| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Luning Sun, Ying Jin, Liming Dong, Ryo Sumi, Rabita Jahan, Zhi L. The neuroprotective effects of Coccomyxa gloeobotrydiformis on the ischemic stroke in a rat model. International journal of biological sciences. vol 9. issue 8. 2014-03-24. PMID:23983614. |
in addition, cgd could effectively attenuate apoptosis by restoring the level of mitochondrial cyt c and regulating the expression of bcl-2, bax and caspase 3. |
2014-03-24 |
2023-08-12 |
rat |
| Yi-Jen Chen, Jui-Hsin Su, Chia-Yu Tsao, Chun-Tzu Hung, Hsiang-Hao Chao, Jen-Jie Lin, Ming-Hui Liao, Zih-Yan Yang, Han Hisang Huang, Feng-Jen Tsai, Shun-Hsiang Weng, Yu-Jen W. Sinulariolide induced hepatocellular carcinoma apoptosis through activation of mitochondrial-related apoptotic and PERK/eIF2α/ATF4/CHOP pathway. Molecules (Basel, Switzerland). vol 18. issue 9. 2014-03-21. PMID:23973991. |
a mechanistic analysis demonstrated that sinulariolide-induced apoptosis was activated through a mitochondria-related pathway, showing up-regulation of bax, bad and aif, and down- regulation of bcl-2, bcl-xl, mcl-1 and p-bad. |
2014-03-21 |
2023-08-12 |
Not clear |
| Landa Zeenelabdin Ali Salim, Syam Mohan, Rozana Othman, Siddig Ibrahim Abdelwahab, Behnam Kamalidehghan, Bassem Y Sheikh, Mohamed Yousif Ibrahi. Thymoquinone induces mitochondria-mediated apoptosis in acute lymphoblastic leukaemia in vitro. Molecules (Basel, Switzerland). vol 18. issue 9. 2014-03-21. PMID:24036512. |
treatment of cemss cells with tq encouraged apoptosis with cell death-transducing signals by a down-regulation of bcl-2 and up-regulation of bax. |
2014-03-21 |
2023-08-12 |
Not clear |
| Daniela Giuliani, Alessandra Ottani, Davide Zaffe, Maria Galantucci, Flavio Strinati, Renzo Lodi, Salvatore Guarin. Hydrogen sulfide slows down progression of experimental Alzheimer's disease by targeting multiple pathophysiological mechanisms. Neurobiology of learning and memory. vol 104. 2014-03-20. PMID:23726868. |
consistently, decrease in tumor necrosis factor-α level, up-regulation of bcl-2, and down-regulation of bax and the downstream executioner caspase-3, also occurred in the hippocampus of 3xtg-ad mice after treatment with tabiano's spa-water, thus suggesting that it is also able to modulate inflammation and apoptosis. |
2014-03-20 |
2023-08-12 |
mouse |
| Azhar Rasul, Jun Di, Faya Martin Millimouno, Mahadev Malhi, Ichiro Tsuji, Muhammad Ali, Jiang Li, Xiaomeng L. Reactive oxygen species mediate isoalantolactone-induced apoptosis in human prostate cancer cells. Molecules (Basel, Switzerland). vol 18. issue 8. 2014-03-20. PMID:23921797. |
in addition, isoalantolactone triggers apoptosis in prostate cancer cells via up-regulation of bax, down-regulation of bcl-2, survivin, and significant activation of caspase-3. |
2014-03-20 |
2023-08-12 |
human |
| Caterina Ierano, Arup R Chakraborty, Alina Nicolae, Julian C Bahr, Zhirong Zhan, Stefania Pittaluga, Susan E Bates, Robert W Robe. Loss of the proteins Bak and Bax prevents apoptosis mediated by histone deacetylase inhibitors. Cell cycle (Georgetown, Tex.). vol 12. issue 17. 2014-03-20. PMID:23966164. |
loss of the proteins bak and bax prevents apoptosis mediated by histone deacetylase inhibitors. |
2014-03-20 |
2023-08-12 |
Not clear |
| Caterina Ierano, Arup R Chakraborty, Alina Nicolae, Julian C Bahr, Zhirong Zhan, Stefania Pittaluga, Susan E Bates, Robert W Robe. Loss of the proteins Bak and Bax prevents apoptosis mediated by histone deacetylase inhibitors. Cell cycle (Georgetown, Tex.). vol 12. issue 17. 2014-03-20. PMID:23966164. |
as proof-of-concept to evaluate the contribution of bax and bak to hdi-mediated apoptosis, we found that apoptosis was unaffected in hct-116 colon carcinoma cells lacking bak, blunted in cells lacking bax, and nearly completely abrogated in cells lacking both bak and bax compared with wild-type cells. |
2014-03-20 |
2023-08-12 |
Not clear |
| Caterina Ierano, Arup R Chakraborty, Alina Nicolae, Julian C Bahr, Zhirong Zhan, Stefania Pittaluga, Susan E Bates, Robert W Robe. Loss of the proteins Bak and Bax prevents apoptosis mediated by histone deacetylase inhibitors. Cell cycle (Georgetown, Tex.). vol 12. issue 17. 2014-03-20. PMID:23966164. |
we thus conclude that hdi-mediated and aki-mediated apoptosis requires mitochondrial engagement, and that baseline bax and bak expression may serve as biomarkers for patients with burkitt lymphoma likely to respond to hdi treatment. |
2014-03-20 |
2023-08-12 |
Not clear |
| Konstantinos Feidantsis, Andreas Anestis, Basile Michaelidi. Seasonal variations of anti-/apoptotic and antioxidant proteins in the heart and gastrocnemius muscle of the water frog Pelophylax ridibundus. Cryobiology. vol 67. issue 2. 2014-03-19. PMID:23850824. |
particularly processes studied included the evaluation of hypoxia through the levels of transcriptional factor hif-1α, of apoptosis through the determination of bcl-2 and bax, ubiquitin conjugates levels and the antioxidant defense through the determination of the activity of enzymes such as superoxide dismutase, catalase and glutathione peroxidase. |
2014-03-19 |
2023-08-12 |
Not clear |
| Ying Cheng, Joshua G Corbin, Richard J Lev. Programmed cell death is impaired in the developing brain of FMR1 mutants. Developmental neuroscience. vol 35. issue 4. 2014-03-19. PMID:23900139. |
both fmr1 mutant strains demonstrated decreased apoptosis in neocortex, hippocampus, and basolateral amygdala, impaired cytochrome c and procaspase-9 release from mitochondria despite intact bax translocation, increased expression of the antiapoptotic protein, bcl-xl, and increased number of neurons. |
2014-03-19 |
2023-08-12 |
mouse |
| Jun Zhou, Huiyong Hu, Jingpei Long, Fang Wan, Lili Li, Suzhan Zhang, Yuenian E Shi, Yiding Che. Vitexin 6, a novel lignan, induces autophagy and apoptosis by activating the Jun N-terminal kinase pathway. Anti-cancer drugs. vol 24. issue 9. 2014-03-18. PMID:23965728. |
vb6-induced apoptosis showed a time-dependent and concentration-dependent relationship with cleaved poly (adp-ribose) polymerase, cleaved caspase-3, bax upregulation, and bcl-2 downregulation. |
2014-03-18 |
2023-08-12 |
Not clear |
| Dongyan Hou, Ying Chen, Jiamei Liu, Lin Xu, Zhiyong Zhang, Juan Zhang, Hua Wang, Xin Wang, Jin Chen, Rongrui Zhao, Aihua Hu, Hakon Hakonarson, Lin Zhang, Yan She. Proteomics screen to reveal molecular changes mediated by C722G missense mutation in CHRM2 gene. Journal of proteomics. vol 89. 2014-03-17. PMID:23743182. |
interestingly, the marked differences in the expression of selected eight proteins (change >4.0-fold), were connected with many proteins related to apoptosis and immune/inflammatory response such as: fos, bax, myc, tp53 and il6. |
2014-03-17 |
2023-08-12 |
Not clear |
| Silvia Alboni, Lara Gibellini, Claudia Montanari, Cristina Benatti, Stefania Benatti, Fabio Tascedda, Nicoletta Brunello, Andrea Cossarizza, Carmine M Pariant. N-acetyl-cysteine prevents toxic oxidative effects induced by IFN-α in human neurons. The international journal of neuropsychopharmacology. vol 16. issue 8. 2014-03-14. PMID:23590859. |
this effect did not depend on reduced cell proliferation, but rather the activation of apoptosis, as revealed by an increased bax:bcl-2 mrna ratio after 72-h ifn-α exposure. |
2014-03-14 |
2023-08-12 |
human |
| Eli Anuka, Natalie Yivgi-Ohana, Sarah Eimerl, Benjamin Garfinkel, Naomi Melamed-Book, Elena Chepurkol, Dan Aravot, Tova Zinman, Asher Shainberg, Edith Hochhauser, Joseph Orl. Infarct-induced steroidogenic acute regulatory protein: a survival role in cardiac fibroblasts. Molecular endocrinology (Baltimore, Md.). vol 27. issue 9. 2014-03-13. PMID:23831818. |
star down-regulation also resulted in a marked increase of bax activation in the mitochondria, an event known to associate with the onset of apoptosis. |
2014-03-13 |
2023-08-12 |
mouse |
| Yana Li, Fang Han, Yuxiu Sh. Increased neuronal apoptosis in medial prefrontal cortex is accompanied with changes of Bcl-2 and Bax in a rat model of post-traumatic stress disorder. Journal of molecular neuroscience : MN. vol 51. issue 1. 2014-03-12. PMID:23381833. |
increased neuronal apoptosis in medial prefrontal cortex is accompanied with changes of bcl-2 and bax in a rat model of post-traumatic stress disorder. |
2014-03-12 |
2023-08-12 |
rat |
| Yana Li, Fang Han, Yuxiu Sh. Increased neuronal apoptosis in medial prefrontal cortex is accompanied with changes of Bcl-2 and Bax in a rat model of post-traumatic stress disorder. Journal of molecular neuroscience : MN. vol 51. issue 1. 2014-03-12. PMID:23381833. |
the objective of this study was to determine the apoptosis-related genes b-cell lymphoma 2 (bcl-2) and bcl2-associated x (bax) expressions and medial prefrontal cortex (mpfc) neuronal apoptosis after ptsd in rat model and therefore to provide experimental evidence to reveal ptsd pathogenesis. |
2014-03-12 |
2023-08-12 |
rat |
| Yuri Morio, Mayumi Tsuji, Manami Inagaki, Mai Nakagawa, Yuri Asaka, Hideto Oyamada, Kanji Furuya, Katsuji Oguch. Ethanol-induced apoptosis in human liver adenocarcinoma cells (SK-Hep1): Fas- and mitochondria-mediated pathways and interaction with MAPK signaling system. Toxicology in vitro : an international journal published in association with BIBRA. vol 27. issue 6. 2014-03-12. PMID:23726865. |
when cells were incubated with inhibitors of p38 mapk and jnk, ethanol-induced apoptosis was decreased while ros generation was unaffected, and examination of pro-apoptotic bax and anti-apoptotic bcl-2 levels showed decrease of the former and increase of the latter. |
2014-03-12 |
2023-08-12 |
human |
| R Hill, M Rabb, P A Madureira, D Clements, S A Gujar, D M Waisman, C A Giacomantonio, P W K Le. Gemcitabine-mediated tumour regression and p53-dependent gene expression: implications for colon and pancreatic cancer therapy. Cell death & disease. vol 4. 2014-03-12. PMID:24008735. |
gemcitabine induced a potent p53-dependent apoptosis that correlated with the accumulation of pro-apoptotic proteins such as puma and bax. |
2014-03-12 |
2023-08-12 |
Not clear |
| R Hill, M Rabb, P A Madureira, D Clements, S A Gujar, D M Waisman, C A Giacomantonio, P W K Le. Gemcitabine-mediated tumour regression and p53-dependent gene expression: implications for colon and pancreatic cancer therapy. Cell death & disease. vol 4. 2014-03-12. PMID:24008735. |
this was in contrast to cr(vi)-induced apoptosis that required bax and was independent of transcription. |
2014-03-12 |
2023-08-12 |
Not clear |
| X Li, Z Li, W Zhou, X Xing, L Huang, L Tian, J Chen, C Chen, X Ma, Z Yan. Overexpression of 4EBP1, p70S6K, Akt1 or Akt2 differentially promotes Coxsackievirus B3-induced apoptosis in HeLa cells. Cell death & disease. vol 4. 2014-03-12. PMID:24030155. |
next, after cvb3 infection, apoptosis in different groups was determined by flow cytometry; the expressions of bim, bax, caspase-9 and caspase-3 were examined by real-time fluorescence quantitative pcr and western blot analysis; the expression of cvb3 mrna and viral capsid protein vp1 were also analyzed by real-time fluorescence quantitative pcr, western blot analysis and immunofluorescence, respectively. |
2014-03-12 |
2023-08-12 |
Not clear |