| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Jingzhen Ding, Blaine H M Mooers, Zhi Zhang, Justin Kale, Domina Falcone, Jamie McNichol, Bo Huang, Xuejun C Zhang, Chengguo Xing, David W Andrews, Jialing Li. After embedding in membranes antiapoptotic Bcl-XL protein binds both Bcl-2 homology region 3 and helix 1 of proapoptotic Bax protein to inhibit apoptotic mitochondrial permeabilization. The Journal of biological chemistry. vol 289. issue 17. 2014-06-25. PMID:24616095. |
bcl-xl binds to bax, inhibiting bax oligomerization required for mitochondrial outer membrane permeabilization (momp) during apoptosis. |
2014-06-25 |
2023-08-12 |
Not clear |
| Mariko Saito, Mitsuo Sait. Involvement of sphingolipids in ethanol neurotoxicity in the developing brain. Brain sciences. vol 3. issue 2. 2014-06-25. PMID:24961420. |
the ethanol-induced apoptosis is mitochondria-dependent, involving bax and caspase-3 activation. |
2014-06-25 |
2023-08-13 |
human |
| Anzhou Xia, Zhi Xue, Yong Li, Wei Wang, Jieyun Xia, Tiantian Wei, Jing Cao, Weidong Zho. Cardioprotective effect of betulinic Acid on myocardial ischemia reperfusion injury in rats. Evidence-based complementary and alternative medicine : eCAM. vol 2014. 2014-06-25. PMID:24963326. |
the expression of bcl-2 and bax and the apoptosis of cardiomyocytes were investigated with western blot and tunel assay, respectively. |
2014-06-25 |
2023-08-13 |
rat |
| Nancy P Gómez-Crisóstomo, Rebeca López-Marure, Estrella Zapata, Cecilia Zazueta, Eduardo Martínez-Abundi. Bax induces cytochrome c release by multiple mechanisms in mitochondria from MCF7 cells. Journal of bioenergetics and biomembranes. vol 45. issue 5. 2014-06-24. PMID:23536162. |
we also, induced apoptosis in mcf7 cell cultures with tnf-α plus cycloheximide to determine the effect of such compounds in apoptosis induction via mptp or bax oligomerization. |
2014-06-24 |
2023-08-12 |
Not clear |
| Nancy P Gómez-Crisóstomo, Rebeca López-Marure, Estrella Zapata, Cecilia Zazueta, Eduardo Martínez-Abundi. Bax induces cytochrome c release by multiple mechanisms in mitochondria from MCF7 cells. Journal of bioenergetics and biomembranes. vol 45. issue 5. 2014-06-24. PMID:23536162. |
cytochrome c release was totally prevented by csa and partially by bcb when apoptosis was induced with recombinant bax in isolated mitochondria from mcf7 cells. |
2014-06-24 |
2023-08-12 |
Not clear |
| Xiao-Mei Zhuang, Guo-Lin Shen, Wei-Bin Xiao, Yan Tan, Chuang Lu, Hua L. Assessment of the roles of P-glycoprotein and cytochrome P450 in triptolide-induced liver toxicity in sandwich-cultured rat hepatocyte model. Drug metabolism and disposition: the biological fate of chemicals. vol 41. issue 12. 2014-06-24. PMID:24065861. |
in addition, hepatotoxicity and the expression of apoptosis proteins bax and bcl-2 were correlated qualitatively with the tp exposure duration and its intracellular concentration, which, in turn, can be modulated by p-gp inhibitors or inducers. |
2014-06-24 |
2023-08-12 |
rat |
| Haiyan Chen, Zhengqing Zhao, Jiaoyang Zheng, Xiangfang Chen, Junjie Zou, Yongquan Shi, Zhimin Li. The effect of IGF-1 on symptoms of sleep deprivation in a rat model of inflammatory heart disease and metabolic syndrome. Biochemical and biophysical research communications. vol 446. issue 4. 2014-06-24. PMID:24613383. |
igf-1 administration also reduced the phosphorylation of akt and expression of bax, a promoter of apoptosis. |
2014-06-24 |
2023-08-12 |
rat |
| Tomas Kolta. Clusterin: a key player in cancer chemoresistance and its inhibition. OncoTargets and therapy. vol 7. 2014-06-24. PMID:24672247. |
isoform 2 is overexpressed under cellular stress conditions and protects cells from apoptosis by impeding bax actions on the mitochondrial membrane and exerts other protumor activities, like phosphatidylinositol 3-kinase/protein kinase b pathway activation, modulation of extracellular signal-regulated kinase 1/2 signaling and matrix metallopeptidase-9 expression, increased angiogenesis, modulation of the nuclear factor kappa b pathway, among others. |
2014-06-24 |
2023-08-12 |
rat |
| Maisa Mahmoud Ali Kamkar, Rasheed Ahmad, Osama Alsmadi, Kazem Behbehan. Insight into the impact of diabetes mellitus on the increased risk of hepatocellular carcinoma: mini-review. Journal of diabetes and metabolic disorders. vol 13. 2014-06-24. PMID:24918094. |
the first approach is to look at the role of inflammatory mediators (tnf-α and il-6) in apoptosis and inflammation during hepatocarcinogenesis through monitoring levels of apoptotic regulators, b-cell lymphoma 2 protein which is encoded by bcl2 gene and apoptosis regulator bax known as bcl-2-like protein 4 which is encoded by the bax gene. |
2014-06-24 |
2023-08-13 |
Not clear |
| Fengzhi L. Anticancer drug FL118 is more than a survivin inhibitor: where is the Achilles' heel of cancer? American journal of cancer research. vol 4. issue 3. 2014-06-24. PMID:24959385. |
fl118 was found to not only inhibit multiple antiapoptotic proteins (survivin, xiap, ciap2) in the inhibitor of apoptosis (iap) family, but to also inhibit the antiapoptotic protein mcl-1 in the bcl-2 family, while inducing the pro-apoptotic proteins bax and bim expression. |
2014-06-24 |
2023-08-13 |
Not clear |
| Dong Zhou, Roderick J Tan, Lili Zhou, Yingjian Li, Youhua Li. Kidney tubular β-catenin signaling controls interstitial fibroblast fate via epithelial-mesenchymal communication. Scientific reports. vol 3. 2014-06-23. PMID:23698793. |
interestingly, less apoptosis was detected in interstitial fibroblasts in knockout mice, which was accompanied by a decreased expression of bax and fas ligand (fasl). |
2014-06-23 |
2023-08-12 |
mouse |
| Q Liao, Z Zeng, X Guo, X Li, F Wei, W Zhang, X Li, P Chen, F Liang, B Xiang, J Ma, M Wu, H Tang, M Deng, X Zeng, K Tang, W Xiong, G L. LPLUNC1 suppresses IL-6-induced nasopharyngeal carcinoma cell proliferation via inhibiting the Stat3 activation. Oncogene. vol 33. issue 16. 2014-06-23. PMID:23708661. |
induction of lplunc1 overexpression inhibited npc cell proliferation, induced npc cell arrest, promoted npc cell apoptosis even after il-6 stimulation and inhibited the growth of implanted npc tumors in vivo, which were associated with decreasing cyclin d1 and bcl-2 expression and the janus kinase 2 (jak2)/stat3 activation, but enhancing bax and p21 expression. |
2014-06-23 |
2023-08-12 |
Not clear |
| Amanda L Edwards, Evripidis Gavathiotis, James L LaBelle, Craig R Braun, Kwadwo A Opoku-Nsiah, Gregory H Bird, Loren D Walensk. Multimodal interaction with BCL-2 family proteins underlies the proapoptotic activity of PUMA BH3. Chemistry & biology. vol 20. issue 7. 2014-06-23. PMID:23890007. |
we further demonstrated that a cell-permeable puma sahb analog induces apoptosis in neuroblastoma cells and, like expressed puma protein, engages bcl-2, mcl-1, and bax. |
2014-06-23 |
2023-08-12 |
human |
| Richard L Jayaraj, Kuppusamy Tamilselvam, Thamilarasan Manivasagam, Namasivayam Elangova. Neuroprotective effect of CNB-001, a novel pyrazole derivative of curcumin on biochemical and apoptotic markers against rotenone-induced SK-N-SH cellular model of Parkinson's disease. Journal of molecular neuroscience : MN. vol 51. issue 3. 2014-06-23. PMID:23900721. |
rotenone insult significantly reduced cell viability (mtt assay) and resulted in 78 % apoptosis (dual staining) by altering bcl-2, bax, caspase-3, and cytochrome c expression. |
2014-06-23 |
2023-08-12 |
Not clear |
| Li Han, Canjie Wu, Hasan Riaz, Liya Bai, Jianguo Chen, Yanhong Zhen, Aizhen Guo, Liguo Yan. Characterization of the mechanism of inhibin α-subunit gene in mouse anterior pituitary cells by RNA interference. PloS one. vol 8. issue 10. 2014-06-23. PMID:24098340. |
the results indicated that inhibin silencing significantly promoted apoptosis by up-regulating caspase-3, bax and bcl-2 genes without affecting p53 both at transcriptional and translational levels. |
2014-06-23 |
2023-08-12 |
mouse |
| Yu-Bin Ji, Chen-Feng Ji, Lei Yu. Human gastric cancer cell line SGC-7901 apoptosis induced by SFPS-B2 via a mitochondrial-mediated pathway. Bio-medical materials and engineering. vol 24. issue 1. 2014-06-23. PMID:24212007. |
it also increased the activity of caspase-9 and caspase-3, down-regulated the expression of bcl-2 and up-regulated the expression of bax, induced the release of cyt-c. sfps-b2 induced sgc-7901 apoptosis through a mitochondrial-mediated pathway, suggesting it may be an agent for cancer treatment. |
2014-06-23 |
2023-08-12 |
human |
| Kaiyu Zhou, Hailong Ji, Tianming Mao, Zhiqiang Ba. Effects of matrine on the proliferation and apoptosis of human medulloblastoma cell line D341. International journal of clinical and experimental medicine. vol 7. issue 4. 2014-06-23. PMID:24955161. |
d341 cell proliferation was analyzed using a cell counting kit-8 assay, apoptosis was detected by annexin-v fitc/pi double-staining, and the expression of bax, bcl-2, caspase-3 and caspase-9 was detected by western blotting. |
2014-06-23 |
2023-08-13 |
human |
| Kaiyu Zhou, Hailong Ji, Tianming Mao, Zhiqiang Ba. Effects of matrine on the proliferation and apoptosis of human medulloblastoma cell line D341. International journal of clinical and experimental medicine. vol 7. issue 4. 2014-06-23. PMID:24955161. |
the study suggests that matrine could induce human medulloblastoma d341 cells apoptosis and inhibit the cells proliferation in vitro by activating bax, caspase-3 and caspase-9 and reducing bcl-2 expression. |
2014-06-23 |
2023-08-13 |
human |
| Martina Croci, Martina Dettwiler, Lloyd Vaughan, Franco Guscett. Immunohistochemical expression of Bax and Bak in canine non-neoplastic tissues. Veterinary journal (London, England : 1997). vol 198. issue 1. 2014-06-19. PMID:23988332. |
the bcl-2 family of proteins plays a key role in intrinsic apoptosis by controlling the integrity of the outer mitochondrial membrane, and the multidomain pro-apoptotic bcl-2 family members bax and bak are essential components of this pathway. |
2014-06-19 |
2023-08-12 |
Not clear |
| Sadegh Fattahi, Ali Motevalizadeh Ardekani, Ebrahim Zabihi, Zeinab Abedian, Amrollah Mostafazadeh, Roghayeh Pourbagher, Haleh Akhavan-Niak. Antioxidant and apoptotic effects of an aqueous extract of Urtica dioica on the MCF-7 human breast cancer cell line. Asian Pacific journal of cancer prevention : APJCP. vol 14. issue 9. 2014-06-18. PMID:24175819. |
this anti proliferative activity was associated with an increase of apoptosis as demonstrated by dna fragmentation, the appearance of apoptotic cells in flow cytometry analysis and an increase of the amount of calpain 1, calpastatin, caspase 3, caspase 9, bax and bcl-2, all proteins involved in the apoptotic pathway. |
2014-06-18 |
2023-08-12 |
human |