activation of a caspase cascade (caspase‑8, -10, -9 and -3) and parp, as well as the decreased expression of survivin. |
2013-10-24 |
2023-08-12 |
mouse |
| Massimo Collino, Alessandro Pini, Niccolò Mugelli, Rosanna Mastroianni, Daniele Bani, Roberto Fantozzi, Laura Papucci, Marilena Fazi, Emanuela Masin. Beneficial effect of prolonged heme oxygenase 1 activation in a rat model of chronic heart failure. Disease models & mechanisms. vol 6. issue 4. 2013-10-24. PMID:23592614. |
the ischemic hearts of the hemin-treated animals displayed reduced oxidative stress and apoptosis in comparison with the non-treated rats, as shown by the decreased levels of lipid peroxidation, free-radical-induced dna damage, caspase-3 activity and bax expression. |
2013-10-24 |
2023-08-12 |
rat |