| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Xiao-Xue Du, Yan-Jing Li, Chun-Long Wu, Jian-Hua Zhou, Yu Han, Hong Sui, Xiao-Li Wei, Lei Liu, Peng Huang, Heng-Heng Yuan, Ting-Ting Zhang, Wen-Jie Zhang, Rui Xie, Xiao-Hui Lang, De-Xin Jia, Yu-Xian Ba. Initiation of apoptosis, cell cycle arrest and autophagy of esophageal cancer cells by dihydroartemisinin. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 67. issue 5. 2014-01-21. PMID:23582790. |
the mechanism was at least partially due to dha induced apoptosis by upregulating the expression of bax, downregulating bcl-2, bcl-xl and procaspase-3, and increasing caspase-9 activation, induced cell cycle arrest by downregulating cyclin e, cdk2 and cdk4. |
2014-01-21 |
2023-08-12 |
Not clear |
| Leigh A Humphries, J Claire Godbersen, Olga V Danilova, Prabhjot Kaur, Brock C Christensen, Alexey V Danilo. Pro-apoptotic TP53 homolog TAp63 is repressed via epigenetic silencing and B-cell receptor signalling in chronic lymphocytic leukaemia. British journal of haematology. vol 163. issue 5. 2014-01-21. PMID:24117128. |
sirna-mediated knockdown of tp63 resulted in partial protection from spontaneous apoptosis accompanied by reductions in pmaip1 (noxa), bbc3 (puma), and bax mrna in cll cells and increased proliferation of raji lymphoma cells. |
2014-01-21 |
2023-08-12 |
Not clear |
| Jolanta Dorszewsk. Cell biology of normal brain aging: synaptic plasticity-cell death. Aging clinical and experimental research. vol 25. issue 1. 2014-01-20. PMID:23740630. |
in the aging brain, apoptosis does not seem to be activated in wild-type p53-expressing cells because the elevated levels of the p53 protein are no longer accompanied by decreased levels of the bcl-2 protein and increased levels of the bax protein. |
2014-01-20 |
2023-08-12 |
Not clear |
| Soo Jin Kwon, So Young Park, Gyoo Taik Kwon, Ki Won Lee, Young-Hee Kang, Myung-Sook Choi, Jong Won Yun, Jae-Ho Jeon, Jong Gab Jun, Jung Han Yoon Par. Licochalcone E present in licorice suppresses lung metastasis in the 4T1 mammary orthotopic cancer model. Cancer prevention research (Philadelphia, Pa.). vol 6. issue 6. 2014-01-16. PMID:23625311. |
in tumor tissues, lice treatment induced a reduction in the expression of ki67, cyclins, and cyclin-dependent kinases and stimulated apoptosis with increased expression of bax and cleaved caspase-3 but decreased expression of bcl-2. |
2014-01-16 |
2023-08-12 |
mouse |
| Chaitanya Mulakayala, Babajan Banaganapalli, Naveen Mulakayala, Madhusudana Pulaganti, Anuradha C M, Suresh Kumar Chitt. Design and evaluation of new chemotherapeutics of aloe-emodin (AE) against the deadly cancer disease: an in silico study. Journal of chemical biology. vol 6. issue 3. 2014-01-16. PMID:24432130. |
since bax-mediated induction of apoptosis is a crucial mechanism in cancerous cells, we aimed at conducting in silico analysis on bax in order to predict the possible interactions for anticancer agents. |
2014-01-16 |
2023-08-12 |
Not clear |
| Aifeng Zhai, Xiaonan Zhu, Xuelan Wang, Ruzhu Chen, Hai Wan. Secalonic acid A protects dopaminergic neurons from 1-methyl-4-phenylpyridinium (MPP⁺)-induced cell death via the mitochondrial apoptotic pathway. European journal of pharmacology. vol 713. issue 1-3. 2014-01-13. PMID:23665112. |
these results indicate that the activation of jnk, p38 mitogen activated protein kinase (mapk) and caspase-3 during apoptosis triggered by mpp(+) could be suppressed by saa; on the other hand, an mpp(+)-induced increase in the expression of bax in sh-sy5y cells was blocked by saa. |
2014-01-13 |
2023-08-12 |
mouse |
| Hongbo Li, Baoying Wang, Chunhui Zhu, Yan Feng, Shaolan Wang, Muhammad Shahzad, Chenghu Hu, Mingshu Mo, Fangying Du, Xiaorui Y. 17β-estradiol impedes Bax-involved mitochondrial apoptosis of retinal nerve cells induced by oxidative damage via the phosphatidylinositol 3-kinase/Akt signal pathway. Journal of molecular neuroscience : MN. vol 50. issue 3. 2014-01-10. PMID:23361188. |
in response to h(2)o(2)-induced apoptosis, bax, acting as one of the pivotal pro-apoptotic members of bcl-2 family, increased significantly, which directly resulted in an increased ratio of bax to anti-apoptotic protein bcl-2 (bax/bcl-2). |
2014-01-10 |
2023-08-12 |
Not clear |
| Diana M González-Gironès, Cristina Moncunill-Massaguer, Daniel Iglesias-Serret, Ana M Cosialls, Alba Pérez-Perarnau, Claudia M Palmeri, Camila Rubio-Patiño, Andreas Villunger, Gabriel Pons, Joan Gi. AICAR induces Bax/Bak-dependent apoptosis through upregulation of the BH3-only proteins Bim and Noxa in mouse embryonic fibroblasts. Apoptosis : an international journal on programmed cell death. vol 18. issue 8. 2014-01-10. PMID:23605481. |
notably, mefs lacking bax and bak were completely resistant to aicar-induced apoptosis, confirming the involvement of the mitochondrial pathway in its mechanism of action. |
2014-01-10 |
2023-08-12 |
mouse |
| Teruyoshi Saito, Dai Tamura, Tatsuro Nakamura, Yukihisa Makita, Hitomi Ariyama, Keiji Komiyama, Tomoko Yoshihara, Ryuji Asan. 4-methylumbelliferone leads to growth arrest and apoptosis in canine mammary tumor cells. Oncology reports. vol 29. issue 1. 2014-01-09. PMID:23124556. |
in particular, our experiments showed that the mechanism of 4-mu-induced apoptosis in cf33 cells involved increased levels of expression of pro-apoptotic bax mrna and protein molecules. |
2014-01-09 |
2023-08-12 |
human |
| Decha Pinkaew, Rachel J Le, Yanjie Chen, Mahmoud Eltorky, Ba-Bie Teng, Ken Fujis. Fortilin reduces apoptosis in macrophages and promotes atherosclerosis. American journal of physiology. Heart and circulatory physiology. vol 305. issue 10. 2014-01-09. PMID:24043250. |
furthermore, peritoneal macrophages from fortilin(+/-) mice expressed more bax and underwent increased apoptosis, both at the baseline level and in response to oxidized ldl. |
2014-01-09 |
2023-08-12 |
mouse |
| Wen-jing Liu, Shu-yang Zhu, Yu-ling Chen, Xia Wu, Wen-jing Ni, Yun-feng Chen, Ling Zha. [The effects of leptin on apoptosis of airway smooth muscle cells via the PI3K/Akt signaling pathway]. Zhonghua jie he he hu xi za zhi = Zhonghua jiehe he huxi zazhi = Chinese journal of tuberculosis and respiratory diseases. vol 35. issue 12. 2014-01-07. PMID:23328183. |
to observe the effects of leptin on the expression of akt, pho-akt, bcl-2, bax, caspase-3 and the apoptosis of airway smooth muscle cells (asmcs), and to explore the possible mechanisms. |
2014-01-07 |
2023-08-12 |
Not clear |
| Thibaud T Renault, Konstantinos V Floros, Jerry E Chipu. BAK/BAX activation and cytochrome c release assays using isolated mitochondria. Methods (San Diego, Calif.). vol 61. issue 2. 2014-01-07. PMID:23567751. |
the mitochondrial pathway of apoptosis proceeds when the outer mitochondrial membrane (omm) is compromised by the pro-apoptotic bcl-2 family members, bak and bax. |
2014-01-07 |
2023-08-12 |
Not clear |
| Thibaud T Renault, Konstantinos V Floros, Jerry E Chipu. BAK/BAX activation and cytochrome c release assays using isolated mitochondria. Methods (San Diego, Calif.). vol 61. issue 2. 2014-01-07. PMID:23567751. |
the use of isolated mitochondria has been instrumental to understanding the key interactions necessary to engage bak and bax activation, momp, and apoptosis. |
2014-01-07 |
2023-08-12 |
Not clear |
| Yoko Matsumoto, E Cao, Ryuichi Ueok. Growth inhibition by novel liposomes including trehalose surfactant against hepatocarcinoma cells along with apoptosis. Anticancer research. vol 33. issue 11. 2014-01-07. PMID:24222107. |
release of cytochrome c from mitochondria and activation of bcl-2 family protein (bax) were recorded, indicating that dmtrecn induced apoptosis of hep-g2 and huh-7 cells through mitochondrial pathway via bax. |
2014-01-07 |
2023-08-12 |
human |
| Shahram Misaghi, Yan Qu, Andrew Snowden, Jennifer Chang, Brad Snedeco. Resilient immortals, characterizing and utilizing Bax/Bak deficient Chinese hamster ovary (CHO) cells for high titer antibody production. Biotechnology progress. vol 29. issue 3. 2014-01-06. PMID:23596153. |
here we demonstrate that puromycin, but not methotrexate, selection can be used to generate antibody-expressing bax and bak deficient clones that are not only resistant to apoptosis, but that can also achieve higher titers relative to parental cho cells due to higher cell density. |
2014-01-06 |
2023-08-12 |
Not clear |
| Shahram Misaghi, Yan Qu, Andrew Snowden, Jennifer Chang, Brad Snedeco. Resilient immortals, characterizing and utilizing Bax/Bak deficient Chinese hamster ovary (CHO) cells for high titer antibody production. Biotechnology progress. vol 29. issue 3. 2014-01-06. PMID:23596153. |
bax and bak deficient cells do not readily apoptose, as shown by the ability to withstand high concentrations of apoptosis inducing agents, such as sodium butyrate, without a reduction in viability, growth, or titer. |
2014-01-06 |
2023-08-12 |
Not clear |
| Gabriel Ichim, Anne-Laure Genevois, Marie Ménard, Li-Ying Yu, Juliana M Coelho-Aguiar, Fabien Llambi, Loraine Jarrosson-Wuilleme, Jonathan Lefebvre, David Tulasne, Elisabeth Dupin, Nicole Le Douarin, Urmas Arumäe, Servane Tauszig-Delamasure, Patrick Mehle. The dependence receptor TrkC triggers mitochondria-dependent apoptosis upon Cobra-1 recruitment. Molecular cell. vol 51. issue 5. 2014-01-06. PMID:24034695. |
cobra1 shuttles trkc kf to the mitochondria, where it promotes bax activation, cytochrome c release, and apoptosome-dependent apoptosis. |
2014-01-06 |
2023-08-12 |
chicken |
| Andrew J Crowther, Vivian Gama, Ariana Bevilacqua, Sha X Chang, Hong Yuan, Mohanish Deshmukh, Timothy R Gersho. Tonic activation of Bax primes neural progenitors for rapid apoptosis through a mechanism preserved in medulloblastoma. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 33. issue 46. 2014-01-06. PMID:24227720. |
tonic activation of bax primes neural progenitors for rapid apoptosis through a mechanism preserved in medulloblastoma. |
2014-01-06 |
2023-08-12 |
mouse |
| Andrew J Crowther, Vivian Gama, Ariana Bevilacqua, Sha X Chang, Hong Yuan, Mohanish Deshmukh, Timothy R Gersho. Tonic activation of Bax primes neural progenitors for rapid apoptosis through a mechanism preserved in medulloblastoma. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 33. issue 46. 2014-01-06. PMID:24227720. |
disruption of bax:bcl-xl binding by bh3-mimetic abt 737 caused rapid apoptosis of cerebellar progenitors and primary murine medulloblastoma cells. |
2014-01-06 |
2023-08-12 |
mouse |
| M Gokila Vani, K J Senthil Kumar, Jiunn-Wang Liao, Shih-Chang Chien, Jeng-Leun Mau, Shen-Shih Chiang, Chin-Chung Lin, Yueh-Hsiung Kuo, Sheng-Yang Wan. Antcin C from Antrodia cinnamomea Protects Liver Cells Against Free Radical-Induced Oxidative Stress and Apoptosis In Vitro and In Vivo through Nrf2-Dependent Mechanism. Evidence-based complementary and alternative medicine : eCAM. vol 2013. 2014-01-06. PMID:24391672. |
in addition, aaph-induced apoptosis was significantly inhibited by antcin c through the down-regulation of pro-apoptotic factors including, bax, cytochrome c, capase 9, -4, -12, -3, and parp. |
2014-01-06 |
2023-08-12 |
mouse |