| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Chen Yan, Li Huang, Hong-Chun Liu, Duo-Zhi Chen, Hai-Yang Liu, Xiao-Hui Li, Yu Zhang, Mei-Yu Geng, Quan Chen, Xiao-Jiang Ha. Spiramine derivatives induce apoptosis of Bax(-/-)/Bak(-/-) cell and cancer cells. Bioorganic & medicinal chemistry letters. vol 24. issue 8. 2014-10-20. PMID:24684844. |
in this study, we report that spiramine derivatives of spiramine c-d bearing α,β-unsaturated ketone induce apoptosis of bax(-/-)/bak(-/-) mefs cell, which is positively corresponding their cytotoxicity of tumor cell lines including multidrug resistance mcf-7/adr. |
2014-10-20 |
2023-08-12 |
Not clear |
| Chen Yan, Li Huang, Hong-Chun Liu, Duo-Zhi Chen, Hai-Yang Liu, Xiao-Hui Li, Yu Zhang, Mei-Yu Geng, Quan Chen, Xiao-Jiang Ha. Spiramine derivatives induce apoptosis of Bax(-/-)/Bak(-/-) cell and cancer cells. Bioorganic & medicinal chemistry letters. vol 24. issue 8. 2014-10-20. PMID:24684844. |
the results indicated that oxazolidine ring is necessary, and derivatives bearing double 'michael reaction acceptor' group would significantly increased activities both of inducing apoptosis of bax(-/-)/bak(-/-) cells and cytotoxicity of tumor cells. |
2014-10-20 |
2023-08-12 |
Not clear |
| Isuru Wijesekara, Chen Zhang, Quang Van Ta, Thanh-Sang Vo, Yong-Xin Li, Se-Kwon Ki. Physcion from marine-derived fungus Microsporum sp. induces apoptosis in human cervical carcinoma HeLa cells. Microbiological research. vol 169. issue 4. 2014-10-15. PMID:24071573. |
physcion has shown cytotoxic effect on human cervical carcinoma hela cells and its apoptosis induction in hela cells was investigated by the expressions of p53, p21, bax, bcl-2, caspase-9, and caspase-3 proteins. |
2014-10-15 |
2023-08-12 |
human |
| Isuru Wijesekara, Chen Zhang, Quang Van Ta, Thanh-Sang Vo, Yong-Xin Li, Se-Kwon Ki. Physcion from marine-derived fungus Microsporum sp. induces apoptosis in human cervical carcinoma HeLa cells. Microbiological research. vol 169. issue 4. 2014-10-15. PMID:24071573. |
the western blot analysis has revealed that physcion could significantly induce cell apoptosis through down-regulating of bcl-2 expression, up-regulating of bax expression, and activating the caspase-3 pathway. |
2014-10-15 |
2023-08-12 |
human |
| Yun Peng, Bo Jiang, Huiling Wu, Ruchun Dai, Liming Ta. Effects of genistein on neuronal apoptosis, and expression of Bcl-2 and Bax proteins in the hippocampus of ovariectomized rats. Neural regeneration research. vol 7. issue 36. 2014-10-15. PMID:25317139. |
effects of genistein on neuronal apoptosis, and expression of bcl-2 and bax proteins in the hippocampus of ovariectomized rats. |
2014-10-15 |
2023-08-13 |
rat |
| Yun Peng, Bo Jiang, Huiling Wu, Ruchun Dai, Liming Ta. Effects of genistein on neuronal apoptosis, and expression of Bcl-2 and Bax proteins in the hippocampus of ovariectomized rats. Neural regeneration research. vol 7. issue 36. 2014-10-15. PMID:25317139. |
at 15 weeks after ovariectomy, the expression of bcl-2 in the hippocampus of rats decreased and bax expression increased, with an obvious upregulation of apoptosis. |
2014-10-15 |
2023-08-13 |
rat |
| Yun Peng, Bo Jiang, Huiling Wu, Ruchun Dai, Liming Ta. Effects of genistein on neuronal apoptosis, and expression of Bcl-2 and Bax proteins in the hippocampus of ovariectomized rats. Neural regeneration research. vol 7. issue 36. 2014-10-15. PMID:25317139. |
however, intraperitoneal injection of genistein or 17β-estradiol for 15 consecutive weeks from the second day after operation upregulated bcl-2 protein expression, downregulated bax protein expression, and attenuated hippocampal neuron apoptosis. |
2014-10-15 |
2023-08-13 |
rat |
| Yun Peng, Bo Jiang, Huiling Wu, Ruchun Dai, Liming Ta. Effects of genistein on neuronal apoptosis, and expression of Bcl-2 and Bax proteins in the hippocampus of ovariectomized rats. Neural regeneration research. vol 7. issue 36. 2014-10-15. PMID:25317139. |
our experimental findings indicate that long-term intervention with genistein can lead to a decrease in apoptosis in hippocampal neurons following ovariectomy, upregulate the expression of bcl-2, and downregulate the expression of bax. |
2014-10-15 |
2023-08-13 |
rat |
| Ruili Li, Binglin Cui, Yuwen Li, Chao Zhao, Na Jia, Chao Wang, Yin Wu, Aidong We. A new synthetic Cu(II) compound, [Cu3(p-3-bmb)2Cl4·(CH3OH)2]n, inhibits tumor growth in vivo and in vitro. European journal of pharmacology. vol 724. 2014-10-14. PMID:24365492. |
cu(ii) compound treatment also induced apoptosis of hela and sgc-7901 cells which were accompanied with decrease in mitochondrial membrane potential, increase in reactive oxygen species production, release of cytochrome c, cleavage of caspase-9, caspase-3 and poly adp-ribose polymerase (parp) as well as activations of bcl-2 and bax. |
2014-10-14 |
2023-08-12 |
mouse |
| Anja Förster, Liane M Preussner, Jens M Seeger, Anja Rabenhorst, Hamid Kashkar, Ulrich Mrowietz, Karin Hartman. Dimethylfumarate induces apoptosis in human mast cells. Experimental dermatology. vol 22. issue 11. 2014-10-13. PMID:24112621. |
dmf-mediated apoptosis was associated with increased expression of bax and bak and activation of caspase-9 and caspase-6. |
2014-10-13 |
2023-08-12 |
human |
| Shiva Kant, Ajay Kumar, Sukh Mahendra Sing. Myelopoietic efficacy of orlistat in murine hosts bearing T cell lymphoma: implication in macrophage differentiation and activation. PloS one. vol 8. issue 12. 2014-10-12. PMID:24349275. |
the expression of apoptosis regulatory caspase-3, bax and bcl2 was modulated in the bmc of orlistat-administered tumor-bearing mice. |
2014-10-12 |
2023-08-12 |
mouse |
| Xin Jiang, Yang Bai, Zhiguo Zhang, Ying Xin, Lu Ca. Protection by sulforaphane from type 1 diabetes-induced testicular apoptosis is associated with the up-regulation of Nrf2 expression and function. Toxicology and applied pharmacology. vol 279. issue 2. 2014-10-12. PMID:24967692. |
diabetes significantly increased testicular apoptosis that was associated with endoplasmic reticulum stress and mitochondrial cell death pathways, shown by the increased expression of c/ebp homologous protein (chop), cleaved caspase-12, bax to bcl2 expression ratio, and cleaved caspase-3. |
2014-10-12 |
2023-08-13 |
mouse |
| Xiaobo Lu, Cuihong Jin, Jinghua Yang, Qiufang Liu, Shengwen Wu, Dandan Li, Yangyang Guan, Yuan Ca. Prenatal and lactational lead exposure enhanced oxidative stress and altered apoptosis status in offspring rats' hippocampus. Biological trace element research. vol 151. issue 1. 2014-10-10. PMID:23086308. |
to better understand the adverse effect on the developing central nervous system (cns) after lead exposure during pregnancy and lactation, the indexes of oxidative stress, apoptosis status, and bax and bcl-2 expression of offspring rats' hippocampus were determined. |
2014-10-10 |
2023-08-12 |
rat |
| Lihua Ye, Zhe Shi, Huixue Liu, Xiaoda Yang, Kui Wan. GdCl3 induced Hep G2 cell death through mitochondrial and external death pathways without significant elevation of ROS generation. Biological trace element research. vol 151. issue 1. 2014-10-10. PMID:23129526. |
cytochrome c (cyt c) and apoptosis inducing factor release, bax translocation, collapse of mitochondria membrane potential, caspase 3 and 8 activation, and bid cleavage were observed along with a sustained activation of extracellular signal-regulated kinase (erk) and c-jun nh2 terminal kinase (jnk). |
2014-10-10 |
2023-08-12 |
Not clear |
| Mi-Sung Kim, Jong-Eun Kim, Do Young Lim, Zunnan Huang, Hanyong Chen, Alyssa Langfald, Ronald A Lubet, Clinton J Grubbs, Zigang Dong, Ann M Bod. Naproxen induces cell-cycle arrest and apoptosis in human urinary bladder cancer cell lines and chemically induced cancers by targeting PI3K. Cancer prevention research (Philadelphia, Pa.). vol 7. issue 2. 2014-10-10. PMID:24327721. |
naproxen-induced cell death was mainly because of apoptosis in which a prominent downregulation of bcl-2 and upregulation of bax were involved. |
2014-10-10 |
2023-08-12 |
human |
| Fan-Min Meng, Jing-Bo Yang, Chun-Hui Yang, Yu Jiang, Yong-Feng Zhou, Bo Yu, Hong Yan. Vitexicarpin induces apoptosis in human prostate carcinoma PC-3 cells through G2/M phase arrest. Asian Pacific journal of cancer prevention : APJCP. vol 13. issue 12. 2014-10-09. PMID:23464460. |
furthermore, our study demonstrated that vitexicarpin induction of pc-3 cell apoptosis was associated with upregulation of the proapoptotic protein bax, and downregulation of antiapoptotic protein bcl-2, release of cytochrome c from mitochondria and decrease in mitochondrial membrane potential. |
2014-10-09 |
2023-08-12 |
human |
| Kangkai Wang, Jian Lei, Jiang Zou, Hui Xiao, Anlan Chen, Xiaoliu Liu, Ying Liu, Lei Jiang, Zihui Xiao, Xianzhong Xia. Mipu1, a novel direct target gene, is involved in hypoxia inducible factor 1-mediated cytoprotection. PloS one. vol 8. issue 12. 2014-10-09. PMID:24349374. |
moreover, our results revealed that mipu1 inhibited the expression of bax, an important pro-apoptosis protein associated with the intrinsic pathway of apoptosis, elevating the cytoprotection of hif-1 against hydrogen peroxide (h2o2)-mediated injury in h9c2 cells. |
2014-10-09 |
2023-08-12 |
Not clear |
| Jianying Huang, Hengmin Cui, Xi Peng, Jing Fang, Zhicai Zuo, Junliang Deng, Bangyuan W. The association between splenocyte apoptosis and alterations of Bax, Bcl-2 and caspase-3 mRNA expression, and oxidative stress induced by dietary nickel chloride in broilers. International journal of environmental research and public health. vol 10. issue 12. 2014-10-09. PMID:24351749. |
the association between splenocyte apoptosis and alterations of bax, bcl-2 and caspase-3 mrna expression, and oxidative stress induced by dietary nickel chloride in broilers. |
2014-10-09 |
2023-08-12 |
cat |
| Jianying Huang, Hengmin Cui, Xi Peng, Jing Fang, Zhicai Zuo, Junliang Deng, Bangyuan W. The association between splenocyte apoptosis and alterations of Bax, Bcl-2 and caspase-3 mRNA expression, and oxidative stress induced by dietary nickel chloride in broilers. International journal of environmental research and public health. vol 10. issue 12. 2014-10-09. PMID:24351749. |
in conclusion, dietary nicl2 in excess of 300 mg/kg caused apoptosis, altered bax, bcl-2 and caspase-3 mrna expression levels and contents, and induced oxidative stress in the spleen. |
2014-10-09 |
2023-08-12 |
cat |
| Jianying Huang, Hengmin Cui, Xi Peng, Jing Fang, Zhicai Zuo, Junliang Deng, Bangyuan W. The association between splenocyte apoptosis and alterations of Bax, Bcl-2 and caspase-3 mRNA expression, and oxidative stress induced by dietary nickel chloride in broilers. International journal of environmental research and public health. vol 10. issue 12. 2014-10-09. PMID:24351749. |
also, splenocyte apoptosis was closely related to the alternations of bax, bcl-2 and caspase-3 mrna expression, and oxidative damage. |
2014-10-09 |
2023-08-12 |
cat |