| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Hengde Zhang, Bin Wu, Hongliang Liu, Mingning Qiu, Jun Liu, Yong Zhang, Fusheng Qua. Improving development of cloned goat embryos by supplementing α-lipoic acid to oocyte in vitro maturation medium. Theriogenology. vol 80. issue 3. 2014-02-03. PMID:23743066. |
in addition, supplementing la significantly reduced the cellular apoptosis rate of nucleus transfer blastocysts by inhibiting the expression of apoptotic activators, such as bax, bad, caspase-3, and cytc genes and promoting cumulus-oocyte complexes to synthesize glutathione (gsh) and express antioxidant enzymes such as gpx4 and sod genes. |
2014-02-03 |
2023-08-12 |
Not clear |
| H-J Li, C-Y Wang, Y Mi, C-G Du, G-F Cao, X-C Sun, D-J Liu, B Shorga. FasL-induced apoptosis in bovine oocytes via the Bax signal. Theriogenology. vol 80. issue 3. 2014-02-03. PMID:23755802. |
fasl-induced apoptosis in bovine oocytes via the bax signal. |
2014-02-03 |
2023-08-12 |
cattle |
| Sarita Saraswati, S S Agrawal, Abdulqader A Alhaide. Ursolic acid inhibits tumor angiogenesis and induces apoptosis through mitochondrial-dependent pathway in Ehrlich ascites carcinoma tumor. Chemico-biological interactions. vol 206. issue 2. 2014-01-30. PMID:24051192. |
ua downregulated vegf & inos expression whereas bax and caspase-3 expressions were upregulated suggesting drug induced tumor cell apoptosis through activating the pro-apoptotic bcl-2 family and caspase-3 and downregulation of vegf. |
2014-01-30 |
2023-08-12 |
mouse |
| Mani Kavitha, Jagatheesan Nataraj, Musthafa Mohammed Essa, Mushtaq A Memon, Thamilarasan Manivasaga. Mangiferin attenuates MPTP induced dopaminergic neurodegeneration and improves motor impairment, redox balance and Bcl-2/Bax expression in experimental Parkinson's disease mice. Chemico-biological interactions. vol 206. issue 2. 2014-01-30. PMID:24095822. |
mptp treatment leads to enhanced oxidative stress, induction of apoptosis (upregulates the expression of bax, proapoptotic protein and downregulates the expression of anti-apoptotic marker bcl-2), and loss of dopominergic neurons which results in motor impairments. |
2014-01-30 |
2023-08-12 |
mouse |
| D Drakulić, N Veličković, M Stanojlović, I Grković, N Mitrović, I Lavrnja, A Horva. Low-dose dexamethasone treatment promotes the pro-survival signalling pathway in the adult rat prefrontal cortex. Journal of neuroendocrinology. vol 25. issue 7. 2014-01-28. PMID:23551329. |
the present study aimed to determine whether low-dose subchronic dex treatment (100 μg/kg for eight consecutive days) exerts long-term effects on apoptosis in the adult rat prefrontal cortex (pfc) by examining the expression of cell death-promoting molecules [poly(adp-ribose) polymerase (parp), p53, procaspase 3, cleaved caspase 3, bax] and cell-survival molecules (akt, bcl-2). |
2014-01-28 |
2023-08-12 |
rat |
| Laura R Lee, Pang-Ning Teng, Huyen Nguyen, Brian L Hood, Leyla Kavandi, Guisong Wang, Jane M Turbov, Larry G Thaete, Chad A Hamilton, George L Maxwell, Gustavo C Rodriguez, Thomas P Conrads, Viqar Sye. Progesterone enhances calcitriol antitumor activity by upregulating vitamin D receptor expression and promoting apoptosis in endometrial cancer cells. Cancer prevention research (Philadelphia, Pa.). vol 6. issue 7. 2014-01-28. PMID:23682076. |
our results showed that progesterone and calcitriol upregulate the expression of bax along with other apoptosis-related proteins, which induce inhibition of endometrial cancer cell growth by apoptosis and cell-cycle arrest. |
2014-01-28 |
2023-08-12 |
human |
| D S Svoboda, A Paquin, D S Park, R S Slac. Pocket proteins pRb and p107 are required for cortical lamination independent of apoptosis. Developmental biology. vol 384. issue 1. 2014-01-27. PMID:24056077. |
here, we eliminate ectopic apoptosis in the developing brain through the deletion of bax, and show that pocket proteins are required for radial migration independent of their role in cell death regulation. |
2014-01-27 |
2023-08-12 |
Not clear |
| Ratan Singh Ray, Syed Faiz Mujtaba, Ashish Dwivedi, Neera Yadav, Ankit Verma, Hari Narayan Kushwaha, Saroj Kumar Amar, Shruti Goel, Deepti Chopr. Singlet oxygen mediated DNA damage induced phototoxicity by ketoprofen resulting in mitochondrial depolarization and lysosomal destabilization. Toxicology. vol 314. issue 2-3. 2014-01-27. PMID:24128752. |
we found apoptosis as the pattern of cell death which was confirmed through caspase-3 activation, cytochrome-c release from mitochondria, up-regulation of bax protein and phosphatidylserine translocation. |
2014-01-27 |
2023-08-12 |
Not clear |
| Mei Shi, Tian Zhang, Lei Sun, Yan Luo, De-Hua Liu, Shu-Tao Xie, Xiao-Yan Song, Guo-Fan Wang, Xiu-Lan Chen, Bai-Cheng Zhou, Yu-Zhong Zhan. Calpain, Atg5 and Bak play important roles in the crosstalk between apoptosis and autophagy induced by influx of extracellular calcium. Apoptosis : an international journal on programmed cell death. vol 18. issue 4. 2014-01-24. PMID:23242420. |
remarkably, tk vi preferentially induced apoptosis that was associated with calpain-mediated bax and atg5 cleavage, which resulted in the collapse of the mitochondrial membrane potential and cytochrome c release. |
2014-01-24 |
2023-08-12 |
Not clear |
| So Jin Bing, Danbee Ha, Min Ju Kim, Eunjin Park, Ginnae Ahn, Dae Seung Kim, Ryeo Kyeong Ko, Jae Woo Park, Nam Ho Lee, Youngheun Je. Geraniin down regulates gamma radiation-induced apoptosis by suppressing DNA damage. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association. vol 57. 2014-01-24. PMID:23541438. |
also, geraniin inhibited apoptosis in radiosensitive splenocytes by reducing the expression level and immunoreactivity of proapoptotic p53 and bax and increasing those of anti-apoptotic bcl-2. |
2014-01-24 |
2023-08-12 |
mouse |
| Yongqiang Chen, Jinjuan Liu, Bo Yuan, Chengliang Cao, Sheng Qin, Xiaoying Cao, Guangkai Bian, Zhe Wang, Jihong Jian. Methylated actinomycin D, a novel actinomycin D analog induces apoptosis in HepG2 cells through Fas- and mitochondria-mediated pathways. Molecular carcinogenesis. vol 52. issue 12. 2014-01-23. PMID:22821714. |
semiquantitative rt-pcr and western blot analysis revealed that mact d induced apoptosis in hepg2 cells through mitochondria-dependent pathway by increasing levels of caspase-9, bax, bak while decreasing levels of bcl-2, bid, and fas-dependent pathway by increasing levels of fas, fasl, fadd, and caspase-8. |
2014-01-23 |
2023-08-12 |
human |
| Zhao-Yang Hu, Geoffrey W Abbott, Ya-Dong Fang, Yue-Sheng Huang, Jin Li. Emulsified isoflurane postconditioning produces cardioprotection against myocardial ischemia-reperfusion injury in rats. The journal of physiological sciences : JPS. vol 63. issue 4. 2014-01-23. PMID:23625523. |
after reperfusion, infarct sizes, myocardial apoptosis and expression of bcl-2, bax and caspase-3 proteins were determined. |
2014-01-23 |
2023-08-12 |
rat |
| Zhao-Yang Hu, Geoffrey W Abbott, Ya-Dong Fang, Yue-Sheng Huang, Jin Li. Emulsified isoflurane postconditioning produces cardioprotection against myocardial ischemia-reperfusion injury in rats. The journal of physiological sciences : JPS. vol 63. issue 4. 2014-01-23. PMID:23625523. |
compared with control and intralipid group, eiso limited infarct size, inhibited apoptosis, increased the expression of bcl-2, decreased the expression of bax, cleaved caspase-3, and enhanced bcl-2/bax ratio. |
2014-01-23 |
2023-08-12 |
rat |
| Long Shi, Xiaoming Yu, Hongling Yang, Xinyi W. Advanced glycation end products induce human corneal epithelial cells apoptosis through generation of reactive oxygen species and activation of JNK and p38 MAPK pathways. PloS one. vol 8. issue 6. 2014-01-23. PMID:23776698. |
we found that age-bsa induced hucls apoptosis and increased bax protein expression, decreased bcl-2 protein expression. |
2014-01-23 |
2023-08-12 |
human |
| Ying-Yan Fang, Su-Dong Guan, Xiao-Lei Guo, Hong-Wei Ye, Hua-Xue Wang, Qin Ga. [The changes of inducible nitric oxide synthase activity and apoptosis-related gene expression in endotoxemia-induced rat diaphragm]. Zhongguo ying yong sheng li xue za zhi = Zhongguo yingyong shenglixue zazhi = Chinese journal of applied physiology. vol 29. issue 3. 2014-01-23. PMID:23940949. |
to study the changes of inducible nitric oxide synthase (inos) activity and apoptosis-related genes bcl-2, bax and caspase-3 mrna expressions in endotoxemia-induced rat diaphragm injury and analyze the related apoptosis mechanism. |
2014-01-23 |
2023-08-12 |
rat |
| Norman Y Liaw, Louise See Hoe, Freya L Sheeran, Jason N Peart, John P Headrick, Michael M H Cheung, Salvatore Pep. Postnatal shifts in ischemic tolerance and cell survival signaling in murine myocardium. American journal of physiology. Regulatory, integrative and comparative physiology. vol 305. issue 10. 2014-01-23. PMID:24068046. |
hearts from male c57bl/6 mice (neonates, 2, 4, 8, and 12 wk of age, n = 6/group) were assayed for survival signaling/effectors [akt, p38mapk, glycogen synthase kinase-3β (gsk-3β), heat shock protein 27 (hsp27), connexin-43, hypoxia-inducible factor-1α (hif-1α), and caveolin-3] and regulators of apoptosis (bax and bcl-2) and autophagy (lc3b, parkin, and beclin1). |
2014-01-23 |
2023-08-12 |
mouse |
| Stephanie Bleicken, Olatz Landeta, Ane Landajuela, Gorka Basañez, Ana J García-Sáe. Proapoptotic Bax and Bak proteins form stable protein-permeable pores of tunable size. The Journal of biological chemistry. vol 288. issue 46. 2014-01-23. PMID:24100034. |
the bcl-2 proapoptotic proteins bax and bak mediate the permeabilization of the mitochondrial outer membrane during apoptosis. |
2014-01-23 |
2023-08-12 |
Not clear |
| Yasuhiro Maejima, Shiori Kyoi, Peiyong Zhai, Tong Liu, Hong Li, Andreas Ivessa, Sebastiano Sciarretta, Dominic P Del Re, Daniela K Zablocki, Chiao-Po Hsu, Dae-Sik Lim, Mitsuaki Isobe, Junichi Sadoshim. Mst1 inhibits autophagy by promoting the interaction between Beclin1 and Bcl-2. Nature medicine. vol 19. issue 11. 2014-01-23. PMID:24141421. |
furthermore, mst1-induced sequestration of bcl-2 and bcl-xl by beclin1 allows bax to become active, thereby stimulating apoptosis. |
2014-01-23 |
2023-08-12 |
mouse |
| Yasuhiro Maejima, Shiori Kyoi, Peiyong Zhai, Tong Liu, Hong Li, Andreas Ivessa, Sebastiano Sciarretta, Dominic P Del Re, Daniela K Zablocki, Chiao-Po Hsu, Dae-Sik Lim, Mitsuaki Isobe, Junichi Sadoshim. Mst1 inhibits autophagy by promoting the interaction between Beclin1 and Bcl-2. Nature medicine. vol 19. issue 11. 2014-01-23. PMID:24141421. |
these results suggest that mst1 coordinately regulates autophagy and apoptosis by phosphorylating beclin1 and consequently modulating a three-way interaction among bcl-2 proteins, beclin1 and bax. |
2014-01-23 |
2023-08-12 |
mouse |
| Sara Busacca, Alex D Chacko, Astero Klabatsa, Kenneth Arthur, Michael Sheaff, Dario Barbone, Luciano Mutti, Vignesh K Gunasekharan, Julia J Gorski, Mohamed El-Tanani, V Courtney Broaddus, Giovanni Gaudino, Dean A Fennel. BAK and NOXA are critical determinants of mitochondrial apoptosis induced by bortezomib in mesothelioma. PloS one. vol 8. issue 6. 2014-01-22. PMID:23762382. |
the multidomain proapoptotic protein bak, but not its orthologue bax, was found to be essential for bortezomib-induced apoptosis in mpm cell lines. |
2014-01-22 |
2023-08-12 |
Not clear |