| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Shenshen Zhang, Shaoping Nie, Danfei Huang, Yanling Feng, Mingyong Xi. A novel polysaccharide from Ganoderma atrum exerts antitumor activity by activating mitochondria-mediated apoptotic pathway and boosting the immune system. Journal of agricultural and food chemistry. vol 62. issue 7. 2014-07-15. PMID:24506418. |
apoptosis was associated with loss of mitochondrial membrane potential, enhancement of mitochondrial cytochrome c release and intracellular ros production, elevation of p53 and bax expression, downregulation of bcl-2, and the activation of caspase-9 and -3. |
2014-07-15 |
2023-08-12 |
mouse |
| Lydia Scarfò, Paolo Ghi. Reprogramming cell death: BCL2 family inhibition in hematological malignancies. Immunology letters. vol 155. issue 1-2. 2014-07-14. PMID:24095849. |
the bcl2 family members play a central role in regulating programmed cell death (apoptosis) and arbitrating the cellular fate through an accurate balance between pro-apoptotic (bax, bak, and bh3-only proteins) and pro-survival (bcl2 and its closest homologues, bclxl, bclw and mcl-1) factors. |
2014-07-14 |
2023-08-12 |
human |
| Kathrine E Theron, Clement B Penny, Margot J Hosi. The Bax/Bcl-2 apoptotic pathway is not responsible for the increase in apoptosis in the RU486-treated rat uterus during early pregnancy. Reproductive biology. vol 13. issue 4. 2014-07-14. PMID:24287037. |
the aim of this study was to assess whether bax and bcl-2 signaling, in response to ru486, could be crucial role players mediating apoptosis in the rat uterus during early pregnancy. |
2014-07-14 |
2023-08-12 |
rat |
| Ioanna-Katerina Aggeli, Triantafyllos Zacharias, Georgia Papapavlou, Catherine Gaitanaki, Isidoros Bei. Calcium paradox induces apoptosis in the isolated perfused Rana ridibunda heart: involvement of p38-MAPK and calpain. Canadian journal of physiology and pharmacology. vol 91. issue 12. 2014-07-14. PMID:24289081. |
in addition to lactate dehydrogenase (ldh) release in the perfusate (indicative of necrosis), we also confirmed the occurrence of apoptosis by using the tunel assay and identifying poly(adp-ribose) polymerase (parp) fragmentation and upregulated bax expression. |
2014-07-14 |
2023-08-12 |
Not clear |
| Jae-Hong Kim, Jeehyeon Ba. MCL-1ES induces MCL-1L-dependent BAX- and BAK-independent mitochondrial apoptosis. PloS one. vol 8. issue 11. 2014-07-11. PMID:24260268. |
mcl-1es was distinct from other proapoptotic bcl-2 members that induce apoptosis by promoting bax or bak oligomerization, leading to mitochondrial outer membrane permeabilization (momp), in that mcl-1es promoted mitochondrial apoptosis independently of both bax and bak. |
2014-07-11 |
2023-08-12 |
Not clear |
| Xia Li, Xueli Zeng, Jianguo Sun, Hua Li, Ping Wu, Kwok-Pui Fung, Feiyan Li. Imperatorin induces Mcl-1 degradation to cooperatively trigger Bax translocation and Bak activation to suppress drug-resistant human hepatoma. Cancer letters. vol 348. issue 1-2. 2014-07-10. PMID:24680709. |
at the molecular level, we identified mcl-1 as the molecular target of imperatorin and determined that imperatorin induces proteosome-dependent mcl-1 degradation to release bak and bax to trigger apoptosis in liver cancer cells. |
2014-07-10 |
2023-08-12 |
human |
| Bin Yu, Xiao-Jing Shi, Yong-Fei Zheng, Yuan Fang, En Zhang, De-Quan Yu, Hong-Min Li. A novel [1,2,4] triazolo [1,5-a] pyrimidine-based phenyl-linked steroid dimer: synthesis and its cytotoxic activity. European journal of medicinal chemistry. vol 69. 2014-07-08. PMID:24077182. |
further mechanistic studies revealed that treatment of ec109 cells with compound 3 caused an obvious g2/m arrest in a concentration- and time-dependent manner and induced apoptosis probably through the mitochondrial pathway accompanied with the decrease of mitochondrial membrane potential, activations of caspase-9/-3, cleavage of mdm2 as well as up-regulation of the expressions of p53 and bax. |
2014-07-08 |
2023-08-12 |
human |
| Kan He, Xingnan Zheng, Lin Zhang, Jian Y. Hsp90 inhibitors promote p53-dependent apoptosis through PUMA and Bax. Molecular cancer therapeutics. vol 12. issue 11. 2014-07-07. PMID:23966620. |
hsp90 inhibitors promote p53-dependent apoptosis through puma and bax. |
2014-07-07 |
2023-08-12 |
Not clear |
| Kan He, Xingnan Zheng, Lin Zhang, Jian Y. Hsp90 inhibitors promote p53-dependent apoptosis through PUMA and Bax. Molecular cancer therapeutics. vol 12. issue 11. 2014-07-07. PMID:23966620. |
in this study, we found that structurally unrelated hsp90 inhibitors induce dna damage and apoptosis via p53-dependent induction of puma, which indirectly triggers bax activation and mitochondrial dysfunction in colon cancer cells. |
2014-07-07 |
2023-08-12 |
Not clear |
| Kan He, Xingnan Zheng, Lin Zhang, Jian Y. Hsp90 inhibitors promote p53-dependent apoptosis through PUMA and Bax. Molecular cancer therapeutics. vol 12. issue 11. 2014-07-07. PMID:23966620. |
deficiency in puma, bax, or p53, at lesser extent, abrogated 17-allylamino-17-demethoxygeldanamycin (17-aag)-induced apoptosis and mitochondrial dysfunction, and enhanced clonogenic cell survival. |
2014-07-07 |
2023-08-12 |
Not clear |
| Zhenjiang Liu, Lu Gan, Xiaobo Yang, Zhenzhen Zhang, Chao Su. Hydrodynamic tail vein injection of SOCS3 eukaryotic expression vector in vivo promoted liver lipid metabolism and hepatocyte apoptosis in mouse. Biochemistry and cell biology = Biochimie et biologie cellulaire. vol 92. issue 2. 2014-07-06. PMID:24697696. |
meanwhile, liver cell apoptosis was observed by hoechst and tunel staining and the expression of apoptosis related proteins bax, bcl-2, and caspase3 were detected as well as the jak2/stat3 signaling pathway. |
2014-07-06 |
2023-08-13 |
mouse |
| Rekha Meena, Man Mohan Misro, Debidas Ghos. Complete sperm suppression in rats with dienogest plus testosterone undecanoate is facilitated through apoptosis in testicular cells. Reproductive sciences (Thousand Oaks, Calif.). vol 20. issue 7. 2014-07-02. PMID:23202726. |
rise in the activities of caspase 8 and 9 was associated with overexpression of upstream marker proteins from extrinsic (fas [fatty acid synthase], fasl [fatty acid synthase ligand], and caspase 8) and intrinsic (bax [bcl2-associated-x protein], bcl2 [b-cell lymphoma 2], and caspase 9) pathways of apoptosis. |
2014-07-02 |
2023-08-12 |
rat |
| Gokulakrishnan Adikesavan, Magendira Mani Vinayagam, Liyakath Ali Abdulrahman, Thirunavukkarasu Chinnasam. (-)-Epigallocatechin-gallate (EGCG) stabilize the mitochondrial enzymes and inhibits the apoptosis in cigarette smoke-induced myocardial dysfunction in rats. Molecular biology reports. vol 40. issue 12. 2014-07-02. PMID:24197690. |
further, cs exposure was found to induce cardiac apoptosis through release of cytochrome c into the cytosol, cleavage of pro-caspase-3 to active caspase-3, up-regulation of pro-apoptotic (bax) and down-regulation of antiapoptotic (bcl-2) molecules. |
2014-07-02 |
2023-08-12 |
rat |
| Gokulakrishnan Adikesavan, Magendira Mani Vinayagam, Liyakath Ali Abdulrahman, Thirunavukkarasu Chinnasam. (-)-Epigallocatechin-gallate (EGCG) stabilize the mitochondrial enzymes and inhibits the apoptosis in cigarette smoke-induced myocardial dysfunction in rats. Molecular biology reports. vol 40. issue 12. 2014-07-02. PMID:24197690. |
egcg administration inhibited apoptosis through the inhibition of cytochrome c release into cytosol, activation of pro-caspase-3, down regulation of bax and significant up regulation of bcl-2. |
2014-07-02 |
2023-08-12 |
rat |
| Jian-ye Zhang, Tao Yi, Jing Liu, Zhong-zhen Zhao, Hu-biao Che. Quercetin induces apoptosis via the mitochondrial pathway in KB and KBv200 cells. Journal of agricultural and food chemistry. vol 61. issue 9. 2014-06-30. PMID:23410218. |
the apoptosis induced by quercetin was not related to the regulation of bcl-2 or bax in kb and kbv200 cells. |
2014-06-30 |
2023-08-12 |
human |
| Anna Bodanovsky, Noga Guttman, Hila Barzilai-Tutsch, Ola Genin, Oshrat Levy, Mark Pines, Orna Halev. Halofuginone improves muscle-cell survival in muscular dystrophies. Biochimica et biophysica acta. vol 1843. issue 7. 2014-06-30. PMID:24703880. |
inhibition of apoptosis or staurosporine-induced apoptosis by halofuginone in mdx primary myoblasts and c2 myogenic cell line, respectively, was reflected by less pyknotic/apoptotic cells and reduced bax expression. |
2014-06-30 |
2023-08-13 |
mouse |
| Nathalia da Costa Pereira Soares, Anderson Junger Teodoro, Felipe Leite Oliveira, Carlos Antonio do Nascimento Santos, Christina Maeda Takiya, Oswaldo Saback Junior, Mario Bianco, Antonio Palumbo Junior, Luiz Eurico Nasciutti, Luciana Bueno Ferreira, Etel Rodrigues Pereira Gimba, Radovan Borojevi. Influence of lycopene on cell viability, cell cycle, and apoptosis of human prostate cancer and benign hyperplastic cells. Nutrition and cancer. vol 65. issue 7. 2014-06-26. PMID:24053141. |
using real time pcr assay, lycopene also induced apoptosis in prostate cancer cells with altered gene expression of bax and bcl-2. |
2014-06-26 |
2023-08-12 |
human |
| Wei Wang, Cheng-Hai Zhao, Ning Zhang, Jian Wan. Vitamin D analog EB1089 induces apoptosis in a subpopulation of SGC-7901 gastric cancer cells through a mitochondrial-dependent apoptotic pathway. Nutrition and cancer. vol 65. issue 7. 2014-06-26. PMID:24099173. |
eb1089 decreased the proliferation, increased apoptosis, and induced mitochondrial damage in the sp cells isolated from 1 cell type (sgc-7901), but not mp cells, through increased bax and decreased bcl-2 and bcl-xl protein expression. |
2014-06-26 |
2023-08-12 |
Not clear |
| Criselda Mendoza-Milla, Ana Valero Jiménez, Claudia Rangel, Alfredo Lozano, Violeta Morales, Carina Becerril, Roberto Chavira, Víctor Ruiz, Lourdes Barrera, Martha Montaño, Annie Pardo, Moisés Selma. Dehydroepiandrosterone has strong antifibrotic effects and is decreased in idiopathic pulmonary fibrosis. The European respiratory journal. vol 42. issue 5. 2014-06-25. PMID:23143540. |
this effect was accompanied by upregulation of several pro-apoptotic proteins (bax and cyclin-dependent kinase-inhibitor cdnk1a) and downregulation of anti-apoptotic proteins, such as cellular inhibitor of apoptosis (c-iap)1 and c-iap2. |
2014-06-25 |
2023-08-12 |
human |
| Aslamuzzaman Kazi, Sevil Ozcan, Awet Tecleab, Ying Sun, Harshani R Lawrence, Saïd M Sebt. Discovery of PI-1840, a novel noncovalent and rapidly reversible proteasome inhibitor with anti-tumor activity. The Journal of biological chemistry. vol 289. issue 17. 2014-06-25. PMID:24570003. |
in intact cancer cells, pi-1840 inhibits ct-l activity, induces the accumulation of proteasome substrates p27, bax, and iκb-α, inhibits survival pathways and viability, and induces apoptosis. |
2014-06-25 |
2023-08-12 |
mouse |