| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Hideyuki Iwayama, Norishi Ued. Role of mitochondrial Bax, caspases, and MAPKs for ceramide-induced apoptosis in renal proximal tubular cells. Molecular and cellular biochemistry. vol 379. issue 1-2. 2013-12-27. PMID:23543151. |
apoptosis and expression of mitochondrial bax and p-mapks were measured by hoechst 33258 staining and western blotting. |
2013-12-27 |
2023-08-12 |
Not clear |
| Hideyuki Iwayama, Norishi Ued. Role of mitochondrial Bax, caspases, and MAPKs for ceramide-induced apoptosis in renal proximal tubular cells. Molecular and cellular biochemistry. vol 379. issue 1-2. 2013-12-27. PMID:23543151. |
c2-ceramide, but not dihydroc2-ceramide, inactive c2-ceramide, induced apoptosis at 24 h. c2-ceramide enhanced the mitochondrial bax expression at 1 h, which was peaked at 3-6 h and decreased at 24 h, but remained increased, compared to control. |
2013-12-27 |
2023-08-12 |
Not clear |
| Hideyuki Iwayama, Norishi Ued. Role of mitochondrial Bax, caspases, and MAPKs for ceramide-induced apoptosis in renal proximal tubular cells. Molecular and cellular biochemistry. vol 379. issue 1-2. 2013-12-27. PMID:23543151. |
egf, which enhanced the expression of p-erk and p-p38mapk but not p-jnk, ameliorated c2-ceramide-induced apoptosis without affecting mitochondrial bax. |
2013-12-27 |
2023-08-12 |
Not clear |
| Hideyuki Iwayama, Norishi Ued. Role of mitochondrial Bax, caspases, and MAPKs for ceramide-induced apoptosis in renal proximal tubular cells. Molecular and cellular biochemistry. vol 379. issue 1-2. 2013-12-27. PMID:23543151. |
mitochondrial bax and caspases, but not mapks, play a role for ceramide-induced apoptosis in rptcs. |
2013-12-27 |
2023-08-12 |
Not clear |
| Shun X Ren, Jin Shen, Alfred S L Cheng, Lan Lu, Ruby L Y Chan, Zhi J Li, Xiao J Wang, Clover C M Wong, Lin Zhang, Simon S M Ng, Franky L Chan, Francis K L Chan, Jun Yu, Joseph J Y Sung, William K K Wu, Chi H Ch. FK-16 derived from the anticancer peptide LL-37 induces caspase-independent apoptosis and autophagic cell death in colon cancer cells. PloS one. vol 8. issue 5. 2013-12-24. PMID:23700428. |
knockdown of p53, genetic ablation of bax, or overexpression of bcl-2 reversed fk-16-induced apoptosis and autophagy. |
2013-12-24 |
2023-08-12 |
Not clear |
| Nishant Mohan, Walden Ai, Mrinmay Chakrabarti, Naren L Banik, Swapan K Ra. KLF4 overexpression and apigenin treatment down regulated anti-apoptotic Bcl-2 proteins and matrix metalloproteinases to control growth of human malignant neuroblastoma SK-N-DZ and IMR-32 cells. Molecular oncology. vol 7. issue 3. 2013-12-23. PMID:23317647. |
we also noticed that the combination therapy decreased expression of the anti-apoptotic proteins bcl-2 and mcl-1, increased expression of the pro-apoptotic proteins bax, noxa, and puma, upregulated p53, and caused activation of caspase-3 for cleavage of the inhibitor of caspase-activated dnase (icad) leading to completion of apoptosis machinery. |
2013-12-23 |
2023-08-12 |
human |
| Man Zou, Shu Xia, Liang Zhuang, Na Han, Qian Chu, Tengfei Chao, Ping Peng, Yu Chen, Qi Gui, Shiying Y. Knockdown of the Bcl-2 gene increases sensitivity to EGFR tyrosine kinase inhibitors in the H1975 lung cancer cell line harboring T790M mutation. International journal of oncology. vol 42. issue 6. 2013-12-23. PMID:23588221. |
we analyzed the protein levels of p-akt, bcl-2, bax between gefitinib-sensitive and gefitinib-resistant lung cancer cell lines and evaluated whether targeting the anti-apoptotic protein bcl-2 induces cell apoptosis and further sensitizes resistant h1975 cells to gefitinib. |
2013-12-23 |
2023-08-12 |
Not clear |
| Xiao-Ming Liu, Fei-Fei Yang, Yi-Feng Yuan, Rui Zhai, Li-Jun Hu. SUMOylation of mouse p53b by SUMO-1 promotes its pro-apoptotic function in ovarian granulosa cells. PloS one. vol 8. issue 5. 2013-12-23. PMID:23696846. |
overexpression of wild-type p53b, but not the mutation of sumoylation site (k375r), significantly induced the expression of apoptosis-related gene, bax, and increased the level of apoptosis in granulosa cells. |
2013-12-23 |
2023-08-12 |
mouse |
| Maria A Carvalho Rodrigues, Marcia C da Silva Faria, Neife A G dos Santos, Glenda C Gobe, Antonio Cardozo dos Santo. Carvedilol efficiently protects kidneys without affecting the antitumor efficacy of cisplatin in mice. Chemico-biological interactions. vol 206. issue 1. 2013-12-23. PMID:24012798. |
the mechanism of protection was associated with significantly decreased (i) oxidative stress markers, (ii) bax expression, (iii) caspase-3 activity and (iv) tunel labeling for apoptosis. |
2013-12-23 |
2023-08-12 |
mouse |
| Annabelle Ballesta, Jonathan Lopez, Nikolay Popgeorgiev, Philippe Gonzalo, Marie Doumic, Germain Gille. Data-driven modeling of SRC control on the mitochondrial pathway of apoptosis: implication for anticancer therapy optimization. PLoS computational biology. vol 9. issue 4. 2013-12-19. PMID:23592961. |
indeed, they all involved bax downregulation such that bax levels would still be high enough to induce apoptosis in src-transformed cells but not in parental ones. |
2013-12-19 |
2023-08-12 |
mouse |
| Yun-Yu Sun, Shu-Jun Wang, Bao-An Chen, Guo-Hua Xia, Jia-Hua Ding, Chong Gao, Hui-Hui Song, Qing-Long Guo, Hai-Wei Zhang, Chun-Rui Li, Jian-Feng Zho. [Effect of gambogic acid on proliferation of SKM-1 cells and its mechanism]. Zhongguo shi yan xue ye xue za zhi. vol 21. issue 1. 2013-12-16. PMID:23484701. |
the expression of bax mrna was up-regulated while that of bcl-2 mrna was down-regulated in skm-1 cells treated with ga for 48 h. it is concluded that ga can induce apoptosis, which may be related to its effect of arresting cells at phase of g0/g1 and down-regulating bcl-2/bax ratio. |
2013-12-16 |
2023-08-12 |
Not clear |
| Shu-ying Yang, Lei Zhang, Ke-ke Miao, Wei Qian, Zi-gui Zhan. Effects of selenium intervention on chronic fluorosis-induced renal cell apoptosis in rats. Biological trace element research. vol 153. issue 1-3. 2013-12-16. PMID:23591959. |
apoptosis was detected by terminal deoxynucleotidyl transferase-mediated dutp nick-end labeling assay and the expressions of bcl-2 and bax proteins were detected by immunohistochemical methods. |
2013-12-16 |
2023-08-12 |
rat |
| Shu-ying Yang, Lei Zhang, Ke-ke Miao, Wei Qian, Zi-gui Zhan. Effects of selenium intervention on chronic fluorosis-induced renal cell apoptosis in rats. Biological trace element research. vol 153. issue 1-3. 2013-12-16. PMID:23591959. |
selenium may inhibit the apoptosis of renal cells in fluorosis rats by regulating the expressions of bcl-2 and bax. |
2013-12-16 |
2023-08-12 |
rat |
| Quanxin Gao, Lili Qi, Tianxing Wu, Jinbo Wan. Ability of Clostridium butyricum to inhibit Escherichia coli-induced apoptosis in chicken embryo intestinal cells. Veterinary microbiology. vol 160. issue 3-4. 2013-12-13. PMID:22771207. |
c. butyricum also showed a significant inhibitory effect on ehec-induced apoptosis by modulating the expression of xiap (x-linked inhibitor of apoptosis protein), bclxl (b-cell lymphoma-extra large), fas, bcl2 (b-cell leukemia/lymphoma-2), bax (bcl-2-associated x protein), p53 (tumor protein 53) and via inhibition of caspase-9 and caspase-3 activation. |
2013-12-13 |
2023-08-12 |
chicken |
| Salimeh Ebrahimnezhad Darzi, Zahra Amirghofra. Dichloromethane fraction of Melissa officinalis induces apoptosis by activation of intrinsic and extrinsic pathways in human leukemia cell lines. Immunopharmacology and immunotoxicology. vol 35. issue 3. 2013-12-13. PMID:23432355. |
this fraction up-regulated fas and bax mrna expression as well as the bax/bcl-2 ratio according to cell type, showing its effect on the activation of both extrinsic and intrinsic pathways of apoptosis. |
2013-12-13 |
2023-08-12 |
human |
| A-Rang Im, Young-Hwa Kim, Md Romij Uddin, Seong Wook Chae, Hye Won Lee, Woo Suk Jung, Yun Hee Kim, Bong Ju Kang, Yeong Shik Kim, Mi-Young Le. Protection from antimycin A-induced mitochondrial dysfunction by Nelumbo nucifera seed extracts. Environmental toxicology and pharmacology. vol 36. issue 1. 2013-12-12. PMID:23542413. |
we found that the extracts reduced cellular apoptosis; preserved the mitochondrial membrane potential; protected mitochondrial atp production; inhibited p53, bax, and caspase 3 activities; and induced bcl-2 production. |
2013-12-12 |
2023-08-12 |
rat |
| Jun Liao, Teng Xu, Jia-Xuan Zheng, Jiu-Mao Lin, Qiao-Yan Cai, De-Biao Yu, Jun Pen. Nitidine chloride inhibits hepatocellular carcinoma cell growth in vivo through the suppression of the JAK1/STAT3 signaling pathway. International journal of molecular medicine. vol 32. issue 1. 2013-12-10. PMID:23613111. |
the analysis of the effects of nc on apoptosis in hcc tumor xenografts in mice was carried out by terminal deoxynucleotidyl transferase-mediated dutp nick end-labeling (tunel) assay; the expression of bcl-2, bax, cyclin-dependent kinase (cdk)4, cyclin d1, p21 and proliferating cell nuclear antigen (pcna) was analyzed by immunohistochemistry; and the protein expression of jak1 and stat3 was examined by western blot analysis. |
2013-12-10 |
2023-08-12 |
mouse |
| Jun Shirakawa, Yu Togashi, Eri Sakamoto, Mitsuyo Kaji, Kazuki Tajima, Kazuki Orime, Hideaki Inoue, Naoto Kubota, Takashi Kadowaki, Yasuo Terauch. Glucokinase activation ameliorates ER stress-induced apoptosis in pancreatic β-cells. Diabetes. vol 62. issue 10. 2013-12-10. PMID:23801577. |
gka suppressed the expressions of chop and bcl2-associated x protein (bax) and protected against β-cell apoptosis under er stress in an erk1/2-dependent, irs-2-independent manner. |
2013-12-10 |
2023-08-12 |
mouse |
| Diptiman Choudhury, Paulrajpillai Lourdu Xavier, Kamalesh Chaudhari, Robin John, Anjan Kumar Dasgupta, Thalappil Pradeep, Gopal Chakrabart. Unprecedented inhibition of tubulin polymerization directed by gold nanoparticles inducing cell cycle arrest and apoptosis. Nanoscale. vol 5. issue 10. 2013-12-09. PMID:23584723. |
further, western blot analysis indicated the upregulation of mitochondrial apoptosis proteins such as bax and p53, down regulation of bcl-2 and cleavage of poly(adp-ribose) polymerase (parp) confirming mitochondrial apoptosis. |
2013-12-09 |
2023-08-12 |
Not clear |
| Kristopher A Sarosiek, Xiaoke Chi, John A Bachman, Joshua J Sims, Joan Montero, Luv Patel, Annabelle Flanagan, David W Andrews, Peter Sorger, Anthony Leta. BID preferentially activates BAK while BIM preferentially activates BAX, affecting chemotherapy response. Molecular cell. vol 51. issue 6. 2013-12-09. PMID:24074954. |
therefore, bid and bim have nonoverlapping roles in the induction of apoptosis via bak and bax, affecting chemotherapy response. |
2013-12-09 |
2023-08-12 |
Not clear |