| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Bangyuan Wu, Hengmin Cui, Xi Peng, Jing Fang, Zhicai Zuo, Junliang Deng, Jianying Huan. Dietary nickel chloride induces oxidative stress, apoptosis and alters Bax/Bcl-2 and caspase-3 mRNA expression in the cecal tonsil of broilers. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association. vol 63. 2014-09-22. PMID:24184595. |
the purpose of this study was to investigate the effects of dietary nicl2 on antioxidant function, apoptosis, and the protein expression, mrna expression and contents of the bcl-2, bax and caspase-3 in the cecal tonsil of broilers. |
2014-09-22 |
2023-08-12 |
cat |
| Boris Sabirzhanov, Zaorui Zhao, Bogdan A Stoica, David J Loane, Junfang Wu, Carlos Borroto, Susan G Dorsey, Alan I Fade. Downregulation of miR-23a and miR-27a following experimental traumatic brain injury induces neuronal cell death through activation of proapoptotic Bcl-2 proteins. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 34. issue 30. 2014-09-22. PMID:25057207. |
importantly, administration of mir-23a and mir-27a mimics significantly reduced activation of puma, noxa, and bax as well as attenuated markers of caspase-dependent and -independent apoptosis after tbi. |
2014-09-22 |
2023-08-13 |
mouse |
| Li-Hua Liu, Ying-Jun Zhou, Lan Ding, Shun-Zhi Zhang, Ji Sun, Jian-Guo Ca. Induction of apoptosis by VB1 in breast cancer cells: the role of reactive oxygen species and Bcl-2 family proteins. International journal of molecular medicine. vol 33. issue 2. 2014-09-18. PMID:24276280. |
in this study, to our knowledge, we provide for the first time mechanistic evidence that vb1-induced apoptosis in the human breast cancer line, mda-mb-231, is associated with the generation of reactive oxygen species (ros), the activation of caspases and the modulation of the expression of myeloid leukemia cell differentiation protein 1 (mcl‑1), b cell lymphoma‑2 (bcl-2) and bcl-2-associated x (bax) proteins. |
2014-09-18 |
2023-08-12 |
human |
| Hongmei Meng, Tao Zhang, Weidong Liu, Huan Wang, Chunlei Wang, Zhe Zhao, Ning Liu, Wenbo Wan. Sodium fluoride induces apoptosis through the downregulation of hypoxia-inducible factor-1α in primary cultured rat chondrocytes. International journal of molecular medicine. vol 33. issue 2. 2014-09-18. PMID:24317498. |
downregulation of the bcl-2 protein and upregulation of bax, cleaved caspase-9, -12 and -3 proteins suggested that naf was capable of inducing apoptosis through the mitochondrial and endoplasmic reticulum pathways. |
2014-09-18 |
2023-08-12 |
rat |
| Tien-Huang Lin, Wen-Chi Chen, Hsi-Chin Wu, Wen-Shin Chien, Shang-Seu Lee, Fu-Jenn Tsai, Chang-Hai Tsai, Wei-Jen Ting, Sheng-Chu Kuo, Chih-Yang Huan. Induction of apoptosis in human DU145 prostate cancer cells by KHC-4 treatment. The Chinese journal of physiology. vol 57. issue 2. 2014-09-18. PMID:24694199. |
khc-4 suppressed the survival signaling p-pi3k and p-akt and protein levels of bcl-2 and bcl-xl, upregulated bax, cytochrome c and caspase 8/9 and induced apoptosis by mitochondrial-dependent pathway. |
2014-09-18 |
2023-08-13 |
human |
| Song Zhang, Yang Yang, Zhenxing Liang, Weixun Duan, Jian Yang, Juanjuan Yan, Ning Wang, Wenqiang Feng, Meiling Ding, Yongzhan Nie, Zhenxiao Ji. Silybin-mediated inhibition of Notch signaling exerts antitumor activity in human hepatocellular carcinoma cells. PloS one. vol 8. issue 12. 2014-09-16. PMID:24386256. |
furthermore, sil treatment decreased the expression of the notch1 intracellular domain (nicd), rbp-jκ, and hes1 proteins, upregulated the apoptosis pathway-related protein bax, and downregulated bcl2, survivin, and cyclin d1. |
2014-09-16 |
2023-08-12 |
human |
| Yiannis Drosos, Mirsini Kouloukoussa, Anne Carine Ostvold, Sophia Havaki, Eleni Katsantoni, Evangelos Marinos, Vassiliki Aleporou-Marino. Dynamic expression of the vertebrate-specific protein Nucks during rodent embryonic development. Gene expression patterns : GEP. vol 14. issue 1. 2014-09-15. PMID:24140890. |
in most tissues analyzed, the levels of nucks correlated with the levels of bax and activated caspase-3, which are indicative of apoptosis. |
2014-09-15 |
2023-08-12 |
mouse |
| Yiannis Drosos, Mirsini Kouloukoussa, Anne Carine Ostvold, Sophia Havaki, Eleni Katsantoni, Evangelos Marinos, Vassiliki Aleporou-Marino. Dynamic expression of the vertebrate-specific protein Nucks during rodent embryonic development. Gene expression patterns : GEP. vol 14. issue 1. 2014-09-15. PMID:24140890. |
the expression of nucks in both proliferating and quiescent cells and its correlation with bax levels and apoptosis strongly suggest that nucks plays complex roles in cell homeostasis. |
2014-09-15 |
2023-08-12 |
mouse |
| Van-Tinh Nguyen, Jung Suck Lee, Zhong-Ji Qian, Yong-Xin Li, Kil-Nam Kim, Soo-Jin Heo, You-Jin Jeon, Won Sun Park, Il-Whan Choi, Jae-Young Je, Won-Kyo Jun. Gliotoxin isolated from marine fungus Aspergillus sp. induces apoptosis of human cervical cancer and chondrosarcoma cells. Marine drugs. vol 12. issue 1. 2014-09-15. PMID:24368570. |
gliotoxin-induced activation of caspase-3, caspase-8 and caspase-9, down-regulation of bcl-2, up-regulation of bax and cytochromec (cyt c) release showed evidence for the gliotoxin activity on apoptosis. |
2014-09-15 |
2023-08-12 |
human |
| Yuan Liu, Yueling Zhang, Zhaohui Gu, Lina Hao, Juan Du, Qian Yang, Suping Li, Liying Wang, Shilei Gon. Cholecystokinin octapeptide antagonizes apoptosis in human retinal pigment epithelial cells. Neural regeneration research. vol 9. issue 14. 2014-09-15. PMID:25221599. |
peroxynitrite triggered apoptosis in these cells, and increased the expression of fas-associated death domain, bax, caspa-se-8 and bcl-2. |
2014-09-15 |
2023-08-13 |
human |
| Y Başımoğlu Koca, S Koc. Expressions and localizations of Bax/Bcl-2 proteins during metamorphosis of Pelophylax ridibundus. Biotechnic & histochemistry : official publication of the Biological Stain Commission. vol 89. issue 1. 2014-09-12. PMID:23957704. |
our results suggest that during tail regression due to metamorphosis, bcl-2 and bax proteins play key roles in the apoptosis of tail epidermis, subepidermal fibroblast layer, muscle and notochord cells. |
2014-09-12 |
2023-08-12 |
Not clear |
| Ping Yan, Shou-Quan Chen, Zhang-Ping Li, Jie Zhang, Ji-Ke Xue, Wan-Tie Wang, Wei-Jia Huang, Jun-Yan Cheng, Hui-Ping L. Effect of exogenous phosphocreatine on cardiomycytic apoptosis and expression of Bcl-2 and Bax after cardiopulmonary resuscitation in rats. World journal of emergency medicine. vol 2. issue 4. 2014-09-12. PMID:25215026. |
effect of exogenous phosphocreatine on cardiomycytic apoptosis and expression of bcl-2 and bax after cardiopulmonary resuscitation in rats. |
2014-09-12 |
2023-08-13 |
rat |
| Ping Yan, Shou-Quan Chen, Zhang-Ping Li, Jie Zhang, Ji-Ke Xue, Wan-Tie Wang, Wei-Jia Huang, Jun-Yan Cheng, Hui-Ping L. Effect of exogenous phosphocreatine on cardiomycytic apoptosis and expression of Bcl-2 and Bax after cardiopulmonary resuscitation in rats. World journal of emergency medicine. vol 2. issue 4. 2014-09-12. PMID:25215026. |
this study aimed to observe changes of cell apoptosis and expression of bcl-2 and bax protein on the myocardium after cpr in rats, and the protective effects of different doses of exogenous phosphocreatine (creatine phosphate, cp) on them. |
2014-09-12 |
2023-08-13 |
rat |
| Hao You, Meng-Meng Kong, Li-Ping Wang, Xiao Xiao, Han-Lin Liao, Zhuo-Yue Bi, Hong Yan, Hong Wang, Chun-Hong Wang, Qiang Ma, Yan-Qun Liu, Yong-Yi B. Inhibition of DNA-dependent protein kinase catalytic subunit by small molecule inhibitor NU7026 sensitizes human leukemic K562 cells to benzene metabolite-induced apoptosis. Journal of Huazhong University of Science and Technology. Medical sciences = Hua zhong ke ji da xue xue bao. Yi xue Ying De wen ban = Huazhong keji daxue xuebao. Yixue Yingdewen ban. vol 33. issue 1. 2014-09-11. PMID:23392706. |
lastly, hydroquinone and nu7026 exhibited synergistic effects on promoting apoptosis by increasing the protein levels of pro-apoptotic proteins bax and caspase-3 but decreasing the protein expression of anti-apoptotic protein bcl-2. |
2014-09-11 |
2023-08-12 |
human |
| Marissa V Powers, Melanie Valenti, Susana Miranda, Alison Maloney, Suzanne A Eccles, George Thomas, Paul A Clarke, Paul Workma. Mode of cell death induced by the HSP90 inhibitor 17-AAG (tanespimycin) is dependent on the expression of pro-apoptotic BAX. Oncotarget. vol 4. issue 11. 2014-09-11. PMID:24185264. |
using an isogenic model for bax knockout in hct116 human colon carcinoma cells, we demonstrate the induction of bax-dependent apoptosis at pharmacologically relevant concentrations of the hsp90 inhibitor 17-aag both in vitro and in tumor xenografts in vivo. |
2014-09-11 |
2023-08-12 |
human |
| Marissa V Powers, Melanie Valenti, Susana Miranda, Alison Maloney, Suzanne A Eccles, George Thomas, Paul A Clarke, Paul Workma. Mode of cell death induced by the HSP90 inhibitor 17-AAG (tanespimycin) is dependent on the expression of pro-apoptotic BAX. Oncotarget. vol 4. issue 11. 2014-09-11. PMID:24185264. |
removal of bax expression by homologous recombination reduces apoptosis in vitro and in vivo but allows a lower level of cell death via a predominantly necrotic mechanism. |
2014-09-11 |
2023-08-12 |
human |
| Marissa V Powers, Melanie Valenti, Susana Miranda, Alison Maloney, Suzanne A Eccles, George Thomas, Paul A Clarke, Paul Workma. Mode of cell death induced by the HSP90 inhibitor 17-AAG (tanespimycin) is dependent on the expression of pro-apoptotic BAX. Oncotarget. vol 4. issue 11. 2014-09-11. PMID:24185264. |
despite reducing apoptosis, the loss of bax does not alter the overall sensitivity to 17-aag in vitro or in vivo. |
2014-09-11 |
2023-08-12 |
human |
| Sopio Simonishvili, Mohit Raja Jain, Hong Li, Steven W Levison, Teresa L Woo. Identification of Bax-interacting proteins in oligodendrocyte progenitors during glutamate excitotoxicity and perinatal hypoxia-ischemia. ASN neuro. vol 5. issue 5. 2014-09-10. PMID:24195677. |
glutamate toxicity is a major cause of oligodendroglial death in diverse cns disorders, and previous studies have demonstrated that ampa/kainate receptors require the pro-apoptotic protein bax in opcs undergoing apoptosis. |
2014-09-10 |
2023-08-12 |
rat |
| Sopio Simonishvili, Mohit Raja Jain, Hong Li, Steven W Levison, Teresa L Woo. Identification of Bax-interacting proteins in oligodendrocyte progenitors during glutamate excitotoxicity and perinatal hypoxia-ischemia. ASN neuro. vol 5. issue 5. 2014-09-10. PMID:24195677. |
cofilin and bax associated in healthy opcs, whereas the bax-cofilin association was disrupted during glutamate-induced opc apoptosis. |
2014-09-10 |
2023-08-12 |
rat |
| Ruiting Wang, Xingbin Shen, Enhong Xing, Lihua Guan, Lisheng Xi. Scutellaria baicalensis stem-leaf total flavonoid reduces neuronal apoptosis induced by amyloid beta-peptide (25-35). Neural regeneration research. vol 8. issue 12. 2014-09-10. PMID:25206402. |
these experimental findings indicate that scutellaria baicalensis stem-leaf total flavonoid dose-dependently attenuates neuronal apoptosis induced by amyloid beta-peptide in the hippocampus, and it might mediate this by regulating the expression of bax, cytochrome c, caspase-3 and bcl-2. |
2014-09-10 |
2023-08-13 |
rat |