| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Jun Liu, Yazhou Yao, Huifang Ding, Renan Che. Oxymatrine triggers apoptosis by regulating Bcl-2 family proteins and activating caspase-3/caspase-9 pathway in human leukemia HL-60 cells. Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine. vol 35. issue 6. 2014-08-19. PMID:24563336. |
the increase in apoptosis upon treatment with oxymatrine was correlated with downregulation of anti-apoptotic bcl-2 expression and upregulation of pro-apoptotic bax expression. |
2014-08-19 |
2023-08-12 |
human |
| Wenna Liang, Xihai Li, Yachan Li, Candong Li, Bizheng Gao, Huijuan Gan, Sumin Li, Jianying Shen, Jie Kang, Shanshan Ding, Xuejuan Lin, Linghong Lia. Gallic acid induces apoptosis and inhibits cell migration by upregulating miR-518b in SW1353 human chondrosarcoma cells. International journal of oncology. vol 44. issue 1. 2014-08-18. PMID:24173143. |
hoechst 33258 staining assay and annexin v/pi staining assay exhibited apoptosis induction by ga. to determine the molecular mechanism of ga-induced apoptosis, the expression levels bcl-2, bax, caspase-3 and caspase-9 were determined in sw1353 cells treated with ga. we found that ga downregulated the expression of the anti-apoptotic protein bcl-2, and upregulated the expression of the pro-apoptotic protein bax, and the activation of caspase-3 and caspase-9. |
2014-08-18 |
2023-08-12 |
human |
| Allal Ouhtit, Mohammed F Ismail, Amira Othman, Augusta Fernando, Mohamed E Abdraboh, Attalla F El-Kott, Yahia A Azab, Sherif H Abdeen, Rajiv L Gaur, Ishita Gupta, Somya Shanmuganathan, Yahya M Al-Farsi, Hamad Al-Riyami, Madhwa H G Ra. Chemoprevention of rat mammary carcinogenesis by spirulina. The American journal of pathology. vol 184. issue 1. 2014-08-18. PMID:24269837. |
in addition, sp increased bax and decreased bcl-2 expression, indicating induction of apoptosis by 48 hours after sp treatment. |
2014-08-18 |
2023-08-12 |
rat |
| Rong-Guo Liu, Wei-Jian Wang, Na Song, Yan-Qing Chen, Li-Huan L. Diazoxide preconditioning alleviates apoptosis of hippocampal neurons induced by anoxia-reoxygenation in vitro through up-regulation of Bcl-2/Bax protein ratio. Sheng li xue bao : [Acta physiologica Sinica]. vol 58. issue 4. 2014-08-15. PMID:16906335. |
the aim of this study was to determine whether dz could restrain neuronal apoptosis induced by anoxia-reoxygenation and to reveal the effect of dz preconditioning on the expressions of bcl-2 and bax proteins in cultured hippocampal neurons. |
2014-08-15 |
2023-08-12 |
rat |
| Rong-Guo Liu, Wei-Jian Wang, Na Song, Yan-Qing Chen, Li-Huan L. Diazoxide preconditioning alleviates apoptosis of hippocampal neurons induced by anoxia-reoxygenation in vitro through up-regulation of Bcl-2/Bax protein ratio. Sheng li xue bao : [Acta physiologica Sinica]. vol 58. issue 4. 2014-08-15. PMID:16906335. |
in conclusion, 100 mumol/l dz prevented cultured hippocampal neurons from apoptosis induced by anoxia-reoxygenation possibly through up-regulating the expression of bcl-2 protein and down-regulating the expression of bax protein. |
2014-08-15 |
2023-08-12 |
rat |
| Hyang Nam, Moon-Moo Ki. Ursolic acid induces apoptosis of SW480 cells via p53 activation. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association. vol 62. 2014-08-15. PMID:24071474. |
above results demonstrate that ursolic acid induces the activation of p53, nf-κb and bax, leading to the enhancement of p21 transcriptional activity and activation of caspase-9 and -3, thus finally induces apoptosis of sw480 cells. |
2014-08-15 |
2023-08-12 |
human |
| Haitao Shen, Jing Liu, Yuan Wang, Hongguang Lian, Juan Wang, Lingxiao Xing, Xia Yan, Junling Wang, Xianghong Zhan. Aflatoxin G1-induced oxidative stress causes DNA damage and triggers apoptosis through MAPK signaling pathway in A549 cells. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association. vol 62. 2014-08-15. PMID:24090735. |
afg1 also triggered apoptosis in a549 cells by regulating fas/fasl, caspase-8, bax, bcl-2, and activating caspase-3. |
2014-08-15 |
2023-08-12 |
human |
| Shun Zhang, Gang Kuang, Guodong Zhao, Xue Wu, Cheng Zhang, Rongrong Lei, Tao Xia, Jianbin Chen, Zhenglun Wang, Rulin Ma, Bei Li, Lu Yang, Aiguo Wan. Involvement of the mitochondrial p53 pathway in PBDE-47-induced SH-SY5Y cells apoptosis and its underlying activation mechanism. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association. vol 62. 2014-08-15. PMID:24140468. |
the apoptosis and ultrastructural alterations in cells, levels of p53, bcl-2, bax, cytochrome c (cyt c), caspase-3 and methylation status of p53 promoter were determined. |
2014-08-15 |
2023-08-12 |
human |
| Chaoming Zhang, Congcong Wang, Shusheng Tang, Yu Sun, Dongxu Zhao, Shen Zhang, Sijun Deng, Yan Zhou, Xilong Xia. TNFR1/TNF-α and mitochondria interrelated signaling pathway mediates quinocetone-induced apoptosis in HepG2 cells. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association. vol 62. 2014-08-15. PMID:24161692. |
taken together, quinocetone induced apoptosis in hepg2 cells via activation of caspase, interaction of tnf-α and tnfr1 and modulation of the protein levels of bid, bax and bcl-2, involving the participation of p53, p38 and jnk. |
2014-08-15 |
2023-08-12 |
Not clear |
| Gabriele Cordara, Harry C Winter, Irwin J Goldstein, Ute Krengel, Kirsten Sandvi. The fungal chimerolectin MOA inhibits protein and DNA synthesis in NIH/3T3 cells and may induce BAX-mediated apoptosis. Biochemical and biophysical research communications. vol 447. issue 4. 2014-08-13. PMID:24747075. |
a peptide-array screen identified the apoptosis mediator bax as a potential proteolytic substrate and further suggests a variety of bacterial and fungal peptides as potential substrates. |
2014-08-13 |
2023-08-13 |
caenorhabditis_elegans |
| Teng Wei, Wulin Tian, Fangning Liu, Guanghong Xi. Protective effects of exogenous β-hydroxybutyrate on paraquat toxicity in rat kidney. Biochemical and biophysical research communications. vol 447. issue 4. 2014-08-13. PMID:24755084. |
caspase-mediated apoptosis pathway contributed importantly to pq toxicity, as revealed by the activation of caspase-9/-3, cleavage of parp, and regulation of bcl-2 and bax, which were also effectively blocked by β-hb. |
2014-08-13 |
2023-08-13 |
rat |
| A Kolesarova, Z Bakova, M Capcarova, B Galik, M Juracek, M Simko, R Toman, A V Sirotki. Consumption of bee pollen affects rat ovarian functions. Journal of animal physiology and animal nutrition. vol 97. issue 6. 2014-08-11. PMID:23137268. |
we evaluated the bee pollen effect on the release of insulin-like growth factor i (igf-i) and steroid hormones (progesterone and estradiol), as well as on the expression of markers of apoptosis (bcl-2, bax and caspase-3) in rat ovarian fragments. |
2014-08-11 |
2023-08-12 |
rat |
| A Kolesarova, Z Bakova, M Capcarova, B Galik, M Juracek, M Simko, R Toman, A V Sirotki. Consumption of bee pollen affects rat ovarian functions. Journal of animal physiology and animal nutrition. vol 97. issue 6. 2014-08-11. PMID:23137268. |
our results contribute to new insights regarding the effect of bee pollen on both secretion activity (release of growth factor igf-i and steroid hormones progesterone and estradiol) and apoptosis (anti- and pro-apoptotic markers bcl-2, bax and caspase-3). |
2014-08-11 |
2023-08-12 |
rat |
| Azhar Rasul, Muhammad Khan, Bo Yu, Muhammad Ali, Yang Jing Bo, Hong Yang, Tonghui M. Isoalantolactone, a sesquiterpene lactone, induces apoptosis in SGC-7901 cells via mitochondrial and phosphatidylinositol 3-kinase/Akt signaling pathways. Archives of pharmacal research. vol 36. issue 10. 2014-08-11. PMID:23881702. |
isoalantolactone-induced apoptosis of sgc-7901 cells was associated with the dissipation of mitochondrial membrane potential (ΔΨ m) that was due to the down-regulation of bcl-2 and up-regulation of bax that led to the cleavage of caspase-3. |
2014-08-11 |
2023-08-12 |
human |
| Ahmed Kamal, N V Subba Reddy, V Lakshma Nayak, V Saidi Reddy, B Prasad, Vijaykumar D Nimbarte, Vunnam Srinivasulu, M V P S Vishnuvardhan, C Suresh Redd. Synthesis and biological evaluation of benzo[b]furans as inhibitors of tubulin polymerization and inducers of apoptosis. ChemMedChem. vol 9. issue 1. 2014-08-11. PMID:24203459. |
furthermore, detailed biological studies such as hoechst 33258 staining, dna fragmentation and caspase-3 assays, and western blot analyses with the pro-apoptotic protein bax and the anti-apoptotic protein bcl-2 also suggested that these compounds induce cell death by apoptosis. |
2014-08-11 |
2023-08-12 |
Not clear |
| Amador Goncalves-Primo, Tuíla B Mourão, Vinícius Andrade-Oliveira, Erika F Campos, José O Medina-Pestana, Hélio Tedesco-Silva, Maria Gerbase-DeLim. Investigation of apoptosis-related gene expression levels in preimplantation biopsies as predictors of delayed kidney graft function. Transplantation. vol 97. issue 12. 2014-08-08. PMID:24503763. |
the purpose of this study was to investigate the expression of the gene coding for the antiapoptotic molecule bcl-2, the proapoptotic molecule bax, and the apoptosis executor enzyme caspase-3 in preimplantation renal biopsies (pib) as markers for delayed graft function. |
2014-08-08 |
2023-08-12 |
Not clear |
| Osamu Sawada, Lindsay Perusek, Hideo Kohno, Scott J Howell, Akiko Maeda, Shigemi Matsuyama, Tadao Maed. All-trans-retinal induces Bax activation via DNA damage to mediate retinal cell apoptosis. Experimental eye research. vol 123. 2014-08-08. PMID:24726920. |
all-trans-retinal induces bax activation via dna damage to mediate retinal cell apoptosis. |
2014-08-08 |
2023-08-13 |
mouse |
| Ling Xu, Jin Yu, Dongxia Zhai, Danying Zhang, Wei Shen, Lingling Bai, Zailong Cai, Chaoqin Y. Role of JNK Activation and Mitochondrial Bax Translocation in Allicin-Induced Apoptosis in Human Ovarian Cancer SKOV3 Cells. Evidence-based complementary and alternative medicine : eCAM. vol 2014. 2014-08-06. PMID:25097657. |
role of jnk activation and mitochondrial bax translocation in allicin-induced apoptosis in human ovarian cancer skov3 cells. |
2014-08-06 |
2023-08-13 |
human |
| Ling Xu, Jin Yu, Dongxia Zhai, Danying Zhang, Wei Shen, Lingling Bai, Zailong Cai, Chaoqin Y. Role of JNK Activation and Mitochondrial Bax Translocation in Allicin-Induced Apoptosis in Human Ovarian Cancer SKOV3 Cells. Evidence-based complementary and alternative medicine : eCAM. vol 2014. 2014-08-06. PMID:25097657. |
jnk activation and mitochondrial bax translocation are involved in allicin-induced apoptosis in skov3 cells. |
2014-08-06 |
2023-08-13 |
human |
| Sushil Kumar Sahu, Tathagata Choudhur. Lack of association between Bax promoter (-248G>A) single nucleotide polymorphism and susceptibility towards cancer: evidence from a meta-analysis. PloS one. vol 8. issue 10. 2014-08-05. PMID:24147019. |
the bcl-2-associated x protein (bax) is a proapoptotic member of the bcl-2 family known to be activated and upregulated during apoptosis. |
2014-08-05 |
2023-08-12 |
Not clear |