| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Yu-ting Chen, Xiang-chen Song, Fu-ping Zhang, Min Lian. [Expression of Bim, Bax and Bak in the process of gingipain-induced osteoblast apoptosis]. Zhonghua kou qiang yi xue za zhi = Zhonghua kouqiang yixue zazhi = Chinese journal of stomatology. vol 48. issue 5. 2014-04-28. PMID:24004622. |
to establish osteoblast apoptosis model induced by gingipains, and to examine the expression of pro-apoptotic protein bcl-2 interacting mediator (bim), bcl-2 associated x protein (bax) and bcl-2 antagonist/killer (bak). |
2014-04-28 |
2023-08-12 |
Not clear |
| Hua Qin, Xiaoyan Du, Yan Zhang, Ru Wan. Platycodin D, a triterpenoid saponin from Platycodon grandiflorum, induces G2/M arrest and apoptosis in human hepatoma HepG2 cells by modulating the PI3K/Akt pathway. Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine. vol 35. issue 2. 2014-04-28. PMID:24048756. |
thus, the increasing ratio of bax to bcl-2, activation of caspase-3 and -9 and parp, and inactivation of the pi3k/akt signaling pathway significantly enhanced pd-induced apoptosis in hepg2 cells. |
2014-04-28 |
2023-08-12 |
human |
| Siyan Zhang, Angel Long, A James Lin. A comparison of two strategies for affinity maturation of a BH3 peptide toward pro-survival Bcl-2 proteins. ACS synthetic biology. vol 1. issue 3. 2014-04-25. PMID:23651073. |
pro-death members of the family, including bak and bax, initiate apoptosis, whereas pro-survival members such as bcl-x(l) and mcl-1 antagonize the function of bak and bax via heterodimeric interactions. |
2014-04-25 |
2023-08-12 |
Not clear |
| Lei Mao, Juncai Chen, Quanhui Peng, Aiming Zhou, Zhisheng Wan. Effects of different sources and levels of zinc on H2O2-induced apoptosis in IEC-6 cells. Biological trace element research. vol 155. issue 1. 2014-04-25. PMID:23912254. |
the present study was designed to investigate effects of three zinc chemical forms on h2o2-induced cell apoptosis in iec-6 cells via analysis of cell vitality, ldh activity, apoptosis percentage, caspase-3 activity, and bcl-2, bax, and caspase-3, -8, and -9 gene expression. |
2014-04-25 |
2023-08-12 |
Not clear |
| Lei Mao, Juncai Chen, Quanhui Peng, Aiming Zhou, Zhisheng Wan. Effects of different sources and levels of zinc on H2O2-induced apoptosis in IEC-6 cells. Biological trace element research. vol 155. issue 1. 2014-04-25. PMID:23912254. |
in the present study, we found the striking cytotoxicity of h2o2 higher than 200 μm on cell vitality, ldh activity, and apoptosis percentage in the cells using five different concentrations (50, 100, 200, 400, and 800 μm) of h2o2 for 4 h. moreover, we observed that cell vitality was increased, ldh activity and apoptotic percentage were decreased, and gene expression level of bax and caspase-3 and -9 was markedly reduced, while gene expression level of bcl-2 and ratio of bcl-2/bax were increased in normal concentration groups of nano-zno and znso4 compared with h2o2 group, but no significant difference was observed in caspase-8 gene expression. |
2014-04-25 |
2023-08-12 |
Not clear |
| Jun Ping Cao, Hong Yan Niu, Hong Jun Wang, Xian Gui Huang, Dian Shuai Ga. NF-κB p65/p52 plays a role in GDNF up-regulating Bcl-2 and Bcl-w expression in 6-OHDA-induced apoptosis of MN9D cell. The International journal of neuroscience. vol 123. issue 10. 2014-04-24. PMID:23590664. |
these results indicated that gdnf could protect mn9d cells from apoptosis induced by 6-ohda via upregulating bcl-2 and bcl-w expressions and downregulating bax and bad expressions. |
2014-04-24 |
2023-08-12 |
Not clear |
| Huanli Xu, Jinmei Yu, Yan Sun, Xiaona Xu, Li Li, Ming Xue, Guanhua D. Scutellaria barbata D. Don extract synergizes the antitumor effects of low dose 5-fluorouracil through induction of apoptosis and metabolism. Phytomedicine : international journal of phytotherapy and phytopharmacology. vol 20. issue 10. 2014-04-24. PMID:23694749. |
tumor growth inhibition both in vitro and in vivo, cell apoptosis, apoptosis related protein expressions (p53, bid, bax, bcl-2), caspase-3 activities and 5-fu related enzymes were assessed. |
2014-04-24 |
2023-08-12 |
Not clear |
| Catherine E Myers, Keria Bermudez-Hernandez, Helen E Scharfma. The influence of ectopic migration of granule cells into the hilus on dentate gyrus-CA3 function. PloS one. vol 8. issue 6. 2014-04-24. PMID:23840835. |
the mice have a deletion of bax, which normally regulates apoptosis. |
2014-04-24 |
2023-08-12 |
mouse |
| Catherine E Myers, Keria Bermudez-Hernandez, Helen E Scharfma. The influence of ectopic migration of granule cells into the hilus on dentate gyrus-CA3 function. PloS one. vol 8. issue 6. 2014-04-24. PMID:23840835. |
however, inferring functional effects of hegcs is difficult in mice with a constitutive bax deletion because there is decreased apoptosis in and outside the dg. |
2014-04-24 |
2023-08-12 |
mouse |
| Qingqing Wei, Guie Dong, Jian-Kang Chen, Ganesan Ramesh, Zheng Don. Bax and Bak have critical roles in ischemic acute kidney injury in global and proximal tubule-specific knockout mouse models. Kidney international. vol 84. issue 1. 2014-04-22. PMID:23466994. |
interestingly, in these models, bax or bak knockout attenuated renal tubular cell apoptosis without significantly affecting necrotic tubular damage. |
2014-04-22 |
2023-08-12 |
mouse |
| Qingqing Wei, Guie Dong, Jian-Kang Chen, Ganesan Ramesh, Zheng Don. Bax and Bak have critical roles in ischemic acute kidney injury in global and proximal tubule-specific knockout mouse models. Kidney international. vol 84. issue 1. 2014-04-22. PMID:23466994. |
thus, our gene-knockout studies support a critical role of bax and bak in tubular cell apoptosis in ischemic acute kidney. |
2014-04-22 |
2023-08-12 |
mouse |
| Jianmin Liang, Ying Yu, Boyu Wang, Bin Lu, Jizhou Zhang, Hongbo Zhang, Pengfei G. Ginsenoside Rb1 attenuates oxygen-glucose deprivation-induced apoptosis in SH-SY5Y cells via protection of mitochondria and inhibition of AIF and cytochrome c release. Molecules (Basel, Switzerland). vol 18. issue 10. 2014-04-22. PMID:24135936. |
to investigate the role of mitochondria in the protective effects of ginsenoside rb1 on cellular apoptosis caused by oxygen-glucose deprivation, in this study, mtt assay, tunel staining, flow cytometry, immunocytochemistry and western blotting were used to examine the cellular viability, apoptosis, ros level, mitochondrial membrane potential, and the distribution of apoptosis inducing factor, cytochrome c, bax and bcl-2 in nucleus, mitochondria and cytoplasm. |
2014-04-22 |
2023-08-12 |
Not clear |
| Jianmin Liang, Ying Yu, Boyu Wang, Bin Lu, Jizhou Zhang, Hongbo Zhang, Pengfei G. Ginsenoside Rb1 attenuates oxygen-glucose deprivation-induced apoptosis in SH-SY5Y cells via protection of mitochondria and inhibition of AIF and cytochrome c release. Molecules (Basel, Switzerland). vol 18. issue 10. 2014-04-22. PMID:24135936. |
additionally, grb1 not only suppressed the translocation of apoptosis inducing factor into nucleus and cytochrome c into cytoplasm, but also inhibited the increase of bax within mitochondria and alleviated the decrease of mitochondrial bcl-2. |
2014-04-22 |
2023-08-12 |
Not clear |
| Weilin Hu, Yumei Ge, David M Ojcius, Dexter Sun, Haiyan Dong, X Frank Yang, Jie Ya. p53 signalling controls cell cycle arrest and caspase-independent apoptosis in macrophages infected with pathogenic Leptospira species. Cellular microbiology. vol 15. issue 10. 2014-04-21. PMID:23521874. |
the intranuclear translocation of p53, increased expression of p53-dependent p21(cip) (1/) (waf) (1) and pro-apoptotic bcl-2 family proteins (bax, noxa and puma), release of aif and endog from mitochondria, and membrane translocation of fas occurred during leptospire-induced macrophage apoptosis. |
2014-04-21 |
2023-08-12 |
mouse |
| W Gibson Wood, Urule Igbavboa, Walter E Muller, Gunter P Ecker. Statins, Bcl-2, and apoptosis: cell death or cell protection? Molecular neurobiology. vol 48. issue 2. 2014-04-21. PMID:23821030. |
what appears to be a contradiction is that, in the case of cancer, it has been suggested that statins increase apoptosis and alter levels of bcl-2 family members (e.g., reduce bcl-2 and increase bax), whereas studies mainly using noncancerous cells report opposite effects. |
2014-04-21 |
2023-08-12 |
Not clear |
| Li Ding, Xiaomin Zhao, Yong Huang, Qian Du, Feng Dong, Hongling Zhang, Xiangjun Song, Wenlong Zhang, Dewen Ton. Regulation of ROS in transmissible gastroenteritis virus-activated apoptotic signaling. Biochemical and biophysical research communications. vol 442. issue 1-2. 2014-04-21. PMID:24225120. |
furthermore, the two scavengers significantly inhibited the activation of p38 mapk and p53 and further blocked apoptosis occurrence through suppressing the tgev-induced bcl-2 reduction, bax redistribution, cytochrome c release and caspase-3 activation. |
2014-04-21 |
2023-08-12 |
Not clear |
| Shenggen Yao, Dana Westphal, Jeffrey J Babon, Geoff V Thompson, Adeline Y Robin, Jerry M Adams, Peter M Colman, Peter E Czabota. NMR studies of interactions between Bax and BH3 domain-containing peptides in the absence and presence of CHAPS. Archives of biochemistry and biophysics. vol 545. 2014-04-21. PMID:24434006. |
activation and oligomerisation of bax, a key pro-apoptotic bcl-2 family protein, are key steps in the mitochondrial pathway to apoptosis. |
2014-04-21 |
2023-08-12 |
Not clear |
| Worlanyo Eric Gato, Stacey R McGee, Dale B Hales, Jay C Mean. Time-Dependent Regulation of Apoptosis by AEN and BAX in Response to 2-Aminoanthracene Dietary Consumption. Toxicology international. vol 21. issue 1. 2014-04-21. PMID:24748736. |
time-dependent regulation of apoptosis by aen and bax in response to 2-aminoanthracene dietary consumption. |
2014-04-21 |
2023-08-13 |
rat |
| Yue Lu, Ruiqin Qian, Juan Xiao, Dong Xu, Hongzheng Fu, Yingyu Che. Kirenol, a compound from Herba Siegesbeckiae, induces apoptosis in human chronic myeloid leukemia K562 cells. Die Pharmazie. vol 69. issue 2. 2014-04-18. PMID:24640606. |
further studies showed that kirenol treatment caused externalization of phosphatidylserine, accumulation of ros (reactive oxygen species), alteration of mitochondrial membrane potential, release of cytochrome c, reduction in the level of the bcl-2 protein and upregulation of bax and tbid, kirenol induced cell apoptosis in a caspase-independent manner. |
2014-04-18 |
2023-08-12 |
human |
| Min Ho Han, Cheol Park, Cheng-Yun Jin, Gi-Young Kim, Young-Chae Chang, Sung-Kwon Moon, Wun-Jae Kim, Yung Hyun Cho. Apoptosis induction of human bladder cancer cells by sanguinarine through reactive oxygen species-mediated up-regulation of early growth response gene-1. PloS one. vol 8. issue 5. 2014-04-17. PMID:23717422. |
sanguinarine-induced apoptosis was correlated with the up-regulation of bax, the down-regulation of bid and xiap, the activation of caspases (-3, -8, and -9), and the generation of increased reactive oxygen species (ros). |
2014-04-17 |
2023-08-12 |
human |