| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Mohammad Rafiqul Islam, Yoon Seok Roh, Jinho Kim, Chae Woong Lim, Bumseok Ki. Differential immune modulation by deoxynivalenol (vomitoxin) in mice. Toxicology letters. vol 221. issue 2. 2014-12-15. PMID:23791694. |
furthermore, don induced apoptosis in spleen, mlns, and pps, and don-induced apoptosis was promoted by increased expression of bax and decreased expression of bcl-2. |
2014-12-15 |
2023-08-12 |
mouse |
| Yu-Ting Tseng, Fang-Rong Chang, Yi-Ching L. The Chinese herbal formula Liuwei dihuang protects dopaminergic neurons against Parkinson's toxin through enhancing antioxidative defense and preventing apoptotic death. Phytomedicine : international journal of phytotherapy and phytopharmacology. vol 21. issue 5. 2014-12-15. PMID:24411708. |
also, lwdh-we inhibited neuronal apoptosis by improving mitochondrial membrane potential, increasing antiapoptotic protein bcl-2 expression, and down-regulating apoptotic signaling (bax, cytochrome c, cleaved-caspase-3) in mpp(+)-treated neurons. |
2014-12-15 |
2023-08-12 |
mouse |
| Huanlong Liu, Xueyan Chen, Yu Han, Chaoyi Li, Pingping Chen, Suwen Su, Yongjian Zhang, Zhenhua Pa. Rho kinase inhibition by fasudil suppresses lipopolysaccharide-induced apoptosis of rat pulmonary microvascular endothelial cells via JNK and p38 MAPK pathway. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 68. issue 3. 2014-12-12. PMID:24406296. |
the results suggested that fasudil effectively prevented lps-induced injury of rat pmvecs, as determined by mtt assay, ldh activity assay, apoptosis and western blot analysis of apoptosis-related proteins bcl-2 and bax. |
2014-12-12 |
2023-08-12 |
rat |
| Huanlong Liu, Xueyan Chen, Yu Han, Chaoyi Li, Pingping Chen, Suwen Su, Yongjian Zhang, Zhenhua Pa. Rho kinase inhibition by fasudil suppresses lipopolysaccharide-induced apoptosis of rat pulmonary microvascular endothelial cells via JNK and p38 MAPK pathway. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 68. issue 3. 2014-12-12. PMID:24406296. |
in addition, inhibiting the jnk and p38 pathways by sp600125 and sb203580 respectively attenuated the lps-induced apoptosis and regulated the expression of apoptosis-related proteins bcl-2 and bax. |
2014-12-12 |
2023-08-12 |
rat |
| W Jiang, L Chen, X J Zhang, J Chen, X C Li, W S Hou, N Xia. Red photon treatment inhibits apoptosis via regulation of bcl-2 proteins and ROS levels, alleviating hypoxic-ischemic brain damage. Neuroscience. vol 268. 2014-12-12. PMID:24607343. |
similar trends were observed for protein and mrna expression of bax and bcl-2, with short-term irradiation (6h) inhibiting apoptosis in pc12 cells. |
2014-12-12 |
2023-08-12 |
rat |
| Fei Xin, Wu Wei, Ai-Fang Ji, Xu-Liang Shen, Guo-Xiang Zhang, Mei-Xiang Zhang, Xian-Xian Li, Hai-Yan Zhan. [Inducing-apoptosis effect of brucine on human monocytic leukemia cell line THP-1 and its mechanism]. Zhongguo shi yan xue ye xue za zhi. vol 22. issue 3. 2014-12-11. PMID:24989276. |
the mechanism of thp-1 cell apoptosis induced by brucine may be related to the inhibition of bcl-2 and activation of bax. |
2014-12-11 |
2023-08-13 |
human |
| Li-Li Shi, Hua-Chao Zhu, Mei Zhang, Yang-Feng Liu, Yuan Wang, Jing Zhao, Fei Lei, Peng-Cheng H. [Effect of realgar on induction of apoptosis in DLBCL cell line SU-DHL-4 and its possible mechanisms]. Zhongguo shi yan xue ye xue za zhi. vol 22. issue 3. 2014-12-11. PMID:24989285. |
western blot showed that the expression of bcl-2 protein was down-regulated while the expressions of bax and caspase-3 protein were up-regulated when treating su-dhl-4 cells with realgar for 48 h. it is concluded that realgar can inhibit cell growth and induce cell apoptosis, which may be related with up-regulation of caspase-3 and bax expression and down-regulation the of bcl-2 expression. |
2014-12-11 |
2023-08-13 |
Not clear |
| Shiwen Zhang, Yunlong Li, Xiaoguang He, Shouan Dong, Yunchao Huang, Xiaojiang Li, Yuxiao Li, Congguo Jin, Yingying Zhang, Yuanling Wan. Photothermolysis mediated by gold nanorods modified with EGFR monoclonal antibody induces Hep-2 cells apoptosis in vitro and in vivo. International journal of nanomedicine. vol 9. 2014-12-10. PMID:24790435. |
egfrmab-aunrs, with appropriate laser irradiation, resulted in higher hep-2 cells apoptosis than aunrs did alone, in vitro, and was accompanied by alteration of reactive oxygen species (ros) production, ca(2+) release, change in mitochondrial membrane potential (ΔΨm), cytochrome c (cyt-c) release, active caspase-3 expression, and level of b-cell lymphoma 2 (bcl-2) and b-cell lymphoma 2 protein-associated x protein (bax). |
2014-12-10 |
2023-08-13 |
Not clear |
| Xian-rong Xiong, Li-jun Wang, Yong-sheng Wang, Song Hua, Xiang-dong Zi, Yong Zhan. Different preferences of IVF and SCNT bovine embryos for culture media. Zygote (Cambridge, England). vol 22. issue 1. 2014-12-09. PMID:22784408. |
moreover, rt-pcr analysis showed that embryos from ivf-produced zygotes cultured in msof had a lower expression level of stress-related and apoptosis genes (hsp70 and bax) than those cells cultured in g1.5/g2.5 medium, while scnt-derived embryos cultured in msof had a higher expression level of these genes than those embryos cultured in g1.5/g2.5 medium. |
2014-12-09 |
2023-08-12 |
cattle |
| Cristiane Oliveira, Gustavo Jacob Lourenço, José Augusto Rinck-Junior, Maria Letícia Cintra, Aparecida Machado Moraes, Carmen Silvia Passos Lim. Association between genetic polymorphisms in apoptosis-related genes and risk of cutaneous melanoma in women and men. Journal of dermatological science. vol 74. issue 2. 2014-12-09. PMID:24461648. |
the p53 arg72pro, mdm2 c.+309t>g, bax c.-248g>a, and bcl2 c.-717c>a polymorphisms have variable roles in the apoptosis pathways. |
2014-12-09 |
2023-08-12 |
Not clear |
| Zhenhong Ni, Bin Wang, Xufang Dai, Wen Ding, Ting Yang, Xinzhe Li, Seth Lewin, Liang Xu, Jiqin Lian, Fengtian H. HCC cells with high levels of Bcl-2 are resistant to ABT-737 via activation of the ROS-JNK-autophagy pathway. Free radical biology & medicine. vol 70. 2014-12-09. PMID:24576507. |
in hcc cells with low levels of bcl-2 (i.e., huh7 cells), abt-737 induced apoptosis via the sequential stimulation of ros, sustained activation of jnk, enhanced translocation of bax from the cytosol to the mitochondria, and release of cytochrome c. in sum, this study indicated that the activation of the ros-jnk-autophagy pathway may be an important mechanism by which hcc cells with high levels of bcl-2 are resistant to abt-737. |
2014-12-09 |
2023-08-12 |
Not clear |
| Zhen-Yu Wang, Jian-Hua Lin, Akram Muharram, Wen-Ge Li. Beclin-1-mediated autophagy protects spinal cord neurons against mechanical injury-induced apoptosis. Apoptosis : an international journal on programmed cell death. vol 19. issue 6. 2014-12-09. PMID:24623173. |
furthermore, by plasmid transfection, we showed that beclin-1-overexpressing neuronal cells responded to mechanical injury with greater lc3ii/lc3i conversion and cell viability, lower levels of apoptosis, higher bcl-2 expression, and unaltered bax expression as compared to vector control cells. |
2014-12-09 |
2023-08-12 |
Not clear |
| Kyriaki Zikaki, Ioanna-Katerina Aggeli, Catherine Gaitanaki, Isidoros Bei. Curcumin induces the apoptotic intrinsic pathway via upregulation of reactive oxygen species and JNKs in H9c2 cardiac myoblasts. Apoptosis : an international journal on programmed cell death. vol 19. issue 6. 2014-12-09. PMID:24668280. |
we also observed curcumin to impair cell survival by promoting apoptosis, evidenced by chromatin condensation, poly(adp-ribose) polymerase (parp) and caspase-3 cleavage, as well as bax translocation and cytochrome c release into the cytosol. |
2014-12-09 |
2023-08-12 |
Not clear |
| Chen Huang, Pei Zhang, Wei Wang, Yongsheng Xu, Minshu Wang, Xiaoyong Chen, Xuran Don. Long-term blue light exposure induces RGC-5 cell death in vitro: involvement of mitochondria-dependent apoptosis, oxidative stress, and MAPK signaling pathways. Apoptosis : an international journal on programmed cell death. vol 19. issue 6. 2014-12-09. PMID:24682673. |
long-term blue light exposure marked an increase in the expression of bax and active caspase-3 (p17), which was accompanied by bcl-2 down-regulation, and displayed features of the mitochondria-dependent apoptosis pathway. |
2014-12-09 |
2023-08-12 |
Not clear |
| Cher-Ming Liou, Shiow-Chwen Tsai, Chia-Hua Kuo, Hua Ting, Shin-Da Le. Cardiac Fas-dependent and mitochondria-dependent apoptosis after chronic cocaine abuse. International journal of molecular sciences. vol 15. issue 4. 2014-12-09. PMID:24722570. |
protein levels of cardiac bax, cytosolic cytochrome c, t-bid-to-bid, bak-to-bcl-xl, bax-to-bcl-2 ratio, activated caspase-9, and activated caspase-3 (mitochondria-dependent apoptosis) were significantly increased in the cocaine group, compared to the pbs group. |
2014-12-09 |
2023-08-13 |
rat |
| Hyun-Soo Shin, Mina Yu, Mijin Kim, Hack Sun Choi, Duk-Hee Kan. Renoprotective effect of red ginseng in gentamicin-induced acute kidney injury. Laboratory investigation; a journal of technical methods and pathology. vol 94. issue 10. 2014-12-09. PMID:25111692. |
gm-induced apoptosis of nrk-52e cells, which was associated with an increased expression of mitochondrial bax, cytosolic cytochrome c, and cleaved caspase-9 and -3, along with a decrease in bcl-2 expression, was also blocked by rge. |
2014-12-09 |
2023-08-13 |
rat |
| Ajda Coker-Gurkan, Elif Damla Arisan, Pinar Obakan, Esin Guvenir, Narcin Palavan Unsa. Inhibition of autophagy by 3-MA potentiates purvalanol-induced apoptosis in Bax deficient HCT 116 colon cancer cells. Experimental cell research. vol 328. issue 1. 2014-12-04. PMID:25088259. |
inhibition of autophagy by 3-ma potentiates purvalanol-induced apoptosis in bax deficient hct 116 colon cancer cells. |
2014-12-04 |
2023-08-13 |
Not clear |
| Ajda Coker-Gurkan, Elif Damla Arisan, Pinar Obakan, Esin Guvenir, Narcin Palavan Unsa. Inhibition of autophagy by 3-MA potentiates purvalanol-induced apoptosis in Bax deficient HCT 116 colon cancer cells. Experimental cell research. vol 328. issue 1. 2014-12-04. PMID:25088259. |
in this paper, our aim was to investigate molecular mechanism of cdk inhibitors on autophagy and apoptosis in wild type (wt) and bax deficient hct 116 cells. |
2014-12-04 |
2023-08-13 |
Not clear |
| Ajda Coker-Gurkan, Elif Damla Arisan, Pinar Obakan, Esin Guvenir, Narcin Palavan Unsa. Inhibition of autophagy by 3-MA potentiates purvalanol-induced apoptosis in Bax deficient HCT 116 colon cancer cells. Experimental cell research. vol 328. issue 1. 2014-12-04. PMID:25088259. |
we also established that both cdk inhibitors induced apoptosis through activating mitochondria-mediated pathway in caspase-dependent manner regardless of bax expression in hct 116 colon cancer cells. |
2014-12-04 |
2023-08-13 |
Not clear |
| Xiao-Ning Wang, Mei Zhan. [Apoptosis-inducing effect of valproic acid combined with arsenic trioxide on RPMI 8226 cells and its mechanism]. Zhongguo shi yan xue ye xue za zhi. vol 22. issue 4. 2014-12-04. PMID:25130820. |
it is concluded that vpa can enhance the sensitivity of rpmi 8226 cells to ato-induced apoptosis, which may be associated with decreasing the bcl-2 expression and increasing the bax, caspase-8 and caspase-9 gene expression. |
2014-12-04 |
2023-08-13 |
human |