| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Hye Eun Yoon, Soo Jeong Kim, Sung Jun Kim, Sungjin Chung, Seok Joon Shi. Tempol attenuates renal fibrosis in mice with unilateral ureteral obstruction: the role of PI3K-Akt-FoxO3a signaling. Journal of Korean medical science. vol 29. issue 2. 2014-10-09. PMID:24550650. |
significantly less apoptosis, a lower ratio of bax to bcl-2 expression and fewer apoptotic cells in tunel staining, and decreased expression of transforming growth factor-β1 were observed in the obstructed kidneys from tempol-treated mice compared with those from control mice. |
2014-10-09 |
2023-08-12 |
mouse |
| Yinkai Xu, Fengjuan Zhang, Lei Qin, Jingcheng Miao, Weihua Sheng, Yufeng Xie, Xiaolan Xu, Jicheng Yang, Haixin Qia. Enhanced in-vitro and in-vivo suppression of A375 melanoma by combined IL-24/OSM adenoviral-mediated gene therapy. Melanoma research. vol 24. issue 1. 2014-10-08. PMID:24300090. |
the bicistronic adenovirus-mediated coexpression of il-24 and osm induced additive growth suppression and apoptosis and an overlapping effect on the upregulation of p21, p53, bax, and cleaved caspase-3 in vitro and in vivo. |
2014-10-08 |
2023-08-12 |
mouse |
| Claudia Bello, Dania Vazquez-Blomquist, Jamilet Miranda, Yanelda Garcia, Lidia Ines Novoa, Daniel Palenzuela, Iraldo Bell. Regulation by IFN-α/IFN-γ co-formulation (HerberPAG®) of genes involved in interferon-STAT-pathways and apoptosis in U87MG. Current topics in medicinal chemistry. vol 14. issue 3. 2014-10-04. PMID:24304312. |
some of the genes involved in the first steps of ifns signaling pathways (stat1 and stat3) and apoptosis events (tp53, bax, bcl-2, bad, caspase3 (casp3), caspase8 (casp8) and caspase9 (casp9)) were studied. |
2014-10-04 |
2023-08-12 |
Not clear |
| Yalda Shokoohinia, Leila Hosseinzadeh, Maryam Alipour, Ali Mostafaie, Hamid-Reza Mohammadi-Motlag. Comparative Evaluation of Cytotoxic and Apoptogenic Effects of Several Coumarins on Human Cancer Cell Lines: Osthole Induces Apoptosis in p53-Deficient H1299 Cells. Advances in pharmacological sciences. vol 2014. 2014-10-03. PMID:25276123. |
moreover, isoimperatorin induced apoptosis by upregulating bax and smac/diablo genes in pc3 and sknmc cells. |
2014-10-03 |
2023-08-13 |
human |
| Yalda Shokoohinia, Leila Hosseinzadeh, Maryam Alipour, Ali Mostafaie, Hamid-Reza Mohammadi-Motlag. Comparative Evaluation of Cytotoxic and Apoptogenic Effects of Several Coumarins on Human Cancer Cell Lines: Osthole Induces Apoptosis in p53-Deficient H1299 Cells. Advances in pharmacological sciences. vol 2014. 2014-10-03. PMID:25276123. |
osthole induced apoptosis by downregulating antiapoptotic bcl-2 in only pc3 cells and upregulating the proapoptotic genes bax and smac/diablo in pc3, sknmc, and h1299 cells. |
2014-10-03 |
2023-08-13 |
human |
| Dong Zhou, Roderick J Tan, Lin Lin, Lili Zhou, Youhua Li. Activation of hepatocyte growth factor receptor, c-met, in renal tubules is required for renoprotection after acute kidney injury. Kidney international. vol 84. issue 3. 2014-09-30. PMID:23715119. |
compared with controls, ksp-met-/- mice displayed higher serum creatinine, more severe morphologic lesions, and increased apoptosis, which was accompanied by an increased expression of bax and fas ligand and decreased phosphorylation/activation of akt. |
2014-09-30 |
2023-08-12 |
mouse |
| S-H Huang, M-H Hsu, S-C Hsu, J-S Yang, W-W Huang, A-C Huang, Y-P Hsiao, C-C Yu, J-G Chun. Phenethyl isothiocyanate triggers apoptosis in human malignant melanoma A375.S2 cells through reactive oxygen species and the mitochondria-dependent pathways. Human & experimental toxicology. vol 33. issue 3. 2014-09-30. PMID:23760257. |
western blot analysis showed that peitc promoted bax expression and inhibited bcl-2 expression associated with the disintegration of the outer mitochondrial membrane causing cytochrome c release, and activation of caspase-9 and -3 cascade leading to apoptosis. |
2014-09-30 |
2023-08-12 |
human |
| J-S Nie, H-M Zhang, J Zhao, H-J Liu, Q Ni. Involvement of mitochondrial pathway in benzo[a]pyrene-induced neuron apoptosis. Human & experimental toxicology. vol 33. issue 3. 2014-09-30. PMID:23839155. |
further analysis showed that b[a]p-induced apoptosis was accompanied by loss of mitochondrial membrane potential, release of cytochrome c from mitochondria to the cytosol, downregulation of antiapoptotic protein b-cell lymphoma-2 (bcl-2) levels with concurrent upregulation in proapoptotic bcl-2-associated x protein (bax) levels, and increase in the levels and activities of caspases-9 and -3. |
2014-09-30 |
2023-08-12 |
rat |
| Ching-Yi Weng, Shu-Yuan Chiou, Lisu Wang, Mei-Chun Kou, Ying-Jan Wang, Ming-Jiuan W. Arsenic trioxide induces unfolded protein response in vascular endothelial cells. Archives of toxicology. vol 88. issue 2. 2014-09-30. PMID:23892647. |
arsenic also induced er stress-inducible genes, bax, puma (p53 upregulated modulator of apoptosis), trb3 (tribbles-related protein 3), and snat2 (sodium-dependent neutral amino acid transporter 2). |
2014-09-30 |
2023-08-12 |
mouse |
| Hong Zhao, Guijun Lin, Mumu Shi, Jingquan Gao, Yanming Wang, Hongzhi Wang, Hongli Sun, Yonggang Ca. The mechanism of neurogenic pulmonary edema in epilepsy. The journal of physiological sciences : JPS. vol 64. issue 1. 2014-09-30. PMID:24142459. |
further study showed that cell apoptosis was mediated by increasing bax, decreasing bcl-2, and activating caspase-3. |
2014-09-30 |
2023-08-12 |
rat |
| Yang Yu, Mingxin Gao, Haitao Li, Fan Zhang, Chengxiong G. Pulmonary artery perfusion with anti-tumor necrosis factor alpha antibody reduces cardiopulmonary bypass-induced inflammatory lung injury in a rabbit model. PloS one. vol 8. issue 12. 2014-09-30. PMID:24386164. |
the apoptotic index in lung tissue and the expression of proteins that play stimulatory roles in apoptosis pathways including the fas ligand (fasl) and bax were markedly reduced during cpb by the perfusion with tnf-α ab. |
2014-09-30 |
2023-08-12 |
rabbit |
| Lisa M Lindqvist, Melanie Heinlein, David C S Huang, David L Vau. Prosurvival Bcl-2 family members affect autophagy only indirectly, by inhibiting Bax and Bak. Proceedings of the National Academy of Sciences of the United States of America. vol 111. issue 23. 2014-09-30. PMID:24912196. |
to directly test the impact of the endogenous antiapoptotic bcl-2 family members on autophagy in the absence of apoptosis, we inhibited their activity in cells lacking the essential cell death mediators bax and bak. |
2014-09-30 |
2023-08-13 |
Not clear |
| Jing Han, Peng Tan, Zhiyong Li, Yan Wu, Chun Li, Yong Wang, Beibei Wang, Shuang Zhao, Yonggang Li. Fuzi attenuates diabetic neuropathy in rats and protects schwann cells from apoptosis induced by high glucose. PloS one. vol 9. issue 1. 2014-09-29. PMID:24466139. |
apoptosis factors (bax, bcl-2, cytoc, caspase-3, and caspase-9) were analyzed using immunofluorescence. |
2014-09-29 |
2023-08-12 |
rat |
| Jing Han, Peng Tan, Zhiyong Li, Yan Wu, Chun Li, Yong Wang, Beibei Wang, Shuang Zhao, Yonggang Li. Fuzi attenuates diabetic neuropathy in rats and protects schwann cells from apoptosis induced by high glucose. PloS one. vol 9. issue 1. 2014-09-29. PMID:24466139. |
furthermore, the apoptosis factors, including bax, bcl-2, cytoc, caspase-3, and caspase-9 were ameliorated in fze treated groups. |
2014-09-29 |
2023-08-12 |
rat |
| Han-Han Zhang, Min Pang, Wei Dong, Jia-Xuan Xin, You-Jie Li, Zi-Cheng Zhang, Liang Yu, Ping-Yu Wang, Bao-Sheng Li, Shu-Yang Xi. miR-511 induces the apoptosis of radioresistant lung adenocarcinoma cells by triggering BAX. Oncology reports. vol 31. issue 3. 2014-09-26. PMID:24402374. |
mir-511 induces the apoptosis of radioresistant lung adenocarcinoma cells by triggering bax. |
2014-09-26 |
2023-08-12 |
Not clear |
| Lu Han, Jing Zhao, Juan Liu, Xiang-Lin Duan, Lu-Hai Li, Xian-Fu Wei, Yen Wei, Xing-Jie Lian. A universal gene carrier platform for treatment of human prostatic carcinoma by p53 transfection. Biomaterials. vol 35. issue 9. 2014-09-26. PMID:24411335. |
western blotting and caspase activation studies revealed that egfp-p53/pei/pah-cit/aunp-cs complexes may induce pc-3 apoptosis via the mitochondria-mediated signaling pathway by up-regulation of bax, down-regulation of bcl-2, and activation of caspase-3. |
2014-09-26 |
2023-08-12 |
human |
| Juhua Wang, Hongguo Cao, Xiuheng Xue, Caiyun Fan, Fugui Fang, Jie Zhou, Yunhai Zhang, Xiaorong Zhan. Effect of vitamin C on growth of caprine spermatogonial stem cells in vitro. Theriogenology. vol 81. issue 4. 2014-09-25. PMID:24368149. |
further, the intracellular reactive oxygen species (ros) level was measured at the 3rd, 6th, and 9th day after culture, and expression of bax, bcl-2, and p53, factors involved in the regulation of apoptosis, were analyzed on the 7th day after culture using reverse transcription polymerase chain reaction and quantitative real-time polymerase chain reaction. |
2014-09-25 |
2023-08-12 |
Not clear |
| Olga S Sizova, Vishal M Shinde, Austin R Lenox, Marina S Gorbatyu. Modulation of cellular signaling pathways in P23H rhodopsin photoreceptors. Cellular signalling. vol 26. issue 4. 2014-09-24. PMID:24378535. |
the translocation of bax to the mitochondria, as well as the release of cytochrome c and aif into the cytosol supports this conclusion and indicates the involvement of mitochondria-induced apoptosis in the progression of adrp. |
2014-09-24 |
2023-08-12 |
Not clear |
| Eric H Andrianasolo, Liti Haramaty, Eileen White, Richard Lutz, Paul Falkowsk. Mode of action of diterpene and characterization of related metabolites from the soft coral, Xenia elongata. Marine drugs. vol 12. issue 2. 2014-09-23. PMID:24562393. |
biological evaluations and assessments were determined using the specific apoptosis induction assay based on genetically engineered mammalian cell line d3 deficient in bak and bax and derived from a mouse epithelial cell. |
2014-09-23 |
2023-08-12 |
mouse |
| Linlin Zhang, Li Li, Yabing Zhu, Guofan Zhang, Ximing Gu. Transcriptome analysis reveals a rich gene set related to innate immunity in the Eastern oyster (Crassostrea virginica). Marine biotechnology (New York, N.Y.). vol 16. issue 1. 2014-09-22. PMID:23907648. |
many key genes of the apoptosis system including iap, bax, bac-2, caspase, fadd, and tnfr were identified, suggesting c. virginica possess advanced apoptosis and apoptosis-regulating systems. |
2014-09-22 |
2023-08-12 |
Not clear |