| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Ting Gui, Yueming Wang, Lixing Zhang, Wenjing Wang, Hao Zhu, Wenlong Din. Krüppel-like factor 6 rendered rat Schwann cell more sensitive to apoptosis via upregulating FAS expression. PloS one. vol 8. issue 12. 2014-07-31. PMID:24324791. |
although klf6 overexpression exacerbated cisplatin- and tnfα-induced apoptosis, expression levels of the apoptosis regulators bcl2 and bax were not significantly affected in either klf6-overexpressing or klf6-depleted rsc96 cells. |
2014-07-31 |
2023-08-12 |
rat |
| Li-Jiang Tao, Xin-Die Zhou, Cheng-Chun Shen, Cheng-Zhen Liang, Bing Liu, Yiqing Tao, Hui-Min Ta. Tetrandrine induces apoptosis and triggers a caspase cascade in U2-OS and MG-63 cells through the intrinsic and extrinsic pathways. Molecular medicine reports. vol 9. issue 1. 2014-07-29. PMID:24173687. |
furthermore, the apoptosis of osteosarcoma cells was accompanied by increased cytochrome c (cyto-c), apoptotic protease-activating factor (apaf)-1, bid and bax activation and reduced bcl-2 and bcl-xl activation, demonstrating that the apoptosis may have occurred through the mitochondrial pathway. |
2014-07-29 |
2023-08-12 |
Not clear |
| Eunhye Kim, Sang-Hwan Hyu. Comparative analysis of various donor cell types for somatic cell nuclear transfer and its association with apoptosis and senescence. Molecular medicine reports. vol 9. issue 1. 2014-07-29. PMID:24190282. |
at the 9th doubling passage, parameters associated with senescence and apoptosis, including morphology, mrna expression (tp53, bcl‑2, bax) and reactive oxygen species (ros) levels, were evaluated. |
2014-07-29 |
2023-08-12 |
human |
| X Xu, H Zhu, T Wang, Y Sun, P Ni, Y Liu, S Tian, P Amoah Barnie, H Shen, W Xu, H Xu, Z S. Exogenous high-mobility group box 1 inhibits apoptosis and promotes the proliferation of lewis cells via RAGE/TLR4-dependent signal pathways. Scandinavian journal of immunology. vol 79. issue 6. 2014-07-29. PMID:24673192. |
in the present study, we firstly found the apoptosis of lewis was increased following hanks' balanced salt solution (hbss)-induced starvation, while it was rescued after exogenous hmgb1 protein was added; furthermore, the receptor for advanced glycation end products (rage) and toll-like receptor (tlr4) could coordinately improve the proliferation of tumour cells in vitro, and hmgb1 could enhance the phosphorylation of pi3k/akt and erk1/2, inhibit the expression of pro-apoptosis protein bax and promote the expression of anti-apoptosis protein bcl-2. |
2014-07-29 |
2023-08-12 |
Not clear |
| Rong Qin, Huiling Shen, Yuan Cao, Yue Fang, Hao Li, Qiaoyun Chen, Wenlin X. Tetrandrine induces mitochondria-mediated apoptosis in human gastric cancer BGC-823 cells. PloS one. vol 8. issue 10. 2014-07-28. PMID:24098511. |
it increased the apoptosis; upregulation of bax, bak, and bad; and downregulation of bcl-2 and bcl-xl in bgc-823 cells. |
2014-07-28 |
2023-08-12 |
mouse |
| Ming Li, Jun Wang, Shi-Yun Tan, Jian-Hua Chen, Wei Cui, Zhi-Qiang Chen, Jian Zhan. Growth inhibition effect of peptide P110 plus cisplatin on various cancer cells and xenotransplanted tumors in mice. Molecular medicine reports. vol 7. issue 4. 2014-07-25. PMID:23447049. |
this synergistic effect may be associated with ddp-induced apoptosis, involving the downregulation of bcl-2 and the upregulation of bax, cytochrome c and caspase-3. |
2014-07-25 |
2023-08-12 |
mouse |
| Tzong-Der Way, Shang-Jie Tsai, Chao-Min Wang, Chi-Tang Ho, Chang-Hung Cho. Chemical constituents of Rhododendron formosanum show pronounced growth inhibitory effect on non-small-cell lung carcinoma cells. Journal of agricultural and food chemistry. vol 62. issue 4. 2014-07-22. PMID:24447325. |
apoptosis was substantiated by activation of caspase-3 and -9, and a decrease in bcl-2 and an elevation of the bax were also observed following ursolic acid treatment. |
2014-07-22 |
2023-08-12 |
Not clear |
| Hai-Yan Hu, Zhi-Hui Cui, Hui-Qin Li, Yi-Ru Wang, Xiang Chen, Ji-Huang Li, Dong-Mei Xv, Guo-Qing Zhen. Fumanjian, a Classic Chinese Herbal Formula, Can Ameliorate the Impairment of Spatial Learning and Memory through Apoptotic Signaling Pathway in the Hippocampus of Rats with Aβ 1-40 -Induced Alzheimer's Disease. Evidence-based complementary and alternative medicine : eCAM. vol 2014. 2014-07-22. PMID:25050129. |
apoptosis was tested using tunel staining in hippocampus neuronal cells; rt-pcr tested expression of bcl-2 and bax mrna; western blotting tested protein level of cleaved caspase-3. |
2014-07-22 |
2023-08-13 |
rat |
| Hai-Yan Hu, Zhi-Hui Cui, Hui-Qin Li, Yi-Ru Wang, Xiang Chen, Ji-Huang Li, Dong-Mei Xv, Guo-Qing Zhen. Fumanjian, a Classic Chinese Herbal Formula, Can Ameliorate the Impairment of Spatial Learning and Memory through Apoptotic Signaling Pathway in the Hippocampus of Rats with Aβ 1-40 -Induced Alzheimer's Disease. Evidence-based complementary and alternative medicine : eCAM. vol 2014. 2014-07-22. PMID:25050129. |
fmj also significantly decreased number of tunel-positive neuronal apoptosis and the expressions of bax and cleaved caspase-3 and increased the expression of bcl-2 (p < 0.01) compared with ad model group. |
2014-07-22 |
2023-08-13 |
rat |
| Linhua Jin, Yoko Tabe, Kensuke Kojima, Masato Shikami, Julina Benito, Vivian Ruvolo, Rui-Yu Wang, Teresa McQueen, Stefan O Ciurea, Takashi Miida, Michael Andreeff, Marina Konoplev. PI3K inhibitor GDC-0941 enhances apoptotic effects of BH-3 mimetic ABT-737 in AML cells in the hypoxic bone marrow microenvironment. Journal of molecular medicine (Berlin, Germany). vol 91. issue 12. 2014-07-18. PMID:23955073. |
the combination of gdc-0941 and abt-737 profoundly downregulated antiapoptotic mcl-1 expression levels, activated bax, and induced mitochondrial apoptosis in aml cells co-cultured with bone marrow stromal cells under hypoxic conditions. |
2014-07-18 |
2023-08-12 |
Not clear |
| Husheng Ding, Jennifer S McDonald, Seongseok Yun, Paula A Schneider, Kevin L Peterson, Karen S Flatten, David A Loegering, Ann L Oberg, Shaun M Riska, Shengbing Huang, Frank A Sinicrope, Alex A Adjei, Judith E Karp, X Wei Meng, Scott H Kaufman. Farnesyltransferase inhibitor tipifarnib inhibits Rheb prenylation and stabilizes Bax in acute myelogenous leukemia cells. Haematologica. vol 99. issue 1. 2014-07-18. PMID:23996484. |
in contrast to the ras/mek/erk pathway-mediated bim upregulation that is responsible for tipifarnib-induced killing of malignant lymphoid cells, inhibition of rheb-induced mtor signaling followed by dose-dependent upregulation of bax and puma occurred in acute myelogenous leukemia cell lines undergoing tipifarnib-induced apoptosis. |
2014-07-18 |
2023-08-12 |
human |
| Patricia Gassó, Sergi Mas, Oriol Molina, Amalia Lafuente, Miquel Bernardo, Eduard Parellad. Increased susceptibility to apoptosis in cultured fibroblasts from antipsychotic-naïve first-episode schizophrenia patients. Journal of psychiatric research. vol 48. issue 1. 2014-07-18. PMID:24128664. |
cell growth, cell viability and various apoptotic hallmarks (caspase-3 activity, translocation of phosphatidylserine, chromatin condensation and gene expression of akt1, bax, bcl2, casp3, gsk3b and p53) were measured in fibroblast cultures obtained from skin biopsies of patients (n = 11) and healthy controls (n = 8), both in basal conditions and after inducing apoptosis with staurosporine. |
2014-07-18 |
2023-08-12 |
Not clear |
| Rheure Alves Moreira Lopes, Karla Bianca Neves, Cezar Rangel Pestana, André Lima Queiroz, Camila Ziliotto Zanotto, Andréia Z Chignalia, Yara Maria Valim, Leonardo R Silveira, Carlos Curti, Rita C Toste. Testosterone induces apoptosis in vascular smooth muscle cells via extrinsic apoptotic pathway with mitochondria-generated reactive oxygen species involvement. American journal of physiology. Heart and circulatory physiology. vol 306. issue 11. 2014-07-17. PMID:24658017. |
ros were determined with lucigenin and dichlorodihydrofluorescein; apoptosis, with annexin v and calcein; o2 consumption, with a clark-type electrode, and procaspases, caspases, cytochrome c, bax, and bcl-2 levels by immunoblotting. |
2014-07-17 |
2023-08-12 |
Not clear |
| Jianliang Chen, Xuesong Li, Jiandong Qiu, Hengxing You, Qingping Zhang, Guangyu Dong, You Zu. Kinetics of apoptosis and expression of apoptosis-related proteins in rat CA3 hippocampus cells after experimental diffuse brain injury. Cell biochemistry and biophysics. vol 67. issue 3. 2014-07-15. PMID:23559276. |
the present study examined kinetics of apoptosis and expression of apoptosis-related proteins bcl-2, bax, and caspase-3 in the ca3 hippocampus cells after diffuse brain injury (dbi) induced experimentally in rats. |
2014-07-15 |
2023-08-12 |
rat |
| Jianliang Chen, Xuesong Li, Jiandong Qiu, Hengxing You, Qingping Zhang, Guangyu Dong, You Zu. Kinetics of apoptosis and expression of apoptosis-related proteins in rat CA3 hippocampus cells after experimental diffuse brain injury. Cell biochemistry and biophysics. vol 67. issue 3. 2014-07-15. PMID:23559276. |
in conclusion, cell apoptosis and altered expressions of bcl-2, bax, and caspase-3 are present in the ca3 region of hippocampus after experimental dbi. |
2014-07-15 |
2023-08-12 |
rat |
| Qing Chen, Rong Zhang, Wei-min Li, Yu-jie Niu, Hui-cai Guo, Xue-hui Liu, Yu-chun Hou, Li-juan Zha. The protective effect of grape seed procyanidin extract against cadmium-induced renal oxidative damage in mice. Environmental toxicology and pharmacology. vol 36. issue 3. 2014-07-15. PMID:23958968. |
however, the coadministration of gspe attenuated cd-induced lipid peroxidation, and antagonized renal apoptosis, probably associated with the expression of bax and bcl-2. |
2014-07-15 |
2023-08-12 |
mouse |
| Omer Kacar, Zelal Adiguzel, Veysel T Yilmaz, Yuksel Cetin, Buse Cevatemre, Nazli Arda, Ahmet T Baykal, Engin Ulukaya, Ceyda Acila. Evaluation of the molecular mechanisms of a palladium(II) saccharinate complex with terpyridine as an anticancer agent. Anti-cancer drugs. vol 25. issue 1. 2014-07-15. PMID:24045367. |
other molecules that could potentially play a role in pd(ii)-induced apoptosis, such as p53 and bax, were also tested using silencing technology. |
2014-07-15 |
2023-08-12 |
human |
| Abdullah H Al-Assaf, Ali M Alqahtani, Ali A Alshatwi, Naveed A Syed, Gowhar Shafi, Tarique N Hasa. Mechanism of cadmium induced apoptosis in human peripheral blood lymphocytes: the role of p53, Fas and Caspase-3. Environmental toxicology and pharmacology. vol 36. issue 3. 2014-07-15. PMID:24100270. |
cd induced p53-dependent apoptosis through cooperation between bak upregulation without changing the bcl-2 and bax expression. |
2014-07-15 |
2023-08-12 |
human |
| Min-Cheol Kang, Kil-Nam Kim, Sung-Myung Kang, Xiudong Yang, Eun-A Kim, Choon Bok Song, Jae-Woon Nah, Mi-Kyeong Jang, Jung-Suck Lee, Won-Kyo Jung, You-Jin Jeo. Protective effect of dieckol isolated from Ecklonia cava against ethanol caused damage in vitro and in zebrafish model. Environmental toxicology and pharmacology. vol 36. issue 3. 2014-07-15. PMID:24189014. |
it was observed that dieckol reduced cell apoptosis through activation of bcl-xl and parp, and down-regulation of bax and caspase-3 in western blot analyses. |
2014-07-15 |
2023-08-12 |
zebrafish |
| Daiwei Zhou, Bingbing Liu, Xiaoshan Xiao, Peng Dai, Songmei Ma, Weihua Huan. The effect of safflower yellow on spinal cord ischemia reperfusion injury in rabbits. Oxidative medicine and cellular longevity. vol 2013. 2014-07-15. PMID:24381717. |
sy could attenuate apoptosis and sciri by enhancing bcl-2 expression and inhibiting bax and caspase-3 activation. |
2014-07-15 |
2023-08-12 |
Not clear |