| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Di Wang, Hei-Kiu Wong, Yi-Bin Feng, Zhang-Jin Zhan. 18beta-glycyrrhetinic acid induces apoptosis in pituitary adenoma cells via ROS/MAPKs-mediated pathway. Journal of neuro-oncology. vol 116. issue 2. 2014-09-02. PMID:24162829. |
ga also caused g0/g1 phase arrest, increased apoptosis rate and increased mitochondrial membrane permeabilization by suppressing the mitochondrial membrane potential and down-regulating a ratio of b cell lymphoma 2 (bcl-2) and bax. |
2014-09-02 |
2023-08-12 |
mouse |
| Evelyn Walenta, Ariane R Pessentheiner, Helmut J Pelzmann, Alexander Deutsch, Madeleine Goeritzer, Dagmar Kratky, Hubert Hackl, Da Young Oh, Andreas Prokesch, Juliane G Bogner-Straus. α/β-hydrolase domain containing protein 15 (ABHD15)--an adipogenic protein protecting from apoptosis. PloS one. vol 8. issue 11. 2014-09-02. PMID:24236098. |
in preconfluent cells, knockdown of abhd15 leads to impaired proliferation, which is caused by apoptosis, as we see an increased subg1 peak, caspase 3/7 activity, and bax protein expression as well as a reduction in anti-apoptotic bcl-2 protein. |
2014-09-02 |
2023-08-12 |
mouse |
| G Li, L Liu, C Shan, Q Cheng, A Budhraja, T Zhou, H Cui, N Ga. RhoA/ROCK/PTEN signaling is involved in AT-101-mediated apoptosis in human leukemia cells in vitro and in vivo. Cell death & disease. vol 5. 2014-09-02. PMID:24434521. |
collectively, these findings suggest that at-101 may preferentially induce apoptosis in leukemia cells by interrupting the rhoa/rock1/pten pathway, leading to akt inactivation, mcl-1 downregulation, bad dephosphorylation, and bax translocation, which culminate in mitochondrial injury and apoptosis. |
2014-09-02 |
2023-08-12 |
mouse |
| L K J Stadler, D C Tomlinson, T Lee, M A Knowles, P Ko Ferrign. The use of a neutral peptide aptamer scaffold to anchor BH3 peptides constitutes a viable approach to studying their function. Cell death & disease. vol 5. 2014-09-02. PMID:24481451. |
particularly, the bh3 domain is of clinical relevance, as it promotes apoptosis through activation of bcl-2-associated x protein (bax) and bcl-2 antagonist killer (bak), as well as by antagonising the anti-apoptotic bcl-2 family members. |
2014-09-02 |
2023-08-12 |
Not clear |
| Maria-Rosa Ghigna, Tanja Reineke, Patricia Rincé, Peter Schüffler, Bouchra El Mchichi, Monique Fabre, Emmanuel Jacquemin, Antoine Durrbach, Didier Samuel, Irène Joab, Catherine Guettier, Marco Lucioni, Marco Paulli, Marianne Tinguely, Martine Raphae. Epstein-Barr virus infection and altered control of apoptotic pathways in posttransplant lymphoproliferative disorders. Pathobiology : journal of immunopathology, molecular and cellular biology. vol 80. issue 2. 2014-08-28. PMID:22868923. |
we analyzed 60 primary ptld for expression of 8 anti- (bcl-2, bcl-xl, and mcl-1) and proapoptotic proteins (bak and bax), the so-called bh3-only proteins (bad, bid, bim, and puma), as well as the apoptosis effector cleaved parp by immunohistochemistry. |
2014-08-28 |
2023-08-12 |
human |
| Justine Renaud, Julie Bournival, Ximena Zottig, Maria-Grazia Martinol. Resveratrol protects DAergic PC12 cells from high glucose-induced oxidative stress and apoptosis: effect on p53 and GRP75 localization. Neurotoxicity research. vol 25. issue 1. 2014-08-28. PMID:24218232. |
moreover, resv significantly reduces hg-induced apoptosis in daergic cells by modulating dna fragmentation and the expression of several genes implicated in the apoptotic cascade, such as bax, bcl-2, cleaved caspase-3, and cleaved parp-1. |
2014-08-28 |
2023-08-12 |
Not clear |
| Smriti P K Mittal, Jinumary Mathai, Abhijeet P Kulkarni, Jayanta K Pal, Samit Chattopadhya. miR-320a regulates erythroid differentiation through MAR binding protein SMAR1. The international journal of biochemistry & cell biology. vol 45. issue 11. 2014-08-27. PMID:23876508. |
in response to mild dna damage, mir-320a expression is decreased resulting in enhanced expression of smar1 protein, which in turn, reduces its targets, bax and puma inhibiting apoptosis. |
2014-08-27 |
2023-08-12 |
Not clear |
| N Chen, Y Gao, N Yan, C Liu, J-G Zhang, W-M Xing, D-M Kong, F-G Men. High-frequency stimulation of the hippocampus protects against seizure activity and hippocampal neuronal apoptosis induced by kainic acid administration in macaques. Neuroscience. vol 256. 2014-08-27. PMID:24200923. |
in addition, administration of ka led to marked neuronal apoptosis in the hippocampus, accompanied by increased levels of bax, activated caspase-3 and decreased levels of bcl-2. |
2014-08-27 |
2023-08-12 |
monkey |
| Hui Liu, Xiaolan Guo, Yi Chu, Shaoping L. Heart protective effects and mechanism of quercetin preconditioning on anti-myocardial ischemia reperfusion (IR) injuries in rats. Gene. vol 545. issue 1. 2014-08-27. PMID:24769323. |
our results still showed that quercetin pretreatment significantly inhibited the apoptosis by decreasing the number of apoptotic cells, decreasing the level of cleaved bax, and increasing the level of bcl-2 in rats subjected to i/r injury. |
2014-08-27 |
2023-08-13 |
rat |
| Zeng Yong Qiao, Jian Hua Huang, Jiang Wei Ma, Ya Wei Xu, Jun Xie, Hua Jin Liu, San Jun Xiong, Guang Hao G. Ginkgo biloba extract reducing myocardium cells apoptosis by regulating apoptotic related proteins expression in myocardium tissues. Molecular biology reports. vol 41. issue 1. 2014-08-26. PMID:24318725. |
the bax, cyt-c and caspase-3 proteins play an important role in regulating the myocardial apoptosis. |
2014-08-26 |
2023-08-12 |
rat |
| Ariele Viacava Follis, Fabien Llambi, Li Ou, Katherine Baran, Douglas R Green, Richard W Kriwack. The DNA-binding domain mediates both nuclear and cytosolic functions of p53. Nature structural & molecular biology. vol 21. issue 6. 2014-08-26. PMID:24814347. |
under conditions of genotoxic stress, human p53 activates the apoptotic effectors bax or bak to result in mitochondrial outer-membrane permeabilization and apoptosis. |
2014-08-26 |
2023-08-13 |
human |
| Syam Mohan, Siddig Ibrahim Abdelwahab, Behnam Kamalidehghan, Suvitha Syam, Koh Sue May, Nabil Saad Mohammed Harmal, Noor Shafifiyaz, A Hamid A Hadi, Najihah Mohd Hashim, Mawardi Rahmani, Manal Mohamed Elhassan Taha, Shiau-Chuen Cheah, Asdren Zajm. Involvement of NF-κB and Bcl2/Bax signaling pathways in the apoptosis of MCF7 cells induced by a xanthone compound Pyranocycloartobiloxanthone A. Phytomedicine : international journal of phytotherapy and phytopharmacology. vol 19. issue 11. 2014-08-25. PMID:22739412. |
treatment of mcf7 cells with pa induced apoptosis with cell death-transducing signals, that regulate the mmp by down-regulation of bcl2 and up-regulation of bax, triggering the cytochrome c release from mitochondria to cytosol. |
2014-08-25 |
2023-08-12 |
human |
| Chunmei Li, Myeong-Hyeon Wan. Aristolochia debilis Sieb. et Zucc. induces apoptosis and reactive oxygen species in the HT-29 human colon cancer cell line. Cancer biotherapy & radiopharmaceuticals. vol 28. issue 10. 2014-08-25. PMID:23848946. |
reverse transcription-polymerase chain reaction and western blot analyses were used to determine changes in the expression of mitochondria-dependent apoptosis markers (bax and bcl-2). |
2014-08-25 |
2023-08-12 |
human |
| Chunmei Li, Myeong-Hyeon Wan. Aristolochia debilis Sieb. et Zucc. induces apoptosis and reactive oxygen species in the HT-29 human colon cancer cell line. Cancer biotherapy & radiopharmaceuticals. vol 28. issue 10. 2014-08-25. PMID:23848946. |
upregulation of bax and corresponding downregulation of bcl-2 expression as well as ros production may be the critical mechanism through which a. debilis induced apoptosis in ht-29 cells. |
2014-08-25 |
2023-08-12 |
human |
| Jasmeet Kaur Chhabra, Brajadulal Chattopadhyay, Bhola Nath Pau. SOCS3 dictates the transition of divergent time-phased events in granulocyte TNF-α signaling. Cellular & molecular immunology. vol 11. issue 1. 2014-08-21. PMID:24037182. |
in vitro, tnf-α (50 ng/ml) induced granulocyte socs3 protein, inhibited nuclear accumulation of the p65nf-κb subunit and enhanced apoptosis, as shown by dna laddering, annexin v positivity, and overexpression of caspase-3 and bax in the late phase, whereas the early phase was marked by nf-κb activation. |
2014-08-21 |
2023-08-12 |
Not clear |
| Le Yang, Zhi-ming Yang, Nan Zhang, Zhen Tian, Shui-bing Liu, Ming-gao Zha. Neuroprotective effects of vitexin by inhibition of NMDA receptors in primary cultures of mouse cerebral cortical neurons. Molecular and cellular biochemistry. vol 386. issue 1-2. 2014-08-21. PMID:24141792. |
vit significantly inhibited the neuronal apoptosis induced by nmda exposure by regulating balance of bcl-2 and bax expression and the cleavages of poly (adp-ribose) polymerase and pro-caspase 3. |
2014-08-21 |
2023-08-12 |
mouse |
| Xing Liu, Qin-Hua Gu, Kaizheng Duan, Zheng L. NMDA receptor-dependent LTD is required for consolidation but not acquisition of fear memory. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 34. issue 26. 2014-08-21. PMID:24966374. |
bax induces cell death in apoptosis, but it plays a nonapoptotic role in nmdar-ltd. |
2014-08-21 |
2023-08-13 |
mouse |
| Yetao Ou, Qingwang Li, Jianjie Wang, Kun Li, Shaobo Zho. Antitumor and Apoptosis Induction Effects of Paeonol on Mice Bearing EMT6 Breast Carcinoma. Biomolecules & therapeutics. vol 22. issue 4. 2014-08-21. PMID:25143814. |
these results suggest that paeonol exhibits antitumor effects and the mechanism of the inhibition is via induction of apoptosis, regulation of bcl-2 and bax expression, and activation of caspase 8 and caspase 3. |
2014-08-21 |
2023-08-13 |
mouse |
| Robert L Jilka, Charles A O'Brien, Paula K Roberson, Lynda F Bonewald, Robert S Weinstein, Stavros C Manolaga. Dysapoptosis of osteoblasts and osteocytes increases cancellous bone formation but exaggerates cortical porosity with age. Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research. vol 29. issue 1. 2014-08-19. PMID:23761243. |
we selectively deleted bak and bax, two genes essential for apoptosis, in two types of terminally differentiated bone cells: the short-lived osteoblasts that elaborate the bone matrix, and the long-lived osteocytes that are immured within the mineralized matrix and choreograph the regeneration of bone. |
2014-08-19 |
2023-08-12 |
Not clear |
| Farhan Murshed, Lulu Farhana, Marcia I Dawson, Joseph A Fontan. NF-κB p65 recruited SHP regulates PDCD5-mediated apoptosis in cancer cells. Apoptosis : an international journal on programmed cell death. vol 19. issue 3. 2014-08-19. PMID:24343129. |
pdcd5 triggered apoptosis through increased bax protein and release of cytochrome c from mitochondria to cytosol. |
2014-08-19 |
2023-08-12 |
Not clear |