| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| F Ke, P Bouillet, T Kaufmann, A Strasser, J Kerr, A K Vos. Consequences of the combined loss of BOK and BAK or BOK and BAX. Cell death & disease. vol 4. 2014-02-25. PMID:23744350. |
the multi-bcl-2 homology domain pro-apoptotic bcl-2 family members bak and bax have critical roles in apoptosis. |
2014-02-25 |
2023-08-12 |
mouse |
| S Obitsu, K Sakata, R Teshima, K Kond. Eleostearic acid induces RIP1-mediated atypical apoptosis in a kinase-independent manner via ERK phosphorylation, ROS generation and mitochondrial dysfunction. Cell death & disease. vol 4. 2014-02-25. PMID:23788031. |
the activation of caspases, bax and parp-1, the cleavage of aif and the phosphorylation of histone h2ax, all of which are characteristics of typical apoptosis, do not occur in esa-treated cells. |
2014-02-25 |
2023-08-12 |
Not clear |
| X-P Xu, D Zhai, E Kim, M Swift, J C Reed, N Volkmann, D Hanei. Three-dimensional structure of Bax-mediated pores in membrane bilayers. Cell death & disease. vol 4. 2014-02-25. PMID:23788040. |
b-cell lymphoma 2 (bcl-2)-associated x protein (bax) is a member of the bcl-2 protein family having a pivotal role in triggering cell commitment to apoptosis. |
2014-02-25 |
2023-08-12 |
Not clear |
| E M Yazlovitskaya, R Uzhachenko, P A Voziyan, W G Yarbrough, A V Ivanov. A novel radioprotective function for the mitochondrial tumor suppressor protein Fus1. Cell death & disease. vol 4. 2014-02-25. PMID:23788044. |
at the molecular level, dysregulated dynamics of activation of main ir response proteins (p53, nfκb, and gsk-3β), as well as key signaling pathways involved in oxidative stress response (sod2, prdx1, and cytochrome c), apoptosis (bax and parp1), cell cycle (cyclins b1 and d1), and dna repair (γh2ax) were found in fus1(-/-) cells after irradiation. |
2014-02-25 |
2023-08-12 |
mouse |
| R A Kireev, E Vara, J A F Tresguerre. Growth hormone and melatonin prevent age-related alteration in apoptosis processes in the dentate gyrus of male rats. Biogerontology. vol 14. issue 4. 2014-02-25. PMID:23852044. |
aging in the dentate gyrus was associated with an increase in apoptosis promoting markers (bax, bad and aif) and with the reduction of some anti-apoptotic ones (xiap, niap, mcl-1). |
2014-02-25 |
2023-08-12 |
rat |
| J-Y Song, S-H Ryu, Y M Cho, Y S Kim, B-M Lee, S-W Lee, J Cho. Wip1 suppresses apoptotic cell death through direct dephosphorylation of BAX in response to γ-radiation. Cell death & disease. vol 4. 2014-02-25. PMID:23907458. |
in this study, we show that wip1 interacts with and dephosphorylates bax to suppress bax-mediated apoptosis in response to γ-irradiation in prostate cancer cells. |
2014-02-25 |
2023-08-12 |
human |
| J-Y Song, S-H Ryu, Y M Cho, Y S Kim, B-M Lee, S-W Lee, J Cho. Wip1 suppresses apoptotic cell death through direct dephosphorylation of BAX in response to γ-radiation. Cell death & disease. vol 4. 2014-02-25. PMID:23907458. |
overexpression of wip1 and bax, but not phosphatase-dead wip1, in bax-deficient cells strongly reduces apoptosis. |
2014-02-25 |
2023-08-12 |
human |
| A Chimento, I Casaburi, M Bartucci, M Patrizii, R Dattilo, P Avena, S Andò, V Pezzi, R Siriann. Selective GPER activation decreases proliferation and activates apoptosis in tumor Leydig cells. Cell death & disease. vol 4. 2014-02-25. PMID:23907461. |
apoptosis after g-1 treatment was asserted by appearance of dna condensation and fragmentation, decrease in bcl-2 and increase in bax expression, cytochrome c release, caspase and poly (adp-ribose) polymerase-1 (parp-1) activation. |
2014-02-25 |
2023-08-12 |
mouse |
| Aaron D Dam, Andrew S Mitchell, Joe Quadrilater. Induction of mitochondrial biogenesis protects against caspase-dependent and caspase-independent apoptosis in L6 myoblasts. Biochimica et biophysica acta. vol 1833. issue 12. 2014-02-24. PMID:23643731. |
analysis of several key apoptosis regulatory proteins (arc, bax, bcl-2, xiap), antioxidant proteins (catalase, mnsod, cuznsod), and reactive oxygen species (ros) measures (dcf and mitosox fluorescence) revealed that these mechanisms were not responsible for the observed cellular protection. |
2014-02-24 |
2023-08-12 |
Not clear |
| D R Cui, L Wang, W Jiang, A H Qi, Q H Zhou, X L Zhan. Propofol prevents cerebral ischemia-triggered autophagy activation and cell death in the rat hippocampus through the NF-κB/p53 signaling pathway. Neuroscience. vol 246. 2014-02-24. PMID:23644056. |
the change in target genes including damage-regulated autophagy modulator (dram), microtubule-associated protein 1 light chain 3 (lc3), beclin 1, cathepsin d, cathepsin b, p53-upregulated modulator of apoptosis (puma), bax and bcl-2 upon p53 inhibition was assessed with the co-administration of the intravenous anesthetic propofol and 3-methyladenine (3-ma), pifithrin-alpha (pft-α) or sn50. |
2014-02-24 |
2023-08-12 |
rat |
| Hiroki Takahashi, Monica C Chen, Hung Pham, Yoichi Matsuo, Hideyuki Ishiguro, Howard A Reber, Hiromitsu Takeyama, Oscar J Hines, Guido Eib. Simultaneous knock-down of Bcl-xL and Mcl-1 induces apoptosis through Bax activation in pancreatic cancer cells. Biochimica et biophysica acta. vol 1833. issue 12. 2014-02-24. PMID:23954445. |
simultaneous knock-down of bcl-xl and mcl-1 induces apoptosis through bax activation in pancreatic cancer cells. |
2014-02-24 |
2023-08-12 |
human |
| Avital Horowitz, Jason F Lapointe, Rawan Eid, Sara Sheibani, Nada Gharib, Natalie K Jones, Hojatollah Vali, Craig A Mandato, Michael T Greenwoo. The human septin7 and the yeast CDC10 septin prevent Bax and copper mediated cell death in yeast. Biochimica et biophysica acta. vol 1833. issue 12. 2014-02-24. PMID:24055994. |
apoptosis is carried out through a cascade of caspase mediated proteolytic cleavages initiated by the oligomerization of bax, a cardinal regulator of mitochondrial-mediated apoptosis. |
2014-02-24 |
2023-08-12 |
human |
| Avital Horowitz, Jason F Lapointe, Rawan Eid, Sara Sheibani, Nada Gharib, Natalie K Jones, Hojatollah Vali, Craig A Mandato, Michael T Greenwoo. The human septin7 and the yeast CDC10 septin prevent Bax and copper mediated cell death in yeast. Biochimica et biophysica acta. vol 1833. issue 12. 2014-02-24. PMID:24055994. |
heterologous expression of bax in yeast causes cell death that shares a number of similarities to processes that occur in mammalian apoptosis. |
2014-02-24 |
2023-08-12 |
human |
| Huijuan Zhang, Shi Tan, Juan Wang, Shana Chen, Jing Quan, Jingrong Xian, Shuai shuai Zhang, Jingang He, Ling Zhan. Musashi2 modulates K562 leukemic cell proliferation and apoptosis involving the MAPK pathway. Experimental cell research. vol 320. issue 1. 2014-02-24. PMID:24076374. |
in addition, knockdown of msi2 promoted cellular apoptosis via the upregulation of bax and downregulation of bcl-2 expression. |
2014-02-24 |
2023-08-12 |
Not clear |
| Yoko Matsumoto, E Cao, Ryuichi Ueok. Novel liposomes composed of dimyristoylphosphatidylcholine and trehalose surfactants inhibit the growth of tumor cells along with apoptosis. Biological & pharmaceutical bulletin. vol 36. issue 8. 2014-02-21. PMID:23697966. |
dmtre induced apoptosis through the activation of caspases and mitochondria via bax. |
2014-02-21 |
2023-08-12 |
human |
| Jie Cao, Xiaoping Chen, Wanglin Li, Jie Xia, Hong Du, Weibiao Tang, Shanming Chen, Hui Wang, Xiwen Chen, Huanqing Xiao, Yuyuan L. Absence of FHIT expression is associated with apoptosis inhibition in colorectal cancer. Frontiers of medicine in China. vol 1. issue 2. 2014-02-21. PMID:24557667. |
in the second experiment, the protein expression of the fhit and other apoptosis related proteins (bax, bcl-2 and survivin) were measured in human crc by tma. |
2014-02-21 |
2023-08-12 |
human |
| Jie Cao, Xiaoping Chen, Wanglin Li, Jie Xia, Hong Du, Weibiao Tang, Shanming Chen, Hui Wang, Xiwen Chen, Huanqing Xiao, Yuyuan L. Absence of FHIT expression is associated with apoptosis inhibition in colorectal cancer. Frontiers of medicine in China. vol 1. issue 2. 2014-02-21. PMID:24557667. |
both tunel and tma experiments demonstrated significantly inhibited apoptosis by down-regulation of bax and the up-regulation of survivin and bcl-2. |
2014-02-21 |
2023-08-12 |
human |
| Abdelouahid El-Khattouti, Denis Selimovic, Youssef Haïkel, Mosaad Megahed, Christian R Gomez, Mohamed Hassa. Identification and analysis of CD133(+) melanoma stem-like cells conferring resistance to taxol: An insight into the mechanisms of their resistance and response. Cancer letters. vol 343. issue 1. 2014-02-20. PMID:24080340. |
in the cd133(-) subpopulation, the exposure to taxol induced the activation of apoptosis signal-regulating kinase1 (ask1)/c-jun-n-terminal kinase (jnk), p38, extracellular signal regulated kinase (erk) pathways and bax expression, while in cd133(+) cells taxol was able only to enhance the activity of the erk pathway. |
2014-02-20 |
2023-08-12 |
Not clear |
| In Seok Song, Soon-Suk Kang, Eun-Soon Kim, Hyun-Min Park, Chul Young Choi, Hungwon Tchah, Jae Yong Ki. Heat shock protein 27 phosphorylation is involved in epithelial cell apoptosis as well as epithelial migration during corneal epithelial wound healing. Experimental eye research. vol 118. 2014-02-18. PMID:24239511. |
the scratch-induced directional wounding assay, western blotting, using antibodies against non-phosphorylated and phosphorylated hsp27, non-phosphorylated and phosphorylated akt, and bcl-2-associated x protein (bax), immunofluorescence staining to determine the filament actin, flow cytometry to measure apoptosis, and proliferation assay were performed to determine the role of hsp27. |
2014-02-18 |
2023-08-12 |
human |
| T Li, Z-R Dong, Z-Y Guo, C-H Wang, Z-Y Tang, S-F Qu, Z-T Chen, X-W Li, X-T Zh. Aspirin enhances IFN-α-induced growth inhibition and apoptosis of hepatocellular carcinoma via JAK1/STAT1 pathway. Cancer gene therapy. vol 20. issue 6. 2014-02-13. PMID:23703473. |
furthermore, aspirin-activated stat1 upregulated the transcription of proapoptotic ifn-stimulated gene (isg) of x-linked inhibitor of apoptosis-associated factor-1 and downregulated the transcription of antiapoptotic isg of g1p3, which in turn promoted the expression of bax and activation of caspase-9 and caspase-3, thereby sensitizing hcc cells to ifn-α-induced apoptosis. |
2014-02-13 |
2023-08-12 |
mouse |