| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Jin-Soo Yoon, Hwa-Mi Kim, Anandam Kasin Yadunandam, Nan-Hee Kim, Hyun-Ah Jung, Jae-Sue Choi, Chi-Yeon Kim, Gun-Do Ki. Neferine isolated from Nelumbo nucifera enhances anti-cancer activities in Hep3B cells: molecular mechanisms of cell cycle arrest, ER stress induced apoptosis and anti-angiogenic response. Phytomedicine : international journal of phytotherapy and phytopharmacology. vol 20. issue 11. 2014-02-13. PMID:23746959. |
our results demonstrated neferine induced er stress and apoptosis, acting through multiple signaling cascades by the activation of bim, bid, bax, bak, puma, caspases-3, -6, -7, -8 and parp, and the protein expression levels of bip, calnexin, pdi, calpain-2 and caspase-12 were also upregulated dramatically by neferine treatment. |
2014-02-13 |
2023-08-12 |
human |
| Yu Wang, Nico Tjandr. Structural insights of tBid, the caspase-8-activated Bid, and its BH3 domain. The Journal of biological chemistry. vol 288. issue 50. 2014-02-13. PMID:24158446. |
one of the pro-apoptotic proteins, tbid, can induce apoptosis by promoting bax activation, bax homo-oligomerization, and mitochondrial outer membrane permeabilization. |
2014-02-13 |
2023-08-12 |
human |
| Yanyi Zhang, Ling Yan, Yi Zhao, Liping Ou, Xiaohou Wu, Chunli Lu. Knockdown of phospholipase C-epsilon by short-hairpin RNA-mediated gene silencing induces apoptosis in human bladder cancer cell lines. Cancer biotherapy & radiopharmaceuticals. vol 28. issue 3. 2014-02-12. PMID:23484808. |
cellular apoptosis was reflected by transmission electron microscopy and the expression of bcl-2 and bax. |
2014-02-12 |
2023-08-12 |
human |
| Yanyi Zhang, Ling Yan, Yi Zhao, Liping Ou, Xiaohou Wu, Chunli Lu. Knockdown of phospholipase C-epsilon by short-hairpin RNA-mediated gene silencing induces apoptosis in human bladder cancer cell lines. Cancer biotherapy & radiopharmaceuticals. vol 28. issue 3. 2014-02-12. PMID:23484808. |
silence of plcɛ might induce apoptosis via modulation of bcl-2 and bax. |
2014-02-12 |
2023-08-12 |
human |
| Cornelia Braicu, Valentina Pileczki, Alexandru Irimie, Ioana Berindan-Neago. p53siRNA therapy reduces cell proliferation, migration and induces apoptosis in triple negative breast cancer cells. Molecular and cellular biochemistry. vol 381. issue 1-2. 2014-02-12. PMID:23881244. |
the present research also emphasizes the important role of bcl-2 pro-apoptotic family of genes (bim, bak, and bax) in activating apoptosis and reducing cell proliferation by p53sirna treatment. |
2014-02-12 |
2023-08-12 |
human |
| Lucia Pronsato, Anabela La Colla, Ana Carolina Ronda, Lorena Milanesi, Ricardo Boland, Andrea Vasconsuel. High passage numbers induce resistance to apoptosis in C2C12 muscle cells. Biocell : official journal of the Sociedades Latinoamericanas de Microscopia Electronica ... et. al. vol 37. issue 1. 2014-02-11. PMID:24396996. |
when we analyzed the behavior of bad, bax, caspase-3 and mitochondrial transmembrane potential, we observed that cells in the h-c2c12 group were resistant to h2o2 induction of apoptosis. |
2014-02-11 |
2023-08-12 |
Not clear |
| Ziyou Cui, Soyun Michelle Hwang, Aldrin V Gome. Identification of the immunoproteasome as a novel regulator of skeletal muscle differentiation. Molecular and cellular biology. vol 34. issue 1. 2014-02-10. PMID:24164898. |
downregulation of the i-proteasome also increased proapoptotic proteins, including bax, as well as cleaved caspase 3, cleaved caspase 9, and cleaved poly(adp-ribose) polymerase (parp), suggesting that impaired differentiation is likely to occur because of significantly increased apoptosis. |
2014-02-10 |
2023-08-12 |
mouse |
| Daoxiong Lei, Faqian Li, Huabo Su, Jinbao Liu, Ning Wei, Xuejun Wan. Hepatic deficiency of COP9 signalosome subunit 8 induces ubiquitin-proteasome system impairment and Bim-mediated apoptosis in murine livers. PloS one. vol 8. issue 7. 2014-02-07. PMID:23840878. |
in addition to bim, massive hepatocyte apoptosis in hs-csn8ko livers is also associated with elevated expression of other members of the bcl2 family, including pro-apoptotic bax as well as anti-apoptotic bcl2 and bcl-xl. |
2014-02-07 |
2023-08-12 |
Not clear |
| Daoxiong Lei, Faqian Li, Huabo Su, Jinbao Liu, Ning Wei, Xuejun Wan. Hepatic deficiency of COP9 signalosome subunit 8 induces ubiquitin-proteasome system impairment and Bim-mediated apoptosis in murine livers. PloS one. vol 8. issue 7. 2014-02-07. PMID:23840878. |
hence, it is concluded that hepatic csn8 deficiency impairs the ups in the liver and the resultant bim upregulation likely plays an important role in triggering hepatocyte apoptosis via sequestering bcl2 away from bax. |
2014-02-07 |
2023-08-12 |
Not clear |
| Liora Lindenboim, Elisa Ferrando-May, Christoph Borner, Reuven Stei. Non-canonical function of Bax in stress-induced nuclear protein redistribution. Cellular and molecular life sciences : CMLS. vol 70. issue 16. 2014-02-06. PMID:23475110. |
our results show that, in this system, bax expression was sufficient to restore npr such as in wt cells undergoing apoptosis. |
2014-02-06 |
2023-08-12 |
mouse |
| S-Y Kim, M H Cordeiro, V A Serna, K Ebbert, L M Butler, S Sinha, A A Mills, T K Woodruff, T Kurit. Rescue of platinum-damaged oocytes from programmed cell death through inactivation of the p53 family signaling network. Cell death and differentiation. vol 20. issue 8. 2014-02-06. PMID:23598363. |
oocytes undergoing apoptosis showed downregulation of tap63 and upregulation of bax. |
2014-02-06 |
2023-08-12 |
mouse |
| Emran Esmaeilzadeh, Mossa Gardaneh, Ehsan Gharib, Farzaneh Saboun. Shikonin protects dopaminergic cell line PC12 against 6-hydroxydopamine-mediated neurotoxicity via both glutathione-dependent and independent pathways and by inhibiting apoptosis. Neurochemical research. vol 38. issue 8. 2014-02-06. PMID:23636806. |
as signs of apoptosis inhibition, the compound upregulated bcl-2, downregulated bax, and prevented cell nuclei from undergoing morphological changes typical of apoptosis. |
2014-02-06 |
2023-08-12 |
rat |
| S Gautam, S Kirschnek, I E Gentle, C Kopiniok, P Henneke, H Häcker, L Malleret, A Belaaouaj, G Häcke. Survival and differentiation defects contribute to neutropenia in glucose-6-phosphatase-β (G6PC3) deficiency in a model of mouse neutrophil granulocyte differentiation. Cell death and differentiation. vol 20. issue 8. 2014-02-06. PMID:23686134. |
impaired glucose utilization was found and was associated with er stress and apoptosis, associated with the upregulation of bim and bax; downregulation of bim protected against apoptosis during differentiation. |
2014-02-06 |
2023-08-12 |
mouse |
| Asmita Samadder, Sreemanti Das, Jayeeta Das, Avijit Paul, Naoual Boujedaini, Anisur Rahman Khuda-Bukhs. The potentized homeopathic drug, Lycopodium clavatum (5C and 15C) has anti-cancer effect on hela cells in vitro. Journal of acupuncture and meridian studies. vol 6. issue 4. 2014-02-06. PMID:23972240. |
the drug-induced modulation in the percent cell viability, the onset of apoptosis, and changes in the expressions of bax, bcl2, caspase 3, and apaf proteins in inter-nucleosomal dna, in mitochondrial membrane potentials and in the release of cytochrome-c were analyzed by utilizing different experimental protocols. |
2014-02-06 |
2023-08-12 |
Not clear |
| Asmita Samadder, Sreemanti Das, Jayeeta Das, Avijit Paul, Naoual Boujedaini, Anisur Rahman Khuda-Bukhs. The potentized homeopathic drug, Lycopodium clavatum (5C and 15C) has anti-cancer effect on hela cells in vitro. Journal of acupuncture and meridian studies. vol 6. issue 4. 2014-02-06. PMID:23972240. |
results revealed that administration of lc-5c and lc-15c had little or no cytotoxic effect in normal peripheral blood mononuclear cells, but caused considerable cell death through apoptosis in cancer (hela) cells, which was evident from the induction of dna fragmentation, the increases in the expressions of protein and mrna of caspase 3 and bax, and the decreases in the expressions of bcl2 and apaf and in the release of cytochrome-c. |
2014-02-06 |
2023-08-12 |
Not clear |
| Jie Yang, Liang Wang, Fei Yang, Haiming Luo, Lingling Xu, Jinling Lu, Shaoqun Zeng, Zhihong Zhan. mBeRFP, an improved large stokes shift red fluorescent protein. PloS one. vol 8. issue 6. 2014-02-05. PMID:23840310. |
to demonstrate the applicability of mberfp for imaging in living cells, we performed dual-color imaging of mberfp and cfp simultaneously excited by a single excitation source, and we demonstrated that these fluorescent proteins allow the clear visualization of the dynamics of bax during cancer cell apoptosis. |
2014-02-05 |
2023-08-12 |
Not clear |
| Stephen Ma, Colin Hockings, Khatira Anwari, Tobias Kratina, Stephanie Fennell, Michael Lazarou, Michael T Ryan, Ruth M Kluck, Grant Dewso. Assembly of the Bak apoptotic pore: a critical role for the Bak protein α6 helix in the multimerization of homodimers during apoptosis. The Journal of biological chemistry. vol 288. issue 36. 2014-02-04. PMID:23893415. |
bak and bax are the essential effectors of the intrinsic pathway of apoptosis. |
2014-02-04 |
2023-08-12 |
Not clear |
| You Ah Kim, Hojun Kim, Youngwan Se. Antiproliferative effect of flavonoids from the halophyte Vitex rotundifolia on human cancer cells. Natural product communications. vol 8. issue 10. 2014-02-04. PMID:24354186. |
compound 2 not only enhanced most remarkably the expression level of tumor suppressor genes p53 and p21, and pro-apoptotic gene bax at a concentration of 25 microm, but also suppressed the expression level of antiapoptotic gene bcl-2 to 20% at the same concentration, thus shifting the bax/bcl-2 ratio in favor of apoptosis. |
2014-02-04 |
2023-08-12 |
human |
| John Stanislav, Jan Mls, Miroslav Červinka, Emil Rudol. The role of autophagic cell death and apoptosis in irinotecan-treated p53 null colon cancer cells. Anti-cancer agents in medicinal chemistry. vol 13. issue 5. 2014-02-03. PMID:22721392. |
the subsequent studies into mechanisms of cell death process revealed the important role of bax in mediating mitochondrial and lysosomal leakage which might serve as leading signals for both apoptosis and autophagic cell death. |
2014-02-03 |
2023-08-12 |
Not clear |
| Juan Liu, Cheng-Kun Qin, Wei Lv, Qi Zhao, Cheng-Yong Qi. OSU-03012, a non-Cox inhibiting celecoxib derivative, induces apoptosis of human esophageal carcinoma cells through a p53/Bax/cytochrome c/caspase-9-dependent pathway. Anti-cancer drugs. vol 24. issue 7. 2014-02-03. PMID:23652278. |
immunoblot analysis demonstrated that osu-03012-induced cellular apoptosis was associated with upregulation of bax, cleaved caspase-3, and cleaved caspase-9. |
2014-02-03 |
2023-08-12 |
human |