| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Yubo Liu, Zhiqiang Li, Ting Song, Zuguang Xue, Zhichao Zhan. Mechanisms of anti-leukemic activity of the Bcl-2 homology domain-3 mimetic S1. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 67. issue 7. 2014-05-22. PMID:23706691. |
s1 induced apoptosis via an intrinsic apoptosis pathway by the disruption of protein-protein interactions of bcl-2 family members and triggered the activation of bax and bak in aml cells. |
2014-05-22 |
2023-08-12 |
Not clear |
| Yubo Liu, Zhiqiang Li, Ting Song, Zuguang Xue, Zhichao Zhan. Mechanisms of anti-leukemic activity of the Bcl-2 homology domain-3 mimetic S1. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 67. issue 7. 2014-05-22. PMID:23706691. |
furthermore, s1-induced apoptosis was largely reduced in cells with shrna-mediated downregulation of bak but not bax. |
2014-05-22 |
2023-08-12 |
Not clear |
| Karina J Matissek, Mohanad Mossalam, Abood Okal, Carol S Li. The DNA binding domain of p53 is sufficient to trigger a potent apoptotic response at the mitochondria. Molecular pharmaceutics. vol 10. issue 10. 2014-05-22. PMID:23968395. |
the tumor suppressor p53 is one of the most studied proteins in human cancer.1-3 while nuclear p53 has been utilized for cancer gene therapy, mitochondrial targeting of p53 has not been fully exploited to date.4,5 in response to cellular stress, p53 translocates to the mitochondria and directly interacts with bcl-2 family proteins including antiapoptotic bcl-xl and bcl-2 and proapoptotic bak and bax.6 antiapoptotic bcl-xl forms inhibitory complexes with proapoptotic bak and bax preventing their homo-oligomerization.7 upon translocation to the mitochondria, p53 binds to bcl-xl, releases bak and bax from the inhibitory complex and enhances their homo-oligomerization.8 bak and bax homotetramer formation disrupts the mitochondrial outer membrane, releases antiapoptotic factors such as cytochrome c and triggers a rapid apoptotic response mediated by caspase induction.9 it is still unclear if the mdm2 binding domain (mbd), the proline-rich domain (prd) and/or dna binding domain (dbd) of p53 are the domains responsible for interaction with bcl-xl.10-17 the purpose of this work is to determine if a smaller functional domain of p53 is capable of inducing apoptosis similarly to full length p53. |
2014-05-22 |
2023-08-12 |
human |
| Victor Jeannot, Benoît Busser, Elisabeth Brambilla, Marie Wislez, Blaise Robin, Jacques Cadranel, Jean-Luc Coll, Amandine Hurbi. The PI3K/AKT pathway promotes gefitinib resistance in mutant KRAS lung adenocarcinoma by a deacetylase-dependent mechanism. International journal of cancer. vol 134. issue 11. 2014-05-22. PMID:24374738. |
the combination of pi3k/akt inhibition with gefitinib restored apoptosis via ku70 downregulation and bax release from ku70. |
2014-05-22 |
2023-08-12 |
Not clear |
| Yong Chan Kim, Seok Bean Song, Sang Kyu Lee, Sang Min Park, Young Sang Ki. The Nuclear Orphan Receptor NR4A1 is Involved in the Apoptotic Pathway Induced by LPS and Simvastatin in RAW 264.7 Macrophages. Immune network. vol 14. issue 2. 2014-05-22. PMID:24851101. |
furthermore, apoptosis was accompanied by bcl-2-associated x protein (bax) translocation to the mitochondria. |
2014-05-22 |
2023-08-13 |
mouse |
| Yong Chan Kim, Seok Bean Song, Sang Kyu Lee, Sang Min Park, Young Sang Ki. The Nuclear Orphan Receptor NR4A1 is Involved in the Apoptotic Pathway Induced by LPS and Simvastatin in RAW 264.7 Macrophages. Immune network. vol 14. issue 2. 2014-05-22. PMID:24851101. |
our findings suggest that nr4a1 expression and mitochondrial translocation of bax are related to simvastatin-induced apoptosis in lps-activated raw 264.7 macrophages. |
2014-05-22 |
2023-08-13 |
mouse |
| Gustavo J S Pereira, Nicole Tressoldi, Hanako Hirata, Claudia Bincoletto, Soraya S Smail. Autophagy as a neuroprotective mechanism against 3-nitropropionic acid-induced murine astrocyte cell death. Neurochemical research. vol 38. issue 11. 2014-05-21. PMID:24085658. |
we showed that 3-np-induced apoptosis, which was accompanied by bax and beclin-1 upregulation, was dependent on acidic vesicular organelle (avo) formation after a continuous exposure to 3-np for 12 h. the upregulation of bax and beclin-1 as well as avo formation were normalized 24 h after 3-np exposure. |
2014-05-21 |
2023-08-12 |
Not clear |
| D Korkmaz, E Bastu, O Dural, C Yasa, E Yavuz, F Buyr. Apoptosis through regulation of Bcl-2, Bax and Mcl-1 expressions in endometriotic cyst lesions and the endometrium of women with moderate to severe endometriosis. Journal of obstetrics and gynaecology : the journal of the Institute of Obstetrics and Gynaecology. vol 33. issue 7. 2014-05-20. PMID:24127964. |
apoptosis through regulation of bcl-2, bax and mcl-1 expressions in endometriotic cyst lesions and the endometrium of women with moderate to severe endometriosis. |
2014-05-20 |
2023-08-12 |
Not clear |
| D Korkmaz, E Bastu, O Dural, C Yasa, E Yavuz, F Buyr. Apoptosis through regulation of Bcl-2, Bax and Mcl-1 expressions in endometriotic cyst lesions and the endometrium of women with moderate to severe endometriosis. Journal of obstetrics and gynaecology : the journal of the Institute of Obstetrics and Gynaecology. vol 33. issue 7. 2014-05-20. PMID:24127964. |
the aim of the study was to evaluate apoptosis through regulation of bcl-2, bax and mcl-1 proteins by comparing their expressions in endometriotic cyst lesions and the endometrium of the patients with moderate to severe endometriosis. |
2014-05-20 |
2023-08-12 |
Not clear |
| Kai Liu, Jinli Lou, Tao Wen, Jiming Yin, Bin Xu, Wei Ding, Anna Wang, Daojie Liu, Chao Zhang, Dexi Chen, Ning L. Depending on the stage of hepatosteatosis, p53 causes apoptosis primarily through either DRAM-induced autophagy or BAX. Liver international : official journal of the International Association for the Study of the Liver. vol 33. issue 10. 2014-05-19. PMID:23875779. |
depending on the stage of hepatosteatosis, p53 causes apoptosis primarily through either dram-induced autophagy or bax. |
2014-05-19 |
2023-08-12 |
Not clear |
| Chae Won Kim, Jing Nan Lu, Se-Il Go, Ji Hyun Jung, Sang Mi Yi, Jae-Hoon Jeong, Young-Sool Hah, Myung Shin Han, Jeong Woo Park, Won Sup Lee, Young Joo Mi. p53 restoration can overcome cisplatin resistance through inhibition of Akt as well as induction of Bax. International journal of oncology. vol 43. issue 5. 2014-05-19. PMID:23970333. |
the induction of wild-type p53 can enhance cddp-induced apoptosis not only by inducing bax protein but also by suppressing anti-apoptotic proteins through inhibition of akt. |
2014-05-19 |
2023-08-12 |
Not clear |
| Yajun Wang, Wanglong Zheng, Xiaojiao Bian, Yan Yuan, Jianhong Gu, Xuezhong Liu, Zongping Liu, Jianchun Bia. Zearalenone induces apoptosis and cytoprotective autophagy in primary Leydig cells. Toxicology letters. vol 226. issue 2. 2014-05-19. PMID:24530352. |
zea treatment upregulated bax expression, promoted cytochrome c release into the cytosol, and triggered mitochondria-mediated apoptosis. |
2014-05-19 |
2023-08-12 |
rat |
| X Y Song, J F Hu, M N Sun, Z P Li, D H Wu, H J Ji, Y H Yuan, Z X Zhu, N Han, G Liu, N H Che. IMM-H004, a novel coumarin derivative compound, protects against amyloid beta-induced neurotoxicity through a mitochondrial-dependent pathway. Neuroscience. vol 242. 2014-05-16. PMID:23523945. |
further study indicated that imm-h004 significantly inhibited aβ-induced cytotoxicity and apoptosis by reversing aβ-induced mitochondrial dysfunction, including mmp (mitochondrial membrane potential) decrease, reactive oxygen species production, and mitochondrial release of cytochrome c. imm-h004 can regulate the interaction between bax and bcl-2, decreased levels of p53 and active caspase-3 protein induced by aβ25-35. |
2014-05-16 |
2023-08-12 |
Not clear |
| Fernando J Reyes-Zurita, Eva E Rufino-Palomares, Pedro P Medina, E Leticia García-Salguero, Juan Peragón, Marta Cascante, José A Lupiáñe. Antitumour activity on extrinsic apoptotic targets of the triterpenoid maslinic acid in p53-deficient Caco-2 adenocarcinoma cells. Biochimie. vol 95. issue 11. 2014-05-14. PMID:23973282. |
this induction of apoptosis was correlated with the early activation of caspase-8 and caspase-3, the activation of caspase-8 was also correlated with higher levels of bid cleavage and decreased bcl-2, but with no change in bax expression. |
2014-05-14 |
2023-08-12 |
human |
| Fernando J Reyes-Zurita, Eva E Rufino-Palomares, Pedro P Medina, E Leticia García-Salguero, Juan Peragón, Marta Cascante, José A Lupiáñe. Antitumour activity on extrinsic apoptotic targets of the triterpenoid maslinic acid in p53-deficient Caco-2 adenocarcinoma cells. Biochimie. vol 95. issue 11. 2014-05-14. PMID:23973282. |
incubation with maslinic acid also resulted in the later activation of caspase-9, which, together with the lack of any bax activation, suggests that the mitochondrial pathway is not required for apoptosis induced by maslinic acid in this cell line. |
2014-05-14 |
2023-08-12 |
human |
| Zitong Zhao, Cheng Yang, Lingyan Wang, Long Li, Tian Zhao, Linkun Hu, Ruiming Rong, Ming Xu, Tongyu Zh. The regulatory T cell effector soluble fibrinogen-like protein 2 induces tubular epithelial cell apoptosis in renal transplantation. Experimental biology and medicine (Maywood, N.J.). vol 239. issue 2. 2014-05-14. PMID:24414480. |
in vitro, sfgl2 remarkably induced tec apoptosis, with a significant up-regulation of proapoptotic genes, including casp-3, casp-8, casp-9, casp-10, tradd, tnfsf10, fadd, fas, faslg, bak1, bad, bax, and nf-kb1. |
2014-05-14 |
2023-08-12 |
human |
| Guoping Zhao, Yanglong Zhu, Colins O Eno, Yanlong Liu, Lynn Deleeuw, Joseph A Burlison, Jonathan B Chaires, John O Trent, Chi L. Activation of the proapoptotic Bcl-2 protein Bax by a small molecule induces tumor cell apoptosis. Molecular and cellular biology. vol 34. issue 7. 2014-05-14. PMID:24421393. |
activation of the proapoptotic bcl-2 protein bax by a small molecule induces tumor cell apoptosis. |
2014-05-14 |
2023-08-12 |
Not clear |
| Guoping Zhao, Yanglong Zhu, Colins O Eno, Yanlong Liu, Lynn Deleeuw, Joseph A Burlison, Jonathan B Chaires, John O Trent, Chi L. Activation of the proapoptotic Bcl-2 protein Bax by a small molecule induces tumor cell apoptosis. Molecular and cellular biology. vol 34. issue 7. 2014-05-14. PMID:24421393. |
the proapoptotic bcl-2 protein bax by itself is sufficient to initiate apoptosis in almost all apoptotic paradigms. |
2014-05-14 |
2023-08-12 |
Not clear |
| Guoping Zhao, Yanglong Zhu, Colins O Eno, Yanlong Liu, Lynn Deleeuw, Joseph A Burlison, Jonathan B Chaires, John O Trent, Chi L. Activation of the proapoptotic Bcl-2 protein Bax by a small molecule induces tumor cell apoptosis. Molecular and cellular biology. vol 34. issue 7. 2014-05-14. PMID:24421393. |
our study has revealed a compound that activates bax and induces bax-dependent apoptosis, which may lead to the development of new therapeutic agents for cancer. |
2014-05-14 |
2023-08-12 |
Not clear |
| Xiaoli Feng, Teresa Holmlund, Chengyun Zheng, Bengt Fadee. Proapoptotic effects of the novel proteasome inhibitor b-AP15 on multiple myeloma cells and natural killer cells. Experimental hematology. vol 42. issue 3. 2014-05-13. PMID:24291587. |
we also demonstrate that b-ap15 induces activation of the mitochondrial apoptosis pathway in mm cells, with activation of the proapoptotic protein bax and a pronounced loss of the mitochondrial transmembrane potential. |
2014-05-13 |
2023-08-12 |
human |