| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| O V Dolgikh, A V Krivtsov, O A Bubnova, R A Predeina, D G Dianova, O O Sinitsyna, N N Maliutina, L A Taranenk. [Immunogenetic features of apoptosis in workers engaged in methanol production]. Meditsina truda i promyshlennaia ekologiia. issue 11. 2014-04-04. PMID:24640084. |
genetic changes in the main group are associated with reliable decrease in occurrence of transcription protein p53 and tnf receptor, and with altered ratio of intracellular apoptosis factors (bax and bcl-2) towards slower programmed cellular death in chemical production. |
2014-04-04 |
2023-08-12 |
Not clear |
| Doris Mangiaracina Benbrook, Suresh Guruswamy, Yuhong Wang, Zhongjie Sun, Altaf Mohammed, Yuting Zhang, Qian Li, Chinthalapally V Ra. Chemoprevention of colon and small intestinal tumorigenesis in APC(min/+) mice by SHetA2 (NSC721689) without toxicity. Cancer prevention research (Philadelphia, Pa.). vol 6. issue 9. 2014-04-03. PMID:23852423. |
western blot analysis also showed sheta2 induction of e-cadherin, bax, and caspase-3 cleavage along with reduction in bcl-2, cox-2, and vegf, consistent with sheta2 regulation of apoptosis, inflammation, and angiogenesis. |
2014-04-03 |
2023-08-12 |
mouse |
| T An, Y Zhang, Y Huang, R Zhang, S Yin, X Guo, Y Wang, C Zou, B Wei, R Lv, Q Zhou, J Zhan. Neuregulin-1 protects against doxorubicin-induced apoptosis in cardiomyocytes through an Akt-dependent pathway. Physiological research. vol 62. issue 4. 2014-04-02. PMID:23590603. |
activation of apoptosis was determined by observing increases in the protein levels of classic apoptosis markers (including cleaved caspase-3, cytochrome c, bcl-2, bax and terminal deoxynucleotidyl transferase-mediated deoxyuridine triphosphate nick-end labeling (tunel) staining). |
2014-04-02 |
2023-08-12 |
human |
| Ayal Ben-Zvi, Sahar Sweetat, Oded Beha. Elimination of aberrant DRG circuitries in Sema3A mutant mice leads to extensive neuronal deficits. PloS one. vol 8. issue 7. 2014-04-02. PMID:23922915. |
we crossed bax null mice, in which drg apoptosis is blocked, with sema3a null mice to induce errors. |
2014-04-02 |
2023-08-12 |
mouse |
| Samik Chakraborty, Minakshi Mazumdar, Shravanti Mukherjee, Pushpak Bhattacharjee, Arghya Adhikary, Argha Manna, Sreeparna Chakraborty, Poulami Khan, Aparna Sen, Tanya Da. Restoration of p53/miR-34a regulatory axis decreases survival advantage and ensures Bax-dependent apoptosis of non-small cell lung carcinoma cells. FEBS letters. vol 588. issue 4. 2014-04-02. PMID:24444609. |
in such a proapoptotic cellular milieu, where drug resistance proteins are also down-regulated, p53-transactivated bcl-2 associated x protein (bax) induces apoptosis via the mitochondrial death cascade. |
2014-04-02 |
2023-08-12 |
Not clear |
| Hui Ma, Qing Fan, Jia Yu, Jile Xin, Ce Zhan. Anticancer activities of tanshinone microemulsion against hepatocellular carcinoma in vitro and in vivo. Molecular medicine reports. vol 7. issue 1. 2014-04-01. PMID:23064251. |
the mrna and protein levels of apoptosis related molecules (bcl-2 and bax) were analyzed in h22 murine hepatoma cells and h22 tumor-bearing mice by flow cytometry, rt-pcr and immunofluorescence staining. |
2014-04-01 |
2023-08-12 |
mouse |
| Hyun Soo Park, Hye Jin Hwang, Gi-Young Kim, Hee-Jae Cha, Wun-Jae Kim, Nam Deuk Kim, Young Hyun Yoo, Yung Hyun Cho. Induction of apoptosis by fucoidan in human leukemia U937 cells through activation of p38 MAPK and modulation of Bcl-2 family. Marine drugs. vol 11. issue 7. 2014-04-01. PMID:23880928. |
the increase in apoptosis was associated with the proteolytic activation of caspases, bid cleavage, insertion of pro-apoptotic bax into the mitochondria, release of cytochrome c from mitochondria to cytosol, and loss of mitochondria membrane potential (mmp) in u937 cells. |
2014-04-01 |
2023-08-12 |
human |
| Hyun Soo Park, Hye Jin Hwang, Gi-Young Kim, Hee-Jae Cha, Wun-Jae Kim, Nam Deuk Kim, Young Hyun Yoo, Yung Hyun Cho. Induction of apoptosis by fucoidan in human leukemia U937 cells through activation of p38 MAPK and modulation of Bcl-2 family. Marine drugs. vol 11. issue 7. 2014-04-01. PMID:23880928. |
furthermore, fucoidan treatment effectively activated the p38 mitogen-activated protein kinase (mapk) and p38 mapk inhibitor, sb203580, and significantly reduced fucoidan-induced apoptosis through inhibition of bax translocation and caspases activation, suggesting that the activation of p38 mapk may play a key role in fucoidan-induced apoptosis. |
2014-04-01 |
2023-08-12 |
human |
| Hsing-Hui Li, Jui-Hsin Su, Chien-Chih Chiu, Jen-Jie Lin, Zih-Yan Yang, Wen-Ing Hwang, Yu-Kuei Chen, Yu-Hsuan Lo, Yu-Jen W. Proteomic investigation of the sinulariolide-treated melanoma cells A375: effects on the cell apoptosis through mitochondrial-related pathway and activation of caspase cascade. Marine drugs. vol 11. issue 7. 2014-04-01. PMID:23880933. |
sinulariolide-induced apoptosis is relevant to mitochondrial-mediated apoptosis via caspase-dependent pathways, elucidated by the loss of mitochondrial membrane potential, release of cytochrome c, and activation of bax, bad and caspase-3/-9, as well as suppression of p-bad, bcl-xl and bcl-2. |
2014-04-01 |
2023-08-12 |
human |
| Yu-Li Lo, Wanjen Wang, Cheng-Ta H. 7,3',4'-Trihydroxyisoflavone modulates multidrug resistance transporters and induces apoptosis via production of reactive oxygen species. Toxicology. vol 302. issue 2-3. 2014-03-28. PMID:22914566. |
7,3',4'-thif and/or epi triggered apoptosis through the upregulation of p53, bax, and caspase-9. |
2014-03-28 |
2023-08-12 |
human |
| b' Marko Pezdirc, Bojana \\xc5\\xbdegura, Metka Filipi\\xc4\\x8. Genotoxicity and induction of DNA damage responsive genes by food-borne heterocyclic aromatic amines in human hepatoma HepG2 cells. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association. vol 59. 2014-03-28. PMID:23810796.' |
however, elevated expression of bcl2 and down-regulation of bax may indicate that haas could suppress apoptosis meaning higher probability of damaged cells to survive and mutate. |
2014-03-28 |
2023-08-12 |
human |
| Seung-Hong Lee, Sung-Myung Kang, Seok-Chun Ko, Min-Cheol Kang, You-Jin Jeo. Octaphlorethol A, a novel phenolic compound isolated from Ishige foliacea, protects against streptozotocin-induced pancreatic β cell damage by reducing oxidative stress and apoptosis. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association. vol 59. 2014-03-28. PMID:23871829. |
these effects were mediated by suppressing apoptosis and were associated with increased anti-apoptotic bcl-xl expression and reduced pro-apoptotic bax and cleaved caspase-3 expression. |
2014-03-28 |
2023-08-12 |
rat |
| Adriana Aporta, Elena Catalán, Patricia Galán-Malo, Ariel Ramírez-Labrada, Marta Pérez, Gemma Azaceta, Luis Palomera, Javier Naval, Isabel Marzo, Julián Pardo, Alberto Ane. Granulysin induces apoptotic cell death and cleavage of the autophagy regulator Atg5 in human hematological tumors. Biochemical pharmacology. vol 87. issue 3. 2014-03-28. PMID:24269628. |
granulysin-induced apoptosis is prevented in jurkat cells over-expressing bcl-xl or bcl2, or lacking bak and bax or bim expression, suggesting a central role of the mitochondrial apoptotic pathway. |
2014-03-28 |
2023-08-12 |
human |
| Heng Zhou, He-Xin Yang, Yuan Yuan, Wei Deng, Jie-Yu Zhang, Zhou-Yan Bian, Jing Zong, Jia Dai, Qi-Zhu Tan. Paeoniflorin attenuates pressure overload-induced cardiac remodeling via inhibition of TGFβ/Smads and NF-κB pathways. Journal of molecular histology. vol 44. issue 3. 2014-03-27. PMID:23417833. |
cardiomyocyte apoptosis and induction of bax and cleaved caspase3 in response to ab were suppressed by paeoniflorin. |
2014-03-27 |
2023-08-12 |
mouse |
| Masayoshi Yamaguch. The anti-apoptotic effect of regucalcin is mediated through multisignaling pathways. Apoptosis : an international journal on programmed cell death. vol 18. issue 10. 2014-03-26. PMID:23670020. |
suppressive effect of regucalcin on apoptosis is related to inhibition of nuclear ca(2+)-activated dna fragmentation, ca(2+)/calmodulin-dependent nitric oxide synthase, caspase-3, bax, cytochrome c, protein tyrosine kinase, protein tyrosine phosphatase in the cytoplasm and nucleus. |
2014-03-26 |
2023-08-12 |
rat |
| Yi Lu, Zhisong Zhang, Zhenwen Yan, Li Chen, Weimin Deng, Michael Lotze, Zhou Wang, Xinli Lin, Lu-Yuan L. Recombinant GnRH-p53 protein sensitizes breast cancer cells to 5-fluorouracil-induced apoptosis in vitro and in vivo. Apoptosis : an international journal on programmed cell death. vol 18. issue 10. 2014-03-26. PMID:23801079. |
treatments of cells from breast cancer cell-lines mda-mb-231, t47d, or skbr-3 with gnrh-p53 in combination with 5-fu significantly enhanced p53-activated apoptosis signals, including puma expression, bax translocation to mitochondria, and activated caspase-3. |
2014-03-26 |
2023-08-12 |
mouse |
| Ya'nan Li, Dongwei Dai, Qiong Lu, Mingyu Fei, Mengmeng Li, Xi W. Sirt2 suppresses glioma cell growth through targeting NF-κB-miR-21 axis. Biochemical and biophysical research communications. vol 441. issue 3. 2014-03-26. PMID:24161395. |
in addition, sirt2 overexpression induced cellular apoptosis via up-regulating cleaved caspase 3 and bax, and down-regulating anti-apoptotic protein bcl-2. |
2014-03-26 |
2023-08-12 |
human |
| Umawadee Laothong, Porntip Pinlaor, Patcharee Boonsiri, Chawalit Pairojkul, Aroonsri Priprem, Nutjaree Pratheepawanit Johns, Lakhanawan Charoensuk, Kitti Intuyod, Somchai Pinlao. Melatonin inhibits cholangiocarcinoma and reduces liver injury in Opisthorchis viverrini-infected and N-nitrosodimethylamine-treated hamsters. Journal of pineal research. vol 55. issue 3. 2014-03-25. PMID:23772655. |
in the tumorous tissues, the high-dose melatonin reduced dna fragmentation and mitochondrial apoptosis by inducing anti-apoptotic protein (bcl-2) in the mitochondrial fraction and down-regulating cytochrome c, pro-apoptotic protein (bax), and caspase-3 in tumor cytosol. |
2014-03-25 |
2023-08-12 |
human |
| Anja Berger, Sandra-Annika Quast, Michael Plötz, Nicholas-Frederik Kuhn, Uwe Trefzer, Jürgen Eberl. RAF inhibition overcomes resistance to TRAIL-induced apoptosis in melanoma cells. The Journal of investigative dermatology. vol 134. issue 2. 2014-03-25. PMID:23955071. |
apoptosis induction by l-779,450/trail was prevented by bcl-2 overexpression and was dependent on bax. |
2014-03-25 |
2023-08-12 |
Not clear |
| Luning Sun, Ying Jin, Liming Dong, Ryo Sumi, Rabita Jahan, Zhi L. The neuroprotective effects of Coccomyxa gloeobotrydiformis on the ischemic stroke in a rat model. International journal of biological sciences. vol 9. issue 8. 2014-03-24. PMID:23983614. |
furthermore, oxidative stress related factors (sod and mda), mitochondrial membrane potential, and apoptosis regulatory factors (mitochondrial cyt-c, bcl-2, bax, and caspase-3) were all investigated in this research. |
2014-03-24 |
2023-08-12 |
rat |