| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Dong Yeok Shin, Gi-Young Kim, Hye Jin Hwang, Wun-Jae Kim, Yung Hyun Cho. Diallyl trisulfide-induced apoptosis of bladder cancer cells is caspase-dependent and regulated by PI3K/Akt and JNK pathways. Environmental toxicology and pharmacology. vol 37. issue 1. 2014-10-28. PMID:24309133. |
with respect to the mechanism underlying the induction of apoptosis, dats reduced the expression of anti-apoptotic bcl-2 and bcl-xl, and inhibitor of apoptosis protein family proteins, but the expression of pro-apoptotic bax and death receptor-related proteins was increased compared with the controls. |
2014-10-28 |
2023-08-12 |
human |
| Soon-Jae Kwon, Ju-Hye Lee, Kwang-Deog Moon, Il-Yun Jeong, Dong-U K Ahn, Mi-Kyung Lee, Kwon-Il Se. Induction of apoptosis by isoegomaketone from Perilla frutescens L. in B16 melanoma cells is mediated through ROS generation and mitochondrial-dependent, -independent pathway. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association. vol 65. 2014-10-28. PMID:24380754. |
this result indicates that ik-induced apoptosis involves ros generation as well as up-regulation of bax and bcl-2 expression, leading to release of cytochrome c and aif. |
2014-10-28 |
2023-08-12 |
Not clear |
| Teruyoshi Saito, Dai Tamura, Ryuji Asan. Usefulness of selective COX-2 inhibitors as therapeutic agents against canine mammary tumors. Oncology reports. vol 31. issue 4. 2014-10-28. PMID:24503782. |
in particular, celecoxib led to apoptosis mediated by the activation of the mitochondrial apoptosis pathway, including the upregulation of bax expression, downregulation of bcl-2 expression and activation of caspase-3/7. |
2014-10-28 |
2023-08-12 |
human |
| Donna Kennedy, Katarzyna Mnich, Afshin Samal. Heat shock preconditioning protects against ER stress-induced apoptosis through the regulation of the BH3-only protein BIM. FEBS open bio. vol 4. 2014-10-28. PMID:25349785. |
hs preconditioning significantly reduced bax, caspase activation and apoptosis in cell cultures treated with the er stress-inducing agents thapsigargin (tg) and tunicamycin (tm). |
2014-10-28 |
2023-08-13 |
Not clear |
| Bengui Ye, Jinrong Yang, Jun Li, Ting Niu, Shu Wan. In vitro and in vivo antitumor activities of tenacissoside C from Marsdenia tenacissima. Planta medica. vol 80. issue 1. 2014-10-27. PMID:24338554. |
western blotting analysis elucidated that: a) tenacissoside c induced k562 cell cycle (g0/g1) arrest via downregulating cycline d1 protein expression; and b) tenacissoside c induced k562 cell apoptosis via the mitochondrial pathway by downregulating bcl-2 and bcl-xl protein expression, upregulating bax and bak protein expression, and activating caspase-9 and caspase-3. |
2014-10-27 |
2023-08-12 |
mouse |
| Xing Zhou, Chao-Fen Su, Zheng Zhang, Chen-Yu Wang, Jin-Qi Luo, Xiao-Wen Zhou, Liang Cai, Li Yan, Wei Zhang, Huan-Min Lu. Neuroprotective effects of methyl 3,4-dihydroxybenzoate against H₂O₂-induced apoptosis in RGC-5 cells. Journal of pharmacological sciences. vol 125. issue 1. 2014-10-24. PMID:24849190. |
mdhb also obstructed h2o2-induced apoptosis by regulating the expression of bcl-2 and bax, as well as suppressing the activation of caspase 9 and caspase 3. |
2014-10-24 |
2023-08-13 |
Not clear |
| Etienne Raemy, Jean-Claude Martino. Involvement of cardiolipin in tBID-induced activation of BAX during apoptosis. Chemistry and physics of lipids. vol 179. 2014-10-22. PMID:24333953. |
involvement of cardiolipin in tbid-induced activation of bax during apoptosis. |
2014-10-22 |
2023-08-12 |
Not clear |
| Etienne Raemy, Jean-Claude Martino. Involvement of cardiolipin in tBID-induced activation of BAX during apoptosis. Chemistry and physics of lipids. vol 179. 2014-10-22. PMID:24333953. |
how bax and bak are activated during apoptosis is still not fully understood. |
2014-10-22 |
2023-08-12 |
Not clear |
| Etienne Raemy, Jean-Claude Martino. Involvement of cardiolipin in tBID-induced activation of BAX during apoptosis. Chemistry and physics of lipids. vol 179. 2014-10-22. PMID:24333953. |
here we review the evidence for and against a role for cardiolipin in bax and bak activation and in the subsequent onset of apoptosis. |
2014-10-22 |
2023-08-12 |
Not clear |
| Li Yang, Xin Liu, Dan Wu, Man Zhang, Guiping Ran, Ying Bi, Hai Huan. Growth inhibition and induction of apoptosis in SGC‑7901 human gastric cancer cells by evodiamine. Molecular medicine reports. vol 9. issue 4. 2014-10-21. PMID:24481835. |
these results suggest that evodiamine is able to inhibit the proliferation of sgc-7901 cells by inhibiting the cell cycle at g2/m phase and inducing apoptosis in sgc-7901 cells by activating caspase-3, -8 and -9, and altering the expression of caspase-3, bax and bcl-2. |
2014-10-21 |
2023-08-12 |
human |
| M Fröhlich, B Dejanovic, H Kashkar, G Schwarz, S Nussberge. S-palmitoylation represents a novel mechanism regulating the mitochondrial targeting of BAX and initiation of apoptosis. Cell death & disease. vol 5. 2014-10-21. PMID:24525733. |
s-palmitoylation represents a novel mechanism regulating the mitochondrial targeting of bax and initiation of apoptosis. |
2014-10-21 |
2023-08-12 |
Not clear |
| M Fröhlich, B Dejanovic, H Kashkar, G Schwarz, S Nussberge. S-palmitoylation represents a novel mechanism regulating the mitochondrial targeting of BAX and initiation of apoptosis. Cell death & disease. vol 5. 2014-10-21. PMID:24525733. |
thus, the initial association with mitochondria represents a critical regulatory step enabling bax to insert into moms, promoting the release of cytochrome c and ultimately resulting in apoptosis. |
2014-10-21 |
2023-08-12 |
Not clear |
| M Fröhlich, B Dejanovic, H Kashkar, G Schwarz, S Nussberge. S-palmitoylation represents a novel mechanism regulating the mitochondrial targeting of BAX and initiation of apoptosis. Cell death & disease. vol 5. 2014-10-21. PMID:24525733. |
a lack of bax palmitoylation reduced bax mitochondrial translocation, bax oligomerization, caspase activity and apoptosis. |
2014-10-21 |
2023-08-12 |
Not clear |
| M Fröhlich, B Dejanovic, H Kashkar, G Schwarz, S Nussberge. S-palmitoylation represents a novel mechanism regulating the mitochondrial targeting of BAX and initiation of apoptosis. Cell death & disease. vol 5. 2014-10-21. PMID:24525733. |
furthermore, ectopic expression of specific palmitoyl transferases in cultured healthy cells increases bax s-palmitoylation and accelerates apoptosis, whereas malignant tumor cells show reduced bax s-palmitoylation consistent with their reduced bax-mediated proapoptotic activity. |
2014-10-21 |
2023-08-12 |
Not clear |
| M Fröhlich, B Dejanovic, H Kashkar, G Schwarz, S Nussberge. S-palmitoylation represents a novel mechanism regulating the mitochondrial targeting of BAX and initiation of apoptosis. Cell death & disease. vol 5. 2014-10-21. PMID:24525733. |
our findings suggest that s-palmitoylation of bax at cys126 is a key regulatory process of bax-mediated apoptosis. |
2014-10-21 |
2023-08-12 |
Not clear |
| Guomin Liu, Xukai Wang, Guoxi Shao, Qinyi Li. Genetically modified Schwann cells producing glial cell line-derived neurotrophic factor inhibit neuronal apoptosis in rat spinal cord injury. Molecular medicine reports. vol 9. issue 4. 2014-10-21. PMID:24549701. |
the engineered scs were characterized by their ability to express and secrete biologically active gdnf, which was shown to inhibit apoptosis of primary rat neurons induced by radiation, and upregulate the expression of b‑cell lymphoma 2 (bcl‑2) and downregulate the expression of bcl‑2 associated x protein (bax) in vitro. |
2014-10-21 |
2023-08-12 |
rat |
| V Gunda, O Bucur, J Varnau, P Vanden Borre, M J Bernasconi, R Khosravi-Far, S Parang. Blocks to thyroid cancer cell apoptosis can be overcome by inhibition of the MAPK and PI3K/AKT pathways. Cell death & disease. vol 5. 2014-10-21. PMID:24603332. |
a decrease in anti-apoptotic proteins, pakt, bcl-xl, mcl-1 and c-flip, coupled with an increase in the activator proteins, bax and bim, results in an increase in the bax to bcl-xl ratio that appears to be critical for sensitization and subsequent apoptosis of these resistant cells. |
2014-10-21 |
2023-08-12 |
Not clear |
| Jingyan Xiang, Yuwu Zhao, Jingjiong Chen, Jian Zho. Expression of basic fibroblast growth factor, protein kinase C and members of the apoptotic pathway in skeletal muscle of streptozotocin-induced diabetic rats. Tissue & cell. vol 46. issue 1. 2014-10-20. PMID:24008114. |
protein and mrna levels of the apoptosis promoting genes caspase-3 and bax were higher in skeletal muscle from stz-induced diabetic rats as compared to control animals (p<0.001 and p=0.037, respectively), while mrna and protein levels of bcl-2, an inhibitor of apoptosis, was lower in stz-induced diabetic rats versus control animals (p=0.026). |
2014-10-20 |
2023-08-12 |
rat |
| Lijun Sun, Jianbao Zhang, Kun Fang, Yan Ding, Liyu Zhang, Yali Zhan. Flavonoids from persimmon (Diospyros kaki) leaves (FPL) attenuate H2O2-induced apoptosis in MC3T3-E1 cells via the NF-κB pathway. Food & function. vol 5. issue 3. 2014-10-20. PMID:24488014. |
the mrna expression of inos, cox-2, bax, bcl-2, and caspase-3 and the protein expression of nf-κb/p65 showed that fpl significantly inhibited apoptosis in h2o2-stimulated mc3t3-e1 cells. |
2014-10-20 |
2023-08-12 |
Not clear |
| Chen Yan, Li Huang, Hong-Chun Liu, Duo-Zhi Chen, Hai-Yang Liu, Xiao-Hui Li, Yu Zhang, Mei-Yu Geng, Quan Chen, Xiao-Jiang Ha. Spiramine derivatives induce apoptosis of Bax(-/-)/Bak(-/-) cell and cancer cells. Bioorganic & medicinal chemistry letters. vol 24. issue 8. 2014-10-20. PMID:24684844. |
spiramine derivatives induce apoptosis of bax(-/-)/bak(-/-) cell and cancer cells. |
2014-10-20 |
2023-08-12 |
Not clear |